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Tenglong Buzhong granules(藤龙补中颗粒) inhibits the growth of SW620 human colon cancer in vivo

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Journal of Traditional Chinese Medicine 2022年第5期42卷 701-706页

作者： LI Miao ZHENG jialu WANG Shuangshuang chen Lei PENG Xiao chen Jinfang AN Hongmei HU Bing Institute of Traditional Chinese Medicine in Oncology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Oncology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Shanghai University of Traditional Chinese Medicine Shanghai 201203China Department of Science and Technology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

OBJECTIVE: To observe the anticancer effects of the granular preparation of Tenglong Buzhong decoction(藤龙补中汤,TBD), i.e Tenglong Buzhong granules(藤龙补中颗粒, TBG), in human SW620 colon cancer. METHODS: BALB/c nude mice were subcutaneously transplanted with SW620 cells, and treated with TBG(2.56 g/kg, once per day) and/or 5-Fu(104 mg/kg, once per week) for 21 d. Apoptosis, Caspase activities and cellular senescence were measured by commercial kits. The protein expression and phosphorylation were detected by Western blot or immunohistochemistry. RESULTS: TBG and 5-Fu inhibited tumor growth. The tumor inhibition rate of the TBG, 5-Fu, and TBG+5-Fu groups was 42.25%, 51.58%, and 76.08%, respectively. Combination of TBG and 5-Fu showed synergetic anticancer effects. TBG and 5-Fu induced apoptosis, activated caspase-3,-8, and-9, increased SMAC expression, inhibited XIAP expression. TBG induced cellular senescence, upregulated cyclin-dependent kinase inhibitor 1a(CDKN1a) and cyclin-dependent kinase inhibitor 2a(CDKN2a) expression, and inhibited phosphorylation of retinoblastoma-associated protein(RB) and expression of cyclin E1(CCNE1) and cyclindependent kinases(CDK) 2. TBG also inhibited angiogenesis accompanied by downregulation of vascular endothelial growth factor(VEGF) and hypoxiainducible factor-1α(HIF-1α). CONCLUSIONS: TBG inhibits SW620 colon cancer growth, induces apoptosis via SMAC-XIAP-Caspases signaling, induces cellular senescence through CDKN1a/CDKN2a-RB-E2F signaling, inhibits angiogenesis by down-regulation of HIF-1α and VEGF, and enhances the effects of 5-Fu.

关键词： colonic neoplasms apoptosis cellular senescence signal transduction angiogenesis Tenglong Buzhong granules

Oral administration of D-glucosamine confers broad-spectrum protection against human coronaviruses including SARS-CoV-2

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3228-3231页

作者： Qi Qi Qi chen Yumei Dong Kun Wang jialu Wang Guiming Jin Aiping Zheng Rong Zhang Yongqiang Deng Yuhuan Li chengfeng Qin Xiaotao Duan State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and ToxicologyBeijingChina State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijingChina General Hospital of PLA Central Theater Command Department of Disease Prevention and Control WuhanChina Institute of Medicinal Biotechnology Chinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina School of Basic Medical Sciences Fudan UniversityShanghaiChina

Dear Editor,The novel human coronavirus(HCoV)SARS-CoV-2 is the causative agent of the current pandemic COVID-19,posing a huge threat to global public health.1 Up to now,seven HCoVs have been *** HCoVs(including SARS-CoV,HCoV-229E,HCoV-NL63,HCoV-OC43,HCoV-HKU1,MERS-CoV,and SARS-CoV-2)cause a range of symptoms from the common cold to severe pathologies.

关键词： spectrum administration threat

肝内胆管癌不同大体病理类型的预后分析及临床特征的多中心回顾性研究

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腹部外科 2023年第3期36卷 189-196页

作者：唐玥于小鹏陈家璐覃德龙陈晨吴泓程张军宋天强毛先海何宇梁霄翟文龙李敬东孙传东马凯邱应和汤地耿智敏汤朝晖全志伟上海交通大学医学院附属新华医院普通外科上海200092 西安交通大学第一附属医院肝胆外科陕西西安710061 四川大学华西医院肝胆外科四川成都610041 东南大学附属中大医院肝胆胰外科江苏南京210009 天津医科大学肿瘤医院肝胆肿瘤科天津300060 湖南省人民医院肝胆外科湖南长沙410005 陆军军医大学第一附属医院肝胆外科重庆400038 浙江大学医学院附属邵逸夫医院肝胆胰外科浙江杭州310020 郑州大学第一附属医院肝胆胰与肝移植外科河南郑州450052 川北医学院附属医院肝胆外科四川南充637000 青岛大学附属医院肝胆胰外科山东青岛266003 海军军医大学第三附属医院胆道外科上海200433 中山大学附属第七医院普外科广东深圳518000

