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Nerve growth factor pretreatment against glutamate-induced hippocampal neuronal injury Action mechanism of phosphatase and tensin homologue deleted on chromosome 10

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Neural Regeneration Research 2010年第1期5卷 5-9页

作者： Yae hu jiahui Mao Yan Zhu Ailing Zhou Department of Pathophysiology Medical School of Nantong University Nantong 226001 Jiangsu Province China

BACKGROUND： Nerve growth factor （NGF） attenuates glutamate-induced injury to hippocampal neurons, and the human tumor suppressor gene phosphatase and tensin homologue deleted on chromosome 10 （PTEN） promotes neuronal apoptosis. However, effects of PTEN in NGF-mediated neuroprotection against glutamate excitotoxicity remain poorly understood. OBJECTIVE： To investigate the relationship between NGF inhibition of glutamate-induced injury and PTEN. DESIGN, TIME AND SE＇I＇rlNG： The randomized, controlled, in vitro study was performed at the Department of Pathophysiology, Medical School of Nantong University, China from October 2007 to March 2008. MATERIALS： Glutamate, NGF, 4, 6-diamidino-2-phenyl-indolediacetate, 3-[4, 5-dimethylthiazol-2-yl]- 2, 5-diphenyl tetrazoliumbromide （M-I-F）, and lactate dehydrogenase kit （Sigma, USA）, fluorescence microscope and inverted phase contrast microscope （Olympus, Japan） were used in this study. METHODS： Hippocampal neurons were obtained from newborn （〈 24 hours） Sprague Dawley rats and cultured for 7 days. The control group was not treated with any intervention factor, the glutamate group was treated with glutamate （0.2 mmol/L）, and NGF groups were treated with NGF （10, 50, 100, and 200 μg/L, respectively） prior to glutamate treatment. MAIN OUTCOME MEASURES： The MTT and lactate dehydrogenase assays were applied to evaluate viability of hippocampal neurons. Morphological changes in hippocampal neurons were observed using an inverted phase-contrast microscope, and neuronal apoptosis was detected by 4, 6-diamidino-2- phenyl-indolediacetate staining. PTEN mRNA and protein expression were measured by reverse transcription-polymerase chain reaction and Western blot analysis, respectively. RESULTS： Glutamate （0.2 mmol/L） induced significantly decreased neuronal viability and greater lactate dehydrogenase efflux compared with the control group （P 〈 0.01）. However, compared with the glutamate group, cell viability significantly increased and lac

关键词： nerve growth factor glutamate phosphatase and tensin homologue deleted on chromosome 10 hippocampus neurons nerve factor

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Compact finite difference schemes for the backward fractional Feynman–Kac equation with fractional substantial derivative

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Chinese Physics B 2019年第10期28卷 226-236页

作者： jiahui hu Jungang Wang Yufeng Nie Yanwei Luo Department of Applied Mathematics Northwestern Polytechnical UniversityXi’an 710129China College of Science Henan University of TechnologyZhengzhou 450001China

The fractional Feynman-Kac equations describe the distributions of functionals of non-Brownian motion, or anomalous diffusion, including two types called the forward and backward fractional Feynman-Kac equations, where the nonlocal time-space coupled fractional substantial derivative is involved. This paper focuses on the more widely used backward version. Based on the newly proposed approximation operators for fractional substantial derivative, we establish compact finite difference schemes for the backward fractional Feynman-Kac equation. The proposed difference schemes have the q-th(q = 1, 2, 3, 4) order accuracy in temporal direction and fourth order accuracy in spatial direction, respectively. The numerical stability and convergence in the maximum norm are proved for the first order time discretization scheme by the discrete energy method, where an inner product in complex space is introduced. Finally, extensive numerical experiments are carried out to verify the availability and superiority of the algorithms. Also, simulations of the backward fractional Feynman-Kac equation with Dirac delta function as the initial condition are performed to further confirm the effectiveness of the proposed methods.

