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浙江省免疫学会第十三次学术大会

作者： Jiaqi Fang Qian Ou Xinpeng Ma Weiwei Luo Wenting Li Sisi Li jiajie jing Ziyan Jiang Jiadong Wang Weiyu Jiang Jianping Pan Institute of Translational Medicine Hangzhou City University Department of Clinical Medicine Hangzhou City University School of Medicine Department of Basic Medical Sciences Zhejiang University School of Medicine

Background:Toll/interleukin 1 receptor domain containing protein encoded by ***（TcpC） is a multifunctional virulence factor in the majority of uropathogenic ***（UPEC） strains and blocks the TLR signaling pathway by serving as an E3 ubiquitin ligase that promotes MyD88 degradation by ubiquitin-proteasome pathway,hereby inhibiting the TLR mediated activation of ***:This study aims to investigate if TcpC can also inhibit the activity of deubiquitinase and its related *** and methods:TcpC secreting wild-type CFT073(CFT073) was kindly provided by Professor Jian-guo *** knock out CFT073 mutant（CFT073Δtcpc） was constructed in our *** human monocytic cell line THP-1 and mouse macrophage cell lines J774 A.1 were obtained from Shanghai Institute of Biochemistry and Cell *** situ co-localization of TcpC with USP14,USP14 with ubiquitin and Rpn1 in kidneys from pyelonephritis mouse model was determined by confocal *** of UPEC in macrophages was observed by holographic 3 D live cell imaging system,flow cytometry and confocal *** of deubiquitinase and proteasome were measured by fluorescent microplate reader.K48-ubiquitination of MyD88 in rTcpC treated macrophages was detected by *** mRNA and protein expression levels of pro-inflammatory cytokines were detected by qRT-PCR and *** abilities of rTcpC with rUSP14 was determined by surface plasmon resonance（SPR） and microscale thermophoresis（MST）.Transcription and protein level of ubiquitin and proteasome related genes were detected by transcriptome and proteome *** amino acids required to maintain the deubiquitinase inhibitory activity in rTcpC were identified by ***:In situ co-localization of TcpC and ubiquitin with USP14 or PSMD2 with USP14 was significantly enhanced or declined respectively in kidney from CFT073 infected mice compared to kidney isolated from mice infect

关键词： TcpC inhibit deubiquitinase USP14 innate immune

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Adaptive OrderWENO Reconstructions for the Semi-Lagrangian Finite Difference Scheme for Advection Problem

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Communications in Computational Physics 2021年第6期30卷 67-96页

作者： jiajie Chen Xiaofeng Cai Jianxian Qiu jing-Mei Qiu Department of Mathematical Sciences University of DelawareNewarkDE19717USA School of Mathematical Sciences and Fujian Provincial Key Laboratory of Mathematical Modeling and High-Performance Scientific Computing Xiamen UniversityXiamenFujian 361005P.R.China

We present a new conservative semi-Lagrangian finite difference weighted essentially non-oscillatory scheme with adaptive *** is an extension of the conservative semi-Lagrangian(SL)finite difference WENO scheme in[Qiu and Shu,JCP,230(4)(2011),pp.863-889],in which linear weights in SL WENO framework were shown to not exist for variable coefficient ***,the order of accuracy is not optimal from reconstruction *** this paper,we incorporate a recent WENO adaptive order(AO)technique[Balsara et al.,JCP,326(2016),pp.780-804]to the SL WENO *** new scheme can achieve an optimal high order of accuracy,while maintaining the properties of mass conservation and non-oscillatory capture of solutions from the original SL *** positivity-preserving limiter is further applied to ensure the positivity of ***,the scheme is applied to high dimensional problems by a fourth-order dimensional *** demonstrate the effectiveness of the new scheme by extensive numerical tests on linear advection equations,the Vlasov-Poisson system,the guiding center Vlasov model as well as the incompressible Euler equations.

关键词： Semi-Lagrangian weighted essentially nonoscillatory WENO adaptive order reconstruction finite difference mass conservation Vlasov-Poisson incompressible Euler

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Correlating the Interfacial Polar-Phase Structure to the Local Chemistry in Ferroelectric Polymer Nanocomposites by Combined Scanning Probe Microscopy

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Nano-Micro Letters 2023年第1期15卷 80-93页

作者： jiajie Liang Shaojie Wang Zhen Luo jing Fu Jun Hu Jinliang He Qi Li State Key Laboratory of Power System Department of Electrical EngineeringTsinghua UniversityBeijing 100084People’s Republic of China

Ferroelectric polymer nanocomposites possess exceptional electric properties with respect to the two otherwise uniform phases,which is commonly attributed to the critical role of the matrix-particle interfacial ***,the structure-property correlation of the interface remains unestablished,and thus,the design of ferroelectric polymer nanocompos-ite has largely relied on the trial-and-error ***,a strategy that combines multi-mode scanning probe microscopy-based electrical charac-terization and nano-infrared spectroscopy is developed to unveil the local structure-property correlation of the interface in ferroelectric polymer *** results show that the type of surface modifiers decorated on the nanoparticles can significantly influence the local polar-phase content and the piezoelectric effect of the polymer matrix surrounding the *** strongly coupled polar-phase content and piezoelectric effect measured directly in the interfacial region as well as the computed bonding energy suggest that the property enhancement originates from the formation of hydrogen bond between the surface modifiers and the ferroelectric *** is also directly detected that the local domain size of the ferroelectric polymer can impact the energy level and distribution of charge traps in the interfacial region and eventually influence the local dielectric strength.

