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Dietary vitamin D_(3) deprivation suppresses fibroblast growth factor 23 signals by reducing serum phosphorus levels in laying hens

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Animal Nutrition 2022年第2期9卷 23-30页

作者： jiakun yan Chong Pan yanli Liu Xujie Liao Jionghao Chen Yufei Zhu Xinhuo Huang Xiaojun yang Zhouzheng Ren College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxiChina Nano Vitamin Engineering Research Center of Shaanxi Province Xi'anChina

The present study was carried out to evaluate the effect of dietary supplemental vitamin D_(3) on fibroblast growth factor 23(FGF23)signals as well as phosphorus homeostasis and metabolism in laying *** 40-week-old Hy-Line Brown layers were randomly assigned into 2 treatments:1)vitamin D_(3) restriction group(n=7)fed 0 IU/kg vitamin D_(3) diet,and 2)regular vitamin D_(3) group(n=7)fed 1,600 IU/kg vitamin D_(3) *** study lasted for 21 *** parameters,phosphorus and calcium excretion status,and tissue expressions of type II sodium-phosphate co-transporters(NPt2),FGF23 signals and vitamin D_(3) metabolic regulators were *** fed the vitamin D_(3) restricted diet had decreased serum phosphorus levels(by 31.3%,P=0.028)when compared to those fed regular vitamin D_(3) *** response to the decreased serum phosphorus,the vitamin D_(3) restricted laying hens exhibited:1)suppressed kidney expressions of 25-hydroxyvitamin D 1-a-hydroxylase(CYP27B1,by 52.8%,P=0.036)and 1,25-dihydroxyvitamin D 24-hydroxylase(CYP24A1,by 99.4%,P=0.032);2)suppressed serum levels of FGF23(by 14.6%,P=0.048)and increased serum alkaline phosphatase level(by 414.1%,P=0.012);3)decreased calvaria mRNA expressions of fibroblast growth factor receptors(FGFR1,by 85.2%,P=0.003,FGFR2,by 89.4%,P=0.014,FGFR3,by 88.8%,P=0.017,FGFR4,by 89.6%,P=0.030);4)decreased kidney mRNA expressions of FGFR1(by 65.5%,P=0.021),FGFR4(by 66.0%,P=0.050)and KLOTHO(by 68.8%,P=0.038);5)decreased kidney protein expression of type 2a sodium-phosphorus co-transporters(by 54.3%,P=0.039);and 6)increased percent excreta calcium(by 26.9%,P=0.002).In conclusion,the deprivation of dietary vitamin D_(3) decreased FGF23 signals in laying hens by reducing serum FGF23 level and suppressing calvaria and kidney mRNA expressions of FGF23 receptors.

关键词： Dietary vitamin D_(3) Fibroblast growth factor 23 Fibroblast growth factor receptor KLOTHO Laying hen

Alterations on vitamin C synthesis and transportation and egg deposition induced by dietary vitamin C supplementation in Hy-Line Brown layer model

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Animal Nutrition 2021年第4期7卷 973-980页

作者： Yufei Zhu Wei Guo Jianfei Zhao Kailong Qin jiakun yan Xinhuo Huang Zhouzheng Ren Xin yang yanli Liu Xiaojun yang College of Animal Science and Technology Northwest A&F UniversityYanglingChina Nano Vitamin Engineering Research Center of Shannxi Province Xi'anChina

In ovo feeding of vitamin C(VC)has positive effects on the growth performance,immune and antioxidant function in poultry,which indicates that increasing VC content in eggs may be of *** study was to investigate the effects of dietary VC supplementation on VC synthesis and transportation and egg *** Exp.1,in order to select a suitable animal model,VC content was detected in different eggs from different layer *** C content was lower in ISA Brown breeder eggs and Hy-Line Brown layer eggs(P<0.05)then in Arbor Acres breeder *** Exp.2,a total of 24 Hy-Line Brown layers(42-week-old)were randomly divided into 3 treatments with 8 replicates and fed a basal diet with VC at 0,200 and 400 mg/***-dependent VC transporter 1 and 2(SVCT1 and SVCT2)expressions were higher in ileum than in duodenum and jejunum(P<0.05).SVCT1 expression was higher but SVCT2 expression was lower in the magnum than in the ovary(P<0.05).L-Gulonolactone oxidase(GLO)and SVCT7 expressions were higher but SVCT2 was lower in the kidney than in the liver(P<0.05).Dietary VC supplementation at 400 mg/kg increased SVCT1 expression in duodenum,ovary and magnum,but decreased GLO and SVCT1 expression in liver(P<0.05).Dietary VC supplementation at 200 and 400 mg/kg increased SVCT2 expression in duodenum,but decreased GLO and SVCT1 expression in kidney and SVCT2 expression in liver(P<0.05).Dietary VC supplementation promoted VC absorption in duodenum and jejunum,but reduced endogenous VC synthesis in liver and *** dietary VC supplementation enhanced VC transportation in ovary and magnum,it did not increase VC deposition in produced eggs.