关键词： backward fractional Feynman-Kac equation fractional substantial derivative compact finite difference scheme numerical inversion of Laplace transforms

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普通烟草PYL基因家族成员鉴定及干旱胁迫下基因表达分析

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核农学报 2025年第1期39卷 47-58页

作者：扈佳慧徐腾航刘杰王雨果刘红峰王世泽余世洲王丰贵州大学农学院贵州贵阳550025 贵州省烟草科学研究院贵州贵阳550081 河北科技师范学院农学与生物科技学院河北秦皇岛066004 贵州省烟草公司贵阳市公司贵州贵阳550001

PYR/PYL/RCAR(PYL)蛋白作为脱落酸(ABA)的直接受体,在ABA信号转导途径中发挥着关键调控作用。为探究PYL基因在烟草中的系统发育和表达模式,本研究利用生物信息学手段在普通烟草品种K326全基因组范围内进行了鉴定分析,并利用实时荧光定量... 详细信息

PYR/PYL/RCAR(PYL)蛋白作为脱落酸(ABA)的直接受体,在ABA信号转导途径中发挥着关键调控作用。为探究PYL基因在烟草中的系统发育和表达模式,本研究利用生物信息学手段在普通烟草品种K326全基因组范围内进行了鉴定分析,并利用实时荧光定量PCR(qRT-PCR)检测了各基因在遭受干旱胁迫0、1、3、6、12、24、36和48 h的基因表达量。结果共鉴定到26个烟草PYL基因,依据系统发育和结构特点可划分为3个亚家族(Ⅰ~Ⅲ),成员数目分别为9、11和6。蛋白理化性质分析结果表明,所有烟草PYL蛋白都呈亲水性,氨基酸长度在173~586 aa之间,相对分子量在16 763.26~65 709.39 Da之间,等电点(pI)在4.73~9.05之间。顺式作用元件分析结果发现,烟草PYL基因启动子区含有MYB、NAC、WARKY、TCP、ZF-HD等逆境胁迫响应相关元件。基因表达结果显示,烟草PYL基因在遭受干旱胁迫后,除NtPYL8、NtPYL9、NtPYL17和NtPYL21基因外、其余基因表达量整体表现为上调趋势,但各亚家族成员间基因表达具有明显差异。其中亚家族Ⅱ中NtPYL1、NtPYL2、NtPYL4基因和亚家族Ⅲ中NtPYL25基因在遭受干旱胁迫6~12 h后基因表达量达到最高,且相对表达量较0 h上升显著,可作为烟草应答干旱胁迫的重要候选基因。本研究为进一步开展烟草候选抗旱PYL基因功能研究及育种利用奠定了基础。

关键词：烟草 PYL家族干旱胁迫基因表达分析脱落酸

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AttrLeaks on the Edge: Exploiting Information Leakage from Privacy-Preserving Co-inference

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Chinese Journal of Electronics 2023年第1期32卷 1-12页

作者： WANG Zhibo LIU Kaixin hu jiahui REN Ju GUO Hengchang YUAN Wei School of Cyber Science and Engineering Wuhan University School of Cyber Science and Technology Zhejiang University Department of Computer Science and Technology Tsinghua University

Collaborative inference(co-inference) accelerates deep neural network inference via extracting representations at the device and making predictions at the edge server, which however might disclose the sensitive information about private attributes of users(e.g.,race). Although many privacy-preserving mechanisms on co-inference have been proposed to eliminate privacy concerns, privacy leakage of sensitive attributes might still happen during inference. In this paper, we explore privacy leakage against the privacy-preserving co-inference by decoding the uploaded representations into a vulnerable form. We propose a novel attack framework named AttrL eaks, which consists of the shadow model of feature extractor(FE), the susceptibility reconstruction decoder,and the private attribute classifier. Based on our observation that values in inner layers of FE(internal representation) are more sensitive to attack, the shadow model is proposed to simulate the FE of the victim in the blackbox scenario and generates the internal ***, the susceptibility reconstruction decoder is designed to transform the uploaded representations of the victim into the vulnerable form, which enables the malicious classifier to easily predict the private attributes. Extensive experimental results demonstrate that AttrLeaks outperforms the state of the art in terms of attack success rate.

关键词： Deep learning Privacy Collaboration Transforms Feature extraction Prediction algorithms Iron

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Flexible nanoimprint lithography enables high-throughput manufacturing of bioinspired microstructures on warped substrates for efficient III-nitride optoelectronic devices

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Science Bulletin 2024年第13期69卷 2080-2088页

作者： Siyuan Cui Ke Sun Zhefu Liao Qianxi Zhou Leonard Jin Conglong Jin jiahui hu Kuo-Sheng Wen Sheng Liu Shengjun Zhou Center for Photonics and Semiconductors School of Power and Mechanical EngineeringWuhan UniversityWuhan 430072China The Institute of Technological Sciences Wuhan UniversityWuhan 430072China Department of Mechanical and Mechatronics Engineering University of WaterlooWaterloo ONN2L 3G1Canada Jiangxi SMTC Semiconductor Co. Ltd.Nanchang 330096China

