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Science China Chemistry 2021年第9期64卷 1596-1604页

作者： jiahui fan Jian Lu Zhou Sha Weiwei Zuo Xiang Fei Meifang Zhu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China

Continuous-flow microreactors offer increased reactivity and reusability via unique reaction pathways to address a wide range of practical nanocatalysis ***,only limited platforms exist to employ these microreactors for versatile nanocatalytic *** this work,we conformally anchored nickel oxide(Ni O)nanosheets onto quartz fibers(QFs),which exhibited a high catalytic activity using the hydrogenation of 4-nitrophenol(4-NP)as a model reaction in a batch reaction *** importantly,we demonstrated that fiber-based QF@Ni O composites(e.g.,cotton,fabric,belt,felt)can be integrated as versatile platforms to develop microreactors for continuous-flow catalytic applications including hydrogenation reactions and dyecatalyzed *** fiber-based three-dimensional(3 D)nanocatalyst architecture effectively drives continuous-flow catalytic reactions with unprecedented efficiency due to the easy diffusion of reactant molecules into the fibrous structure,allowing contact with catalytic active *** approach to continuous-flow microreactor design uses surface hybridization as a guideline to immobilize nanocatalysts onto the *** QF-based platforms,coupled with rational design,are expected to be applied to a wide range of nanocatalytic reactions.

关键词： quartz fiber platform nanocatalyst immobilization microreactor continuous-flow catalysis

Phenotype and metabolism alterations in PCB-degrading Rhodococcus biphenylivorans TG9^(T) under acid stress

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Journal of Environmental Sciences 2023年第5期127卷 441-452页

作者： Aili Li jiahui fan Yangyang Jia Xianjin Tang Jingwen Chen Chaofeng Shen Department of Environmental Engineering College of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China MOE Key Lab of Environmental Remediation and Ecosystem Health College of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China

Environmental acidification impairs microorganism diversity and their functions on substance *** is a ubiquitously distributed genus for contaminant detoxification in the environment,and it can also adapt a certain range of *** work interpreted the acid responses from both phenotype and metabolism in strain Rhodococcus biphenylivorans TG9^(T)(TG9)induced at pH *** phenotype alterations were described with the number of culturable and viable cells,intracellular ATP concentrations,cell shape and entocyte,degradation efficiency of polychlorinated biphenyl(PCB)31 and *** number of culturable cells maintained rather stable within the first 10 days,even though the other phenotypes had noticeable alterations,indicating that TG9 possesses certain capacities to survive under acid *** metabolism responses were interpreted based on transcription analyses with four treatments including log phase(LP),acid-induced(PER),early recovery after removing acid(RE)and later recovery(REL).With the overview on the expression regulations among the 4 treatments,the RE sample presented more upregulated and less downregulated genes,suggesting that its metabolism was somehow more active after recovering from acid *** addition,the response mechanism was interpreted on 10 individual metabolism pathways mainly covering protein modification,antioxidation,antipermeability,H+consumption,neutralization and ***,the transcription variations were verified with RT-qPCR on 8 genes with 24-hr,48-hr and 72-hr acid *** together,TG9 possesses comprehensive metabolism strategies defending against acid ***,a model was built to provide an integrate insight to understand the acid resistance/tolerance metabolisms in microorganisms.

关键词： Environmental acidification Rhodococcus biphenylivorans Contaminant degradation Phenotypic response Transcription analysis Metabolism pathway Mechanism model

Sirt1-ROS-TRAF6 Signaling-Induced Pyroptosis Contributes to Early Injury in Ischemic Mice

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Neuroscience Bulletin 2020年第8期36卷 845-859页

作者： Weijie Yan Wei Sun jiahui fan Haiqing Wang Song Han Junfa Li Yanling Yin Department of Neurobiology Ministry of Education Key Laboratory for Neurodegenerative DisordersCapital Medical UniversityBeijing 100069China Department of Neurology The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China

