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A redox-responsive self-assembling COA-4-arm PEG prodrug nanosystem for dual drug delivery suppresses cancer metastasis and drug resistance by downregulating hsp90 expression

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Acta Pharmaceutica Sinica B 2023年第7期13卷 3153-3167页

作者： Yi Zhou Yingling Miao Qiudi Huang Wenwen Shi Jiacui Xie jiachang lin Pei Huang Chengfeng Yue Yuan Qin Xiyong Yu He Wang linghao Qin Jianhai Chen Nanfang Hospital Southern Medical UniversityGuangzhou 510515China Key Laboratory of Molecular Target and Clinical Pharmacology and the State Key Laboratory of Respiratory Disease and the Fifth Affiliated Hospital School of Pharmaceutical SciencesGuangzhou Medical UniversityGuangzhou 511436China Center of Cancer Research The Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510260China School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhou 510006China

Metastasis and resistance are main causes to affect the outcome of the current anticancer *** shock protein 90(Hsp90)as an ATP-dependent molecular chaperone takes important role in the tumor metastasis and *** Hsp90 and downregulating its expression show promising in inhibiting tumor metastasis and *** this study,a redox-responsive dual-drug nanocarrier was constructed for the effective delivery of a commonly used chemotherapeutic drug PTX,and a COAmodified 4-arm PEG polymer(4PSC)was ***,an active component in oleanolic acid that exerts strong antitumor activity by downregulating Hsp90 expression,was used as a structural and functional element to endow 4PSC with redox responsiveness and Hsp90 inhibitory *** results showed that 4PSC/PTX nanomicelles efficiently delivered PTX and COA to tumor locations without inducing systemic *** blocking the Hsp90 signaling pathway,4PSC significantly enhanced the antitumor effect of PTX,inhibiting tumor proliferation and invasiveness as well as chemotherapy-induced resistance in *** results were further confirmed in vivo with two preclinical tumor *** findings demonstrate that the COA-modified 4PSC drug delivery nanosystem provides a potential platform for enhancing the efficacy of chemotherapies.

关键词： 3-O-(Z)-Coumaroyloleanolic acid Cancer metastasis Drug resistance Hsp90 Codelivery Prodrug nanosystem Chemotherapies Redox responsiveness

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应用Markov-Monte Carlo模型评价抗血小板药物CYP2C19基因检测的药物经济学分析

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广东药科大学学报 2021年第2期37卷 118-123页

作者：汤敏婷谢伟蓉林嘉昌广东省人民医院南海医院药剂科广东佛山528200 广东省中西医结合医院静脉配置中心广东佛山528200

目的应用Markov-Monte Carlo模型评价抗血小板药物CYP2C19基因检测指导抗血小板药物应用的可行性。方法回顾性分析2017年9月-2019年8月广东省人民医院南海医院心血管内科收治的213例拟接受经皮冠状动脉介入术ACS患者资料,根据治疗策略... 详细信息

目的应用Markov-Monte Carlo模型评价抗血小板药物CYP2C19基因检测指导抗血小板药物应用的可行性。方法回顾性分析2017年9月-2019年8月广东省人民医院南海医院心血管内科收治的213例拟接受经皮冠状动脉介入术ACS患者资料,根据治疗策略分为氯吡格雷组(n=52)、替格瑞洛组(n=83)和基因检测组(n=78)。建立Markov模型,比较3种治疗策略用于中国ACS患者抗血小板治疗的有效性和经济学优势。结果与氯吡格雷比较,替格瑞洛和基因检测治疗1年质量调整寿命年(QALYs)增加,但成本相应增加且增量成本-效果比(ICER)>中国社会意愿支付阈值(WTP);对ICER影响最显著的不确定因素为替格瑞洛无事件状态成本、氯吡格雷无事件状态成本;当WTP为59 660元/QALY时,净收益占比从高到低依次为替格瑞洛、氯吡格雷、基因检测;替格瑞洛具有成本-效果性概率随WTP增加呈上升趋势;当WTP阈值为59 660元/QALY时,替格瑞洛显示出最具成本效果优势,本研究模型评价结果稳定。结论相对氯吡格雷而言,替格瑞洛和CYP2C19基因检测指导的个性化治疗方案对中国ACS患者均具有一定药物经济学优势,根据中国人均国内生产总值水平,替格瑞洛显示出更显著的药物经济学优势。

