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Natural product chlorogenic acid achieves pharmacological activity and health protection via regulating gut microbiota

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Food Science and Human Wellness 2024年

作者： Ke Fu Shu Dai Yafang zhang jia.Gong Cheng Wang Chenhao Yao Shenglin zhang Cheng Peng Yunxia Li State Key Laboratory of Southwestern Chinese Medicine Resources Key Laboratory of Standardization for Chinese Herbal Medicine Ministry of Education School of Pharmacy Chengdu university of Traditional Chinese Medicine College of Enology Northwest A&F university

Chlorogenic acid (CA) is a natural plant-derived polyphenol compound that is widely present in beverages (coffee and tea)， fruits (blueberry， apple， and mulberry)， and medicinal plants (Lonicera japonica， Eucommia ulmoides， and Cichorium intybus). In recent years， CA has attracted extensive attention due to its various health benefits， such as anti-inflammatory， immunomodulatory， anti-obesity， anti-diabetes mellitus， and neuroprotection activities. Interestingly， the low bioavailability of CA corresponds to high bioactivity， which raises a key scientific question of how low bioavailability CA can achieve high biological activity. In this review， we highlight the gut microbiota as a key target for connecting the two by summarizing a large amount of evidence. Specifically， the composition and abundance of gut microbiota， its metabolites， intestinal immunity， barrier function and so on were all changed under different pathological conditions such as inflammatory bowel disease， liver disease， kidney disease， cardiovascular disease， diabetes mellitus， obesity， etc. Conversely， these changes could be reversed by CA. In a word， CA could achieve pharmacological activity as well as health-protective effects by modulating intestinal immune and barrier function， gut microbiota composition， gut microbiota metabolites， and signaling pathways. This review provides new targets for the prevention and treatment of diseases by CA. Meanwhile， regulating the composition of the gut microbiota through natural products may be a potential strategy to achieve health protection.

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Combining network pharmacology， molecular docking， and experimental verification to investigate the anti-rheumatoid arthritis effect and mechanism of Baeckea frutescens leaves

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Food Science and Human Wellness 2024年

作者： Xueyang Guo Mengyao zhang Haixia Cai Xinyue jia.g Siyuan zh.u Wen Gong Zijia. Wei Weili Qiao Beixi jia Department of Pharmacognosy School of Pharmaceutical Science zhengzh.u university Department of Pharmacy Henan Provincial People's Hospital

The aromatic Baeckea frutescens leaves (BFL) known as “Gang-Song-Cha” is a popular drink (Tea) in South China. To explore the healthcare value， a systematic and in-depth study on BFL alleviating rheumatoid arthritis (RA) was carried out by integrating network pharmacology， molecular docking， and experimental verification. The efficacy was first evaluated， and the BFL extract could ameliorate RA by inhibiting articular swelling， lowering immune organ index， improving the ankle pathologies， and regulating serum levels of TNF-α， IL-6， and IL-10 in CIA rats. Then the anti-RA mechanism of BFL was investigated by leveraging the high-content and active component 5-hydroxy-7-methoxy-2-isopropylchromone (Chro.)， and the potential signaling pathway and related target proteins for Chro. acting on RA were analyzed by KEGG enrichment and docking simulation. Finally， the experimental validations were conducted on RA-FLS cells， and compound Chro. could inhibit cell invasion and migration， block cell cycle at G2/M phase and induce apoptosis， and reduce the secretion of inflammatory cytokines by suppressing the PI3K-Akt pathway. These results provided pharmacological basis for the folk usage of “Gang-Song-Cha (Tea)” for intervening RA.

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Consensus on rapid screening for prodromal Alzheimer's disease in China

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General Psychiatry 2024年第1期37卷 1-16页

作者： Lin Huang Qinjie Li Yao Lu Fengfeng Pan Liang Cui Ying Wang Ya Miao Tianlu Chen Yatian Li Jingnan Wu Xiaochun Chen jia.ping jia.Qihao Guo Department of Gerontology Shanghai Sixth People's Hospital Afiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina shanghai BestCovered ShanghaiChina ADepartment of Neurology Fujan Medical University Union HospitalFuzhouChina Department of Neurology National Clinical Research Center for Geriatric DiseasesBeijingChina

