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The Influence of Significant Public Health Events on Offline Consumption and Its Pathways

Journal of Systems Science and Systems Engineering 2024年第5期33卷 627-648页

作者： Baile Lu Kewei zhou Shuai Hao La Ta Hongyan Dai Weihua zhou College of Systems Engineering National University of Defense TechnologyChangsha 410073China Business School Central University of Finance and EconomicsBeijing 100081China Department of Marketing and Operations Management College of BusinessSouthern University of Science and TechnologyShenzhen 518055China School of Management Zhejiang UniversityHangzhou 310058China

In the face of a significant public health event,consumers may either increase their panic buying or decrease their willingness to make *** study focuses on the impact of a significant public health event on offline store sales and consumer consumption,utilizing data from chain convenience stores in Hefei and Wuhu during early 2019 and early 2020 in *** a difference-in-differences model,the study investigates the effect of the significant public health event outbreak on weekly store sales,order numbers,and consumer consumption in terms of product quantities,transaction amount,average amount per order,and transaction *** from prior literature that finds hoarding behavior of consumers online,the findings of this paper indicate a significant reduction in stores’offline weekly sales and order numbers,as well as consumers’offline weekly consumption across the four dimensions,as a result of the significant public health event ***,employing a mediation model,the study explores the pathway of population mobility through which the significant public health event adversely affects offline ***,subset analysis is conducted for stores located in different areas and consumers with varying characteristics,revealing that the aforementioned conclusions predominantly apply to stores situated in office areas and residential areas,as well as consumers with either no apparent preference for different product categories or a noticeable preference for food.

关键词： Significant public health event offline consumption population mobility mediating effect

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Perturbation of autophagy pathways in murine alveolar macrophage by 2D TMDCs is chalcogen-dependent

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Journal of Environmental Sciences 2024年第1期135卷 97-107页

作者： Xiaofei zhou Weitao Jin Rui Zhang Xuan Mao Jianbo Jia Hongyu zhou College of Science&Technology Hebei Agricultural UniversityHuanghua 061100China Institute of Environmental Research at Greater Bay Area Key Laboratory for Water Quality and Conservation of the Pearl River DeltaMinistry of EducationGuangzhou UniversityGuangzhou 510006China

Increasing risks of incidental and occupational exposures to two-dimensional transition metal dichalcogenides(2D TMDCs)due to their broad application in various areas raised their public health *** the composition-dependent cytotoxicity of 2D TMDCs has been well-recognized,how the outer chalcogenide atoms and inner transition metal atoms differentially contribute to their perturbation on cell homeostasis at non-lethal doses remains to be *** the present work,we compared the autophagy induction and related mechanisms in response to WS_(2),NbS_(2),WSe_(2)and Nb Se_(2)nanosheets exposures in MH-S murine alveolar *** these 2D TMDCs had comparable physicochemical properties,overall cytotoxicity and capability in triggering autophagy in MH-S cells,but showed outer chalcogen-dependent subcellular localization and activation of autophagy ***,WS_(2)and NbS_(2)nanosheets adhered on the cell surface and internalized in the lysosomes,and triggered m TOR-dependent activation of ***,WSe_(2)and Nb Se_(2)nanosheets had extensive distribution in cytoplasm of MH-S cells and induced autophagy in an m TOR-independent ***,the 2D TMDCs-induced perturbation on autophagy aggravated the cytotoxicity of respirable benzo[a]*** findings provide a deeper insight into the potential health risk of environmental 2D TMDCs from the perspective of homeostasis perturbation.

关键词： Chalcogen group Autophagy pathway Cell function Endosomal escape Inhalation toxicity

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欧盟教育数字化转型之路:目标、路径与特征

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外国教育研究 2023年第6期50卷 49-65页

作者：钱小龙周佳琦黄蓓蓓南通大学未来教育研究所江苏南通226019

数字化转型是世界范围内教育改革的重要载体和方向。而在深入推进教育数字化转型的过程中,诸多问题逐渐显露。欧盟率先登场于数字化舞台,剖析其教育数字化转型之路,可以寻欧盟之策,破转型之难。欧盟基于打造欧洲高质量、包容性、无障碍... 详细信息

