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Improving properties of fluxed iron ore pellets with high-silica by regulating liquid phase

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Journal of Iron and Steel Research International 2022年第9期29卷 1381-1392页

作者： Yuan-bo zhang Xijun chen Zi-jian Su shuo Liu Fang chen nan-yong Wu Tao jiang School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina Yangzhou Pacific Special Materials Co. Ltd.Yangzhou 225211JiangsuChina

With rapid development of the pellet production under the background of green development,high-quality iron concentrates were gradually exhausted;thus,using high-silica iron concentrates was expected to be a promising way to relieve resource pressure for pellet ***,increasing the proportion of high-silica acid pellets into the furnace led to worse blast furnace slag,and the metallurgical properties of high-silica pellets were *** understand the reciprocal effects of basicity(CaO/SiO_(2))and MgO content on the properties of the high-silica pellets,the phase compositions and microstructure were investigated using X-ray diffraction and scanning electron microscope,equipped with energy dispersive X-ray *** results indicated that simply increasing MgO content from O to 2.50 wt.%could decrease the reduction swelling index,but the compressive strength rapidly declined due to the formation of ***,adding CaO to 2.50 wt.%MgO pellets greatly improved the pellet qualities,which could be attributed to a substantial increase in the amount of high-melting-point silicate liquid phase.

关键词： Fluxed pellet High-silica Liquid phase Compressive strength-Reduction swelling

ENHANCING CHAIN SEGMENTS MOBILITY TO IMPROVE THE FRACTURE TOUGHNESS OF POLYPROPYLENE

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Chinese Journal of Polymer Science 2013年第2期31卷 232-241页

作者： Jing-wei chen jian Dai Jing-hui Yang nan zhang Ting huang 王勇 Key Laboratory of Advanced Technologies of Materials (Ministry of Education) School of Materials Science & Engineering Southwest Jiaotong University

As a part of a serial work about the annealing inducing improvement of fracture toughness of polypropylene （PP） articles, in this work, a highly efficient mobilizer was introduced into PP and the injection-molded samples were annealed at different temperatures. The mobility of chain segments of PP was investigated by measuring the glass transition temperature. Differential scanning calorimetry （DSC） and wide angle X-ray diffraction （WAXD） were used to characterize the variation of crystalline structure of PP during the annealing process. The fracture behaviors including notched Izod impact fracture and universal tensile fracture were investigated to detect the mechanical properties in response to the variations of both chain segments mobility and crystalline structures. It was found that the mobilizer greatly improved the chain segments mobility. Further results showed that the mobilizer also induced apparent changes of the glass transition temperature and the degree of crystallinity of PP during the annealing process. Consequently, the annealed PP samples containing a few amount of mobilizer exhibited largely increased fracture toughness.

关键词： Chain segments mobility Fracture toughness Mobilizer Annealing.

Annealing Induced Microstructure and Mechanical Property Changes of Impact Resistant Polypropylene Copolymer

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Chinese Journal of Polymer Science 2015年第9期33卷 1211-1211,1212-1224页

作者： Jing-wei chen jian Dai Jing-hui Yang nan zhang Ting huang 王勇 Chao-liang zhang Key Laboratory of Advanced Technologies of Materials (Ministry of Education) School of Materials Science & Engineering Southwest Jiaotong University State Key Laboratory of Oral Diseases Sichuan University

The effects of annealing on microstructure and mechanical properties of an impact resistant polypropylene copolymer （IPC） were investigated. Different annealing temperatures ranging from 80 ℃ to 160 ℃ were selected. The phase reorganization of IPC during annealing process was studied through morphological characterization technologies, including scanning electron microscopy （SEM） and transmission electron microscopy （TEM）. The crystalline structure changes in the IPC sample, including the iPP matrix and PE component, were investigated using wide angle X-ray diffraction （WAXD） and differential scanning calorimetry （DSC）. Dynamic mechanical analysis （DMA） was used to analyze the relaxation extent of 1PC before and after annealing. The results showed that annealing induced phase reorganization in IPC and the degree of phase reorganization depended on annealing temperature. The annealed IPC samples exhibited largely increased crystallinity compared with the unannealed one. Intensified damping peak with increased molecular chain mobility was achieved for the annealed IPC samples. At an appropriate annealing tem. perature （140 ℃）, largely enhanced impact strength was achieved for the annealed IPC sample. The toughening mechanisms were analyzed based on the phase reorganization and relaxation behavior.

关键词： Impact resistant polypropylene copolymer Annealing Microstructure Mechanical properties.