Stroke is an acute cerebro-vascular disease with high incidence and poor prognosis,most commonly ischemic in *** recent years,increasing attention has been paid to inflammatory reactions as symptoms of a ***,the role of inflammation in stroke and its underlying mechanisms require *** this study,we evaluated the inflammatory reactions induced by acute ischemia and found that pyroptosis occurred after acute ischemia both in vivo and in vitro,as determined by interleukin-1β,apoptosis-associated speck-like protein,and *** early inflammation resulted in irreversible ischemic injury,indicating that it deserves thorough ***,acute ischemia decreased the Sirtuin 1(Sirtl)protein levels,and increased the TRAF6(TNF receptor associated factor 6)protein and reactive oxygen species(ROS)*** further exploration,both Sirtl suppression and TRAF6 activation were found to contribute to this *** Sirtl levels were responsible for the production of ROS and increased TRAF6 protein levels after ischemic ***,N-acetyl-L-cysteine,an ROS scavenger,suppressed the TRAF6 accumulation induced by oxygen-glucose deprivation via suppression of ROS *** phenomena indicate that Sirtl is upstream of ROS,and ROS bursts result in increased TRAF6 ***,the activation of Sirtl during the period of ischemia reduced ischemiainduced injury after 72 h of reperfusion in mice with middle cerebral artery *** sum,these results indicate that pyroptosis-dependent machinery contributes to the neural injury during acute ischemia via the Sirt1-ROS-TRAF6 signaling *** propose that inflammatory reactions occur soon after oxidative stress and are detrimental to neuronal survival;this provides a promising therapeutic target against ischemic injuries such as a stroke.

关键词： ROS Stroke Pyroptosis TRAF6 Sirt1

lncRNA ZNF593-AS inhibits cardiac hypertrophy and myocardial remodeling by upregulating Mfn2 expression

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Frontiers of Medicine 2024年第3期18卷 484-498页

作者： Xiang Nie jiahui fan Yanwen Wang Rong Xie Chen Chen Huaping Li Dao Wen Wang Division of Cardiology Department of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Wuhan430030China

lncRNA ZNF593 antisense(ZNF593-AS)transcripts have been implicated in heart failure through the regulation of myocardial *** decreased transcriptional activity of ZNF593-AS has also been detected in cardiac ***,the function of ZNF593-AS in cardiac hypertrophy remains ***,we report that the expression of ZNF593-AS reduced in a mouse model of left ventricular hypertrophy and cardiomyocytes in response to treatment with the hypertrophic agonist phenylephrine(PE).In vivo,ZNF593-AS aggravated pressure overload–induced cardiac hypertrophy in knockout *** contrast,cardiomyocyte-specific transgenic mice(ZNF593-AS MHC-Tg)exhibited attenuated TAC-induced cardiac *** vitro,vector-based overexpression using murine or human ZNF593-AS alleviated PE-induced myocyte hypertrophy,whereas GapmeR-induced inhibition aggravated hypertrophic *** using RNA-seq and gene set enrichment analyses,we identified a link between ZNF593-AS and oxidative phosphorylation and found that mitofusin 2(Mfn2)is a direct target of ***593-AS exerts an antihypertrophic effect by upregulating Mfn2 expression and improving mitochondrial ***,it represents a promising therapeutic target for combating pathological cardiac remodeling.

关键词： lncRNA ZNF593-AS cardiac hypertrophy Mfn2 oxidative phosphorylation

Nuclear miR-665 aggravates heart failure via suppressing phosphatase and tensin homolog transcription

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Science China(Life Sciences) 2020年第5期63卷 724-736页

作者： jiahui fan Xudong Zhang Xiang Nie Huaping Li Shuai Yuan Beibei Dai Jiabing Zhan Zheng Wen Jiangang Jiang Chen Chen Daowen Wang Division of Cardiology Department of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Wuhan 430030China

Although numerous miRNAs have been discovered,their functions in the different subcellular organelles have remained *** this study,we found that miR-665 was enriched in the nucleus of cardiomyocytes,and then investigated the underlying role of nuclear miR-665 in heart *** fluorescence in situ hybridization assays in human heart tissue sections and primary cardiomyocytes showed that miR-665 was localized in the nucleus of *** expression of nuclear miR-665 was observed not only in the cardiomyocytes isolated from the heart of mice treated in vivo by transverse aortic constriction(TAC),but also in phenylephrine(PE)-treated cultured cardiomyocytes in *** further explore the role of miR-665 in heart failure,a type 9 recombinant adeno-associated virus(rAAV)system was employed to manipulate the expression of miR-665 in *** of miR-665 aggravated TAC-induced cardiac dysfunction,while down-expression of miR-665 showed opposite *** prediction and biological validation confirmed that the PTEN(phosphatase and tensin homolog)gene was one of the targets of miR-665 in the ***,restoring PTEN expression significantly eliminated the destructive effects of miR-665 over-expression in TAC-induced cardiac *** data showed that nuclear miR-665 aggravates heart failure via inhibiting PTEN expression,which provided a therapeutic approach for heart failure.

