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Renal drug transporters and their significance in drug–drug interactions

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Acta Pharmaceutica Sinica B 2016年第5期6卷 363-373,518页

作者： jia Yin Joanne wang Department of Pharmaceutics University of Washington

The kidney is a vital organ for the elimination of therapeutic drugs and their *** drug transporters,which are primarily located in the renal proximal tubules,play an important role in tubular secretion and reabsorption of drug molecules in the *** secretion is characterized by high clearance capacities,broad substrate specificities,and distinct charge selectivity for organic cations and *** the past two decades,substantial progress has been made in understanding the roles of transporters in drug disposition,efficacy,toxicity and drug–drug interactions(DDIs).In the kidney,several transporters are involved in renal handling of organic cation(OC) and organic anion(OA) *** transporters are increasingly recognized as the target for clinically significant *** review focuses on the functional characteristics of major human renal drug transporters and their involvement in clinically significant DDIs.

关键词： Renal drug transporters Drug–drug interactions Organic cations Organic anions Nephrotoxicity

Global weak solutions to Landau-Lifshitz equations into compact Lie algebras

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Frontiers of Mathematics in China 2019年第6期14卷 1163-1196页

作者： Zonglin jia Youde wang Institute of Applied Physics and Computational Mathematics China Academy of Engineering PhysicsBeijing 100088China College of Mathematics and Information Sciences Guangzhou UniversityGuangzhou 510006China Hua Loo-Keng Key Laboratory of Mathematics Institute of MathematicsAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

We consider a parabolic system from a bounded domain in a Euclidean space or a closed Riernannian manifold into a unit sphere in a compact Lie algebra g,which can be viewed as the extension of Landau-Lifshitz(LL)equation and was proposed by *** follow the ideas taken from the work by the second author to show the existence of global weak solutions to the Cauchy problems of such LL equations from an n-dimensional closed Riernannian manifold T or a bounded domain in R^n into a unit sphere Sg(1)in *** particular,we consider the Hamiltonian system associated with the nonlocal energy micromagnetic energy defined on a bounded domain of R^31 and show the initial-boundary value problem to such LL equation without damping terms admits a global weak *** key ingredient of this article consists of the choices of test functions and approximate equations.

关键词： Landau-Lifshitz(LL)equations Lie algebra test functions

Research on the influence of building convex exit on crowd evacuation and its design optimization

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Building Simulation 2022年第4期15卷 669-684页

作者： jiachen Li Jinghong wang jia Li Zhirong wang Yan wang jiangsu Key Laboratory of Urban and Industrial Safety College of Safety Science and EngineeringNanjing Tech UniversityNanjing 210009China Deportment of Public Administration School of LawNanjing Tech UniversityNanjing 211800China

Building exit has always been an emphasis of research in the field of *** studies on crowd flow characteristics at building evacuation bottlenecks usually focus on plane exit,but insufficient attention has been paid to the characteristics of crowd flow at the convex *** exit can be considered as such a structure like a double-bottleneck linked *** paper aims to study the influence of geometric structure characteristics of the convex exit on crowd evacuation and put forward the optimal design strategy of this structure,so as to improve the efficiency of evacuation in an *** social force model-based software,MassMotion,it is found that convex exit is indeed more efficient and safer than common plane exit in terms of evacuation time and pedestrians'congestion,especially when the desired speed is relatively higher,indicating that convex exits are more suitable for crowd evacuation in case of *** size-related parameters of convex exit are analyzed in detail,namely the width of the bottleneck at passage(W_(p)),the passage width(W),the passage length(L),and the exit width(W_(e)),to find out the optimum design of convex *** research shows that the optimal size ratio is that Wp:W:L:We equals 1.5:1.75:3.5:1,and as the overall magnification of building size and the number of pedestrians increases,the evacuation time gradually tends to a stable value,which indicates that this optimal ratio has good adaptability in size ***,based on the in-depth mechanism of pedestrian flow at the convex exit,three possible application scenarios are proposed to illustrate the feasible optimum design of the convex *** results of this study can provide new ideas for research on the structure of building exits.

关键词： convex exit social force model crowd evacuation MassMotion design optimization

Metal-based inorganic nanocrystals for biological sonodynamic therapy applications:recent progress and perspectives

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Rare Metals 2024年第2期43卷 413-430页

作者： Dong wang jia-Tao Zhang Institute of Medical-Industrial Integration Beijing Key Laboratory of Structurally Controllable Advanced Functional Materials and Green ApplicationsSchool of Materials Science and EngineeringBeijing Institute of TechnologyBeijing100081China Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Ministry of Industry and Information TechnologySchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing100081China

With the fast development of technology for the treatment of tumor and bacteria,photo-therapeutic strate-gies emerge as a kind of highly effective and common treatment,but the low tissue penetration depth of light limits their *** therapy(SDT),as an efficient and non-invasive treatment,attracts more people's attention due to the inherent property of high tissue *** soft tissue penetration depth of ultrasound(US)can even reach more than 10 cm,which has great advantage over that of ***,many sonosensitizers are studied and applied to SDT-based ***-based inorganic nanocrystals are able to generate more reactive oxygen species(ROS)due to the special composition and band *** representative achievements and the specific functions of the nanocrystals sonosensitizers are summarized in this work,and the relationship of structure/composition-SDT performance and the internally regulated composite is ***-gistic effects of SDT in combination with other therapeutic modalities are mainly *** the same time,the critical and potential issues and future perspectives are addressed.