关键词： Vitamin C Sodium-dependent vitamin C transporter L-Gulonolactone oxidase Albumen Yolk

Adjusting phosphate feeding regimen according to daily rhythm increases eggshell quality via enhancing medullary bone remodeling in laying hens

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Journal of Animal Science and Biotechnology 2023年第3期14卷 1274-1286页

作者： jiakun yan Jiajie Wang Jie Chen Hao Shi Xujie Liao Chong Pan yanli Liu Xin yang Zhouzheng Ren Xiaojun yang College of Animal Science and Technology Northwest A&F UniversityYangling 712100ShaanxiChina

Background Body phosphorus metabolism exhibits a circadian rhythm over the 24-h daily *** egg laying behavior makes laying hens a very special model for investigating phosphorus circadian *** is lack of information about the impact of adjusting phosphate feeding regimen according to daily rhythm on the phosphorus homeostasis and bone remodeling of laying *** and results Two experiments were *** Exp.1,Hy-Line Brown laying hens(n=45)were sampled according the oviposition cycle(at 0,6,12,and 18 h post-oviposition,and at the next oviposition,respectively;n=9 at each time point).Diurnal rhythms of body calcium/phosphorus ingestions and excretions,serum calcium/phosphorus levels,oviduct uterus calcium transporter expressions,and medullary bone(MB)remodeling were *** Exp.2,two diets with different phosphorus levels(0.32%and 0.14%non-phytate phosphorus(NPP),respectively)were alternately presented to the laying ***,four phosphorus feeding regimens in total(each included 6 replicates of 5 hens):(1)fed 0.32%NPP at both 09:00 and 17:00;(2)fed 0.32%NPP at 09:00 and 0.14%NPP at 17:00;(3)fed 0.14%NPP at 09:00 and 0.32%NPP at 17:00;(4)fed 0.14%NPP at both 09:00 and 17:*** a result,the regimen fed 0.14%NPP at 09:00 and 0.32%NPP at 17:00,which was designed to strengthen intrinsic phosphate circadian rhythms according to the findings in Exp.1,enhanced(P<0.05)MB remodeling(indicated by histological images,serum markers and bone mineralization gene expressions),elevated(P<0.05)oviduct uterus calcium transportation(indicated by transient receptor potential vanilloid 6 protein expression),and subsequently increased(P<0.05)eggshell thickness,eggshell strength,egg specific gravity and eggshell index in laying *** These results underscore the importance of manipulating the sequence of daily phosphorus ingestion,instead of simply controlling dietary phosphate concentrations,in modifying the bone remodeling *** phosp

关键词： Body phosphorus rhythm Bone remodeling Eggshell formation Laying hen Phosphorus feeding regimen

A simple daily dynamic feeding regimen for reducing phosphorus consumption and excretion in laying hens

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Animal Nutrition 2022年第4期11卷 132-141页

作者： Xujie Liao jiakun yan Jionghao Chen Zhenyu Huang Tianshuai Xiao Changqing Li Chong Pan Xin yang yanli Liu Thomas D.Crenshaw Xiaojun yang Zhouzheng Ren College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxi 712100China Department of Animal Sciences University of Wisconsin-MadisonMadisonWI 53706USA