III-nitride materials are of great importance in the development of modern optoelectronics,but they have been limited over years by low light utilization rate and high dislocation densities in heteroepitaxial films grown on foreign substrate with limited refractive index contrast and large lattice ***,we demonstrate a paradigm of high-throughput manufacturing bioinspired microstructures on warped substrates by flexible nanoimprint lithography for promoting the light extraction *** design a flexible nanoimprinting mold of copolymer and a two-step etching process that enable high-efficiency fabrication of nanoimprinted compound-eye-like Al2O3 microstructure(NCAM)and nanoimprinted compound-eye-like SiO_(2)microstructure(NCSM)template,achieving a 6.4-fold increase in throughput and 25%savings in economic costs over stepper projection *** to NCAM template,we find that the NCSM template can not only improve the light extraction capability,but also modulate the morphology of AlN nucleation layer and reduce the formation of misoriented GaN grains on the inclined sidewall of microstructures,which suppresses the dislocations generated during coalescence,resulting in 40%reduction in dislocation *** study provides a low-cost,high-quality,and high-throughput solution for manufacturing microstructures on warped surfaces of III-nitride optoelectronic devices.

关键词： Flexible nanoimprint lithography Bioinspired Micro-and nano-manufacturing III-nitride epitaxy Optoelectronic devices

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Growth of InGaN-based blue-LED on AlN/sapphire sputtered with different oxygen flow rate

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Frontiers of Optoelectronics 2021年第4期14卷 507-512页

作者： jiahui hu Feng WU Jiangnan DAI Changqing CHEN Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China

Indium gallium nitride(InGaN)based blue light-emitting diodes(LEDs)suffer from insufficient crystal quality and serious efficiency droop in large forward *** this paper,the InGaN-based blue LEDs are grown on sputtered aluminum nitride(AlN)films to improve the device light power and weaken the efficiency *** effects of oxygen flow rate on the sputtering of AlN films on sapphire and device performance of blue LEDs are studied in *** mechanism of external quantum efficiency improvement is related to the change of V-pits density in multiple quantum *** external quantum efficiency of 66%and 3-V operating voltage are measured at a 40-mA forward current of with the optimal oxygen flow rate of 4 SCCM.

关键词： light-emitting diode(LED) sputtered aluminum nitride(AlN) physical vapor deposition(PVD) metalorganic chemical vapor deposition(MOCVD)

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TSCompiler: efficient compilation framework for dynamic-shape models

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Science China(Information Sciences) 2024年第10期67卷 67-84页

作者： Xiang LUO Chen ZHANG Chenbo GENG Yanzhi YI jiahui hu Renwei ZHANG Zhen ZHANG Gianpietro CONSOLARO Fan YANG Tun LU Ning GU Li SHANG School of Computer Science Fudan University School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University School of Computer Science and Technology Harbin Institute of Technology huawei Technologies Co. Ltd. huawei Paris Research Center School of Microelectronics Fudan University

Today's deep learning models face an increasing demand to handle dynamic shape tensors and computation whose shape information remains unknown at compile time and varies in a nearly infinite range at runtime. This shape dynamism brings tremendous challenges for existing compilation pipelines designed for static models which optimize tensor programs relying on exact shape values. This paper presents TSCompiler, an end-to-end compilation framework for dynamic shape models. TSCompiler first proposes a symbolic shape propagation algorithm to recover symbolic shape information at compile time to enable subsequent optimizations. TSCompiler then partitions the shape-annotated computation graph into multiple subgraphs and fine-tunes the backbone operators from the subgraph within a hardware-aligned search space to find a collection of high-performance schedules. TSCompiler can propagate the explored backbone schedule to other fusion groups within the same subgraph to generate a set of parameterized tensor programs for fused cases based on dependence analysis. At runtime, TSCompiler utilizes an occupancy-targeted cost model to select from pre-compiled tensor programs for varied tensor shapes. Extensive evaluations show that TSCompiler can achieve state-of-the-art speedups for dynamic shape models. For example, we can improve kernel efficiency by up to 3.97× on NVIDIA RTX3090, and 10.30× on NVIDIA A100 and achieve up to five orders of magnitude speedups on end-to-end latency.

关键词： machine learning tensor compilers dynamic shape operator fusion code generation auto-tuning

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Pricing and Rebate Strategies in a Dual-Channel Supply Chain with Customer Returns

Pricing and Rebate Strategies in a Dual-Channel Supply Chain...

