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结合MGCC特征与多尺度通道注意力的环境声深度学习分类方法

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应用声学 2024年第3期43卷 513-524页

作者：杨俊杰丁家辉杨柳冯丽杨超广东工业大学自动化学院广州510006 物联网智能信息处理与系统集成教育部重点实验室广州510006 广州大学计算机科学与网络工程学院广州510006 澳门科技大学资讯科技学院中国澳门999078

环境声分类技术在家居安全监测、人机语声交互等领域具有关键作用。然而,声源的多样性与混合性给环境声分类方法设计带来了重大挑战。为提高分类准确率与节约计算资源,该文提出一种基于多尺度通道注意力机制的深度学习分类模型。所提模... 详细信息

环境声分类技术在家居安全监测、人机语声交互等领域具有关键作用。然而,声源的多样性与混合性给环境声分类方法设计带来了重大挑战。为提高分类准确率与节约计算资源,该文提出一种基于多尺度通道注意力机制的深度学习分类模型。所提模型由特征提取模块、多尺度卷积模块、高效通道注意力模块、输出层四部分组成。首先,通过引入加权型梅尔Gammatone频率倒谱系数(MGCC)挖掘环境声频谱幅值与相位结构信息;其次,融合多尺度卷积核与高效通道注意力机制优选出声频关键局部细节和通道特征;最后,在全连接层采用softmax函数映射特征并输出环境声类型的概率值。所提模型在6种环境声的iFLYTEK、10种环境声的Urbansound8k数据集上开展测试验证,分别取得了94%、76.52%、79.24%(iFLYTEK+Urbansound8k)的分类准确率。消融实验结果进一步表明:引入的多尺度卷积模块、通道注意力机制模块对分类准确率的提升贡献率分别接近于3.77%和1.89%。实验还详细对比了7种现有的深度学习分类方法,所提算法在分类准确率上排名第二;另外,在同级别算法中如ResNet18、GoogLeNet,所提算法在模型参数量和计算复杂度方面上实现了进一步的约减。

关键词：环境声分类梅尔Gammatone频率倒谱多尺度核卷积高效通道注意力卷积神经网络

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伴多系统受累的渐进性坏死性黄色肉芽肿1例

中国皮肤性病学杂志 2024年第10期38卷 1154-1157页

作者：丁家慧柳君如高冬高天文烟台毓璜顶医院莱山院区皮肤医疗美容科第四军医大学西京医院皮肤科

患者男，65岁，头皮、眼睑等处黄色斑块逐渐增多5年，近4个月出现声嘶。皮肤科情况：全身片状浸润性、无痛性、界限不清、质韧的黄红色斑块及盘状暗红色斑块。皮损组织病理示：真皮内渐进性坏死与肉芽肿性病变交替分布，以类上皮细胞及... 详细信息

患者男，65岁，头皮、眼睑等处黄色斑块逐渐增多5年，近4个月出现声嘶。皮肤科情况：全身片状浸润性、无痛性、界限不清、质韧的黄红色斑块及盘状暗红色斑块。皮损组织病理示：真皮内渐进性坏死与肉芽肿性病变交替分布，以类上皮细胞及泡沫样组织细胞为主，可见Touton巨细胞、胆固醇裂隙和脂质空泡。免疫组织化学染色示：CD68(+)、CD1α(-)、S100(-)。颅脑CT示：颅骨及耳软骨骨质破坏；纤维喉镜示：声带增厚；淋巴结超声示：全身多部位淋巴结肿大；眼科查体示：右眼角膜上皮损害；骨髓细胞学示：骨髓增生减低。诊断：渐进性坏死性黄色肉芽肿，伴多系统损害。静脉滴注甲泼尼龙琥珀酸钠联合口服沙利度胺后，无新发皮损，原有皮损明显变平消退，但声嘶改善不明显，目前仍在随访中。

关键词：黄色肉芽肿渐进性坏死系统性

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Alum split applications strengthened phosphorus fixation and phosphate sorption in high legacy phosphorus calcareous soil

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Journal of Environmental Sciences 2021年第3期33卷 87-97页

作者： Bingqian Fan Owen Fenton Karen Daly jiahui ding Shuo Chen Qing Chen Beijing Key Laboratory of Farmyard Soil Pollution Prevention-control and Remediation College of Resources and Environmental SciencesChina Agricultural UniversityBeijing 100193China Teagasc Environmental Research CentreJohnstown CastleCo.WexfordIreland