关键词：急性冠状动脉综合征氯吡格雷替格瑞洛 CYP2C19基因 Markov模型 Monte Carlo模拟药物经济学

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Weak coupling between heterotrophic nanoflagellates and bacteria in the Yellow Sea Cold Water Mass area

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Acta Oceanologica Sinica 2014年第9期33卷 125-132页

作者： lin Shiquan HUANG lingfeng LU jiachang Key Laboratory of Marine Ecosystem and Biogeochemistry Second Institute of Oceanography State Oceanic Administration Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems (Xiamen University) College of Ocean and Earth Sciences Xiamen University

A study was carried out to investigate the grazing pressure of heterotrophic nanoflagellates （HNF） on bac-teria assemblages in the Yellow Sea Cold Water Mass （YSCWM） area in October, 2006. The results show that the HNF abundance ranges from 303 to 1388 mL-1, with a mean of 884 mL-1. The HNF biomass is equivalent to 10.6%-115.6% of that of the bacteria. The maximum abundance of the HNF generally occurred in the upper 30 m water layer, with a vertical distribution pattern of surface layer abundance greater than middle layer abundance, then bottom layer abundance. The hydrological data show that the YSCWM is located in the northeastern part of the study area, typically 40 m beneath the surface. A weak correlation is found be- tween the abundances of HNF and bacteria in both the YSCWM and its above water layer. One-way ANOVA analysis reveals that the abundance of HNF and bacteria differs between inside the YSCWM and in the above water mass. The ingestion rates of the HNF on bacteria was 8.02±3.43 h-1 in average. The grazing rate only represented 22.75%±6.91% of bacterial biomass or 6.55%±4.24% of bacterial production, implying that the HNF razinR was not the major factor contributing to the bacterial loss in the YSCWM areas.

关键词： Yellow Sea Cold Water Mass heterotrophic nanoflagellates bacteria trophic coupling,temperature

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Transfer RNA-derived small RNA serves as potential non-invasive diagnostic marker and a novel therapeutic target for acute pancreatitis

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World Journal of Gastroenterology 2025年第1期31卷 152-156页

作者： Jing Zhang Chun-lin Ou Department of Immunology School of Basic MedicineCentral South UniversityChangsha 410000Hunan ProvinceChina Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

Transfer RNA(tRNA)-derived fragments,a new type of tRNA-derived small RNA(tsRNA),can be cleaved from tRNA by enzymes to regulate target gene expression at the transcriptional and translational *** are not only degradation fragments but also have biological functions,including those in immune inflammation,metabolic disorders,and cell *** dysregulation is closely associated with multiple diseases,including various cancers and acute pancreatitis(AP).AP is a common gastrointestinal disease,and its incidence increases *** development is associated with tsRNAs,which regulate cell injury and induce inflammation,especially pyroptosis and ***,serum tRF36 has the potential to serve as a non-invasive diagnostic biomarker and leads to pancreatic acinar cell ferroptosis causing inflammation to promote *** show the characteristics of tsRNAs and their diagnostic value and function in AP,and discuss the potential opportunities and challenges of using tsRNAs in clinical applications and research.

关键词： Transfer RNA derived small RNAs Acute pancreatitis Liquid biopsy Biomarker Cell pyroptosis Ferroptosis

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Abnormal behavior of fluorescence quenching of gramicidin A inphase transition of lipid vesicles by hypocrellin B——Does anelectron transfer inverted region exist?