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作者： hua Ke jiahui hu School of Economics and Management Tongji University

This paper studies the optimal customer rebate strategy in a dual-channel supply chain, in which online customers can obtain rebates or return unsatisfactory products. We consider that providing rebates can reduce online customers’ willingness to return. Three rebate strategies are discussed: no one offering rebates, the manufacturer offering rebates and the retailer offering rebates. We investigate the impact of customer preference and rebate strategies on supply chain members’ optimal decisions and manufacturer’s performance. It is found that when the manufacturer offers rebates, wholesale price decreases as more customers prefer the online store. Through the numerical study, we find that the manufacturer can always get more profits by providing rebates.

关键词： Dual channel Customer rebate Customer return Pricing Game theory

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Mapping the knowledge of international Chinese medicines treatment on type 2 diabetes:A biblimetrical study

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Journal of Traditional Chinese Medical Sciences 2016年第4期3卷 263-272页

作者： jiahui hu Kangle Shi Qinggang Meng School of Basic Medical Science Beijing University of Chinese MedicineBeijing 100029China

Objective:To uncover and identify the hot topic and frontier of Chinese medicines treatment of type 2 diabetes mellitus(T2DM).Methods:Web of Science TM was searched for published articles for Chinese medicines treatment of T2DM ranging from January 1st,2002 to July 6th,*** maps of the international Chinese medicines treatment of T2DM are visualized by using document cooccurrence analysis and word frequency analysis(Institution and Journal),co-citation clustering analysis(Co-reference),keyword co-occurrence clustering analysis with CiteSpac III,a tool of ***:Universidad Nacional Autonoma de Mexico is the institution with the highest number of published papers that had been cited in this field,while China has four institutions among the top *** journal of the highest frequency of co-cited journal was Diabetes Care,a core one in the *** co-occurrence network was composed of 185 nodes,541 lines,and divided into 10 ***-citation network of co-reference was composed of 407 nodes,1199 lines,and divided into 20 *** Chinese medicine to improve insulin resistance and Chinese medicine research on blood glucose control are the hot *** frontier contains two aspects:new drugs development and application of intestinal insulin treatment and development and use of traditional Chinese medicine antidiabetic ***:Institutions from China still plays a major role in TCM-focused T2DM *** effect of TCM herbs on insulin resistance is the hot topic of the *** new TCM herbal medicine that regulates incretin effect is the domain *** on the Chinese medicines treatment of T2DM needs more high-quality evidence to support,and its mechanism requires further exploration.

关键词： Chinese medicine CiteSpace Knowledge map Type 2 diabetes mellitus

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近区爆炸作用下砌体填充墙损伤破坏与动态响应的数值模拟

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振动与冲击 2021年第9期40卷 1-11页

作者：胡嘉辉吴昊方秦同济大学土木工程学院上海200092 陆军工程大学爆炸冲击防灾减灾国家重点实验室南京210007

民用建筑中广泛使用的砌体填充墙在爆炸荷载作用下产生的碎块严重威胁着建筑物内部人员和设备的安全。尤其是近区爆炸作用下,墙体会产生更为严重的局部破坏,碎片飞散速度更快,但已有的相关研究工作仍旧较少。基于已有普通黏土烧结砖填... 详细信息

民用建筑中广泛使用的砌体填充墙在爆炸荷载作用下产生的碎块严重威胁着建筑物内部人员和设备的安全。尤其是近区爆炸作用下,墙体会产生更为严重的局部破坏,碎片飞散速度更快,但已有的相关研究工作仍旧较少。基于已有普通黏土烧结砖填充墙的近区爆炸试验,开展了近区爆炸作用下砌体填充墙损伤破坏和动态响应的数值模拟,对比验证了Load Blast法、任意拉格朗日欧拉(arbitrary Lagrange-Eulerian,ALE)法和冲量法模拟近区爆炸荷载作用、预测墙体损伤破坏和动态响应的适用性。通过冲量法进一步讨论了相同比例距离下的爆炸距离、砌块砂浆界面黏结强度以及砌块材料模型的影响。结果表明:近区爆炸中,相同比例距离下,墙体损伤通常随爆炸距离增加而加剧,由局部破坏向整体坍塌破坏模式发展;墙体的抗爆性能随砌块砂浆黏结强度增强而得到强化,主要受剪切失效应力控制;MAT_BRITTLE_DAMAGE和MAT_WINFRITH_CONCRETE模型较MAT_SOIL_AND_FOAM模型预测效果更好。

关键词：砌体填充墙近区爆炸动态响应数值模拟比例距离

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