关键词： nucleus miR-665 heart failure phosphatase and tensin homolog

Fibroblast-localized lncRNA CFIRL promotes cardiac fibrosis and dysfunction in dilated cardiomyopathy

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Science China(Life Sciences) 2024年第6期67卷 1155-1169页

作者： Shuai Yuan Xudong Zhang Jiabing Zhan Rong Xie jiahui fan Beibei Dai Yanru Zhao Zhongwei Yin Qian Liu Dao Wen Wang Huaping Li Chen Chen Division of Cardiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Wuhan 430030China Department of Forensic Medicine Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

CFIRL is a long noncoding RNA(lnc RNA),we previously identified as the most significantly upregulated lnc RNA in the failing hearts of patients with dilated cardiomyopathy(DCM).In this study,we determined the function of CFIRL and its role in ***-time polymerase chain reaction and in situ hybridization assays revealed that CFIRL was primarily localized in the nucleus of cardiac fibroblasts and robustly increased in failing *** knockdown or fibroblast-specific knockout of CFIRL attenuated transverse aortic constriction(TAC)-induced cardiac dysfunction and fibrosis in *** of CFIRL in vitro promoted fibroblast proliferation and aggravated angiotensin II-induced differentiation to *** knockdown attenuated these ***,RNA pull-down assay and gene expression profiling revealed that CFIRL recruited ENO1,a newly identified noncanonical transcriptional factor,to activate ***-6 exerted a paracrine effect on cardiomyocytes to promote cardiac hypertrophy,which can be prevented by CFIRL *** findings uncover the critical role of CFIRL,a fibroblast-associated lnc RNA,in heart failure by facilitating crosstalk between fibroblasts and *** knockdown might be a potent strategy to prevent cardiac remodeling in heart failure,particularly in DCM.

关键词： lncRNA fibroblast fibrosis dilated cardiomyopathy heart failure

The double face of miR-320:cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constriction

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Signal Transduction and Targeted Therapy 2021年第3期6卷 950-961页

作者： Xudong Zhang Shuai Yuan Huaping Li Jiabing Zhan Feng Wang jiahui fan Xiang Nie Yan Wang Zheng Wen Yanghui Chen Chen Chen Dao Wen Wang Division of Cardiology Tongji HospitalTongji Medical College and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiologic DisordersHuazhong University of Science and TechnologyWuhan 430030China

MicroRNAs(miRNAs)are aberrantly expressed in the pathophysiologic process of heart failure(HF).However,the functions of a certain miRNA in different cardiac cell types during HF are scarcely reported,which might be covered by the globe effects of it on the *** the current study,Langendorff system was applied to isolate card io myocytes(CMs)and cardiac fibroblasts(CFs)from transverse aortic constriction(TAC)-induced *** increase of miR-320 expression was observed in the whole heart tissue of TAC ***,miR-320 was significantly elevated in CMs but decreased in CFs from TAC mice at different time ***,recombinant adeno-associated virus 9 with cell-type-specific promoters were used to manipulate miR-320 expressions in *** in vitro and in vivo experiments showed the miR-320 overexpression in CMs exacerbated cardiac dysfunction,whereas overexpression of miR-320 in CFs alleviated cardiac fibrosis and ***,downstream signaling pathway analyses revealed that miR-320 might induce various effects via targeting PLEKHM3 and IFITM1 in CMs and CFs,***,miR-320 mediated effects could be abolished by PLEKHM3 re-expression in CMs or IFITM1 re-expression in ***,miR-320 treated CFs were able to indirectly affect CMs function,but not vice ***,upstream signaling pathway analyses showed that miR-320 expression and decay rate were rigorously manipulated by Ago2,which was regulated by a cluster of cell-type-specific TFs distinctively expressed in CMs and CFs,***,we demonstrated that miR-320 functioned differently in various cell types of the heart during the progression of HF.