High phosphorus(P)saturation arising from historic P inputs to protected vegetable fields(PVFs)drives high P mobilisation to *** of soils with alum has shown potential in terms of fixing labile P and protecting water *** present 15 month pot experiment investigated P stabilisation across single alum application(Alum-1 treatment,20 g alum/kg soil incorporated into soil before the maize was sown),alum split applications(Alum-4 treatment,5 g alum/kg soil incorporated into soil before each crop was sown i.e.4×5 g/kg)and soil only treatment(Control).Results showed that the Alum-1 treatment caused the strongest stabilisation of soil labile P after maize plant removal,whereas the P stabilisation effect was gradually weakened due to the transformation of soil non-labile P to labile P and the reduced active Al^(3+)in soil *** the Alum-4 treatment,soil labile P decreased gradually with each crop planting and was lower than the Alum-1 treatment at the end of the final crop removal,without any impairment on plant *** better P stabilisation at the end of Alum-4 treatment was closely correlated with a progressive supply of Al^(3+)and a gradual decrease of pH,which resulted in higher contents of poorlycrystalline Al,Fe and exchangeable *** aspects were conducive to increasing the soil P stabilisation and phosphate *** terms of management,growers in continuous cropping systems could utilise split alum applications as a strategy to alleviate P losses in high-P enriched calcareous soil.

关键词： High legacy phosphorus Calcareous soil Phosphorus stabilisation Alum split applications Non-crystalline Fe/Al

Hydrothermal synthesis of hydroxyapatite coating on the surface of medical magnesium alloy and its corrosion resistance

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Progress in Natural Science:Materials International 2021年第2期31卷 324-333页

作者： Shifeng Wen Xianglei Liu jiahui ding Yulai Liu Ziting Lan Zimeng Zhang Guangmeng Chen School of Mechanics and Civil & Architecture Northwestern Polytechnical University

The early corrosion control of biomedical magnesium alloy is an important measure to determine its good performance during implantation into human body. The deposition of calcium phosphate biological coating is the most effective solution at present. In this paper, hydroxyapatite（HAP） coating was hydrothermal synthesized on the surface of AZ31 B magnesium alloy, and the influence mechanism of hydrothermal synthesis temperature, time and solution concentration was investigated. The synthesis conditions and deposition mechanism of hydroxyapatite coating without DCPA（CaHPO4） were proposed. The surface morphology of the coating was observed by field emission electron scanning microscope（FESEM）. The types and contents of microelements in the material were analyzed by energy disperse spectroscopy（EDS）. Fourier transform infrared spectroscopy（FTIR） was used to analyze the functional group information of the coating surface. The corrosion resistance of different experimental groups was studied by electrochemical test. The results showed that when the calcium phosphate solution concentration was 0.1 mol/L and the calcium/phosphorus ratio was 1.67, the coating had better morphology structure and corrosion resistance, and the calcium/phosphorus ratio of HAP crystals reached 1.58, the epit of the prepared AZ31 B-HAP coating by bare metal increased from -1.51 V to -1.18 V, the impedance value reached 1.0×10～5Ω·cm2, and the early corrosion of magnesium alloy substrate was effectively delayed.

关键词： Medical magnesium alloy Hydroxyapatite coating Corrosion property Electrochemistry

Co-delivery of luteolin and TGF-β1 plasmids with ROS-responsive virus-inspired nanoparticles for microenvironment regulation and chemo-gene therapy of intervertebral disc degeneration

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Nano Research 2022年第9期15卷 8214-8227页

作者： Yifan ding Huan Wang Yunyun Wang Long Li jiahui ding Caiyan Yuan Tao Xu Haoran Xu Hui Xie Ning Zhu Xin Hu Huang Fang Songwei Tan Department of Orthopedic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Pharmacy Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Cardiology the Fifth Hospital in WuhanWuhan 430030China Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China College of Biotechnology and Pharmaceutical Engineering Nanjing Tech UniversityNanjing 211800China State Key Laboratory of Materials-Oriented Chemical Engineering Nanjing Tech UniversityNanjing 211800China College of Materials Science and Engineering Nanjing Tech UniversityNanjing 211800China