关键词： Interfaces Ferroelectric polymers Nanocomposites Scanning probe microscopy Nano-infrared spectroscopy

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激光技术在钛合金表面改性中的应用

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铸造技术 2021年第9期42卷 820-824页

作者：徐加乐段薇薇怀旭荆佳杰李恒奚晓晗江苏省先进结构材料与应用技术重点实验室江苏南京211167 南京工程学院材料科学与工程学院江苏南京211167

在总结钛合金在摩擦磨损、高温抗氧化和疲劳敏感性等表面性能不足的基础上,介绍了激光表面改性技术的原理和特点。综述了当前国内激光熔覆、激光合金化和激光冲击强化技术等在钛合金表面改性中的应用,展望了钛合金激光改性研究新方向。

关键词：钛合金表面性能激光表面改性研究进展

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Prognostics of radiation power degradation lifetime for ultraviolet light-emitting diodes using stochastic data-driven models

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Energy and AI 2021年第2期4卷 91-100页

作者： jiajie Fan Zhou jing Yixing Cao Mesfin Seid Ibrahim Min Li Xuejun Fan Guoqi Zhang Institute of Future Lighting Academy for Engineering&TechnologyFudan UniversityShanghai 200433China Shanghai Research Center for Silicon Carbide Power Devices Engineering&Technology Fudan UniversityShanghai 200433China College of Mechanical and Electrical Engineering Hohai UniversityChangzhou 213022China EEMCS Faculty Delft University of TechnologyDelft 2628the Netherlands Changzhou Institute of Technology Research for Solid State Lighting Changzhou 213161China Department of Industrial and System Engineering The Hong Kong Polytechnic UniversityHung HomHong Kong Department of Mechanical Engineering Lamar UniversityBeaumontTX 77710USA

With their advantages of high efficiency,long lifetime,compact size and being free of mercury,ultraviolet light-emitting diodes(UV LEDs)are widely applied in disinfection and purification,photolithography,curing and biomedical ***,it is challenging to assess the reliability of UV LEDs based on the traditional life test or even the accelerated life *** this paper,radiation power degradation modeling is proposed to estimate the lifetime of UV LEDs under both constant stress and step stress degradation *** data-driven predic-tions with both Gamma process and Wiener process methods are implemented,and the degradation mechanisms occurring under different aging conditions are also *** results show that,compared to least squares regression in the IESNA TM-21 industry standard recommended by the Illuminating Engineering Society of North America(IESNA),the proposed stochastic data-driven methods can predict the lifetime with high accuracy and narrow confidence intervals,which confirms that they provide more reliable information than the IESNA TM-21 standard with greater robustness.

关键词： Ultraviolet light-emitting diodes(UV LEDs) Degradation modeling Gamma process Wiener process IESNA TM-21

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一种鲁棒的户外建筑物图像校正方法

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计算机辅助设计与图形学学报 2014年第7期26卷 1084-1091页

作者：国佳杰王涌天陈靖北京理工大学计算机科学技术学院北京100081 北京理工大学光电学院北京100081

针对在海量场景识别中现有透视失真校正方法的鲁棒性尚不理想,不足以用于对场景复杂、干扰较多的户外建筑物图像进行准确校正的问题,提出一种改进的户外建筑物透视失真校正方法.该方法针对建筑物的形状特点,结合手机的重力感应功能对Ho... 详细信息

针对在海量场景识别中现有透视失真校正方法的鲁棒性尚不理想,不足以用于对场景复杂、干扰较多的户外建筑物图像进行准确校正的问题,提出一种改进的户外建筑物透视失真校正方法.该方法针对建筑物的形状特点,结合手机的重力感应功能对Hough变换直线检测算法进行了改进,并使用RANSAC方法剔除部分错误直线,提高了算法的鲁棒性;利用消隐点坐标对图像进行校正,恢复建筑物的仿射结构,使其与训练图像更加接近;在实验中,将校正后的图像用于图像识别,并提出一种基于互信息的融合策略,将侧视图和校正后的图像结合在一起进行识别.实验结果表明,该方法能够鲁棒地对户外建筑物图像进行透视校正,极大地提高了户外建筑物识别正确率.