数字化转型是世界范围内教育改革的重要载体和方向。而在深入推进教育数字化转型的过程中,诸多问题逐渐显露。欧盟率先登场于数字化舞台,剖析其教育数字化转型之路,可以寻欧盟之策,破转型之难。欧盟基于打造欧洲高质量、包容性、无障碍的数字教育这一转型目标,逐步落实以项目资金投入为支撑、以基础设施建设为门槛、以教育资源开发为前提、以教育技术融合为动力、以能力素养提升为关键、以教育福祉增强为阶梯的独特的教育数字化转型之路,呈现出教育数字化转型的典型特征,具体表现为在“目标对象”上彰显全面性、在“工具方法”上昭示融创性、在“过程实践”上映射精准性、在“监管治理”上突出伦理性。

关键词：欧盟教育数字化转型行动目标实施路径典型特征

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基于日发电计划的电力系统运行风险概率评估

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电力系统自动化 2008年第4期32卷 6-10页

作者：王成亮赵渊周家启刘威韩松柏重庆大学输配电装备及系统安全与新技术国家重点实验室重庆市400030 重庆市水利局重庆市401147

为了提高运行风险评估的精度,提出了一种计及元件运行状态时变性和自动装置调节作用的运行风险概率评估算法。该算法将元件分成时变元件和非时变元件2种类型,在日发电计划基础上推导出了各类元件的时间相关停运概率,并在故障后果分析中... 详细信息

为了提高运行风险评估的精度,提出了一种计及元件运行状态时变性和自动装置调节作用的运行风险概率评估算法。该算法将元件分成时变元件和非时变元件2种类型,在日发电计划基础上推导出了各类元件的时间相关停运概率,并在故障后果分析中考虑了自动装置的调节作用,最后从失负荷量、越限程度和系统所处各类运行状态的概率3个方面构建了适合调度的运行风险指标。通过对IEEE-RTS可靠性测试系统的计算分析验证了所提出算法的有效性。

关键词：风险评估日发电计划时间相关停运概率风险指标低频减载装置

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Natural polysaccharide-based smart CXCR4-targeted nano-system for magnified liver fibrosis therapy

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Chinese Chemical Letters 2024年第2期35卷 341-346页

作者： Liqiong Sun Xinping Luo Chenxi zhou Zhanwei zhou Minjie Sun College of Horticulture Nanjing Agricultural UniversityNanjing 210095China NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients State Key Laboratory of Natural MedicinesDepartment of PharmaceuticsChina Pharmaceutical UniversityNanjing 210009China

Activated hepatic stellate cells(aHSCs),the main source of extracellular matrix deposition,are key targets in liver ***,no effective drug specific to aHSCs has been clinically applied due to poor drug delivery ***,we designed a CXC chemokine receptor 4(CXCR4)-targeted reactive oxygen species(ROS)-responsive platform AMD-Dex-ROS-responsive-sorafenib(ARS)based on natural polysaccharide and thioctic acid frame,which can deliver anti-fibrosis drug represented by sorafenib specifically to aHSCs on account of CXCR4 over-expression on aHSCs,and smartly disassemble via ROS-responsive thioketal rupture relying on high intracellular ROS in HSCs,realized on-demand drug release and effective liver fibrosis ***,in this platform,the CXCR4 antagonist AMD3100 not only enhanced aHSCs targeting efficiency of sorafenib but also effectively magnified the aHSCs elimination of sorafenib by blocking stroma cell derived factor-1(SDF-1)/CXCR4-induced aHSCs protection,resulting in synergistic anti-fibrosis *** platform provided a new approach for drug delivery system design and liver fibrosis treatment.

关键词： Nanoparticle CXCR4 antagonism ROS-responsive Hepatic stellate cells Liver fibrosis

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Intrinsic correlation between the generalized phase equilibrium condition and mechanical behaviors in hydrate-bearing sediments

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2822-2832页

作者： Jiazuo zhou Changfu Wei Rongtao Yan Yuan zhou Yi Dong Hubei Key Laboratory of Marine Geological Resources College of Marine Science and TechnologyChina University of GeosciencesWuhanChina State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhanChina Guangxi Key Laboratory of New Energy and Building Energy Saving College of Civil Engineering and ArchitectureGuilin University of TechnologyGuilinChina