Alzheimer's disease(AD)is a common cause of dementia,characterised by cerebral amyloid-βdeposition,pathological tau and *** prodromal stage of AD(pAD)refers to patients with mild cognitive impairment(MCl)and evidence of AD's *** this stage,disease-modifying interventions should be used to prevent the progression to *** the inherent heterogeneity of MCl,more specific biomarkers are needed to elucidate the underlying AD's *** the uses of cerebrospinal fluid and positron emission tomography are widely accepted methods for detecting AD's pathology,their clinical applications are limited by their high costs and invasiveness,particularly in low-income areas in ***,to improve the early detection of Alzheimer's disease(AD)pathology through cost-effective screening methods,a panel of 45neurologists,psychiatrists andgerontologistswas invited to establish a formal consensus on the screening of pAD in *** supportive evidence and grades of recommendations are based on a systematic literature review andfocus group *** meetings were held to allow participants to review,vote and provide their expert opinions to reach a consensus.A majority(two-thirds)decision was used for questions for which consensus could not be *** screening methods are presented in this publication,including neuropsychological assessment,peripheral biomarkers and brain *** addition,a general workflow for Screening pAD in China is established,which will help clinicians identify individuals at high risk and determine therapeutic targets.

关键词： Alzheimer income screening

Helicobacter pylori and immunotherapy for gastrointestinal cancer

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The Innovation 2024年第2期5卷 51-60页

作者： Keren jia.Yang Chen Yi Xie Xicheng Wang Yajie Hu Yu Sun Yanshuo Cao Liyan zhang Yakun Wang zhenghang Wang zhihao Lu jia. Li Xiaotian zhang Lin Shen Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of PathologyPeking University Cancer Hospital&InstituteBeijing 100142China

Helicobacter pylori infection is associated with the risk of gastrointestinal(GI)cancers;however,its impact on immunotherapy for GI cancers remains *** this study,we included 10,122 patients who underwent ^(13)C-urea breath *** 636 patients with Epstein-Barr virus–negative microsatellite-stable gastric cancer(GC)who were treated with anti-PD-1/PD-L1 therapy,***–positive patients exhibited significantly longer immune-related progression-free survival(irPFS)compared with ***–negative patients(6.97 months versus 5.03 months,pup demonstrated a trend of 4 months longer median immune-related overall survival(irOS)than the ***–negative ***–positive GC displayed higher densities of PD-L1+cells and nonexhausted CD8+T cells,indicative of a“hot”tumor *** analysis revealed that ***–positive GC shared molecular characteristics similar to those of immunotherapy-sensitive ***,***–positive patients with DNA mismatch repair–deficient(dMMR)/microsatellite instability–high(MSI-H)colorectal adenocarcinoma and esophageal squamous cell carcinoma(ESCC)had shorter irPFS compared with ***–negative patients(16.13 months versus not reached,p=0.042,HR 2.26,95%CI 1.13–4.50,p=0.021 and 5.57 months versus 6.97 months,p=0.029,HR 1.59,95%CI 1.14–2.23,p=0.006,respectively).The difference in irOS between ***–positive and–negative patients had the same trend as that between dMMR/MSI-H colorectal adenocarcinoma and ESCC *** also identified a trend of shorter irPFS and irOS in ***–positive liver cancer and pancreatic cancer *** summary,our findings supported that *** infection is a beneficial factor for GC immunotherapy by shaping hot tumor ***,in dMMR/MSI-H colorectal adenocarcinoma and ESCC patients,*** adversely affects the efficacy of immunothera

关键词： immunotherapy gastrointestinal pylori

Liver stiffness in hepatocellular carcinoma and chronic hepatitis patients:Hepatitis B virus infection and transaminases should be considered

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World Journal of Hepatology 2024年第7期16卷 1018-1028页

作者： jia.Yao Huang jia.-Yun Peng Hai-Yi Long Xian zhong Yu-Hua Xie Lu Yao Xiao-Yan Xie Man-Xia Lin Department of Medical ultrasonics The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina

BACKGROuND Liver condition is a crucial prognostic factor for patients with hepatocellular carcinoma(HCC),but a convenient and comprehensive method to assess liver condition is *** stiffness(LS)measured by two-dimensional shear wave elastography may help in assessing liver fibrosis and liver *** hepatitis B(CHB)is an important risk factor for HCC progression,but LS was found to be less reliable in assessing liver fibrosis following hepatitis viral *** hypothesize that the status of hepatitis virus infection would affect the accuracy of LS in assessing the liver *** To test the feasibility and impact factors of using LS to assess liver condition in patients with HCC and *** A total of 284 patients were retrospectively recruited and classified into two groups on the basis of serum CHB virus hepatitis B virus(HBV)-DNA levels[HBV-DNA≥100.00 Iu/mL as Pos group(n=200)andu/mL as Neg group(n=84)].Correlation analyses and receiver operating characteristic analyses were conducted to evaluate the relationship between LS and liver *** A significant correlation was found between LS and most of the parameters considered to have the ability to evaluate liver condition(Pu/L),LS was correlated with liver condition indices(Put the optimal cutoff of LS to identify a Child-Pugh score of 5 was higher in the Neg group(9.30 kPa)than the Pos group(7.40 kPa).When ALT levels were elevated(>40 u/L),the correlations between LS and liver condition indices were not significant(P>0.05).CONCLuSION LS was significantly correlated with most liver condition indices in patients with CHB and ***,these correlations varied according to differences in HBV-DNA and transaminase concentrations.

关键词： Liver function Liver stiffness Elastography Chronic hepatitis B Hepatocellular carcinoma

Effects of Curcumin on Neuroinflammation and the Nrf2/HO-1 Pathway in Rat Brains Following Gas Explosion

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Biomedical and Environmental Sciences 2024年第8期37卷 943-947页

作者： Xinwen Dong Yaguang Su zheng Luo Lyufei Deng Xiaofeng Han Yifang Liang Sanqiao Yao Weidong Wu jia.Cao Linqiang Tian Yichun Bai Wenjie Ren Health School of Public Health Xinxiang Medical UniversityXinxiang 453003HenanChina Toxicology Research Institute PLA Army Medical UniversityChongqing 400038China Institute of Trauma and Orthopaedics Xinxiang Medical UniversityXinxiang 453003HenanChina Institutes of Health Central Plains Xinxiang Medical UniversityXinxiang 453003HenanChina

Gas explosions,a major occupational hazard in China’s coal industry,endanger the lives and health of *** explosions cause a specific type of traumatic brain injury with complex mechanisms,leading to disability and death.A study by zhao et *** magnetic resonance imaging on 49 gas explosion survivors revealed significant damage to brain regions like the hippocampus and cerebral cortex.

关键词： damage Nrf2 cerebral

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采用自复位u形连接件的装配式钢框架-复合墙结构性能研究

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哈尔滨工程大学学报 2024年第2期45卷 262-269页

作者：龚超贾明明刘信中冶建筑研究总院(深圳)有限公司广东深圳518055 哈尔滨工业大学结构工程灾变与控制教育部重点实验室黑龙江哈尔滨150090 哈尔滨工业大学土木工程智能防灾减灾工业和信息化部重点实验室黑龙江哈尔滨150090 哈尔滨工业大学土木工程学院黑龙江哈尔滨150090

对于内填RC墙的框架结构,为有效减小结构的损伤,改善结构力学性能,本文研究了一种在框架与墙之间设置开缝并安装耗能连接件,能够耗散能量从而有效地保护主体结构。采用ABAQuS分析了不同类型耗能连接件的内力特性以及节点的受力破坏模式... 详细信息

对于内填RC墙的框架结构,为有效减小结构的损伤,改善结构力学性能,本文研究了一种在框架与墙之间设置开缝并安装耗能连接件,能够耗散能量从而有效地保护主体结构。采用ABAQuS分析了不同类型耗能连接件的内力特性以及节点的受力破坏模式。通过在两侧开缝的密肋复合墙-钢框架结构中设置可滑移连接,实现了节点的耗能作用。研究结构表明:u形连接件水平段长度对连接件极限位移影响较大,可以通过双折线理想弹塑性荷载-位移曲线描述u形连接件在竖向压力与水平剪切作用下的荷载-位移关系。采用耗能连接件的结构在加载前期残余变形小,具有一定的自复位能力,并且能满足结构的大变形要求。通过以上分析,本文基于承载能力极限状态提出了耗能连接件的设计公式。