Intervertebral disc degeneration(IDD)is closely related to inflammation and imbalance of synthesis/catabolism of extracellular matrix(ECM)in intervertebral disc(IVD).Considering this,luteolin(LUT),a kind of natural flavonoid with good anti-inflammatory effect and TGF-β1(a gene that promotes the regeneration of ECM)plasmid was co-loaded and co-delivered to nucleus pulposus cells(NPCs).Reactive oxygen species(ROS)responsive cationic copolymer,poly(β-amino ester)-poly(ε-caprolactone)(PBC),with high plasmid DNA(pDNA)compression affinity was *** can self-assemble into nano-sized polyplexes(pDNA@PBC)with virus-inspired structure and function through which it can transfect pDNA into NPCs with very high efficiency and negligible *** was encapsulated in the hydrophobic core of pDNA@*** co-delivery system,LUT-pTGFβ1@PBC,could enhance the cellular uptake of NPCs and manifest excellent sustained drug release in *** time quantitative polymerase chain reaction(RT-qPCR)and Western blot experiments reveal that the co-delivery system could inhibit inflammation in NPCs and restore the balance of anabolism and catabolism in vitro by activating TGF/SMAD3 and inhibiting NFkB/***,LUT-pTGF-β1@PBC retards IDD in vivo as detected by radiological and histological methods with good biosafety in ***-pTGF-β1@PBC may be a promising option for the treatment of IDD.

关键词： intervertebral disc degeneration poly(β-amino ester) luteolin TGF-β1 co-delivery

Large-area flexible and transparent UV photodetector based on cross-linked Ag NW@ZnO NRs with high performance

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Journal of Materials Science & Technology 2022年第15期110卷 65-72页

作者： Lin Zhang Nuomei Li Qiuchen Ma jiahui ding Chuang Chen Zhaocheng Hu Weiwei Zhao Yufeng Li Huanhuan Feng Mingyu Li Hongjun Ji Sauvage Laboratory for Smart Materials ShenzhenKey Laboratory of Flexible Printed Electronics TechnologySchool of Materials Science and EngineeringHarbin Institute of TechnologyShenzhen 518055China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyShenzhen 518055China

A series of large-area,flexible and transparent ultraviolet(UV)photodetectors(PDs)based on Ag nanowire(NW)@ZnO nanorods(NRs)are fabricated by an inexpensive,facile and effective *** Ag NW@ZnO NRs are successfully synthesized using a two-step method in an oil bath with a high surface-to-volume ratio and good *** PDs are fabricated by drop-coating with different drop-coating times on the surface of polyethylene terephthalate(PET)coupled with Au *** optimizing the cross-linked network of Ag NW@ZnO NRs,PD2 with a size greater than 25 mm exhibits excellent photoresponse under UV light illumination of 365 nm(1.3 m W cm^(-2))with a bias of 5 V:a high sensitivity of over 10^(3),and a much shorter rise/decay time of 2.6 s/2.3 ***,the detector exhibits an average transmittance of more than 70%in the visible light region,as well as good flexibility and excellent mechanical stability under a bending angle of 120°over 1000 circles *** integral advantages have significant potential for practical applications and mass production.

关键词： Ag NW@ZnO NRs Low dark current Rapid response Transparent Flexible Large-area

过表达解偶联蛋白2抑制氧化应激减轻糖尿病小鼠心肌缺血再灌注损伤

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国际心血管病杂志 2024年第1期51卷 53-58页

作者：丁佳慧吴建江程虎朱阔于文彬王江新疆医科大学第一附属医院麻醉科乌鲁木齐830011

目的:探讨过表达解偶联蛋白2(UCP2)减轻糖尿病小鼠心肌缺血再灌注损伤(IRI)的机制。方法:60只8周龄C57BL小鼠高脂喂养6周后,注射链脲佐菌素建立小鼠糖尿病模型,采用随机数字表法分为5组,假手术组(Sham组)、缺血再灌注组(I/R组)、UCP2抑... 详细信息

目的:探讨过表达解偶联蛋白2(UCP2)减轻糖尿病小鼠心肌缺血再灌注损伤(IRI)的机制。方法:60只8周龄C57BL小鼠高脂喂养6周后,注射链脲佐菌素建立小鼠糖尿病模型,采用随机数字表法分为5组,假手术组(Sham组)、缺血再灌注组(I/R组)、UCP2抑制剂组(Genipin组)、空载9型腺相关病毒(AAV9-NC)组(AN组)和携带UCP2基因的AAV9组(AU组),每组12只。Sham组仅切开皮肤后缝合,其余4组开胸结扎冠状动脉左前降支,缺血60 min后松开结扎线结,再灌注120 min建立IRI模型。酶联免疫吸附试验检测血清肌钙蛋白I(cTnI)、丙二醛(MDA)、超氧化物歧化酶(SOD)水平,流式细胞仪观察活性氧(ROS)的产生情况,透射电镜观察线粒体超微结构的变化,Western blot检测UCP2的表达水平,超声心动图评估心功能。结果:与Sham组相比,I/R组、Genipin组、AN组及AU组cTnI、MDA水平明显升高,SOD水平明显下降,ROS产生增多,线粒体结构紊乱,每搏输出量(SV)、射血分数(EF)、左室短轴缩短率(FS)明显降低(P0.05)。结论:过表达的UCP2通过抑制ROS产生,降低氧化应激水平,改善糖尿病小鼠心肌IRI。