Phosphorus metabolism in laying hens is a highly dynamic process over the course of the 24 h egg-laying *** the phosphorus feeding regimen according to the daily egg-laying cycle may help to improve phosphorus utilization ***-Line Brown layers(n=120;70 wk old)were offered 4different phosphorus daily regimens:(1)RR,fed regular phosphorus at both 09:00 and 17:00;(2)RL,fed regular phosphorus at 09:00 and low phosphorus at 17:00;(3)LR,fed low phosphorus at 09:00 and regular phosphorus at 17:00;(4)LL,fed low phosphorus at both 09:00 and 17:*** regular and low phosphorus diets contained 0.32% and 0.14% non-phytate phosphorus,*** feeding trial lasted for 12 *** a result,layers on the RL regimen had decreased laying rate(P0.05);(2)decreased phosphorus excretion(P<0.05)during the period of09:00 to 17:00;(3)increased jejunal calbindin D28k protein expression(P<0.05)2 h after feeding in the morning;(4)decreased serum fibroblast growth factor 23 and calcitriol levels(P<0.05),decreased jejunal type Ⅲ sodium-phosphate cotransporter 2 gene and protein expression(P<0.05),and decreased renal type Ⅲ sodium-phosphate cotransporter 1 protein expression(P<0.05),2 h after feeding in the *** summary,when dietary phosphorus was supplemented in accordance with daily serum phosphorus rhythms(i.e.,the LR regimen),laying performance and egg quality were well supported whilst significantly decreasing phosphorus consumption and ***,serum phosphorus rhythms will need to be carefully maintained when developing dietar

关键词： Phosphorus-calcium homeostasis Dynamic feeding regimen Egg production Laying hen Phosphorus excretion

Dietary supplementation of sulfur amino acids improves intestinal immunity to Eimeria in broilers treated with anti-interleukin-10 antibody

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Animal Nutrition 2022年第3期10卷 382-389页

作者： Zhouzheng Ren jiakun yan Rose Whelan Xujie Liao Daniel E.Bütz Maria K.Arendt Mark E.Cook Xiaojun yang Thomas D.Crenshaw College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxiChina Department of Animal Sciences University of WisconsinMadisonWIUSA Evonik Operations GmbH Hanau-WolfgangGermany

Oral antibody to interleukin-10(anti-IL-10)enhances the intestinal immune defense against *** sulfur amino acids methionine and cysteine(MtC)play essential roles in inducing and maintaining protective immune responses during intestinal ***,increased dietary MtC may support the anti-IL-10-induced intestinal immunity to ***(n=640)were arranged in a 2×2×2 factorial design with 2 levels of each of the 3 main factors:dietary standardized ileal digestible(SID)MtC levels(0.6%or 0.8%),dietary anti-IL-10 supplementation(with or without),and coccidiosis challenge(control or challenge).Briefly,the broilers were supplied with either 0.6%or 0.8%SID MtC,each with or without anti-IL-10(300 mg/kg),from d 10 to *** d 14,broilers from each diet were gavaged with either PBS or *** resulting Eimeria infection induced fecal oocyst shedding and intestinal *** fed 0.8%SID MtC(main effects,P≤0.05)had decreased feed-to-gain ratio,increased duodenum and cecum luminal anti-Eimeria IgA titers,and decreased fecal oocyst counts,when compared to 0.6%SID *** supplementation of anti-IL-10(main effects,P≤0.05)increased cecum luminal total IgA concentration and decreased cecum ***(P≤0.05)were detected for growth performance and cecum luminal IFN-γ.Briefly,the highest body weight gain and feed intake were reached in PBS-gavaged broilers fed 0.8%SID MtC with no anti-IL-10 and in Eimeria-challenged broilers fed 0.8%SID MtC with *** Eimeria-infected broilers,anti-IL-10 increased intestinal luminal IFN-γ and body weight gain only at 0.8%SID ***,anti-IL-10 increased intestinal luminal IFN-γ levels,decreased cecum lesions and restored growth only when fed with adequate amounts of sulfur amino *** findings underscore the importance of providing sufficient essential nutrients to support the anti-IL-10 induced immunity against coccidiosis.

关键词： Chicken Coccidiosis Egg yolk antibody Interleukin-10 Sulfur amino acid

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APP技术下小学英语教学变革探析

吉林省教育学院学报 2017年第12期33卷 31-34页

作者：闫佳坤吉林师范大学教育科学学院吉林长春130000

在"互联网+"的背景下,"APP"技术不断走进教育,影响改变着教育教学的诸多方面。将APP技术应用于小学英语教学具有搭建弹性多变的学习形式、倡导积极合作的学习过程;建构便捷高效的评价体系等优势。为此,学校应加强信息化校园的建设,教师... 详细信息

