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Nano Research 2022年第8期15卷 7655-7661页

作者： jialu Li Dengfeng Wang Guofeng Zhang Changgang Yang Wenli Guo xue Han Xiuqing Bai Ruiyun Chen Chengbing Qin Jianyong Hu Liantuan Xiao Suotang Jia State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser SpectroscopyCollaborative Innovation Center of Extreme OpticsShanxi UniversityTaiyuan 030006China

The two frequently observed phenomena,photoluminescence(PL)blinking and quantum-confined Stark effect(QCSE)-induced spectral diffusion,are not conducive to the applications of colloidal quantum dots(QDs).It remains elusive how these two phenomena are linked to each *** the potential link between blinking and QCSE could facilitate the adoption of appropriate strategies that can simultaneously suppress both PL blinking and spectral *** this work,we investigated the blinking mechanism and QCSE of single CdSe/CdS/ZnS QDs in the presence of positive and negative surface charges using single-dot PL *** found that the negative surface charges can simultaneously suppress PL blinking and spectral diffusion of single *** the other hand,the positive surface charges could change the blinking mechanisms of QDs from Auger-blinking to band-edge carrier(BC)-*** types of QCSE were observed,and a significant QCSE-induced spectral broadening of 5.25 nm was measured,which could be attributed to the hopping of surface charges between different surface-trap *** on these findings,several theoretical models are proposed to explain various phenomena observed.

关键词： single quantum dots blinking mechanisms quantum-confined Stark effect surface charges surface traps

孤独症谱系障碍和精神分裂症青少年的面部表情识别能力

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中国心理卫生杂志 2024年第4期38卷 289-295页

作者：苏醒吉兆正尹婷妮王慧宫小云赵荔阳刘勤一韩刚强孙秉玺彭舒晨陈佳璐李雪刘靖北京大学第六医院北京大学精神卫生研究所国家卫生健康委员会精神卫生学重点实验室(北京大学)国家精神心理疾病临床医学研究中心(北京大学第六医院)北京100083

目的:探讨孤独症谱系障碍、精神分裂症青少年的面部表情识别能力特点。方法:入组12~18岁孤独症谱系障碍患者77例、精神分裂症患者67例及年龄相匹配的正常发育青少年68例,完成面部表情识别任务测查。结果:孤独症谱系障碍组基础面部表情... 详细信息

目的:探讨孤独症谱系障碍、精神分裂症青少年的面部表情识别能力特点。方法:入组12~18岁孤独症谱系障碍患者77例、精神分裂症患者67例及年龄相匹配的正常发育青少年68例,完成面部表情识别任务测查。结果:孤独症谱系障碍组基础面部表情识别任务总分低于精神分裂症组及正常发育组(Ps0.05);孤独症谱系障碍组和精神分裂症组间复杂表情识别任务总分差异无统计学意义(P>0.05),但两组均低于正常对照组(均P<0.001)。结论:孤独症谱系障碍和精神分裂症青少年均存在面部表情识别缺陷,孤独症谱系障碍表现为基础和复杂面部表情识别缺陷,而精神分裂症表现为复杂面部表情识别缺陷。

关键词：孤独症谱系障碍精神分裂症面部表情识别青少年

Dedifferentiated human umbilical cord mesenchymal stem cell reprogramming of endogenous hSDF-1a expression participates in neural restoration in hypoxic-ischemic brain damagerats

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Genes & Diseases 2021年第3期8卷 331-343页

作者： Zhou Xiaoqin Liu Jia Dai Mengjie Gu jialu Bi Yang Wang Yuting Hu Huajian Liu Bo Zhang Xiaojun Li Zhongyue Chen Jie Li Tingyu Zhan xue Department of Gastroenterology Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and Disorders(Chongqing)401122PR China International Science and Technology Cooperation Base of Child Development and Critical Disorders Children’sHospital of Chongqing Medical UniversityChongqing401122PR China Department of Pediatric Research Institute Chongqing Key Laboratory of Child Health and NutritionChildren’s Hospital of Chongqing Medical UniversityChongqing401122PR China Department of Neonatology Chongqing Health Center for Womenand Children400021PR China Child Health Centre of Northwest Women and Children’s Hospital USA

