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Light-controlled soft bio-microrobot

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Light(Science & Applications) 2024年第3期13卷 531-543页

作者： jianyun Xiong xing Li Ziyi he Yang Shi Ting Pan Guoshuai Zhu Dengyun Lu Hongbao Xin Guangdong Provincial Key Laboratory of Nanophotonic Manipulation Institute of NanophotonicsJinan University511443 GuangzhouChina

Micro/nanorobots hold exciting prospects for biomedical and even clinical applications due to their small size and high ***,it is still a big challenge to maneuver micro/nanorobots into narrow spaces with high deformability and adaptability to perform complicated biomedical ***,we report a light-controlled soft bio-microrobots(called“Ebot”)based on Euglena gracilis that are capable of performing multiple tasks in narrow microenvironments including intestinal mucosa with high controllability,deformability and *** motion of the Ebot can be precisely navigated via light-controlled polygonal flagellum ***,the Ebot shows highly controlled deformability with different light illumination duration,which allows it to pass through narrow and curved microchannels with high *** these features,Ebots are able to execute multiple tasks,such as targeted drug delivery,selective removal of diseased cells in intestinal mucosa,as well as photodynamic *** light-controlled Ebot provides a new bio-microrobotic tool,with many new possibilities for biomedical task execution in narrow and complicated spaces where conventional tools are difficult to access due to the lack of deformability and bio-adaptability.

关键词： narrow illumination curved

Knockdown of circular RNA (CircRNA)_001896 inhibits cervical cancer proliferation and stemness in vivo and in vitro

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BIOCELL 2024年第4期48卷 571-580页

作者： jia SHAO CAN ZHANG YAONAN TANG AIQIN he WEIPEI ZHU Department of Obstetrics and Gynecology The Second Affiliated Hospital of Soochow UniversitySuzhou215004China Department of Gynecology Oncology Affiliated Tumor Hospital of Nantong UniversityNantong226361China

Objective:Previous studies indicated that aberrant circular RNA(circRNA)expression affects gene expression regulatory networks,leading to the aberrant activation of tumor pathways and promoting tumor cell ***,the expression,clinical signiﬁcance,and effects on cell propagation,invasion,and dissemination of circRNA_001896 in cervical cancer(CC)tissues remain ***:The Gene Expression Omnibus(GEO)datasets(GSE113696 and GSE102686)were used to examine differential circRNA expression in CC and adjacent *** expression of circRNA_001896 was detected in 72 CC patients usingﬂuorescence quantitative *** analysis with clinical pathological features was performed through COX multivariate and univariate *** effect of circRNA_001896 downregulation on CC cell propagation was examined using the cell counting kit-8(CCK-8)test,clonogenic,3D sphere formation,and in vivo tumorigenesis ***:Intersection of the GSE113696 and GSE102686 datasets revealed an increased expression of four circRNAs,including circRNA_001896,in CC *** quantitative PCR conﬁrmed circRNA_001896 as a circular *** expression of circRNA_001896 was considerably associated with lymph node metastasis,International Federation of Gynecologists and Obstetricians(FIGO)stage,tumor diameter,and survival period in CC *** hazards model(COX)univariate and multivariate analyses revealed that circRNA_001896 expressions are a distinct risk factor affecting CC patients’*** functional experiments showed that downregulating circRNA_001896 substantially suppressed CC cell growth,colony formation,and 3D sphere-forming *** vivo,tumorigenesis analysis in nude mice demonstrated that downregulating circRNA_001896 remarkably reduced the in vivo proliferation capacity of CC ***:CircRNA_001896 is highly expressed in CC tissues and is substantially related to lymph node metastasis,FIGO stage,tumor size,and surviva

关键词： Uterine cervical neoplasms RNA Circular Cell proliferation Cancer stem cells

Evaluation of the Oxidation Reactivity and Behavior of Exhaust Soot Particles from Diesel Engines with Different Emission Levels

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China Petroleum Processing & Petrochemical Technology 2024年第2期26卷 72-80页

作者： Wang Yajun Lin Lei xing jianqiang LüXu Yang he Song Haiqing SINOPEC Research Institute of Petroleum Processing Co. Ltd.Beijing 100083China State Key Laboratory of Engines Tianjin UniversityTianjin 300072China

