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Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ERα signaling

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2210-2227页

作者： Qing Zhao Junjie Feng Fubin Liu Qianxin Liang Manlin Xie jiaming dong Yanfang Zou Jiali Ye Guilong Liu Yue Cao Zhaodi Guo Hongzhi Qiao Lei Zheng Kewei Zhao Guangzhou Key Laboratory of Chinese Medicine Research on Prevention and Treatment of Osteoporosis the Third Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510378China Guangdong Engineering Research Center of Chinese Herbal-derived Vesicles Guangzhou University of Chinese MedicineGuangzhou 510006China Department of Laboratory Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Guangdong Engineering and Technology Research Center for Rapid Diagnostic Biosensors Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China The Fifth Affiliated Hospital Sun Yat-sen University Zhuhai 519000China Department of Blood Transfusion Guangdong Heyou International HospitalFoshan 528306China School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China

Although various anti-osteoporosis drugs are available,the limitations of these therapies,including drug resistance and collateral responses,require the development of novel anti-osteoporosis agents.Rhizoma Drynariae displays a promising anti-osteoporosis effect,while the effective component and mechanism remain unclear.Here,we revealed the therapeutic potential of Rhizoma Drynariae-derived nanovesicles(RDNVs)for postmenopausal osteoporosis and demonstrated that RDNVs potentiated osteogenic differentiation of human bone marrow mesenchymal stem cells(hBMSCs)by targeting estrogen receptor-alpha(ERα).RDNVs,a natural product isolated from fresh Rhizoma Drynariae root juice by differential ultracentrifugation,exhibited potent bone tissue-targeting activity and anti-osteoporosis efficacy in an ovariectomized mouse model.RDNVs,effectively internalized by hBMSCs,enhanced proliferation and ERαexpression levels of hBMSC,and promoted osteogenic differentiation and bone formation.Mechanistically,via the ERαsignaling pathway,RDNVs facilitated mRNA and protein expression of bone morphogenetic protein 2 and runt-related transcription factor 2 in hBMSCs,which are involved in regulating osteogenic differentiation.Further analysis revealed that naringin,existing in RDNVs,was the active component targeting ERαin the osteogenic effect.Taken together,our study identified that naringin in RDNVs displays exciting bone tissue-targeting activity to reverse osteoporosis by promoting hBMSCs proliferation and osteogenic differentiation through estrogen-like effects.

关键词： Rhizoma Drynariae-derived nanovesicles Bone marrow mesenchymal stem cells Bone targeting Osteogenic differentiation ERαsignaling Naringin Bone morphogenetic protein 2 Runt-related transcription factor 2

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Dendrite-free Zn deposition initiated by nanoscale inorganic-organic coating-modified 3D host for stable Zn-ion battery

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SusMat 2024年第2期4卷 13-27页

作者： jiaming dong Junwen Duan Ruirui Cao Wang Zhang Kangkang Fang Hao Yang Ying Liu Zhitao Shen Fumin Li Rong Liu Mengqi Jin Longhui Lei Huilin Li Chong Chen Henan Key Laboratory of Photovoltaic Materials College of Future TechnologyHenan UniversityKaifengChina College of Optoelectronic Engineering Shenzhen UniversityShenzhenChina Institute of Solid-State Physics Chinese Academy of SciencesHefeiChina

A 3D nanostructured scaffold as the host for zinc enables effective inhibition of anodic dendrite growth.However,the increased electrode/electrolyte interface area provided by using 3D matrices exacerbates the passivation and localized corrosion of the Zn anode,ultimately bringing about the degradation of the electrochemical performance.Herein,a nanoscale coating of inorganic-organic hybrid(α-In_(2)Se_(3)-Nafion)onto a flexible carbon nanotubes(CNTs)framework(ISNF@CNTs)is designed as a Zn plating/stripping scaffold to ensure uniform Zn nucleation,thus achieving a dendrite-free and durable Zn anode.The intro-duced inorganic-organic interfacial layer is dense and sturdy,which hinders the direct exposure of deposited Zn to electrolytes and mitigates the side reactions.Meanwhile,the zincophilic nature of ISNF can largely reduce the nucleation energy barrier and promote the ion-diffusion transportation.Consequently,the ISNF@CNTs@Zn electrode exhibits a low-voltage hysteresis and a superior cycling life(over 1500 h),with dendrite-free Zn-plating behaviors in a typical symmetrical cell test.Additionally,the superior feature of ISNF@CNTs@Zn anode is further demonstrated by Zn-MnO_(2)cells in both coin and flexible quasi-solid-state configurations.This work puts forward an inspired remedy for advanced Zn-ion batteries.

