Binding *** to human serum albumin for improving pharmacokinetics of protein drugs
作者单位：School of Biological EngineeringDalian Polytechnic University
会议名称：《中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议》
会议日期：2010年
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
摘 要：Human Serum Albumin(HSA)(molecular mass 67 kDa) contributes about 50%-60%of total protein in human plasma,presents at 50 mg/ml and has a half-life of 19 *** maintains blood osmotic pressure and plasma pH,functions as carrier of many metabolites and fatty acids,and serves as a major drug transport protein in *** has currently become a long half-life carrier protein to enhance the pharmacokinetic properties of protein *** are two approaches of using HSA as a carrier protein:one is fusion to HAS and the other is binding to *** compared the