The transplantation of human umbilical cord mesenchymal stem cells(hUC-MSCs)can promote hypoxic-ischemic brain damage(HIBD)nerve repair,but finding suitable seed cells to optimize transplantation and improve treatment efficiency is an urgent problem to be *** this study,we induced hUC-MSCs into dedifferentiated hUC-MSCs(De-hUC-MSCs),and the morphology,stem cell surface markers,proliferation and tri-directional differentiation ability of the De-hUC-MSCs and hUC-MSCs were detected.A whole-gene chip was utilized for genome cluster,gene ontology and KEGG pathway analyses of differentially expressed ***-hUC-MSCs were transplanted into HIBD rats,and behavioral experiments and immunofluorescence assays were used to assess the therapeutic effect.A lentivirus vector for human stromal cell-derived factor-1(hSDF-1a)was constructed,and the role of hSDF-1a in the neuroprotective effect and mechanism of De-hUC-MSCs was ***-hUC-MSCs displayed similar cell morphology,stem cell surface marker expression,cell proliferation and even three-dimensional differentiation ability as hUC-MSCs but exhibited greater treatment potential in *** reprogramming mechanism of hSDF-1a participated in the dedifferentiation *** successfully constructing a stable hSDF-1a cell line,we found that De-hUC-MSCs might participate in nerve repair through the hSDF-1a/CXCR4/PI3K/Akt ***-hUC-MSCs reprogramming of endogenous hSDF-1a expression may mediate the hSDF-1a/CXCR4/PI3K/Akt pathway involved in nerve repair in HIBD rats.

关键词： Dediffer entiation Human umbilicalcord mesenchymal stem cells Hypoxic-ischemic brain damage Neurorestoration Reprogramming Stromal cell-derived factor-1

Textbook outcome in gallbladder carcinoma after curative-intent resection:a 10-year retrospective single-center study

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Chinese Medical Journal 2023年第14期136卷 1680-1689页

作者： Qi Li Hengchao Liu Qi Gao Feng xue jialu Fu Mengke Li Jiawei Yuan Chen Chen Dong Zhang Zhimin Geng Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Department of Pediatric Surgery The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710004China

Background:Textbook outcome(TO)can guide decision-making among patients and clinicians during preoperative patient selection and postoperative quality *** explored the factors associated with achieving a TO for gallbladder carcinoma(GBC)after curative-intent resection and analyzed the effect of adjuvant chemotherapy(ACT)on TO and non-TO ***:A total of 540 patients who underwent curative-intent resection for GBC at the Department of Hepatobiliary Surgery of the First Affiliated Hospital of Xi’an Jiaotong University from January 2011 to December 2020 were retrospectively *** logistic regression was used to investigate the factors associated with ***:Among 540 patients with GBC who underwent curative-intent resection,223 patients(41.3%)achieved a *** incidence of TO ranged from 19.0%to 51.0%across the study period,with a slightly increasing trend over the study *** multivariate analysis showed that non-TO was an independent risk factor for prognosis among GBC patients after resection(P=0.003).Age≤60 years(P=0.016),total bilirubin(TBIL)level≤34.1 mmol/L(P<0.001),well-differentiated tumor(P=0.008),no liver involvement(P<0.001),and T1-2 stage disease(P=0.006)were independently associated with achieving a TO for GBC after *** and after propensity score matching(PSM),the overall survival outcomes of non-TO GBC patients who received ACT and those who did not were statistically significant;ACT improved the prognosis of patients in the non-TO group(P<0.05).Conclusion:Achieving a TO is associated with a better long-term prognosis among GBC patients after curative-intent resection,and ACT can improve the prognosis of those with non-TO.