The phase equilibrium and mechanical behaviors of natural gas hydrate-bearing sediment are essential for gas recovery from hydrate *** heating closed systems,the temperature-pressure path of hydrate-bearing sediment deviates from that of pure bulk hydrate,reflecting the porous media effect in phase equilibrium.A generalized phase equilibrium equation was established for hydrate-bearing sediments,which indicates that both capillary and osmotic pressures cause the phase equilibrium curve to shift leftward on the temperature-pressure *** contrast to bulk hydrate,hydrate-bearing sediment always contains a certain amount of unhydrated water,which keeps phase equilibrium with the hydrate within the hydrate stability *** changes in temperature and pressure,a portion of pore hydrate and unhydrated water may transform into each other,affecting the shear strength of hydrate-bearing sediment.A shear strength model is proposed to consider not only hydrate saturation but also the change in temperature and pressure of hydrate-bearing *** model is validated by experimental data with various hydrate saturation,temperature and pressure *** deformation induced by partial dissociation was studied through depressurization tests under constant effective *** reduction in gas pressure within the hydrate stability field indeed caused sediment *** dissociation-induced deformation can be reasonably estimated as the difference in volume between hydrate-bearing and hydrate-free sediments from the compression curves.

关键词： Hydrate-bearing sediment Generalized phase equilibrium Unhydrated water Partial dissociation Mechanical behavior

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The role of proteasomes in tumorigenesis

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Genes & Diseases 2024年第4期11卷 155-169页

作者： Xiangyi zhou Ruqing Xu Yue Wu Li zhou Tingxiu Xiang Department of Oncology The First Affliated Hospital of Chongqing Medical UniversityChongqing 400016China Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer HospitalChongqing 400030China

Protein homeostasis is the basis of normal life activities,and the proteasomefamily plays an extremely important function in this *** proteasome 2os is a concentric circle structure with twoαrings and twoβrings *** proteasome 2os can perform both ATP-dependent and non-ATP-dependent ubiquitination proteasome degradation by binding to various subunits(such as 19S,11S,and 200 PA),which is performed by its active subunitβ1,β2,andβ*** proteasome can degrade misfolded,excess proteins tomaintain *** the same time,it can be utilized by tumors to degrade over-proliferate and unwanted proteins to support their *** can affect the development of tumors from several aspects including tumor signaling pathways such as NF-kB and p53,cell cycle,immune regulation,and drug ***-encoding genes have been found to be overexpressed in a variety of tumors,providing a potential novel target for cancer *** addition,proteasome inhibitors such as bortezomib,carfilzomib,and ixazomib have been put into clinical application as the first-line treatment of multiple *** and more studies have shown that it also has different therapeutic effects in other tumors such as hepatocellular carcinoma,non-small cell lung cancer,glioblastoma,and ***,proteasome inhibitors are not much effective due to their tolerance and singleness in other ***,further studies on their mechanisms of action and drug interactions are needed to investigate their therapeutic potential.

关键词： Bortezomib Cancer therapy Immunoproteasome Multiplemyeloma Proteasome 20S Proteasome inhibitor Thymoproteasom

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Combined proteomic and metabolomic studies on the liver of Amur sturgeon Acipenser schrenckii under titanium dioxide nanoparticle exposure

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Journal of Oceanology and Limnology 2024年第3期42卷 1001-1015页

作者： zhou zhou Ting LIU Jie KONG Zhenxing ZHAO Junquan ZHU Key Laboratory of Aquacultural Biotechnology Ministry of Educationand Key Laboratory of Marine Biotechnology of Zhejiang ProvinceCollege of Marine SciencesNingbo UniversityNingbo 315000China Guizhou Fisheries Research Institute Guizhou Academy of Agriculture SciencesGuiyang 550000China

