检索结果-南通市图书馆

非金属矿 2012年第6期35卷 32-34页

作者：刘家弟山东理工大学资源与环境工程学院山东淄博255049

讨论了石材加工粉末废料生产建筑砌墙砖的原料配比、粒级组成、成型水分、成型压力和养护制度,确定了最佳工艺参数,探讨了制品强度机理。在最佳参数条件下,制品的抗压强度可达到10级砖以上标准。

关键词：石材花岗岩粉末废料成型养护

Allergenic risk assessment of porcine myoglobin expressed by engineered Komagataella Phaffii

在线全文

学校读者我要写书评

暂无评论

Fundamental Research 2024年第5期4卷 1339-1348页

作者： Yongli Ye jiadi Sun Jiayuan Xu Peipei Li Lina Sheng Yuan Qian Jian Ji Xiaomin Han Xinrui Zhao Jingwen Zhou Xiulan Sun School of Food Science and Technology International Joint Laboratory on Food SafetySynergetic Innovation Center of Food Safety and Quality ControlJiangnan UniversityWuxi 214122China Yixing Institute of Food and Biotechnology Co. Ltd.Yixing 214200China Science Center for Future Foods National Engineering Laboratory for Cereal Fermentation Technology(NELCF)Engineering Research Center of Ministry of Education on Food Synthetic BiotechnologyJiangnan UniversityWuxi 214122China NHC Key Laboratory of Food Safety Risk Assessment China National Center for Food Safety Risk AssessmentBeijing 100021China

Myoglobin produced by fermentation using engineered Komagataella phaffii is an important color additive in meat analogue products,but its allergenicity is poorly ***,we initially searched the Allergen Online database and did not find any allergic or cross-reactive proteins in porcine myoglobin(PM).In vitro simulated digestion demonstrated that PM did not exhibit notable acid-base resistance or anti-digestion ***,sensitization was observed in BALB/c mice,including a significant increase in specific antibodies and biomarkers for allergic reactions,as well as alterations in gut microbiome and serum ***,the intensity of sensitization exhibited a negative correlation with the purity of PM.60%and 88%purities showed weaker sensitization compared to the ovalbumin control *** allergic reactions were likely due to the non-myoglobin protein portion,highlighting the importance of purification processes and the urgent need to assess the allergenicity of this portion.

关键词： Porcine myoglobin Komagataella phaffii Allergenic risk assessment Immune response Purification process

Airway administration of bisphosphate and dexamethasone inhibits SARS-CoV-2 variant infection by targeting alveolar macrophages

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2022年第5期7卷 1375-1378页

作者： Zhenfeng Wang Yabo Zhou Linlin Bao Dan Li jiadi Lv Dianheng Wang Shunshun Li Jiangning Liu Chuan Qin Wei-Min Tong Bo Huang Department of Immunology&National Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences(CAMS)&Peking Union Medical College100005 BeijingChina NHC Key Laboratory of Human Disease Comparative Medicine Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceCAMS and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina Department of Pathology Institute of Basic Medical SciencesCAMS and Peking Union Medical CollegeBeijingChina Department of Biochemistry&Molecular Biology Tongji Medical CollegeHuazhong University of Science&Technology430030 WuhanChina

Dear Editor,Alveolar macrophages(AMs)are among the first immune cells to encounter SARS-CoV-2 during an infection due to their abundant numbers and physical location in the ***,the reaction of AMs to SARS-CoV-2 has a profound impact on the outcome of the *** most cases,AMs can release cytokines and prime adaptive T-and B-cell immune responses to resolve the infection.

关键词： infection alveolar release

乡村振兴视域下农村党员公共精神的培塑——基于湖北Z镇的实证分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

探索 2021年第6期 126-136页

作者：付佳迪中南财经政法大学马克思主义学院湖北武汉430073

农村党员是乡村振兴最直接的参与者,是乡村振兴的"主心骨"和"领头雁",通过参与党组织活动和村庄公共事务,培塑公共精神,有助于推进乡村治理和乡村振兴。研究以湖北Z镇的两个村庄案例作为考察对象,发现受党员吸纳能力不足、党员老龄化制... 详细信息

农村党员是乡村振兴最直接的参与者,是乡村振兴的"主心骨"和"领头雁",通过参与党组织活动和村庄公共事务,培塑公共精神,有助于推进乡村治理和乡村振兴。研究以湖北Z镇的两个村庄案例作为考察对象,发现受党员吸纳能力不足、党员老龄化制约、党员分化、私人关系支配等因素影响,农村党员面临一系列公共精神挑战。为此,要以完善组织内外的"参与机制"为抓手,从党员参与党组织活动、党内民主、移风易俗、志愿服务出发,构建农村党员公共精神的培塑路径。

关键词：农村党员公共精神乡村振兴培塑路径

Prognosis of lymph node-negative colorectal cancer:preoperative carcinoembryonic antigen level play a key role

在线全文

学校读者我要写书评

暂无评论

Prognosis of lymph node-negative colorectal cancer:preoperat...

microRNAs and ceRNAs: RNA networks in pathogenesis of cancer

第八届中国肿瘤学术大会暨第十三届海峡两岸肿瘤学术会议

作者： chenghai zhang ming cui jiadi xing hong yang zhendan yao nan zhang xiangqian su Department of Minimally Invasive Gastrointestinal Surgery Beijing Cancer Hospital and Institute Peking University School of Oncology Key laboratory of Carcinogenesis and Translational Research （ Ministry of Education）