在"互联网+"的背景下,"APP"技术不断走进教育,影响改变着教育教学的诸多方面。将APP技术应用于小学英语教学具有搭建弹性多变的学习形式、倡导积极合作的学习过程;建构便捷高效的评价体系等优势。为此,学校应加强信息化校园的建设,教师应该加强交流,实现资源的共享,家长则要做好监督和指导的工作。

关键词： “APP”技术移动学习小学英语教学变革

基于等几何分析的电热驱动柔顺机构拓扑优化设计

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机械工程学报 2023年第21期59卷 177-187页

作者：占金青晏家坤蒲圣鑫朱本亮刘敏华东交通大学机电与车辆工程学院南昌330013 华南理工大学广东省精密装备与制造技术重点实验室广州510641

为了提高计算效率,提出一种基于等几何分析(Isogeometric analysis,IGA)的电热驱动柔顺机构拓扑优化设计方法。采用NURBS曲线表达几何模型和分析模型,利用改进的固体各向同性材料惩罚法和密度分布函数描述材料分布,采用顺序耦合方法进行... 详细信息

为了提高计算效率,提出一种基于等几何分析(Isogeometric analysis,IGA)的电热驱动柔顺机构拓扑优化设计方法。采用NURBS曲线表达几何模型和分析模型,利用改进的固体各向同性材料惩罚法和密度分布函数描述材料分布,采用顺序耦合方法进行电-热-结构多物理场耦合有限元分析,以电热驱动柔顺机构的输出位移最大化为目标函数,以机构的体积为约束,建立基于等几何分析的电热驱动柔顺机构拓扑优化数学模型,利用移动渐近线算法求解拓扑优化问题。数值算例验证了提出的设计方法的有效性。与基于有限元分析的优化结果相比,基于等几何分析获得的电热驱动柔顺机构拓扑构型有所不同,边界更加光滑,机构的输出位移更大;并且等几何分析能够有效地减少迭代步数,显著地提高了计算效率。分析不同的输出刚度对电热驱动柔顺机构拓扑构型和机构性能的影响规律。

关键词：柔顺机构电热驱动器拓扑优化等几何分析

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中华民族海洋意识影响因素探析

世界经济与政治论坛 2009年第3期 79-86页

作者：张德华冯梁颜家坤江苏社会科学院 210013 海军指挥学院 210016 南海舰队

海洋意识作为人们对海洋在人类社会发展中的作用、地位和价值的认识,对国家和民族发展有着深远影响。历史证明,有没有海洋意识,海洋意识是否强烈,不仅关系到能否有效地开发、利用海洋,而且影响到国家民族的安危兴衰。深入探析中国传统... 详细信息

海洋意识作为人们对海洋在人类社会发展中的作用、地位和价值的认识,对国家和民族发展有着深远影响。历史证明,有没有海洋意识,海洋意识是否强烈,不仅关系到能否有效地开发、利用海洋,而且影响到国家民族的安危兴衰。深入探析中国传统中海洋意识淡薄的原因,是进一步探求增强21世纪中华民族海洋意识对策建议的基本前提。

关键词：中华民族海洋意识影响因素

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从《牡丹亭》看女性教育

贵州文史丛刊 2015年第1期 60-64页

作者：伏涛闫佳坤吉林师范大学吉林四平136000

《牡丹亭》是汤显祖"至情论"在"临川四梦"中最集中的体现,其中女主角杜丽娘堪称"至情论"最佳诠释者。一部经典剧作的内涵往往不是单一的,作者在《牡丹亭》中除了建构"情教论",反科举外,还有对女性教育的思考。《闺塾》一出极为精彩,其... 详细信息

《牡丹亭》是汤显祖"至情论"在"临川四梦"中最集中的体现,其中女主角杜丽娘堪称"至情论"最佳诠释者。一部经典剧作的内涵往往不是单一的,作者在《牡丹亭》中除了建构"情教论",反科举外,还有对女性教育的思考。《闺塾》一出极为精彩,其中塾师陈最良、女学生杜丽娘及其伴读春香一同演绎了明末私塾教育的一个场景。通过《闺塾》以及相关剧情的解读,可以反观晚明社会女性教育的林林总总。如:教材的选用,教学内容的拟定,教育方法的采用,教育环节的把握等,这些均直接影响教学效果的实现,教学目标的达成,这有助于我们了解那个时代女性教育的情状,对当下的女性教育亦不无启迪意义。

关键词：汤显祖《牡丹亭》《闺塾》陈最良杜丽娘春香女性教育