The aim of this study was to investigate the oxidation reactivity and behavior of exhaust particulate matter(PM)from diesel *** samples from two diesel engines(1K,CY4102)with different emission levels were collected by a thermophoretic system and a quartz *** oxidation reactivity,oxidation behaviors,and physicochemical properties of the PM samples were analyzed using thermogravimetric analysis(TGA),high-resolution transmission electron microscopy(HRTEM),Fourier-transform infrared spectrometry(FTIR),and Raman *** results showed that there was a great difference in the oxidation reactivity of soot particles emitted by the two different diesel engines.A qualitative analysis of the factors influencing oxidation reactivity showed that the nanostructure,degree of graphitization,and relative concentration of aliphatic C—H functional groups were the most important factors,whereas no significant correlation was found between the primary particle size and activation energy of the diesel *** on the oxidation behavior analysis,the diesel soot particles exhibited both internal and surface oxidation modes during the oxidation *** oxidation was dominant during the initial stage,and as oxidation progressed,the mode gradually changed to internal *** oxidation mode of soot particles from the 1K engine was significantly higher than that of CY4102.

关键词： diesel engine soot particles oxidation reactivity oxidation behavior

System error iterative identification for underwater positioning based on spectral clustering

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Journal of Systems Engineering and Electronics 2024年第4期35卷 1028-1041页

作者： LU Yu WANG Jiongqi he Zhangming ZHOU Haiyin xing Yao ZHOU Xuanying College of Sciences National University of Defense TechnologyChangsha 410073China

The observation error model of the underwater acous-tic positioning system is an important factor to influence the positioning accuracy of the underwater *** the position inconsistency error caused by considering the underwater tar-get as a mass point,as well as the observation system error,the traditional error model best estimation trajectory(EMBET)with little observed data and too many parameters can lead to the ill-condition of the parameter *** this paper,a multi-station fusion system error model based on the optimal polynomial con-straint is constructed,and the corresponding observation sys-tem error identification based on improved spectral clustering is ***,the reduced parameter unified modeling for the underwater target position parameters and the system error is achieved through the polynomial *** a multi-sta-tion non-oriented graph network is established,which can address the problem of the inaccurate identification for the sys-tem ***,the similarity matrix of the spectral cluster-ing is improved,and the iterative identification for the system errors based on the improved spectral clustering is ***,the comprehensive measured data of long baseline lake test and sea test show that the proposed method can accu-rately identify the system errors,and moreover can improve the positioning accuracy for the underwater target positioning.

关键词： acoustic positioning reduced parameter system error identification improved spectral clustering accuracy analy-sis

Microstructural evolution,mechanical properties and degradation mechanism of PS-PVD quasi-columnar thermal barrier coatings exposed to glassy CMAS deposits

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Rare Metals 2024年第7期43卷 3329-3340页

作者： Zi-Yue Yu Liang-Liang Wei xing-Ye Guo Bao-Peng Zhang Qing he Hong-Bo Guo School of Materials Science and Engineering Beihang UniversityBeijing100191China Key Laboratory of High-Temperature Structure Materials and Protective Coatings(Ministry of Industry and Information Technology) Beihang UniversityBeijing 100191China Surface Engineering Research Institute Chinese Academy of Agricultural Mechanization SciencesBeijing 100083China

Thermal barrier coatings(TBCs) applied in aeroengines tend to be attacked by molten calcia-magnesiaalumino-silicate(CMAS) at high operating ***-stabilized zirconia(YSZ) coatings with quasicolumnar microstructure were fabricated by plasma spray physical vapor deposition(PS-PVD) *** chemic al changes,micros tructural transform ation,mechanical properties and degradation mechanisms of the CM AS-interacted TBCs in the thermal cycling tests were *** YSZ grains were dissolved in the CMAS melts,and then the ZrO_(2) grains were reprecipitated with spherical shape,accompanying with phase transformation from tetragonal(t) to monoclinic(m).The thermal cycling tests reveal that the YSZ coating fails at the early stage due to the attack of *** fractures in intracolumns lead to partial spallation of the *** failure of the coating occurs at the interfaces between thermally grown oxides(TGO) layer and YSZ topcoat;especially,the hardness and Young's modulus of the YSZ coatings increase intensively,as the coatings were infiltrated by the CMAS for a long time.

