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Shenmai Injection Attenuates Myocardial Ischemia/Reperfusion Injury by Targeting Nrf2/GPX4 Signalling-Mediated Ferroptosis

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Chinese Journal of Integrative Medicine 2022年第11期28卷 983-991页

作者： MEI Sheng-lan XIA Zhong-yuan QIU Zhen jia yi-fan ZHOU Jin-jian ZHOU Bin Department of Anaesthesiology Renmin Hospital of Wuhan UniversityWuhan(430060)China

Objective:To examine the effect of Shenmai Injection(SMJ)on ferroptosis during myocardial ischemia reperfusion(I/R)injury in rats and the underlying ***:A total of 120SPF-grade adult male SD rats,weighing 220–250 g were randomly divided into different groups according to a random number *** I/R model was established by occluding the left anterior descending artery for 30 min followed by 120 min of *** was injected intraperitoneally at the onset of 120 min of reperfusion,and erastin(an agonist of ferroptosis),ferrostatin-1(Fer-1,an inhibitor of ferroptosis)and ML385(an inhibitor of nuclear factor erythroid-2 related factor 2(Nrf2))were administered intraperitoneally separately 30 min before myocardial ischemia as different *** function before ischemia,after ischemia and after reperfusion was *** changes in the myocardium and the ultrastructure of cardiomyocytes were observed,and the myocardial infarction area was ***,the concentration of Fein heart tissues and the levels of creatine kinase-MB(CK-MB),troponin I(cTnI),malondialdehyde(MDA)and superoxide dismutase(SOD)in serum were measured using assay kits,and the expressions of Nrf2,glutathione peroxidase 4(GPX4)and acyl-CoA synthetase long-chain family member 4(ACSL4)were examined by Western ***:Compared with the sham group,I/R significantly injured heart tissues,as evidenced by the disordered,ruptured and oedematous myocardial fibres;the increases in infarct size,serum CK-MB,cTnI and MDA levels,and myocardial Feconcentrations;and the decreases in SOD activity(P<0.05).These results were accompanied by ultrastructural alterations to the mitochondria,increased expression of ACSL4 and inhibited the activation of Nrf2/GPX4 signalling(P<0.05).Compared with the I/R group,pretreatment with 9 mL/kg SMJ and 2 mg/kg Fer-1 significantly reduced myocardial I/R injury,Feconcentrations and ACSL4 expression and attenuated mitochondr

关键词： ferroptosis Shenmai Injection myocardial ischemia reperfusion injury pretreatment

车用双电源开绕组电机驱动系统绕组模式切换及电流控制策略

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吉林大学学报（工学版） 2018年第1期48卷 20-29页

作者：贾一帆初亮许楠徐哲吉林大学汽车仿真与控制国家重点实验室长春130022 中国第一汽车股份有限公司技术中心长春130011

针对电动车用双电源双逆变器开绕组永磁同步电机驱动系统,提出星形、角形、独立3种绕组模式及实现方法。在分析各模式电机外特性的基础上,制定了绕组模式切换策略,其中的转矩饱和判定算法可实现对电机参数变化不敏感的绕组模式自动向上... 详细信息

针对电动车用双电源双逆变器开绕组永磁同步电机驱动系统,提出星形、角形、独立3种绕组模式及实现方法。在分析各模式电机外特性的基础上,制定了绕组模式切换策略,其中的转矩饱和判定算法可实现对电机参数变化不敏感的绕组模式自动向上切换。同时提出了用于独立模式的多电平电流滞环调制算法,增加了电平数量及触发机制,可指定主电源并实时切换,从而实现两电源间的能量分配;其具有低开关频率和大功率差值两种控制方式,可达到不同的节能与能量分配效果。仿真结果表明:本文方法充分利用了各绕组模式的工作区间,减少了器件损耗并提高了系统效率,为双电源构型下车用动力系统的建立提供了理论依据与工程方案。

关键词：车辆工程开绕组永磁同步电机绕组模式切换转矩饱和判定电流滞环调制能量分配

One LeuRS leucylates type Ⅰ and Ⅱ tRNALeus in Streptomyces coelicolor

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One LeuRS leucylates type Ⅰ and Ⅱ tRNALeus in Streptomyces...