目的分析肝内胆管癌(intrahepatic cholangiocarcinoma,ICC)不同大体病理类型对预后的影响以及不同大体病理类型与临床特征的关系。方法采用回顾性病例对照研究方法,收集于2010-2020年中国13家三级甲等医院行根治性切除术的660例ICC病... 详细信息

目的分析肝内胆管癌(intrahepatic cholangiocarcinoma,ICC)不同大体病理类型对预后的影响以及不同大体病理类型与临床特征的关系。方法采用回顾性病例对照研究方法,收集于2010-2020年中国13家三级甲等医院行根治性切除术的660例ICC病人的临床和病理学资料,进行1∶1倾向性评分匹配(卡钳值:0.02),采用Kaplan-Meier法绘制生存曲线,log-rank检验进行生存分析。单因素分析采用χ^(2)检验,P<0.05为差异有统计学意义。结果1∶1倾向性评分匹配后,肿块型ICC病人与管周浸润型ICC病人的预后差异有统计学意义(P<0.05)。当ICC病人处于T1分期时,肿块型ICC病人与管周浸润型ICC病人的预后差异有统计学意义(P<0.05)。肿块型ICC病人(513例)和管周浸润型ICC病人(102例)在地区、年龄、结石病史、Child-Pugh分级、腹痛、腹胀、黄疸、发热、中性粒细胞计数、淋巴细胞计数、谷丙转氨酶、总胆红素、总白蛋白、肿瘤位置、肿瘤大小方面比较,差异均有统计学意义(均P<0.05);肿块型ICC和管内生长型ICC病人(45例)在地区、年龄、谷丙转氨酶、肿瘤大小情况比较,差异均有统计学意义(均P<0.05)。结论与肿块型相比,管周浸润型ICC病人具有更良好的预后。可进一步探究对管周浸润型ICC病人进行免疫治疗的有效性,以及肿块型ICC病人对靶向治疗的敏感性。

关键词：肝内胆管癌大体病理类型多中心研究回顾性研究

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不同国家护士执业权限的比较

中华现代护理杂志 2024年第16期30卷 2212-2217页

作者：张雨陈洁王晓杰张嘉璐张蒙梁晓英王天一薄海欣中国医学科学院北京协和医院急诊医学科北京100730 中国医学科学院北京协和医院妇科内分泌与生殖中心北京100730 中国医学科学院北京协和医院乳腺外科病房北京100730 中国医学科学院北京协和医院护理部北京100730

目的对各国护士执业权限政策及文献进行比较研究,为优化国内护士执业权限的扩展提供参考。方法系统PubMed、Web of Science、中国知网、万方数据库以及各国的护理政策组织网站中护士执业的相关文献。检索时限为建库至2023年6月。结果共... 详细信息

目的对各国护士执业权限政策及文献进行比较研究,为优化国内护士执业权限的扩展提供参考。方法系统PubMed、Web of Science、中国知网、万方数据库以及各国的护理政策组织网站中护士执业的相关文献。检索时限为建库至2023年6月。结果共纳入6个国家的19篇文献。共纳入注册种类及要求、执业方式、处方权限、监管部门、相关法律等要素。对我国护士分层管理的启示主要包括完善分层注册及管理体系,明确护士工作职责;引导护理人才合理流动,鼓励护士多点执业;培养护士处方能力,赋予护士处方权限;完善监管与法律保护,保证护士执业有法律可依共4个方面。结论我国护士团队亟需执业权限的补充,补充基层医疗卫生人才,承担起慢病患者的个案管理、改善患者的生活质量等职能,满足社区、家庭护理需求的重任。

关键词：综述护士执业权限

Identification of two migratory colon ILC2 populations differentially expressing IL-17A and IL-5/IL-13

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Science China(Life Sciences) 2023年第1期66卷 67-80页

作者： Hongzhi Liu Liang Li Yanyun Hao jialu Li Zhaoyuan Liu Jingjing Qi Jingjing Zhang Ningbo Wu Dandan Wu Caixia Gao Lei chen Lei Shen Jinke cheng Bing Su Shanghai Institute of Immunology Department of Immunology and Microbiologythe Ministry of Education Key Laboratory of Cell Death and DifferentiationShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Biochemistry and Molecular Cell Biology Shanghai Key Laboratory for Tumor Microenvironment and InflammationShanghai Jiao Tong University School of MedicineShanghai 200025China State Key Laboratory for Oncogenes and Related Genes Key Laboratory of Gastroenterology and HepatologyMinistry of HealthDivision of Gastroenterology and HepatologyShanghai Institute of Digestive DiseaseRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai Cancer InstituteShanghai Institute of Digestive DiseaseShanghai 200001China Department of Biliary and Pancreatic Surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Group 2 innate lymphoid cells(ILC2s)play important tissue resident roles in anti-parasite immunity,allergic immune response,tissue homeostasis,and tumor ***2s are considered tissue resident cells with little proliferation at steady *** studies have shown that a subset of small intestinal ILC2s could leave their residing tissues,circulate and migrate to different organs,including lung,liver,mesenteric LN and spleen,upon ***,it remains unknown whether other ILC populations with migratory behavior *** this study,we find two major colon ILC2 populations with potential to migrate to the lung in response to IL-25 *** subset expresses IL-17A and resembles inflammatory ILC2s(iILC2s)but lacks CD27 expression,whereas the other expresses CD27 but not *** addition,the IL-17A^(+)ILC2s express lower levels of CD127,CD25,and ST2 than CD27^(+)ILC2s,which express higher levels of IL-5 and ***,we found that both colon ILC2 populations still maintained their colonic features of preferential expression of IL-17A and CD27,IL-5/IL-13,***,our study identifies two migratory colon ILC2 subsets with unique surface markers and cytokine profiles which are critical in regulating lung and colon immunity and homeostasis.

