Syrosingopine,an anti-hypertensive drug and lactate transporter(MCT1/4)inhibitor,activates hepatic stellate cells and exacerbates liver fibrosis in a mouse model

作     者：Meichun Guo Yannian Gou Xiangyu Dong Jiamin Zhong Aohua Li Ailing Hao Tongchuan He Jiaming Fan Meichun Guo;Yannian Gou;Xiangyu Dong;Jiamin Zhong;Aohua Li;Ailing Hao;Tong-Chuan He;Jiaming Fan

作者机构：Ministry of Education Key Laboratory of Diagnostic Medicineand the School of Laboratory Diagnostic MedicineChongqing Medical UniversityChongqing 400016China Molecular Oncology LaboratoryDepartment of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2024年第11卷第4期

页      面：28-30页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported in part by research grants from the National Natural Science Foundation of China(No.82102696 to JMF)and the National Institutes of Health(USA)(No.CA226303 to T.-C.He) supported by the Mabel Green Myers Research Endowment Fund and The University of Chicago Orthopaedics Alumni Fund 

主　　题：hypertensive MCT1 drug 

摘      要：Syrosingopine is an anti-hypertensive drug and can cause high intracellular lactate levels and end-product inhibition of lactate dehydrogenase by inhibiting the lactate transporters MCT1 and *** studies have shown that syrosingopine plays an essential role in the process of glycolytic blockade,ATP depletion,and cell death in cancer due to high intracellular levels of lactate.