关键词：透视失真消隐点图像校正图像识别

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激励性政策工具如何更科学有效——民办学前教育管理中的政府支持探析

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教育发展研究 2023年第12期43卷 33-39页

作者：高敬瞿佳杰上海学前教育学院上海200234 上海市教育委员会托幼工作处上海200003

由我国相关政策文件可知,政府在民办学前教育的管理中履行关键职责。我国各级政府承担了规范和支持民办幼儿园健康发展的主导责任,组合运用了多元政策工具,其中不乏激励性政策工具的使用。然而,从政府民办学前教育激励性政策工具的使用... 详细信息

由我国相关政策文件可知,政府在民办学前教育的管理中履行关键职责。我国各级政府承担了规范和支持民办幼儿园健康发展的主导责任,组合运用了多元政策工具,其中不乏激励性政策工具的使用。然而,从政府民办学前教育激励性政策工具的使用现状来看,具体操作中的支持路径较依赖民办园的外部属性,造成强者恒强的“马太”效应,公平性尚不够。为科学有效达成支持民办幼儿园、促进民办学前教育实现公益性和可持续发展的政策目标,政府可借鉴政府治理理论,创新激励性政策工具的操作,以民办幼儿园内部办园成本为支持路径,参考生均成本数量、成本项目和相应金额等实证数据,兼顾我国民办幼儿园分类管理制度,对不同类型的民办幼儿园进行针对性支持。

关键词：民办学前教育激励性政策工具办园成本政府治理

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《内经》中经脉病候表述形式探讨

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中国针灸 2007年第1期27卷 63-65页

作者：贾杰赵京生南京中医药大学针灸推拿学院江苏210029

采用文献梳理的方法对《内经》中属于经脉病候范畴的内容进行表述形式划分。结果表明《内经》中经脉病候表述形式有十二脉、足六脉、腧穴主治、脏腑病候等4种。明确经脉病候的不同表述形式,有利于认识经脉、腧穴不同形式的针灸治疗规律... 详细信息

采用文献梳理的方法对《内经》中属于经脉病候范畴的内容进行表述形式划分。结果表明《内经》中经脉病候表述形式有十二脉、足六脉、腧穴主治、脏腑病候等4种。明确经脉病候的不同表述形式,有利于认识经脉、腧穴不同形式的针灸治疗规律,以便更好地指导临床。

关键词：《内经》十二经脉病证/历史

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Study on the Deformation Behavior of Mg-Gd-Y-Zn-Mn Wrought Magnesium Alloys by Visco-plastic Self-consistent Modeling

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上海航天（中英文） 2022年第1期39卷 77-83,136页

作者： WANG Yuye ZHANG Junfa WANG Shiwei KANG jing MENG jiajie WANG Yanbo XU Yuling ZHOU Haitao Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China Beijing Institute of Space Long March Vehicle Beijing 100076China

The plastic deformation behavior of new Mg-Gd-Y-Zn-Mn magnesium alloys gains great necessity to clarify and understand the mechanism deeply. In the present work,the tensile mechanical property test and visco-plastic self-consistent (VPSC) model are used to investigate the activities of deformation modes of VW84M and VW94M magnesium alloys during the tensile deformation. The results show that the mechanical properties of the above extruded alloys are similar but VW94M has higher strength than VW84M after the same aging process. Compared with the extruded alloys,the as-aged alloys have significantly higher activation of pyramidal slip at the later stage of plastic deformation. In addition,the as-aged VW94M alloy with higher strength has the largest activity of pyramidal slip. In summary,the addition of Gd increases the critical resolved shear stress (CRSS)in each slip system of VW94M,while the increase in the strength and the decrease in the elongation of as-aged alloys are associated with the significant activation of pyramidal slip.

关键词： Mg-RE alloy wrought magnesium alloy visco-plastic self-consistent(VPSC)model deformation behavior

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SOCS的免疫调节机制及其在慢性肝病中的作用

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中国免疫学杂志 2022年第17期38卷 2140-2146页

作者：赵家洁游晶(指导) 李静赵寅洲昆明医科大学第一附属医院感染性疾病和肝病科昆明650032 昆明医科大学公共卫生学院昆明650500

细胞因子转导抑制因子(SOCS)是细胞外信号引起的信号转导过程中关键的负调控因子,SOCS家族通过一系列机制负调控Janus激酶/信号转导子和转录激活子(JAK/STAT)信号通路,从而调节靶基因的表达而发挥生物学作用,在免疫相关疾病、肿瘤疾病... 详细信息

细胞因子转导抑制因子(SOCS)是细胞外信号引起的信号转导过程中关键的负调控因子,SOCS家族通过一系列机制负调控Janus激酶/信号转导子和转录激活子(JAK/STAT)信号通路,从而调节靶基因的表达而发挥生物学作用,在免疫相关疾病、肿瘤疾病中扮演重要角色。目前越来越多的研究证明,在各种慢性肝病(CLD),包括慢性病毒性肝炎、非酒精性脂肪肝、肝纤维化、肝癌等疾病中存在SOCS蛋白表达异常,研究SOCS在慢性肝病中的作用机制,可能为相关肝病的治疗提供新的策略。本文简要介绍了SOCS的免疫调节机制,重点阐述了其在各种慢性肝病中的作用。

关键词：细胞因子转导抑制因子 Janus激酶信号转导子和转录激活子信号通路慢性肝病

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