关键词： 2D/3D configuration dendrite-free inorganic-organic layer interfacial protection Zn-ion batteries

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Hopf Algebra of Labeled Simple Graphs

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Open Journal of Applied Sciences 2023年第1期13卷 120-135页

作者： jiaming dong Huilan Li School of Mathematics and Statistics Shandong Normal University Jinan China

A lot of combinatorial objects have a natural bialgebra structure. In this paper, we prove that the vector space spanned by labeled simple graphs is a bialgebra with the conjunction product and the unshuffle coproduct. In fact, it is a Hopf algebra since it is graded connected. The main conclusions are that the vector space spanned by labeled simple graphs arising from the unshuffle coproduct is a Hopf algebra and that there is a Hopf homomorphism from permutations to label simple graphs.

关键词： Hopf Algebra Labeled Simple Graph Conjunction Product Unshuffle Coproduct Compatibility

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Semi-interpenetrating polymer networks toward sulfonated poly(ether ether ketone) membranes for high concentration direct methanol fuel cell

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Chinese Chemical Letters 2019年第2期30卷 299-304页

作者： Xupo Liu Yunfeng Zhang Shaofeng Deng Cuicui Li jiaming dong Jiaying Wang Zehui Yang Deli Wang Hansong Cheng Sustainable Energy Laboratory Faculty of Materials Science and Chemistry China University of Geosciences (Wuhan) Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education Hubei Key Laboratory of Material Chemistry and Service Failure School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Low methanol permeability of proton exchange membranes (PEMs) is greatly important for direct methanol fuel cells (DMFCs). Here, sulfonated poly (ether ether ketone) (SPEEK) based semiinterpenetrating polymer networks (semi-IPNs) are successfully prepared by interpenetrating SPEEK into the in-situ synthesized crosslinking networks. The polymeric networks are formed by the covalent bonds between bromobenzyl groups of bro mo methylated poly (phenylene oxide) and amine groups of diamine linkers as well as the ionic bonds between amine species and sulfonated groups. Two linkers without and with sulfonated groups are applied to fabricate the semi-IPNs. The core properties of the membranes, like phase separation, water uptake, proton conductivity and methanol permeability, are systematically studied and compared. The DMFCs assembled by using the semi-IPN membranes display better performance than Nafion 117 in high concentration methanol solutions. The present work provides a facile way to prepare PEMs with enhanced DMFC performance.

关键词： Direct methanol fuel cell Proton exchange membrane Semi-interpenetrating polymer networks Sulfonated poly(ether ether ketone) Bromomethylated poly(phenylene oxide)

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LPI雷达信号调制识别及参数估计研究进展

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系统工程与电子技术 2024年第6期46卷 1908-1924页

作者：王海英张群英成文海董家铭刘小军中国科学院空天信息创新研究院北京100090 电磁辐射与探测技术院重点实验室北京100090 中国科学院大学电子电气与通信工程学院北京100049

低截获概率(low probability of intercept,LPI)雷达已成为新时代雷达装备中关键的技术体制或工作模式,针对LPI雷达信号调制识别及参数估计方法的研究是当前雷达对抗侦察领域的热点。首先,分析了几种典型LPI雷达信号的脉内特征,梳理了LP... 详细信息

低截获概率(low probability of intercept,LPI)雷达已成为新时代雷达装备中关键的技术体制或工作模式,针对LPI雷达信号调制识别及参数估计方法的研究是当前雷达对抗侦察领域的热点。首先,分析了几种典型LPI雷达信号的脉内特征,梳理了LPI雷达信号调制识别及参数估计的传统和主流方法,并说明其原理、优缺点和研究现状。最后,总结了现有LPI雷达信号调制识别及参数估计方法尚存的问题,并指出其未来发展趋势,旨在为今后的研究提供参考。

关键词：雷达对抗侦察低截获概率雷达信号脉内特征调制识别参数估计

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Effect of wire mesh casing treatment on axial compressor performance and stability

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Chinese Journal of Aeronautics 2024年第3期37卷 60-76页

作者： Ming ZHANG jiaming ZHANG Jiahao HU Xu dong Dakun SUN Xiaofeng SUN School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beihang Hangzhou Innovation Institute Yuhang Hangzhou 310023China National Key Laboratory of Science and Technology on Aero-Engine Aero-Thermodynamics Beihang UniversityBeijing 100191China

In this paper,a kind of Wire Mesh Casing Treatment(WMCT)is proposed to improve the stable operating range of the compressor.In contrast to the traditional circumferential groove,as for WMCT,a layer of wire mesh is laid on the surface of the circumferential groove.Parametric studies were conducted on the low-speed axial flow compressor,including the groove width,axial location,and mesh count.The optimum axial location for WMCT is related to its groove width.A higher wire mesh count results in a smaller compressor stall margin improvement.Steady simulations were carried out to study the effect of WMCT on the flow structure of the compressor.The wire mesh in the WMCT has a certain flow resistance,which restricts the flow into and out of the groove.Due to the WMCT,the flow parameter in the tip region of the rotor is less sensitive to changes in the operating conditions of the compressor.The WMCT causes the rotor tip blade loading to shift backward,inhibiting the formation of spill forward of the leakage flow,and thus improving the stability of the compressor.The flow resistance on the groove surface is a new degree-of-freedom for the casing treatment designer.

