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Diagnostic Analysis of Potential Vorticity in a Heavy Precipitation Process in Qujing in September 2017

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Meteorological and Environmental Research 2019年第6期10卷 1-8,15页

作者： Tian Menglin cheng jiali Miao Rong Qujing Meteorological Bureau

Based on the observation data from the automatic rainfall station and NCEP/NCAR reanalysis data,circulation analysis and diagnosis analysis of potential vorticity in a heavy rainfall process in September 2017 in Qujing were *** results show that the heavy rainfall was mainly affected by the convergence zone between the two high pressures and shear line system,the precipitation area developed from the west to the southeast of Qujing,and the heavy rainfall area was concentrated in the central *** southerly airflow in the middle and lower layers of the troposphere provided favorable water vapor conditions for heavy *** precipitation was characterized by high intensity,strong suddenness and small time *** heavy precipitation was concentrated from 04:00 to 06:00 on September *** high-and low-value centers of dry potential vorticity PV at 500 h Pa were indicative of the activities of cold and warm air in the process of heavy rainfall,and representative of the development of the convergence zone and the activities of shear *** is to say,the high-value zone of dry potential vorticity PV at 500 h Pa was strengthened to penetrate into the center of Yunnan,leading the northerly airflow to the convergence *** deep southerly airflow in the relatively low-value zone of PV was uplifted to the north,converging the cold and warm air at the front of the convergence zone,resulting in heavy precipitation in *** high-value zone of wet potential vorticity MPV at 700 h Pa can also indicate the characteristics of unstable warm and humid air flow ***10,which easily caused the unstable energy release of wet convection and formed heavy precipitation.

关键词： Heavy precipitation Convergence zone between two high pressures Shear line Diagnosis of potential vorticity

T cells expressing CD5/CD7 bispecific chimeric antigen receptors with fully human heavy-chain-only domains mitigate tumor antigen escape

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1322-1333页

作者： Zhenyu Dai Wei Mu Ya Zhao jiali cheng Haolong Lin Kedong Ouyang Xiangyin Jia Jianwei Liu Qiaoe Wei Meng Wang Chaohong Liu Taochao Tan Jianfeng Zhou Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Nanjing IASO Biotherapeutics NanjingJiangsu 210000China Department of Pathogen Biology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China

Bispecific chimeric antigen receptor T-cell(CAR-T)therapies have shown promising results in clinical trials for advanced B-cell ***,it is challenging to broaden the success of bispecific CAR-T therapies to treat refractory/relapse(r/r)T-cell leukemia/lymphoma because targeting multiple T-cell-expressing antigens leads to exacerbated CAR-T cell fratricide and potential safety *** human heavy chain variable(FHVH)antibodies that specifically target CD5 or CD7 were screened and constructed to CD5/CD7 bispecific CARs.A truncated Epidermal growth factor receptor were integrated into CAR constructs to address safety *** tackle the fratricidal issue of CAR-T cells targeting T-cell-pan marker(s),CRISPR/Cas9-based CD5 and CD7 genes knockout were performed before lentiviral transduction of bispecific *** comparison between different bispecific CAR structures:tandem CARs and dual CAR were performed in vitro and in vivo to determine the optimal construct suitable for addressing T-cell malignancy antigen escape in clinical *** of CD5 and CD7 prevents fratricide of CD5/CD7 bispecific CAR-T cells,and FHVH-derived CD5/CD7 bispecific CAR-T cells demonstrate potent antitumor activity in vitro and in *** fratricide-resistant FHVH-derived CD5/CD7 bispecific CAR-T cells have potent antitumor activity against T-cell malignancies,and tandem CARs are more effective than dual CAR in preventing tumor escape in heterogeneous leukemic *** meaningful clinical efficacy and safety of tandem CD5/CD7 CAR-T cells deserve to be explored urgently.

关键词： CD7 CRISPR/Cas9 expressing

Risk Regionalization of Drought for Flue-cured Tobacco Planting in Qujing City Based on GIS

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Meteorological and Environmental Research 2019年第5期10卷 119-124页

作者： Pu Jicun cheng jiali Zhang Maosong Yuan Jiafeng Bai Bo Meteorological Bureau of Qujing City Qujing 655000Ch Yunnan Climate Center Kunming 650034China

The risk regionalization of drought for flue-cured tobacco planting in Qujing City was studied to provide reference for drawing on advantages and avoiding disadvantages in flue-cured tobacco planting,disaster reduction,and disaster relief *** to the production practice of flue-cured tobacco and local climate analysis,the risk of disaster-causing factors,sensitivity of disaster-breeding environment,vulnerability of carriers,and disaster prevention and reduction capability were analyzed and evaluated ***,starting from the formation mechanism of drought,a risk assessment model of the meteorological disaster was established by GIS ***,the risk assessment and regionalization of drought in the critical periods for drought-stricken flue-cured tobacco (transplanting period,root extending stage and vigorous growth period) in Qujing City were carried *** results showed that in Qujing City,the risk areas of drought for flue-cured tobacco planting were divided into five grades in the transplanting period and six grades in the root extending stage and vigorous growth period.