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Chinese Science Bulletin 1999年第21期44卷 1978-1983页

作者： jiachang Yue Yeping Li Yaxian Su Kechun lin Chinese Acad Sci Inst Biophys Natl Biol Macromol Lab Beijing 100101 Peoples R China Beijing Med Univ Dept Biophys Beijing 100083 Peoples R China

The fluorescence of gramicidin A(GA) in lipid bilayer may be quenched by Hypocre-Ilin B. When the phospholipids undergo a phase transition from gel to liquid crystalline phase, the reaction rate decreases unusually. This phenomenon has been analyzed by Marcus’ pho-toinduced electron theory, and an electron transfer inverted region hypothesis is proposed,

关键词： fluorescence quenching hypocrellin B Marcus theory.

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Effect of cholesterol metabolism on hepatolithiasis

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World Journal of Gastroenterology 2025年第1期31卷 157-162页

作者： lin Zheng Zi-Yu Ye Jun-Ji Ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after *** metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of ***,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after *** dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating *** article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关键词： Hepatolithiasis Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct

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复合组织瓣修复合并静脉功能障碍组织缺损的应用研究

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微创医学 2017年第3期12卷 331-333,337页

作者：罗远国覃万安吴家昌林舟丹杨华中国人民解放军第三0三医院骨科广西南宁市530021

目的探讨复合组织瓣修复静脉功能障碍的组织缺损的应用价值。方法 12例接受复合组织瓣修复手术患者,均合并有不同程度的静脉功能障碍。通过动脉口吻合,让动脉血流经皮瓣滋养动脉时,在动脉管腔内形成一个压力差,同时皮瓣周缘皮肤与受区... 详细信息

目的探讨复合组织瓣修复静脉功能障碍的组织缺损的应用价值。方法 12例接受复合组织瓣修复手术患者,均合并有不同程度的静脉功能障碍。通过动脉口吻合,让动脉血流经皮瓣滋养动脉时,在动脉管腔内形成一个压力差,同时皮瓣周缘皮肤与受区皮肤疏松缝合,允许无法通过静脉回流的血液外渗。术后常规皮下注射肝素抗凝治疗,术后120 h可停止皮瓣边缘的肝素外敷抗凝,换药并保证皮瓣切口清洁。结果本组12例皮瓣均全部成活,创面修复良好。皮瓣于术后3 d内瘀紫,无法回流,血液外渗较多,疏松缝合皮肤后,均无须再次拆缝线减压,3 d后皮瓣颜色逐渐转红润,渗出减少,术后10 d皮瓣达到稳定的循环状态。其中Ⅰ期愈合5例,Ⅱ期愈合6例,Ⅲ期愈合1例。1例皮瓣远端部分伤口液化,皮瓣边缘坏死约15%,再次清创缝合后痊愈出院。术后随访6~24个月,平均18个月,创面均恢复良好,修复后肢体外观形态良好,无压痛,肢体功能及外观恢复基本满意。结论复合组织皮瓣修复合并静脉功能障碍患者的组织缺损是安全、有效的手术方式,皮瓣成活率高,可以较好的恢复肢体功能。

关键词：静脉功能障碍复合组织皮瓣组织缺损

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Pyroptosis,ferroptosis,and autophagy in spinal cord injury:regulatory mechanisms and therapeutic targets

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Neural Regeneration Research 2025年第10期20卷 2787-2806页

作者： Qingcong Zheng Du Wang Rongjie lin Weihong Xu Department of Spinal Surgery the First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Arthritis Clinical and Research Center Peking University People’s HospitalBeijingChina Department of Orthopedic Surgery Fujian Medical University Union HospitalFuzhouFujian ProvinceChina