关键词： Axial compressor Wire mesh casing treatment Tip clearance flow Stall margin Blade loading

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Syrosingopine,an anti-hypertensive drug and lactate transporter(MCT1/4)inhibitor,activates hepatic stellate cells and exacerbates liver fibrosis in a mouse model

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Genes & Diseases 2024年第4期11卷 28-30页

作者： Meichun Guo Yannian Gou Xiangyu dong Jiamin Zhong Aohua Li Ailing Hao Tongchuan He jiaming Fan Ministry of Education Key Laboratory of Diagnostic Medicine and the School of Laboratory Diagnostic MedicineChongqing Medical UniversityChongqing 400016China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA

Syrosingopine is an anti-hypertensive drug and can cause high intracellular lactate levels and end-product inhibition of lactate dehydrogenase by inhibiting the lactate transporters MCT1 and MCT4.Previous studies have shown that syrosingopine plays an essential role in the process of glycolytic blockade,ATP depletion,and cell death in cancer due to high intracellular levels of lactate.

关键词： hypertensive MCT1 drug

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A simplified noncryogenic strategy to transport mesenchymal stem cells: Potential applications in cell therapy and regenerative medicine

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Genes & Diseases 2024年第3期11卷 26-29页

作者： Xiangyu dong Yannian Gou Meichun Guo Jiamin Zhong Aohua Li Ailing Hao Wei Zeng Rex C.Haydon Hue H.Luu Russell R.Reid Tongchuan He Yan Xu jiaming Fan Ministry of Education Key Laboratory of Diagnostic Medicine And Department of Clinical BiochemistryCollege of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Laboratory of Craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Institute of Sports Medicine Beijing Key Laboratory of Sports InjuriesPeking University Third HospitalBejing 100191China

With the rapid advances in stem cell research and po-tential cell-based therapies,there is an urgent need to develop safe and reliable cell transport strategies.Except for autologous stem cell-based therapies,allogeneic stem cell therapies and ex vivo genetically engineered cell therapies would require safe,efficient,and reliable cell preservation and transport methods.

关键词： transport methods simplified

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基于风电机组可靠性的风电场平准化成本模型研究

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太阳能学报 2022年第10期43卷 304-311页

作者：刘喜梅崔阳董建明王开让河北金融学院管理学院保定071051 电力规划设计总院(电力规划总院有限公司) 北京100011 国网冀北电力有限公司电力科学研究院(华北电力科学研究院有限责任公司) 北京100045 风光储并网运行技术国家电网公司重点实验室北京100045

考虑综合风电场总体运行成本、风电机组可靠性及风电场发电量等多个维度,从风电场全生命周期视角出发,建立基于风电机组可靠性的风电场平准化成本模型,并通过算例分析得出,提升风电机组可靠性可降低风电机组的故障维护成本,提高风电场... 详细信息

考虑综合风电场总体运行成本、风电机组可靠性及风电场发电量等多个维度,从风电场全生命周期视角出发,建立基于风电机组可靠性的风电场平准化成本模型,并通过算例分析得出,提升风电机组可靠性可降低风电机组的故障维护成本,提高风电场运行小时数,进而降低风电场平准化成本。在此基础上测算当前阶段风电实现平价上网需达到的利用小时数,最后给出促进风电发展的合理化建议。

关键词：风电成本风电机组可靠性风电运维平准化成本风电利用小时数

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注意力优化的轻量目标检测网络及应用

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智能系统学报 2023年第3期18卷 506-516页

作者：吴珺董佳明刘欣王春枝湖北工业大学计算机学院湖北武汉430068 武汉理工大学材料科学与工程学院湖北武汉430070

本文以轻量化改进YOLO网络为主要目标,选取具有代表性的(squeeze and excitation,SE)通道注意力模块和比较新颖的(coordinate attention,CA)空间注意力模块与YOLOv5s目标检测网络进行融合,提出新的轻量网络模型YOLOv5s-CCA(YOLOv5s-C3-coordinate attention)和YOLOv5s-CSE(YOLOv5s-C3-squeeze-and-excitation)。通过进一步探索,论证出SE和CA注意力模块在YOLOv5s目标检测网络中最优插入位置的策略,实验论证了在轻量化网络模型中CA优于SE注意力模块。本文所提出的YOLOv5s-CCA网络模型在PASCAL VOC 2012数据集和Global Wheat 2020数据集中实现了网络轻量化并且精度较原始网络有所提升;并证实了YOLOv5s-CCA具有一定的通用性和泛化性,为其在实际生产与生活中进行轻量化部署提供了可靠的数据支撑和一定参考价值。

关键词：目标检测深度学习计算机视觉轻量化网络空间注意力通道注意力一阶目标检测网络损失函数

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