关键词： GIS technology Drought Risk regionalization Flue-cured tobacco planting in Qujing City

Analysis of Characteristics of Hail Disaster and a Typical Hail Suppression Process in Qujing City

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Meteorological and Environmental Research 2023年第6期14卷 58-63页

作者： Tao ZHANG jiali cheng Shiwen LI Menglin TIAN Jin CHEN Cunying WEN Qujing Meteorological Bureau Qujing 655000China Fuyuan Meteorological Bureau Qujing 655500China

Based on the data of hail disaster in Qujing City and the detection data of the new generation of Doppler weather radar, the spatial and temporal distribution characteristics of hail disaster and hail suppression operations in Qujing City were analyzed statistically, and the hail suppression operations of a typical cell case was analyzed. The results showed that the number of hail days and hail frequency showed an increasing trend in Qujing City from 2017 to 2022, and the number of artificial hail suppression operations increased accordingly. Hail disaster occurred most frequently in Xuanwei City. Through the analysis of hail suppression operations of a typical cell case, it is found that the operations were timely, and the location was reasonable. The ammunition used was sufficient, and the overall effect of the hail suppression operations was good.

关键词： Hail disaster Hail suppression Operation Qujing

美国高中生物教材《Biology-Principles&Explorations》介绍

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外国中小学教育 2007年第7期 58-62页

作者：程佳莉汪忠上海师范大学教育学院南京师范大学生命科学学院

《Biology-Principles&Explorations》是美国Holt,Rinehart and Winston公司出版的高中生物教材。本文整体介绍该教材的结构和内容,再以教材中细胞生物学的部分为例,对其图表、栏目和正文内容进行了微观分析,总结了该教材的特点,为我国... 详细信息

《Biology-Principles&Explorations》是美国Holt,Rinehart and Winston公司出版的高中生物教材。本文整体介绍该教材的结构和内容,再以教材中细胞生物学的部分为例,对其图表、栏目和正文内容进行了微观分析,总结了该教材的特点,为我国生物教育的发展和新一轮课程改革的深化提供借鉴。

关键词：高中生物生物教材美国

典型燃煤电厂周边蔬菜重金属累积特征及人体健康风险

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卫生研究 2016年第2期45卷 241-245页

作者：程家丽张信伟唐阵武中国疾病预防控制中心营养与健康所北京100050 重庆市忠县环境监测站

目的探讨和分析燃煤电厂重金属排放对周边蔬菜质量安全的影响。方法选取典型燃煤电厂,分析其东南西北4个方向、5 km范围内(基于不同气象条件下的最大浓度的落地距离)叶菜类、豆类和茄果类蔬菜中As、Cd、Cr、Cu、Hg和Pb重金属累积特征,... 详细信息

目的探讨和分析燃煤电厂重金属排放对周边蔬菜质量安全的影响。方法选取典型燃煤电厂,分析其东南西北4个方向、5 km范围内(基于不同气象条件下的最大浓度的落地距离)叶菜类、豆类和茄果类蔬菜中As、Cd、Cr、Cu、Hg和Pb重金属累积特征,并使用膳食暴露模型评估该地区蔬菜重金属污染的人体健康风险。结果调查的10种蔬菜中,叶菜类、豆类和茄果类Cu超标率分别为17.4%、14.3%和14.3%,叶菜Hg和Cr超标率分别为21.7%和17.4%,其他蔬菜重金属均未超出相应的国家食品卫生标准限值。儿童摄入Cu的非致癌风险值平均为1.09,其他金属对暴露人群的非致癌风险值均小于1.0,但该区域蔬菜中多种重金属对成人和儿童的总非致癌风险值分别为2.18和3.00。结论该区域蔬菜的重金属污染程度整体较低,燃煤电厂排放并没有造成周边蔬菜重金属的严重污染。该燃煤电厂周边蔬菜中除Cu累积对人体会造成非致癌风险,其他金属无明显的健康危害,但复合污染风险需重视。