FGF/FGFR signaling in health and disease

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Signal Transduction and Targeted Therapy 2020年第1期5卷 927-964页

作者： Yangli Xie nan Su Jing Yang Qiaoyan Tan shuo huang Min Jin Zhenhong Ni Bin zhang Dali zhang Fengtao Luo Hangang chen Xianding Sun jian Q.Feng Huabing Qi Lin chen Department of Wound Repair and Rehabilitation Medicine State Key Laboratory of TraumaBurns and Combined InjuryTrauma CenterResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqingChina Department of Biomedical Sciences Texas A&M University College of DentistryDallasTX 75246USA

Growing evidences suggest that the fibroblast growth factor/FGF receptor(FGF/FGFR)signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment,differentiation,proliferation,and apoptosis of various types of *** this review,we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development,injury repair,and the pathophysiology of spectrum of diseases,which is a consequence of FGF signaling dysregulation,including cancers and chronic kidney disease(CKD).In this context,the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems.

关键词： homeostasis FGF diseases

Impact of baseline steroids on the efficacy of neoadjuvant immunochemotherapy in locally advanced esophageal squamous cell carcinoma

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3887-3897页

作者： Yuan-Heng huang Guo-Zhen Yang Hui-Guo chen Xiao-Jun Li Yong-Hui Wu Kai zhang jian-nan Xu jian zhang Department of Cardiothoracic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer MedicineGuangzhou 510060Guangdong ProvinceChina Guangdong Esophageal Cancer Institute Guangzhou 510060Guangdong ProvinceChina

BACKGROUND Immunochemotherapy involving the combination of programmed cell death 1/programmed cell death ligand 1 inhibitors with chemotherapy has advanced the treatment of locally advanced esophageal squamous cell carcinoma(ESCC).The use of corticosteroids as pretreatment might reduce immunotherapy *** To investigate the impact of baseline corticosteroid use on neoadjuvant immunochemotherapy(nIC)outcomes in locally advanced ESCC *** Patients with locally advanced ESCC who received nIC at Sun Yat-sen University Cancer Center and the Third Affiliated Hospital of Sun Yat-sen University were *** were divided into dexamethasone and antihistamine groups on the basis of the administered *** efficacy and safety were evaluated,as well as its impact on short-term efficacy[complete pathological response(pCR),major pathological response(MPR)]and long-term efficacy[overall survival(OS),progression-free survival(PFS)]of *** From September 2019 to September 2023,142 patients were *** severe treatment-related adverse events or deaths were *** occurrence was greater in the antihistamine group(P=0.014).Short-term efficacy was not significantly different:The pCR rates were 29.9%and 40.0%,and the MPR rates were 57.9%and 65.7%in the dexamethasone and antihistamine groups,*** long-term efficacy was not significantly different:The 2 years OS rates were 95.2%and 93.5%,and the 2 years PFS rates were 90.3%and 87.8%.Subgroup analysis revealed no difference in OS between the 20 mg dexamethasone group and the<20 mg dexamethasone group,but PFS was significantly greater in the 20 mg dexamethasone group(93.9%vs 56.4%,P=0.001).CONCLUSION Dexamethasone or antihistamines can be used before nIC in locally advanced ESCC without affecting short-or long-term *** 20 mg dexamethasone before nIC may improve PFS in ESCC.

关键词： Esophageal squamous cell carcinoma Neoadjuvant immunochemotherapy Dexamethasone Antihistamines Treatment efficacy

Ultrasonic vibration enabled under-liquid forming of metallic glasses

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Science Bulletin 2024年第2期69卷 163-166页

作者： Xin Li Luyao Li Sajad Sohrabi Jia'nan Fu Zhen Li Zhe chen Rongce Sun Yu zhang Jinbiao huang Heting zhang jian Zhu Xiangyan chen Kaikai Song jiang Ma School of Mechanical Electrical&Information EngineeringShandong UniversityWeihai 264209China State Key Laboratory of Radio Frequency Heterogeneous Integration College of Mechatronics and Control EngineeringShenzhen UniversityShenzhen 518060China Department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhen 518055China Shenzhen Research Institute of Shandong University Shenzhen 518057China

Advancements in forming technology offer significant advantages for the manufacturing industry,including enhanced efficiency,energy conservation,and improved material utilization[1].However,traditional additive manufacturing[2],thermoplastic forming[3],and laser cutting[4]encounter challenges when applied in under-liquid environments,mainly due to difficulties in temperature control and heat source provision.

关键词： glasses liquid metallic

Biological nano agent produced by hypoxic preconditioning stem cell for stroke treatment

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nano Research 2023年第5期16卷 7413-7421页

作者： Xin-Chi jiang Hong-Hui Wu Tianyuan zhang Yun-Fei Dong Yao-Sheng Li Ting huang An-Hao Tian Peng-Xiang chen Xian-Ming Lin Ying-Zhi huang Chong Liu Xiang-nan zhang Zhong chen Yasuhiko Tabata jian-Qing Gao Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang UniversityHangzhou 310058China Department of Pathology and Pathophysiology and Department of Neurosurgery of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310058China The Third Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310058China SinoCell Biotechnology Ltd. Ningbo 315000China Key Laboratory of Medical Neurobiology of the Ministry of Health of China Institute of Pharmacology&ToxicologyCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Laboratory of Biomaterials Department of Regeneration Science and EngineeringInstitute for Frontier Life and Medical SciencesKyoto UniversityKyoto 606-8501Japan