关键词： colon ILC2s IL-17A CD27 iILC2 lung inflammation

Dedifferentiated human umbilical cord mesenchymal stem cell reprogramming of endogenous hSDF-1a expression participates in neural restoration in hypoxic-ischemic brain damagerats

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Genes & Diseases 2021年第3期8卷 331-343页

作者： Zhou Xiaoqin Liu Jia Dai Mengjie Gu jialu Bi Yang Wang Yuting Hu Huajian Liu Bo Zhang Xiaojun Li Zhongyue chen Jie Li Tingyu Zhan Xue Department of Gastroenterology Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and Disorders(Chongqing)401122PR China International Science and Technology Cooperation Base of Child Development and Critical Disorders Children’sHospital of Chongqing Medical UniversityChongqing401122PR China Department of Pediatric Research Institute Chongqing Key Laboratory of Child Health and NutritionChildren’s Hospital of Chongqing Medical UniversityChongqing401122PR China Department of Neonatology Chongqing Health Center for Womenand Children400021PR China Child Health Centre of Northwest Women and Children’s Hospital USA

The transplantation of human umbilical cord mesenchymal stem cells(hUC-MSCs)can promote hypoxic-ischemic brain damage(HIBD)nerve repair,but finding suitable seed cells to optimize transplantation and improve treatment efficiency is an urgent problem to be *** this study,we induced hUC-MSCs into dedifferentiated hUC-MSCs(De-hUC-MSCs),and the morphology,stem cell surface markers,proliferation and tri-directional differentiation ability of the De-hUC-MSCs and hUC-MSCs were detected.A whole-gene chip was utilized for genome cluster,gene ontology and KEGG pathway analyses of differentially expressed ***-hUC-MSCs were transplanted into HIBD rats,and behavioral experiments and immunofluorescence assays were used to assess the therapeutic effect.A lentivirus vector for human stromal cell-derived factor-1(hSDF-1a)was constructed,and the role of hSDF-1a in the neuroprotective effect and mechanism of De-hUC-MSCs was ***-hUC-MSCs displayed similar cell morphology,stem cell surface marker expression,cell proliferation and even three-dimensional differentiation ability as hUC-MSCs but exhibited greater treatment potential in *** reprogramming mechanism of hSDF-1a participated in the dedifferentiation *** successfully constructing a stable hSDF-1a cell line,we found that De-hUC-MSCs might participate in nerve repair through the hSDF-1a/CXCR4/PI3K/Akt ***-hUC-MSCs reprogramming of endogenous hSDF-1a expression may mediate the hSDF-1a/CXCR4/PI3K/Akt pathway involved in nerve repair in HIBD rats.

关键词： Dediffer entiation Human umbilicalcord mesenchymal stem cells Hypoxic-ischemic brain damage Neurorestoration Reprogramming Stromal cell-derived factor-1

Textbook outcome in gallbladder carcinoma after curative-intent resection:a 10-year retrospective single-center study

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Chinese Medical Journal 2023年第14期136卷 1680-1689页

作者： Qi Li Hengchao Liu Qi Gao Feng Xue jialu Fu Mengke Li Jiawei Yuan chen chen Dong Zhang Zhimin Geng Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Department of Pediatric Surgery The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710004China