关键词： Gallbladder neoplasms Textbook outcome Curative-intent resection Adjuvant chemotherapy Prognosis Nomogram

Efficient generation of mouse ESCs-like pig induced pluripotent stem cells

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Protein & Cell 2014年第5期5卷 338-342页

作者： Qi Gu Jie Hao Tang Hai Jianyu Wang Yundan Jia Qingran Kong Juan Wang Chunjing Feng Binghua xue Bingteng Xie Shichao Liu Jinyu Li Yilong He jialu Sun Lei Liu Liu Wang Zhonghua Liu Qi Zhou State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of Sciences Intelligent Polymer Research Institute ARC Center of Excellence for Electromaterials Science AIIM Facility University of Wollongong College of Life Science Northeast Agricultural University of China

Dear Editor,Porcine induced pluripotency stem cells (piPSCs) are promised in basic research, animal husbandry and regenerative medicine. However, the efficiency of the piPSCs induction has been low and the generated piPSCs varied in cell morphology and cell characteristics. Here we report a novel approach to improve efficiency of piPSCs generation.

关键词： Nuclear Transfer Human ESCs Mouse ESCs Nuclear Transfer Embryo Oct4 Promoter

多GPU异构模型实现放射治疗中卷积/积分算法的快速计算

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核技术 2021年第12期44卷 20-26页

作者：赖佳路宋莹周莉白雪侯氢四川大学华西医院放疗科成都610041 四川大学原子核科学技术研究所辐射物理及技术教育部重点实验室成都610064

卷积/积分(Convolution/Superposition,CS)算法是精度仅次于蒙特卡罗(Monte Carlo,MC)的光子线剂量计算算法。该算法的计算速度远远快于蒙特卡罗算法,但仍不能完全满足临床放射治疗要求。借助单颗图形显卡GPU(Tesla C1060)对CS算法进行... 详细信息

卷积/积分(Convolution/Superposition,CS)算法是精度仅次于蒙特卡罗(Monte Carlo,MC)的光子线剂量计算算法。该算法的计算速度远远快于蒙特卡罗算法,但仍不能完全满足临床放射治疗要求。借助单颗图形显卡GPU(Tesla C1060)对CS算法进行加速后,与传统的CPU串行计算相比,计算速度可以提高60倍,单野计算时间达到1 min左右,能适用于简单的三维适形计划(3DCRT),但无法满足调强放射治疗计划(Intensity Modulated Radiation Therapy,IMRT)的速度要求。本文通过设计"CPU+多GPU"异构模型加速方案,探讨使用不同GPU个数的加速情况。结果表明:CS算法加速倍数与GPU使用个数并非呈线性关系,通过合理选择GPU的使用数量和程序代码优化可达到相关计算的速度要求;基于中高端的Tesla C2015 GPU,采用"CPU+7个GPU"模型的CS算法,单野计算时间缩减到9 s,与单用CPU相比能提高207倍,可满足临床调强计划设计要求。

关键词：卷积/积分算法多GPU 剂量计算

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优化乳杆菌高产共轭亚油酸的研究进展

中国食品学报 2022年第10期22卷 391-405页

作者：成晓艳张丁洁田艾迪刘瑛陈佳璐陈莹莹洛雪沈阳农业大学食品学院沈阳110866

共轭亚油酸(CLA)是亚油酸(LA)的一组位置和空间异构体的总称,其中具有生理活性的异构体是c9,t11-CLA和t10,c12-CLA,它们具有丰富的营养价值和医药价值。在乳球菌属和链球菌属等乳酸菌、丙酸杆菌、瘤胃细菌以及其它菌属中,分离纯化得到... 详细信息