Regulated cell death is a form of cell death that is actively controlled by *** studies have shown that regulated cell death plays a key role after spinal cord *** and ferroptosis are newly discovered types of regulated cell deaths that have been shown to exacerbate inflammation and lead to cell death in damaged spinal ***,a complex form of cell death that is interconnected with various regulated cell death mechanisms,has garnered significant attention in the study of spinal cord *** injury triggers not only cell death but also cellular survival *** signaling pathways play pivotal roles in influencing the processes of both deterioration and repair in spinal cord injury by regulating pyroptosis,ferroptosis,and ***,this review aims to comprehensively examine the mechanisms underlying regulated cell deaths,the signaling pathways that modulate these mechanisms,and the potential therapeutic targets for spinal cord *** analysis suggests that targeting the common regulatory signaling pathways of different regulated cell deaths could be a promising strategy to promote cell survival and enhance the repair of spinal cord ***,a holistic approach that incorporates multiple regulated cell deaths and their regulatory pathways presents a promising multi-target therapeutic strategy for the management of spinal cord injury.

关键词： autophagy cell death ferroptosis inflammation pathological mechanisms pyroptosis regulated cell death regulatory pathways spinal cord injury therapeutic targets

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Prussian Blue Analogue‑Templated Nanocomposites for Alkali‑Ion Batteries:Progress and Perspective

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Nano-Micro Letters 2025年第1期17卷 216-261页

作者： Jian‑En Zhou Yilin Li Xiaoming lin Jiaye Ye Key Laboratory of Theoretical Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006People’s Republic of China School of Chemistry and Physics Faculty of ScienceQueensland University of Technology2 George StreetBrisbaneQLD 4000Australia Centre for Materials Science Queensland University of Technology2 George StreetBrisbaneQLD 4000Australia

Lithium-ion batteries(LIBs)have dominated the portable electronic and electrochemical energy markets since their commercialisation,whose high cost and lithium scarcity have prompted the development of other alkali-ion batteries(AIBs)including sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs).Owing to larger ion sizes of Na^(+)and K^(+)compared with Li^(+),nanocomposites with excellent crystallinity orientation and well-developed porosity show unprecedented potential for advanced lithium/sodium/potassium *** enticing open rigid framework structures,Prussian blue analogues(PBAs)remain promising self-sacrificial templates for the preparation of various nanocomposites,whose appeal originates from the well-retained porous structures and exceptional electrochemical activities after thermal *** review focuses on the recent progress of PBA-derived nanocomposites from their fabrication,lithium/sodium/potassium storage mechanism,and applications in AIBs(LIBs,SIBs,and PIBs).To distinguish various PBA derivatives,the working mechanism and applications of PBA-templated metal oxides,metal chalcogenides,metal phosphides,and other nanocomposites are systematically evaluated,facilitating the establishment of a structure–activity correlation for these *** on the fruitful achievements of PBA-derived nanocomposites,perspectives for their future development are envisioned,aiming to narrow down the gap between laboratory study and industrial reality.

关键词： Prussian blue analogues Self-sacrificial template Lithium-ion batteries Sodium-ion batteries Potassium-ion batteries

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Prediction and stratification for the surgical adverse events after minimally invasive esophagectomy:A two-center retrospective study

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World Journal of Gastroenterology 2025年第3期31卷 50-61页

作者： Qi-Hong Zhong Jiang-Shan Huang Fei-Long Guo Jing-Yu Wu Mao-Xiu Yuan Jia-Fu Zhu Wen-Wei lin Sui Chen Zhen-Yang Zhang Jiang-Bo lin Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina The Graduate School Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina

BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term *** preoperative identification of high-risk patients is critical for improving *** To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with *** This retrospective study included 747 patients who underwent MIE at two centers from January 2019 to February *** were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of *** SAEs occurred in 10.2%of patients in train set and 13.6%in the validation *** with SAE had significantly higher complication rate and a longer hospital stay after *** key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin *** stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation *** The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.

关键词： Surgical adverse events Minimally invasive esophagectomy Esophageal cancer Stratification model Perioperative management

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