＜正＞Objective Many studies revealed that the recurrence rate of lymph node-negative（pN0）colorectal cancer（CRC）was up to 25%-40%.Regrettably,the exact risk factors for recurrence of pN0 CRCs remain *** we conduct...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2013年第2期25卷 235-239页

作者： Xiangqian Su jiadi Xing Zaozao Wang Lei Chen Ming Cui Beihai Jiang Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Minimally Invasive Gastrointestinal Surgery Peking University Cancer Hospital & Institute

microRNAs （miRNAs） are a class of endogenous, single-stranded non-coding RNAs of 20- 23 nucleotides in length, functioning as negative regulators of gene expression at the post-transcriptional level. The dysregulation of miRNAs has been demonstrated to play critical roles in tumorigenesis, either through inhibiting tumor suppressor genes or activating oncogenes inappropriately. Besides their promising clinical applications in cancer diagnosis and treatment, recent studies have uncovered that miRNAs could act as a regulatory language, through which messenger RNAs, transcribed pseudogenes, and long noncoding RNAs crosstalk with each other and form a novel regulatory network. RNA transcripts involved in this network have been termed as competing endogenous RNAs （ceRNAs）, since they influence each other＇s level by competing for the same pool of miRNAs through miRNA response elements （MREs） on their target transcripts. The discovery of miRNA-ceRNA network not only provides the possibility of an additional level of post-transcriptional regulation, but also dictates a reassessment of the existing regulatory pathways involved in cancer initiation and progression.

关键词： miRNA ceRNA cancer

在线全文

学校读者我要写书评

暂无评论

石材加工粉末废料生产加气混凝土砌块研究

非金属矿 2014年第4期37卷 50-52页

作者：刘家弟山东理工大学资源与环境工程学院山东淄博255049

讨论了石材加工粉末废料生产加气混凝土砌块的原料性质、原料配比、发泡剂用量、料浆水分和养护制度等影响因素,确定了最佳工艺参数,探讨了砌块强度机理。在最佳工艺参数条件下,可生产出10级以上加气混凝土砌块。

关键词：石材加工粉末废料养护加气混凝土砌块

在线全文

学校读者我要写书评

暂无评论

抵销权行使规则的细化及其具体适用

中国法律评论 2024年第1期 75-84页

作者：蒋家棣最高人民法院研究室民事处

我国《民法典》发展完善了抵销制度。为确保抵销制度的统一正确实施,《合同编通则司法解释》结合审判实践需要,对抵销的具体法律适用作了安排,特别是对如何处理若干认识不统一的问题作出了明确指引。具体包括:细化了抵销的法律效果,明... 详细信息

我国《民法典》发展完善了抵销制度。为确保抵销制度的统一正确实施,《合同编通则司法解释》结合审判实践需要,对抵销的具体法律适用作了安排,特别是对如何处理若干认识不统一的问题作出了明确指引。具体包括:细化了抵销的法律效果,明确抵销不具有溯及力,并在此基础上对已过诉讼时效的债权能否抵销作出规定;明确抵销可以参照适用清偿抵充的规则;区分侵害人身权益和财产权益产生的债务,对侵权行为之债的抵销问题作出细化。这些规定有利于指导司法实践正确适用法律,统一裁判尺度。

关键词：抵销溯及力诉讼时效抵充侵权行为

SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterolincreased endosomal pH of alveolar macrophages

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2022年第2期19卷 210-221页

作者： Zhenfeng Wang jiadi Lv Pin Yu Yajin Qu Yabo Zhou Li Zhou Qiangqiang Zhu Shunshun Li Jiangping Song Wei Deng Ran Gao Yuying Liu Jiangning Liu Wei-Min Tong Chuan Qin Bo Huang Department of Immunology&National Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences(CAMS)&Peking Union Medical CollegeBeijing 100005China NHC Key Laboratory of Human Disease Comparative Medicine Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceCAMS and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesCAMS and Peking Union Medical CollegeBeijingChina Department of Pathology Institute of Basic Medical SciencesCAMS and Peking Union Medical CollegeBeijingChina Department of Biochemistry&Molecular Biology Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430030China

Exploring the cross-talk between the immune system and advanced biomaterials to treat SARS-CoV-2 infection is a promising ***,we show that ACE2-overexpressing A549 cell-derived microparticles(AO-MPs)are a potential therapeutic agent against SARS-CoV-2 *** administered AO-MPs dexterously navigate the anatomical and biological features of the lungs to enter the alveoli and are taken up by alveolar macrophages(AMs).Then,AO-MPs increase the endosomal pH but decrease the lysosomal pH in AMs,thus escorting bound SARS-CoV-2 from phago-endosomes to lysosomes for *** pH regulation is attributable to oxidized cholesterol,which is enriched in AO-MPs and translocated to endosomal membranes,thus interfering with proton pumps and impairing endosomal *** addition to promoting viral degradation,AO-MPs also inhibit the proinflammatory phenotype of AMs,leading to increased treatment efficacy in a SARS-CoV-2-infected mouse model without side *** findings highlight the potential use of AO-MPs to treat SARS-CoV-2-infected patients and showcase the feasibility of MP therapies for combatting emerging respiratory viruses in the future.

关键词： SARS-CoV-2 microparticles Alveolar macrophages Endosomes Lysosomes

Binding *** to human serum albumin for improving pharmacokinetics of protein drugs

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Binding *** to human serum albumin for improving pharmacokin...