共轭亚油酸(CLA)是亚油酸(LA)的一组位置和空间异构体的总称,其中具有生理活性的异构体是c9,t11-CLA和t10,c12-CLA,它们具有丰富的营养价值和医药价值。在乳球菌属和链球菌属等乳酸菌、丙酸杆菌、瘤胃细菌以及其它菌属中,分离纯化得到的亚油酸异构酶,可催化LA异构化为CLA,利用酶法合成CLA可以有效弥补传统化学合成法的缺陷。本文概述了近年来国内外利用紫外、微波、等离子体诱变、离子注入等物理或化学方法诱变、改造亚油酸异构酶,优化产酶条件和酶学特性,还阐述利用定点突变、基因敲除等基因工程方法,对生产菌株进行改造和培养条件优化,提高CLA产量的相关研究,为进一步筛选出高产共轭亚油酸菌株和CLA的产业化应用提供理论依据。

关键词：共轭亚油酸亚油酸异构酶诱变基因敲除优化

Construction of Ecological City from the Perspective of Ecological Progress—A Case Study of Liaocheng City

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Journal of Landscape Research 2013年第3期5卷 17-18页

作者： LIU Kai WANG Chengxin SHI jialu SUN xue School of Population Resources and Environment Shandong Normal University

Ecological progress is a new stage in the development of human civilization and ecological city is a new city development model under the concept of ecological progress. In this paper, favorable conditions and constraints for constructing an ecological city are analyzed and construction concepts are put forward. It contributes to the construction of Liaocheng into an ecological city and has a referential value for other cities.

关键词： Ecological progress Ecological city Liaocheng

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叉车整车装配工艺及调试技术

时代汽车 2020年第21期 136-138页

作者：陆珈璐薛文灵柳州市第二职业技术学校广西柳州市545006

叉车是工业搬运车辆,由车架系统、传动系统、门架系统、属具系统等部件的有机组合,通过机、电、液的有效联动实现生产的半自动化;叉车的装配,是将各种零部件或总成按一定的工艺要求组装出完整产品的生产过程本文主要是针对柳工叉车的流... 详细信息

叉车是工业搬运车辆,由车架系统、传动系统、门架系统、属具系统等部件的有机组合,通过机、电、液的有效联动实现生产的半自动化;叉车的装配,是将各种零部件或总成按一定的工艺要求组装出完整产品的生产过程本文主要是针对柳工叉车的流水线进行装配工艺和调试技术研究。

关键词：叉车装配工艺调试技术

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“中钰半夏1号”新品种选育研究

世界科学技术-中医药现代化 2022年第4期24卷 1452-1458页

作者：王家禄李西文冯雪杨一零陈士林中国中医科学院中药研究所北京100800 武汉九州钰民医药科技有限公司武汉430074

目的选育繁殖系数高、丰产的半夏新品种,阐明“中钰半夏1号”的选育过程,明确该新品种的推广价值。方法收集全国不同地区半夏种质并建立半夏种质资源圃,经过综合评比最终选择以复叶多、双珠芽的贵州省农家优良品系DB-CL-03为繁育对象,... 详细信息

目的选育繁殖系数高、丰产的半夏新品种,阐明“中钰半夏1号”的选育过程,明确该新品种的推广价值。方法收集全国不同地区半夏种质并建立半夏种质资源圃,经过综合评比最终选择以复叶多、双珠芽的贵州省农家优良品系DB-CL-03为繁育对象,采用集团化选育连续择优去劣,通过品比试验、区域试验,优选出符合新品种要求的“中钰半夏1号”。结果“中钰半夏1号”的复叶数平均5枚,繁殖系数约为9.2,是对照的2.6倍“。中钰半夏1号”平均每亩产量291.47 kg,较对照增产44.38%;总有机酸(以琥珀酸计)含量比对照提高15.2%。结论“中钰半夏1号”繁殖系数高、丰产性好、性状表现稳定,适宜引种于中国西南部和中部半夏种植区,具有良好的推广价值。

关键词：半夏育种繁殖系数珠芽复叶