Nanomaterials,particularly titanium dioxide nanoparticles(TiO_(2)-NPs),are extensively utilized across various ***,their environmental release has raised concerns regarding their potential ecological and environmental *** reproductive toxicity of TiO_(2)-NPs in fish species has attracted considerable attention,yet conflicting research outcomes have been *** investigated the effects of TiO_(2)-NPs exposure on the liver of juvenile Amur sturgeon Acipenser schrenckii using label-free proteomic and untargeted metabolomic *** experiment included a control group and three groups exposed to different concentrations of TiO_(2)-NPs(low,TL;medium,TM;high,TH).Compared to the control group,9,19,and 25 proteins and 35,73,and 158 metabolites were differentially expressed in the TH,TM,and TL TiO_(2)-NP-exposed groups,*** differentially expressed genes(DEGs)were enriched in the Kyoto Encyclopedia for Genes and Genomes(KEGG)pathways related to glycolysis and ***,among the 126 correlated proteins,the most enriched pathways were associated with endocytosis and protein processing in the endoplasmic ***,syringic acid was significantly downregulated across all three TiO_(2)-NP-exposed *** obtain a comprehensive overview of the TiO_(2)-NP-induced expression changes,a co-regulated network of proteins and metabolites associated with TiO_(2)-NPs exposure was *** to TiO_(2)-NPs led to enrichment and alteration of pathways related to immune responses,including endocytosis,protein processing in the endoplasmic reticulum,and peroxisome proliferator-activated receptor(PPAR)*** conclusion,our findings indicate that exposure to TiO_(2)-NPs might disrupt glucose metabolism and induce immune responses,thus contributing to our understanding of the environmental impacts of nanomaterials and highlighting the need for further research and development of potential mitigation strategies.

关键词： TiO_(2)-nanoparticle exposure proteomics metabolomics glucose metabolism immune response

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Competition of Composition Fluctuation Modes in Weakly Segregated Salt-doped Symmetric Diblock Copolymers

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Chinese Journal of Polymer Science 2024年第9期42卷 1375-1385,I0008页

作者： Yuan-Xin zhou Xian Kong South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou510640China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou510640China

Salt-doped block copolymers have widespread applications in batteries,fuel cells,semiconductors,and various industries,where their properties crucially depend on phase separation ***,investigations into salt-doped diblock copolymers have predominantly focused on microphase separation,overlooking the segregation between ionic and polymeric *** study employs weak segregation theory to explore the interplay between phase separation dominated by the polymer-modulated mode and the salt-out-modulated mode,corresponding to microscopic and macroscopic phase separations,*** comparing diblock copolymers doped with salts to those doped with neutral solvents,we elucidate the significant role of charged species in modulating phase *** phase separation mode exhibits a transition between the polymer-modulated and salt-out-modulated modes at different *** systems doped with neutral solvents,this transition is stepwise,while in salt-ion-doped systems,it is *** a sufficiently large Flory-Huggins parameter between ions and polymers,the salt-out-modulated mode becomes dominant,promoting macrophase *** to the solvation effect of salt ions,salt-doped systems are more inclined to undergo microphase ***,we explore factors influencing the critical wavenumber of phase separation,including doping level and the Flory-Huggins parameters between two blocks and between ions and polymeric *** findings reveal that in a neutral solvent environment,these factors alter only the boundary between micro-and macro-phase separations,leaving the critical wavenumber unchanged in microphase separation ***,in a salt-doped environment,the critical wavenumber of microphase separation varies with these *** provides valuable insights into the pivotal role of electrostatics in the phase separation of salt-doped block copolymers.

关键词： Block copolymer Phase separation Field theory Salt-doped

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Intelligent feedforward gust alleviation based on neural network

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Chinese Journal of Aeronautics 2024年第3期37卷 116-132页

作者： Yitao zhou Zhigang WU Chao YANG School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China

This paper proposes a neural network-based intelligent feedforward gust alleviation framework,which includes a neural network identification model and a neural network controller.A neural network training dataset is formed by collecting flight data and the gust data encountered during the aircraft flight.A neural network identification model is first trained to accurately predict the aircraft’s ***,based on the output of the identification model and the collected flight data,the parameters of the time-delay neural network controller are obtained through a learning *** simulation results show that the designed intelligent controller has good gust alleviation effects for both continuous turbulence excitation and discrete gust *** example,when the aircraft is 40000 kg and the flight speed is 0.81Ma,the controller achieves a 67.82%reduction in wingtip acceleration and a 35.90%reduction in center of mass acceleration under continuous turbulence *** considering the measurement uncertainties,such as noise existing in the collected data,the trained controller can still achieve an acceptable gust alleviation ***,considering a flight in which the aircraft mass is constantly changing,the intelligent controller,which continuously learns from new flight data,maintains a good gust alleviation effect throughout the flight.

关键词： Gust alleviation Intelligent control Feedforward control Neural networks Time-varying aircraft

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