关键词： Metal-based inorganic nanocrystals Sonodynamic therapy(SDT) Tumor treatment Antibacteria

Closed-loop subspace identification algorithm based on correlation function estimates

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Science China(Information Sciences) 2015年第3期58卷 173-182页

作者： wang jia MILLER Daniel wang HongWei GU Hong Department of Biotechnology Dalian Medical University School of Control Science and Engineering Dalian University of Technology Department of Mechanical Engineering University of California San Diego

A novel subspace identification method based on correlation function which estimates a state-space system dynamics of unknown plant operating in closed-loop experimental condition is proposed in this *** is shown that the cross-correlation function of the output and external input signals are equal to the crosscorrelation function of the input and external signals filtered through the system dynamics since noise signal has no correlation with the external *** proposed algorithm is developed to obtain unbiased estimates of system matrices based on time-shifted invariance of the correlation function *** the algorithm is compared to other popular subspace methods in the simulation study and the results show the effectiveness of our method in the presence of colored noise and low signal-to-noise ratios.

关键词： subspace identification method correlation function estimates closed-loop system asymptotic properties the system dynamics

Coding function for non-coding RNA in plants—insights from miRNA encoded peptide(miPEP)

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Science China(Life Sciences) 2015年第5期58卷 503-505页

作者： wang Long wang jia-Wei National Key Laboratory of Plant Molecular Genetics Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Shanghai Tech University

Non-coding RNAs （ncRNAs） refer to a large and diverse collection of polyadenylated or non-polyadenylated RNA transcripts with low protein coding potential. In general, the house-keeping ncRNAs （e.g., ribosomal RNAs and transfer RNAs）, primary transcripts of microRNAs （miRNAs） and plant specific RNA polymerase V （Pol V）-dependent ncRNA transcripts also fall into this definition. The application of next-generation sequencing leads to identification of over 30,000 putative ncRNAs in plants . While it is possible that some ncRNAs are transcription noises or the by-products of RNA processing and degradation, growing lines of evidence suggest that a large fraction of them are functional and play various regulatory activities during development.

关键词：非编码RNA miRNA 植物核糖体RNA RNA聚合酶 RNA加工转录物微RNA

Mechanisms and strategies to overcome immunotherapy resistance in hepatobiliary malignancies

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 430-439页

作者： jia Xiong Qing-Qing wang Institute of Immunology Zhejiang University School of MedicineHangzhou 310058China The Key Laboratory for Immunity and Inflammatory Diseases of Zhejiang Province Hangzhou 310058China

Unprecedented advances have been achieved in hepatobiliary cancer treatment with immune checkpoint blockade(ICB).However,the efflcacy of ICB in patients with hepatobiliary malignancies is still *** to immunotherapies is often orchestrated by complicated tumor-host-microenvironment interactions but could also occur after initial efflcacy,mostly when only partial responses are *** of cancer-resistance mechanisms will be beneficial to provide the rationale for the administration of personalized ***,we review the factors related to resistance to immune-targeted therapies in hepatobiliary malignancies and discuss the potential strategies for overcoming resistance and future directions of immunotherapy development.

关键词： Cancer immunotherapy Hepatobiliary malignancies Immune checkpoint blockade Drug resistance

Perenniality:From model plants to applications in agriculture

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Molecular Plant 2024年第1期17卷 141-157页

作者： Bo Zhao jia-Wei wang National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant Sciences(CEMPS)Institute of Plant Physiology and Ecology(SIPPE)Chinese Academy of Sciences(CAS)Shanghai 200032China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Key Laboratory of Plant Carbon Capture CASShanghai 200032China New Cornerstone Science Laboratory Shanghai 200032China

To compensate for their sessile nature,plants have evolved sophisticated mechanisms enabling them to adapt to ever-changing *** such prominent feature is the evolution of diverse life history strategies,particularly such that annuals reproduce once followed by seasonal death,while perennials live longer by cycling growth *** intrinsic phenology is primarily genetic and can be altered by environmental *** evolutionary transitions between annual and perennial life history strategies are common,perennials account for most species in nature because they survive well under year-round *** proportion,however,is reversed in ***,perennial crops promise to likewise protect and enhance the resilience of agricultural ecosystems in response to climate *** significant endeavors that have been made to generate perennial crops,progress is slow because of barriers in studying perennials,and many developed species await further *** findings in model species have illustrated that simply rewiring existing genetic networks can lead to lifestyle *** implies that engineering plant life history strategy can be achieved by manipulating only a few key *** this review,we summarize our current understanding of genetic basis of perenniality and discuss major questions and challenges that remain to be addressed.

关键词： perenniality developmental plasticity flowering time poplar Arabis alpina perennial crops life history strategy

Comparison of Riemann Solutions for Non-isentropic Modified and Pure Chaplygin Gas Dynamics

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Acta Mathematicae Applicatae Sinica 2023年第3期39卷 733-751页

作者： Wen-jia WU Li wang Department of Arts and Sciences Shanghai Dianji UniversityShanghai 201306China

In this paper,we investigate the Riemann solutions of the non-isentropic Euler equations for the modified Chaplygin gas and the pure Chaplygin gas,which are the set of all rarefaction waves,shock waves,contact discontinuity andδ-shock *** some appropriate conditions,by studing the limiting behavior,we find that the Riemann solutions of modified Chaplygin gas is the same as pure Chaplygin gas including theδ-shock waves.

关键词： modified Chaplygin gas δ-shock waves Riemann problem generalized Rankine-Hugoniot conditions