Background:Textbook outcome(TO)can guide decision-making among patients and clinicians during preoperative patient selection and postoperative quality *** explored the factors associated with achieving a TO for gallbladder carcinoma(GBC)after curative-intent resection and analyzed the effect of adjuvant chemotherapy(ACT)on TO and non-TO ***:A total of 540 patients who underwent curative-intent resection for GBC at the Department of Hepatobiliary Surgery of the First Affiliated Hospital of Xi’an Jiaotong University from January 2011 to December 2020 were retrospectively *** logistic regression was used to investigate the factors associated with ***:Among 540 patients with GBC who underwent curative-intent resection,223 patients(41.3%)achieved a *** incidence of TO ranged from 19.0%to 51.0%across the study period,with a slightly increasing trend over the study *** multivariate analysis showed that non-TO was an independent risk factor for prognosis among GBC patients after resection(P=0.003).Age≤60 years(P=0.016),total bilirubin(TBIL)level≤34.1 mmol/L(P<0.001),well-differentiated tumor(P=0.008),no liver involvement(P<0.001),and T1-2 stage disease(P=0.006)were independently associated with achieving a TO for GBC after *** and after propensity score matching(PSM),the overall survival outcomes of non-TO GBC patients who received ACT and those who did not were statistically significant;ACT improved the prognosis of patients in the non-TO group(P<0.05).Conclusion:Achieving a TO is associated with a better long-term prognosis among GBC patients after curative-intent resection,and ACT can improve the prognosis of those with non-TO.

关键词： Gallbladder neoplasms Textbook outcome Curative-intent resection Adjuvant chemotherapy Prognosis Nomogram

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基于有机小分子近红外发光材料的研究进展

海南师范大学学报（自然科学版） 2024年第1期37卷 78-86页

作者：方媛媛张程陈嘉荟刘佳潞芮风蝶李梦瑶孙伟熊雯婧彭明生海南师范大学化学与化工学院海南海口571158 海南省激光技术与光电功能材料重点实验室/海口市功能材料与光电化学重点实验室海南海口571158 海南师范大学热带药用植物化学教育部重点实验室海南海口571158

近红外有机发光二极管(Organic light emitting diodes,OLEDs)在夜间显示、生物传感和通讯等领域具有广阔的应用前景。其中有机小分子发光材料具有制作成本低、重现性好、结构和发光特性易调节、发光效率高等优点,根据其发光特性主要分... 详细信息

近红外有机发光二极管(Organic light emitting diodes,OLEDs)在夜间显示、生物传感和通讯等领域具有广阔的应用前景。其中有机小分子发光材料具有制作成本低、重现性好、结构和发光特性易调节、发光效率高等优点,根据其发光特性主要分为传统荧光材料、热激发延迟荧光(Thermally activated delayed fluorescence,TADF)材料、局部电荷转移杂化态(Hybrid locally-electron and charge-transfer,HLCT)材料等几类。本文主要综述了近五年来报道的基于有机小分子的近红外发光材料的研究进展,并根据不同的特性对材料进行了分类,对未来的发展前景进行了展望,为进一步合成各方面性能良好的近红外有机小分子发光材料提供了一定的理论基础。

关键词：近红外有机小分子有机发光材料

室旁核H_(2)S对高盐性高血压大鼠内质网应激蛋白GRP78的影响

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黑龙江医药科学 2024年第3期47卷 1-5页

作者：李宇恒孙晓明张东东苏嘉璐陈淑月尤清欣谷青芸梁衍锋佳木斯大学基础医学院黑龙江佳木斯154007

目的:通过外源给予高盐性高血压大鼠室旁核(paraventricular nucleus,PVN)硫化氢(hydrogen sulfide,H 2S)供体GYY4137,观察PVN中GRP78的蛋白表达含量变化,探讨室旁核H 2S对高盐性高血压GRP78的影响。方法:雄性Dahl盐敏感大鼠40只,随机分... 详细信息

目的:通过外源给予高盐性高血压大鼠室旁核(paraventricular nucleus,PVN)硫化氢(hydrogen sulfide,H 2S)供体GYY4137,观察PVN中GRP78的蛋白表达含量变化,探讨室旁核H 2S对高盐性高血压GRP78的影响。方法:雄性Dahl盐敏感大鼠40只,随机分成4组,即正常对照组、正常给药组、模型组和模型给药组。分别饲喂正常盐饲料(0.3%NaCl)和高盐饲料(8%NaCl)4周后,双侧PVN插管持续微量注射GYY4137,采用尾动脉无创测量平均动脉压(mean arterial pressure,MAP),ELISA法检测血浆去甲肾上腺素(norepinephrine,NE),采用免疫组织化学技术及Western blotting法检测PVN中GRP78蛋白表达。结果:(1)与正常对照组相比,高盐模型组的MAP、血浆NE水平明显升高(P<0.01);与高盐模型组相比,高盐干预组MAP、血浆NE水平明显下降(P<0.01);(2)与正常对照组相比,高盐模型组室旁核中GRP78的蛋白表达明显升高(P<0.01);与高盐模型组相比,高盐干预组室旁核中GRP78的蛋白表达明显下降(P<0.01)。结论:室旁核H 2S可通过降低外周交感神经活动改善高盐性高血压,其机制可能与抑制室旁核内质网应激有关。

关键词：室旁核硫化氢高盐性高血压 GRP78