关键词：燃煤电厂蔬菜重金属环境污染人体健康风险

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学习惰性研究综述

心理科学 2008年第6期31卷 1458-1460页

作者：樊琪程佳莉上海师范大学心理学系 200234

学习惰性是一种普遍存在的消极心理现象,它对学生和成人的学习造成负面影响。相关的研究国外已有而国内尚无。本研究为帮助学习者克服惰性、更好地学习和发展,在文献检索和典籍查阅的基础上,界定了惰性和学习惰性的概念;探讨了学习惰性... 详细信息

学习惰性是一种普遍存在的消极心理现象,它对学生和成人的学习造成负面影响。相关的研究国外已有而国内尚无。本研究为帮助学习者克服惰性、更好地学习和发展,在文献检索和典籍查阅的基础上,界定了惰性和学习惰性的概念;探讨了学习惰性的危害、成因及其影响因素;从认知、情绪、行为和易发人群等方面辨析了学习惰性与学习倦怠的异同;建议对学习惰性与学习倦怠采取不同的评估、教育和心理干预措施;最后对如何拓宽与深化学习惰性的研究进行了思考。

关键词：学习惰性研究综述

不同光照对荞麦芽黄酮类化合物及相关代谢酶基因表达的影响

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食品科学 2021年第23期42卷 72-79页

作者：程佳丽刘军毛佳奇李翠刘海杰中国农业大学食品科学与营养工程学院北京100083

通过分析不同品种荞麦的发芽形态及发芽后总酚、总黄酮的含量,从10个荞麦品种(7个苦荞和3个甜荞)中筛选出2个最适合生产荞麦芽的品种:‘蒙古2号’苦荞和‘西农9976’甜荞。将筛选出的品种进行不同发光二极管(light-emitting diode,LED)... 详细信息

通过分析不同品种荞麦的发芽形态及发芽后总酚、总黄酮的含量,从10个荞麦品种(7个苦荞和3个甜荞)中筛选出2个最适合生产荞麦芽的品种:‘蒙古2号’苦荞和‘西农9976’甜荞。将筛选出的品种进行不同发光二极管(light-emitting diode,LED)光照发芽处理,比较荞麦芽中总酚及黄酮的含量,同时分析不同光照下苦荞芽中苯丙氨酸解氨酶、黄酮醇合酶、查耳酮合酶及查耳酮异构酶的基因表达,探讨其作用机理。结果表明,‘蒙古2号’提高黄酮类化合物含量的最佳处理方式是白光光照,其中荭草苷、异荭草苷含量分别提高了63%、69%(发芽6 d),总黄酮含量提高了40%~53%(发芽2~6 d);‘西农9976’提高黄酮类化合物含量的最佳处理方式是红光光照,其中芦丁含量提升70%(发芽6 d),总黄酮含量最多提高111%(发芽2~6 d)。荞麦芽中总酚含量均是在红光作用下提高最多,其中‘西农9976’总酚含量最多提高83%(发芽2~6 d),且光照处理可明显上调4种代谢酶基因的表达水平。

关键词：荞麦品种荞麦芽黄酮类化合物光照基因表达

武汉典型湖泊沉积物中重金属累积特征及其环境风险

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湖泊科学 2009年第1期21卷 61-68页

作者：唐阵武程家丽岳勇陈玉敏华北电力大学能源与环境研究中心北京102206 水环境模拟国家重点实验室北京师范大学环境学院 100875 中国石油集团安全环保技术研究院北京100083

采集武汉市8个典型湖泊的表层沉积物,分析11种重金属的含量及其不同形态组成,研究了不同湖泊金属元素的富集与污染程度,探讨了沉积物中重金属的污染来源及其潜在生态风险.结果表明,沉积物中重金属Cd累积最严重,Zn和Hg也发生明显累积,龙... 详细信息

采集武汉市8个典型湖泊的表层沉积物,分析11种重金属的含量及其不同形态组成,研究了不同湖泊金属元素的富集与污染程度,探讨了沉积物中重金属的污染来源及其潜在生态风险.结果表明,沉积物中重金属Cd累积最严重,Zn和Hg也发生明显累积,龙阳湖污染较重,南太子湖和墨水湖污染中等,其它湖泊污染总体较轻.沉积物性质对重金属累积的影响不显著,城市工业活动强烈影响着重金属的分布.不同重金属的形态分布差异较大,Cd生物可利用态含量最高,其次为Mn、Zn、Co、Cu和Pb;而Sb和Hg以残留态占绝对优势,生态风险较小.相关分析和主成分分析表明,化石燃料燃烧、金属冶炼等是武汉市湖泊沉积物中重金属来源的主要贡献者,同时岩石风化等地球化学过程也影响着重金属的污染.

关键词：湖泊沉积物重金属地累积指数形态主成分分析武汉