Exosomes make a significant contribution during stem cell-based therapy due to the abundant *** evidence implies exosomes can act as potential biological nano *** herein propose hypoxic preconditioning for neural stem cells(NSCs)that could produce hypoxic exosomes for efficient treatment of ischemic *** preconditioning on NSCs significantly altered the miRNAs encapsulated in ***,hypoxic exosomes could target the injured brain to regulate the microenvironment to inhibit neuroinflammation and promote blood–brain barrier permeability ***,the autologous NSCs in Nestin-CreER mice could be activated by hypoxic exosomes to facilitate nerve *** hypoxic preconditioning,exosomes further exerted therapeutic effects on both survival(25%)and behavioral outcomes in ischemic stroke ***,hypoxic preconditioning NSCs can produce effective nano agent and may represent a promising strategy for clinical neurorestorative therapy.

关键词： exosomes hypoxia-preconditioning stem cells ischemic stroke microenvironment

Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters

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Protein & Cell 2020年第6期11卷 446-451页

作者： Meng Gao jian huang Xin jiang Yafei Yuan Huanhuan Pang Shuchen Luo nan Wang chengbo Yao Zuwan Lin Debing Pu shuo zhang Pengcheng Sun Zhuoyi Liu Yu Xiao Qian Wang Zeping Hu Hang Yin Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing 100084China Tsinghua University-Peking University Joint Center for Life Sciences Tsinghua UniversityBeijing 100084China Beijing Advanced Innovation Center for Structural Biology Tsinghua UniversityBeijing 100084China State Key Laboratory of Membrane Biology School of Life SciencesTsinghua UniversityBeijing 100084China Department of Molecular Biology Princeton UniversityPrincetonNJ 08544USA School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China Laboratory Medicine Center Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Dear Editor,Different from normal differentiated cells,metabolic reprogramming was spotted in cancer cells,due to increased demand for energy and macromolecule synthesis during their rapid proliferation(Hanahan and Weinberg,2011;Pavlova and Thompson,2016).Most cancer cells prefer anaerobic glycolysis even with oxygen in the environment due to its higher speed to produce macromolecular materials required for biosynthesis(Vander Heiden et al.,2009;DeBerardinis and Chandel,2016).But to compensate for the lower efficiency of anaerobic glycolysis in producing ATP,these cancer cells demand much higher glucose supply(Warburg,1956;Vander Heiden et al.,2009).These metabolic characteristics point to the huge demand of cancer cells for carbohydrate substrates,which creates the possibility of treating tumors by exploiting this feature(Patra et al.,2013;DeBerardinis and Chandel,2016).

关键词： al. glycolysis cancer

Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

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Signal Transduction and Targeted Therapy 2024年第1期9卷 259-270页

作者： Yan Sun Xiu-Na Yang Shuang-Shuang Yang Yi-Zhu Lyu Bing zhang Kai-Wen Liu Na Li Jia-chen Cui Guang-Xiang huang cheng-Lin Liu Jie Xu jian-Qing Mi Zhu chen Xiao-Hu Fan Sai-Juan chen shuo chen Shanghai Institute of Hematology National Research Center for Translational MedicineState Key Laboratory of Medical GenomicsRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Department of Hematology Second Hospital of Dalian Medical UniversityDalian 116023China National Facility for Protein Science Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Legend Biotech China Nanjing 211112China Shanghai Immune Therapy Institute Shanghai Cancer InstituteState Key Laboratory of Oncogenes and Related GenesRenji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Wondercel Biotechnology Shenzhen 518052China

Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity,safeguarding receptor activation,and facilitating amplification of signal transduction across the cellular ***,cell-surface antigeninduced multimerization(dubbed AIM herein)has not yet been consciously leveraged in chimeric antigen receptor(CAR)engineering for enriching T cell-based *** co-developed ciltacabtagene autoleucel(cilta-cel),whose CAR incorporates two B-cell maturation antigen(BCMA)-targeted nanobodies in tandem,for treating multiple *** we elucidated a structural and functional model in which BCMA-induced cilta-cel CAR multimerization amplifies myeloma-targeted T cell-mediated *** analysis of BCMA–nanobody complexes revealed atomic details of antigen–antibody hetero-multimerization whilst analytical ultracentrifugation and small-angle X-ray scattering characterized interdependent BCMA apposition and CAR juxtaposition in ***-induced nanobody CAR multimerization enhanced cytotoxicity,alongside elevated immune synapse formation and cytotoxicity-mediating cytokine release,towards myeloma-derived *** results provide a framework for contemplating the AIM approach in designing next-generation CARs.

关键词： cytotoxicity Antigen elevated