关键词： miR elevated transverse

世行新营商环境评估视野下我国动产担保制度审思

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比较法研究 2023年第5期 149-166页

作者：范佳慧清华大学法学院

在世行新营商环境评估项目下,“金融服务”主题旨在考察企业运营与扩张中的金融准入因素,“动产担保交易与登记系统的运营”是其下围绕经济体的动产担保法制进行考察的领域。在“统一的动产担保交易法律框架”指标下,通过对我国民法典... 详细信息

在世行新营商环境评估项目下,“金融服务”主题旨在考察企业运营与扩张中的金融准入因素,“动产担保交易与登记系统的运营”是其下围绕经济体的动产担保法制进行考察的领域。在“统一的动产担保交易法律框架”指标下,通过对我国民法典相关规则的展开解释,可以将动产让与担保纳入现有动产担保制度体系内,并使应收账款的担保性让与和完全让与平等地适用规则,但未来应当赋予非基于保理的应收账款完全让与以登记能力。在“动产担保物与担保债权的类型”指标下,我国的失分点是抵押权的效力不能自动及于抵押物所生孳息,担保物权的效力不能自动及于担保物的转让对价,解决方案是通过当事人的合意实现动产担保物权效力的自动延伸。在“动产担保物权的优先顺位与权利实现”指标下,我国的问题是担保债权与税收债权的优先顺位需要更明确、合理的规则。虽然流担保契约的效力受到限制,但我国承认了担保物权庭外实现约定的效力。在“动产担保登记系统的运营”指标下,我国的动产融资统一登记公示系统能够最大程度地满足世行要求,但我国未来的制度设计须考虑到如何降低相对人的信息获取成本、避免担保权人虚假登记。

关键词：营商环境动产担保登记收益优先顺位

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论融资租赁交易中的权利冲突与利益实现

法学家 2023年第5期 103-117,194页

作者：范佳慧清华大学法学院

融资租赁交易的功能化,所着眼的是出租人与第三人的权利冲突如何协调、出租人的利益如何实现,其路径是将出租人所有权的物权保护与动产抵押权同等对待。在《民法典》体系下,应当依据案件客观事实,识别普通租赁与融资租赁,再适用具体的... 详细信息

融资租赁交易的功能化,所着眼的是出租人与第三人的权利冲突如何协调、出租人的利益如何实现,其路径是将出租人所有权的物权保护与动产抵押权同等对待。在《民法典》体系下,应当依据案件客观事实,识别普通租赁与融资租赁,再适用具体的规则。普通动产的融资租赁应在动产融资统一登记公示系统进行登记,特殊动产的融资租赁登记则应继续在原有权利登记系统展开。在出租人与第三人就租赁物产生权利冲突时,应当依据《民法典》第745条,参照适用动产抵押权的登记对抗规则。至于出租人所有权与其他担保权的竞存顺位,则参照适用动产抵押权的顺位规则,并以《民法典》第416条作为特别适用的规则。在承租人违约后,出租人可以准用担保债权的实现路径,即在主张租金加速到期的前提下,可通过普通民事诉讼程序或“实现担保物权案件”的特别程序,同时主张就租赁物价值受偿。同时,出租人还可以依据《民法典》第752条,选择解除合同、收回租赁物。在承租人破产时,出租人无权行使破产取回权,但在其权利已登记时,可以申报担保债权,否则只能申报普通债权。

关键词：融资租赁功能主义顺位违约破产

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论一人公司关联担保的效力

法学论坛 2021年第2期36卷 111-120页

作者：范佳慧中国人民大学民商事法律科学研究中心北京100872

一人公司与股东之间存在紧密的利益联系,无论是股东为公司担保还是公司为股东担保,都属于商业活动中的正常交易安排。一人公司为股东担保具有无可替代的融资价值,且在功能上并不等同于股东以股权作为债权的一般担保。若债权人的利益受... 详细信息

一人公司与股东之间存在紧密的利益联系,无论是股东为公司担保还是公司为股东担保,都属于商业活动中的正常交易安排。一人公司为股东担保具有无可替代的融资价值,且在功能上并不等同于股东以股权作为债权的一般担保。若债权人的利益受到关联担保的损害,债权人可以通过法人人格否认等事后制度予以救济,故而一人公司的关联担保具有价值上的正当性。《公司法》第16条的适用对象并不包括一人公司,现行法也未限制一人公司的关联担保能力,因此一人公司为股东担保的效力应予肯定。至于公司债权人的利益,可以通过一人公司的法人人格否认制度予以保护。在实质一人公司为股东提供担保时,其效力在解释上亦应与形式一人公司保持一致。在具体诉讼中,则可以通过证明责任倒置解决实质一人公司认定困难的问题。

关键词：一人公司关联担保融资价值目的限缩证明责任