关键词：解偶联蛋白2 心肌再灌注损伤糖尿病氧化应激

IL-6 IL-10 WBC/LYM在口腔颌面部间隙感染患者中的表达差异及临床价值

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安徽医学 2024年第9期45卷 1094-1099页

作者：张银银郑纪伟朱岩岩丁嘉慧孙玉华周田园徐州医科大学口腔医学院江苏徐州221000 徐州医科大学附属医院口腔颌面外科江苏徐州221000

目的分析白介素-6(IL-6)、白介素-10(IL-10)、白细胞计数/淋巴细胞比值(WBC/LYM)在口腔颌面部间隙感染患者中的表达水平差异及诊断价值。方法选取2019年1月至2022年3月因口腔颌面部间隙感染(OMSI)就诊于徐州医科大学附属医院的144例患... 详细信息

目的分析白介素-6(IL-6)、白介素-10(IL-10)、白细胞计数/淋巴细胞比值(WBC/LYM)在口腔颌面部间隙感染患者中的表达水平差异及诊断价值。方法选取2019年1月至2022年3月因口腔颌面部间隙感染(OMSI)就诊于徐州医科大学附属医院的144例患者为病例组。选取同期无炎症的腮腺良性肿瘤患者136例为对照组,收集两组患者治疗前IL-6、IL-10、WBC/LYM、C-反应蛋白(CRP)、中性粒细胞百分比(NEU%)、白细胞计数(WBC),采用单因素分析和受试者工作特征(ROC)曲线分析IL-6、IL-10、WBC/LYM与OMSI患者临床特征的关系及诊断价值。结果病例组IL-6、IL-10、WBC/LYM水平较对照组增高,差异有统计学意义(P<0.05);ROC曲线结果显示,IL-10、IL-6、WBC/LYM的曲线下面积(AUC)分别为0.868、0.947和0.942,5种因子联合检测的AUC为0.985,灵敏度为0.962,特异度为0.948。结论IL-10、IL-6、WBC/LYM可联合CRP、WBC和NEU%高效准确地诊断OMSI,高水平IL-6、IL-10、WBC/LYM是OMSI患者住院时间延长、发生并发症和术后需要ICU监护的重要参考指标。

关键词：口腔颌面部间隙感染白介素-10 白介素-6 白细胞计数/淋巴细胞比值诊断

Multifunctional high-performance pressure/proximity/temperature sensors enabled by hybrid resistive-supercapacitive response

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Nano Research 2024年第6期17卷 5604-5613页

作者： Huijun Kong Zhongqian Song Meichun ding Changxiang Shao jiahui Yu Baolei Wang Weiyan Li Chenwei Li Li Niu School of Chemistry and Pharmaceutical Engineering Shandong First Medical University and Shandong Academy of Medical SciencesJinan 250117China College of Artificial Intelligence and Big Data for Medical Sciences Shandong First Medical University and Shandong Academy of Medical SciencesJinan 250117China School of Chemical Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China

The issue of sensitivity attenuation in high-pressure region has been a persistent concern for pressure-sensitive electronic *** order to tackle such trade-off between sensitivity and linear range,herein,a hybrid piezoresistive-supercapacitive(HRSC)strategy is proposed via introducing a piezoresistive porous aerogel layer between the charge collecting electrodes and iontronic films of the pressure ***,the HRSC-induced impedance regulation and supercapacitive behavior contribute to significant mitigation in sensitivity attenuation,achieving high sensitivity across wide linear range(44.58 kPa^(−1)from 0 to 3 kPa and 23.6 kPa^(−1)from 3 to 12 kPa).The HRSC pressure sensor exhibits a low detection limit of 1 Pa,fast responsiveness(~130 ms),and excellent cycling stability,allowing to detect tiny pressure of air flow,finger bending,and human ***,the HRSC sensor exhibits exceptional perception capabilities for proximity and temperature,broadening its application scenarios in prosthetic perception and electronic *** proposed HRSC strategy may boost the ongoing research on structural design of high-performance and multimodal electronic sensors.

关键词： multimodal sensor pressure sensor high sensitivity MXene/poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS)aerogel structural design