关键词： CMAS Thermal barrier coatings Young's modulus Thermal cycling behavior PS-PVD

Gradient layered MXene/Fe3O4@CNTs/TOCNF ultrathin nanocomposite paper exhibiting effective electromagnetic shielding and multifunctionality

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Nano Research 2024年第9期17卷 8233-8242页

作者： Zhengkun Ma Jingzong he Shilin Liu Xiaoxuan Qie Meiheng Gan Ruonan Cheng Qilin Wu Malcolm xing State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China College of Chemistry and Chemical Engineering Donghua UniversityShanghai 201620China Department of Mechanical Engineering University of ManitobaWinnipegMB R3T 2N2Canada

As wearable electronic devices are rapidly developing,there is an urgent need for lightweight,flexible,and ultrathin multifunctional electromagnetic interference(EMI)shielding ***,the flexible ultrathin paper that combines efficient shielding and multifunctional integration remains a considerable ***,a novel MXene/Fe_(3)O_(4)@CNTs/TOCNF(MCT,MXene=transition metal carbide/carbonitride,CNTs=carbon nanotubes,TOCNF=TEMPO-oxidized cellulose nanofiber,TEMPO=2,2,6,6-tetramethylpiperidine-1-oxyl radical)nanocomposite paper with a multilayer electromagnetic gradient structure and electromagnetic dual losses was successfully prepared by a simple filtration *** from effective gradient design and adjusting the proportion of TOCNF,the composite paper(only 18μm)exhibits outstanding shielding effectiveness(SE)of 66 dB in the X-band,ultrahigh thickness-specific SE and surface-specific SE values of 3300 dB·mm-1 and 31,428 dB·cm^(2)·g^(-1)***,dehydroxylation treatment improves MCT paper's hydrophobicity,environmental stability,and mechanical strength,expanding its range of ***,the highly efficient Joule heating properties and hydrophobicity provide MCT additional de-icing *** also simulated the electromagnetic shielding effects of MCT composite paper,which was applied in *** study documents an innovative and intriguing material combination,providing a simple and effective manufacturing strategy for developing EMI shielding *** paper is highly suitable for outdoor portable or wearable electronic devices and has significant application potential in humid/severe cold environments.

关键词： cellulose fiber thin papers nanocomposites electromagnetic interference(EMI)shielding

Degradation of o-dichlorobenzene by DBD-NTP co-modified titanium gel catalyst

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Journal of Environmental Sciences 2024年第9期143卷 71-84页

作者： Wenbo Zhang Yi xing Wei Su jiaqing Wang Haoqi jia Yongkang Cui Jing Chen Hui Zhang School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants University of Science and Technology BeijingBeijing 100083China Guangdong Province Engineering Laboratory for Air Pollution Control Guangzhou 510530China College of Environmental and Resource Sciences Shanxi UniversityTaiyuan 030006China Sinosteel Maanshan Mine Research Institute Co.Ltd. Anhui 243071China

In order to study the degradation process of dioxins in industrial flue gas,the decomposition of o-dichlorobenzene(o-DCB)in a DBD plasma catalytic reactor was *** results showed that an NTP-catalyzed system,especially using the Cu Mn Ti Oxcatalyst,had better o-DCB degradation performance compared to plasma *** combination of the Cu Mn Ti Oxcatalyst with NTP can achieve a degradation efficiency of up to 97.2%for o-DCB;the selectivity of CO and CO_(2)and the carbon balance were 40%,45%,and 85%,*** dielectric constant and electrical property results indicated that the surface discharge capacity of the catalysts played a major role in the degradation of o-DCB,and a higher dielectric constant could suppress the plasma expansion and enhance the duration of the plasma discharge per discharge *** to the O1s XPS and O_(2)-TPD results,the conversion of CO to CO_(2)follows the M-v-K mechanism;thus,the active species on the catalyst surface play an important ***,the Cu Mn Ti Oxand NTP mixed system exhibited excellent stability,which is probably because Cu doping improved the lifetime of the *** work can provide an experimental and theoretical basis for research in the degradation of o-DCB by plasma catalyst systems.