关键词： u形连接件自复位性能受力模式塑性损伤滞回曲线装配式结构框架-复合墙抗震性能

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扬子陆块西缘寒武系砂岩的物源分析:对古地理位置重建和构造背景的指示

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地质学报 2024年第2期98卷 363-380页

作者：张英利贾晓彤中国地质科学院矿产资源研究所自然资源部成矿作用与资源评价重点实验室北京100037 浙江省地震局信息中心(应急服务中心) 浙江杭州310013

扬子陆块西缘寒武系主要为一套碎屑岩-碳酸盐岩的岩石组合,前人研究多认为形成于相对稳定的克拉通盆地。但同时期出现的大陆岩浆作用显然与前期认定的克拉通盆地性质不符,需要借助扬子西缘的物质来源探讨构造背景。基于野外露头等资料,... 详细信息

扬子陆块西缘寒武系主要为一套碎屑岩-碳酸盐岩的岩石组合,前人研究多认为形成于相对稳定的克拉通盆地。但同时期出现的大陆岩浆作用显然与前期认定的克拉通盆地性质不符,需要借助扬子西缘的物质来源探讨构造背景。基于野外露头等资料,本文通过对扬子陆块西缘会泽和会东附近寒武系3件砂岩样品进行重矿物分析、电气石电子探针和碎屑锆石u-Pb测年分析,确定扬子西缘寒武纪沉积物的源区;并结合沉积序列等综合探讨扬子陆块西缘寒武纪的构造背景。沉积序列表明,扬子西缘寒武系沧浪铺组、西王庙组和二道水组主要由砂岩和白云岩等组成,沉积环境为滨岸—潮坪。细—粗砂岩碎屑颗粒为次棱角状—次圆状,分选较差;碎屑组分主要为石英,岩屑几乎全部为燧石,长石含量较少。测试分析结果表明:重矿物分析指示扬子西缘寒武系砂岩重矿物主要由锆石、赤—褐铁矿、电气石、钛铁矿、金红石、磷灰石等组成,重矿物组合指示岩浆岩为其主要母岩;电气石电子探针分析结果表明,物源主要来自于贫锂花岗岩和变砂岩、变泥岩;碎屑锆石测年分析表明物源区母岩主要为983~540 Ma岩浆岩。碎屑锆石年龄对比等综合分析表明,寒武系沉积物部分源自康滇古陆983~708 Ma的岩浆岩和变沉积岩,部分源自冈瓦纳大陆东非造山带663~540 Ma的岩石,物源区岩石经历再旋回产物作用。扬子西缘寒武系的沉积序列、碎屑锆石年龄谱图和碎屑组成等特征综合分析表明,扬子陆块西缘寒武系形成于前陆盆地。

关键词：碎屑重矿物物源分析寒武纪碰撞环境前陆盆地扬子陆块西缘

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退火工艺对热轧态含氮马氏体不锈钢420u6显微组织和硬度的影响

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金属热处理 2024年第3期49卷 98-102页

作者：贾元伟山西太钢不锈钢股份有限公司山西太原030003

热轧态含氮马氏体不锈钢420u6经800~950℃加热保温8~48 h退火处理后,采用激光共焦显微镜和维氏硬度计,研究了不同退火工艺下420u6钢的组织形貌和硬度的变化规律。结果表明,退火态组织由铁素体基体和基体上分布的碳化物组成,不同热处理... 详细信息

热轧态含氮马氏体不锈钢420u6经800~950℃加热保温8~48 h退火处理后,采用激光共焦显微镜和维氏硬度计,研究了不同退火工艺下420u6钢的组织形貌和硬度的变化规律。结果表明,退火态组织由铁素体基体和基体上分布的碳化物组成,不同热处理工艺下碳化物的大小和形态明显不同。退火温度在850℃下保温16~24 h时,碳化物形态呈球状且大小总体上均匀,其平均尺寸为0.4~0.5μm。随着退火温度的升高和保温时间的延长,420u6含氮马氏体不锈钢的硬度先降低后小幅升高,硬度的升高主要是由于片状碳化物的出现。

关键词：马氏体不锈钢退火显微组织硬度

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