关键词： o-dichlorobenzene(o-DCB) Non-thermal plasma catalysis Ozone concentration

Deep insight of unique phase transition behaviors and mechanism in Zr_(2)Co-H isotope system with ultra-low equilibrium pressure

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Rare Metals 2024年第1期43卷 212-224页

作者： Yang Liu Pan-Pan Zhou Xue-Zhang Xiao jia-Cheng Qi jia-Peng Bi Tiao Ying xing-Wen Feng Yan Shi Wen-Hua Luo Li-Xin Chen State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Institute of Materials China Academy of Engineering PhysicsMianyang 621907China Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang Province Hangzhou 310013China

Efficient capture,safe storage and release of tritium from the international thermonuclear experimental reactor(ITER) reaction exhaust gas is a perplexing problem,and the development of an efficient tritium-getter material with ultra-low hydrogenation equilibrium pressure is considered as a reliable *** this work,Zr_(2)Co alloy was selected as a tritium-getter material and prepared through induction levitation *** performance test results show that Zr_(2)Co exhibits an ultra-low hydrogenation equilibrium pressure of 3.22 × 10^(-6) Pa at 25℃ and excellent hydriding kinetics under a low hydrogen pressure of 0.005 ***,unique phase transition behaviors were presented in Zr_(2)Co-H ***,Zr_(2)CoH_(5) formed by Zr_(2)Co hydrogenated at room temperature is initially decomposed into ZrH_(2) and ZrCoH_(3) at200 ℃.With the temperature increasing to 350 ℃,ZrCoH_(3)is dehydrogenated to ZrCo,and then ZrCo further reacts with ZrH_(2) at 650 ℃ to reform Zr_(2)Co and *** the staged phase transition pathways during dehydrogenation,the decomposition of Zr_(2)CoH_(5) occurs preferentially,which is well accordance with both the smallest reaction energy barrier and the maximum reaction spontaneity that are determined respectively from kinetics activation energy and thermodynamics Gibbs free ***,first principles calculation results indicate that the stronger binding of hydrogen in interstitial environments of ZrCoH_(3)and ZrH_(2) triggers the hydrogen-stabilized phase transformation of Zr_(2)CoH_(5).The unique phase transition mechanisms in Zr_(2)Co-H system can shed light on the further exploration and regulation of analogous staged phase transition of hydrogen storage materials.

关键词： Zr_(2)Co alloy Tritium-getter materials Ultralow equilibrium hydrogen pressure Phase transition mechanism

DMF-scMT-seq linking methylome and transcriptome within single cells with digital microfluidics

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Science China Chemistry 2024年第6期67卷 2070-2078页

作者： xing Xu Xi Zeng Xin Lin Shiyan Lin Shanshan Liang Tian Tian Rui Su jia Song Chaoyong Yang Collaborative Innovation Center of Chemistry for Energy Materials The MOE Key Laboratory of Spectrochemical Analysis and InstrumentationState Key Laboratory of Physical Chemistry of Solid SurfacesDepartment of Chemical BiologyCollege of Chemistry and Chemical EngineeringThe First Affiliated Hospital of Xiamen UniversityXiamen UniversityXiamen361005China Institute of Molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai200127China Chemistry and Materials Science College Shanghai Normal UniversityShanghai200234China Chemistry and Biomedicine Innovation Center(ChemBIC) School of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023China

Single-cell joint analysis of methylome and transcriptome reveals how the methylation regulates the transcriptional ***,traditional bench-top protocols for single-cell DNA methylation and RNA transcription co-detection are laborintensive,cost-ineffective and ***,we establish the DMF-sc MT-seq,a highly-efficient and cost-effective method to simultaneously analyze single-cell DNA methylation and transcriptional activity based on digital *** MT-seq automates the workflow of single-cell isolation,cellular hypotonic lysis,nucleic acid separation and methylome/transcriptome library construction in a contactless and addressable *** system ensures high accuracy(R>0.85),high gene detection ability(14,697 genes per cell at 4 million sequencing depth),and high CpG coverage(677,198 CpG sites per cell at 1million sequencing depth).By using DMF-sc MT-seq,the relationship of DNA methylation and RNA transcription under different genomic contexts is *** further apply DMF-sc MT-seq to study the dynamics of transcription regulation with methylation-inhibiting anti-tumor Decitabine,and identify the methylated promoter/gene body driven genes in response to Decitabine ***-sc MT-seq facilitates the construction of the correlation of DNA methylation and transcriptional activity at the single-cell level in a flexible,sensitive and accurate way,which is anticipated to be a powerful tool in studying single-cell biological systems.

关键词： single-cell analysis digital microfluidics methylome sequencing transcriptome sequencing

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