Clinical study of thumb-tack needle therapy for cervical radiculopathy based onmeridian differentiation

中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： jia-yi fan Quan-Quan Ji Qian Huang En-Duo Wang Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Science

Transfer RNAs(tRNAs) are divided into two types according to their variable arm *** canonical bacterial and eukaryotic cytoplasmic tRNA belongs to the type II tRNAs with a long variable arm,and the eukaryotic mitochondrial tRNA belongs to the type I tRNAs with a short variable ***,aminoacylation of type I tRNA or type II t RNA was catalyzed by its cognate leucyl-tRNA synthetase(LeuRS),***,there are two types of tRNA and only one LeuRS in Streptomyces coelicolor(Sco).We purified Sco LeuRS and confirmed its activity of catalyzing both type I Scot RNA(CAA) and type II Scot RNA(UAA),yet Sco LeuRS has a higher catalytic velocity for Scot RNA(UAA) than Scot RNA(CAA).We identified A14-U8 pair and its own unique structure of variable stem as mutual identity elements in Scot RNA(CAA) and Scot RNA(UAA) for ***,we discovered that the discriminator base was not canonical A73 but shifted to *** further determined the in vivo effect of mutants of Scot RNA(UAA),and found that the interacting residues on Sco LeuRS were different between Scot RNA(CAA) and Scot RNA(UAA).We further identified leucine specific domain(LSD) of Sco LeuRS as a domain helping LeuRS from Stremptomyces purpurogeneiscleroticus,which only aminoacylate type II tRNA originally,to aminoacylate type I Scot RNA(CAA).Taken together,our findings showed a rare recognition mechanism of LeuRS aminoacylating tRNA.

关键词： tRNA leucyl-tRNA synthetase Streptomyces coelicolor

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Journal of Acupuncture and Tuina Science 2020年第2期18卷 129-134页

作者： Zhao Yu Yu Nian-tang Lai Zhong-tao jia yi-fan Tonglu TCM Hospital Hangzhou 311500China Anhui University of Chinese Medicine Hefei 230038China 不详

Objective:To observe the clinical efficacy and eligibility of thumb-tack needle therapy based on meridian differentiation in treating cervical ***:A total of 70 patients with cervical radiculopathy were randomized into an observation group and a control group,with 35 cases in each *** in the control group received thumb-tack needle based on conventional point selection,while those in the observation group received thumb-tack needle according to meridian *** visual analog scale(VAS)and clinical symptom scores in the two groups were compared before and after treatment,and the clinical efficacy of the two treatments was ***:After treatment,the VAS score in both groups dropped significantly(both P<0.01),and the VAS score in the observation group was lower than that in the control group(P<0.01).The clinical symptoms score in both groups dropped significantly(all P<0.01),and the clinical symptoms score in the observation group was lower than that in the control group(P<0.01).The total effective rate in the observation group was higher than that in the control group(P<0.05).Conclusion:Thumb-tack needle therapy based on meridian differentiation can reduce pain score,improve clinical symptoms in patients with cervical radiculopathy,and produce more significant efficacy compared with conventional thumb-tack needle therapy.

关键词： Acupuncture Therapy Embedding Therapy Intradermal Needle Therapy Cervical Spondylopathy Neck Pain Radiculopathy Running Course of Meridian Syndrome Differentiation of Meridian

SiO_2气凝胶复合型隔热涂层的制备及性能研究

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表面技术 2017年第5期46卷 99-105页

作者：丁逸栋刘朝辉王飞贾艺凡舒心中国人民解放军后勤工程学院化学与材料工程系中国人民解放军94786部队中国人民解放军61517部队

目的探究SiO_2气凝胶在复合隔热涂料中的应用,从隔热机理出发,通过降低复合隔热涂层的导热系数,提高反射率、辐射率等方式,使涂层达到隔热降温的目的。方法首先通过单掺实验确定各填料的含量,并采用紫外/可见光/近红外分光光度计、红外... 详细信息

目的探究SiO_2气凝胶在复合隔热涂料中的应用,从隔热机理出发,通过降低复合隔热涂层的导热系数,提高反射率、辐射率等方式,使涂层达到隔热降温的目的。方法首先通过单掺实验确定各填料的含量,并采用紫外/可见光/近红外分光光度计、红外辐射率测量仪和自制的测试隔热装置等,分析涂层的发射率、辐射率和隔热性能,最后通过正交实验方法得到最优涂层配方。结果 SiO_2气凝胶能显著降低涂层的导热系数,在此基础上,添加钛白粉、空心玻璃微珠、红外陶瓷粉等颜填料,能有效提高涂层的反射率和辐射率,从而进一步增强了涂层的隔热效果。分别添加质量分数为5%的SiO_2气凝胶、5%的钛白粉、5%的空心玻璃微珠和10%的红外陶瓷粉时,复合隔热涂层具有最优的隔热性能。SiO_2气凝胶复合型隔热涂层的干膜厚度为60μm时,与未涂覆的空白样板对比,温度最高可降低14.8℃。结论 SiO_2气凝胶复合型隔热涂层具有优异的隔热性能,并且具有薄层、轻质、环保等优点,具有一定的实际应用价值。

关键词： SiO2气凝胶复合型隔热涂料导热系数反射率红外发射率

超声介导一氧化氮微泡辅助骨髓间充质干细胞移植治疗心肌梗死

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中国组织工程研究 2017年第17期21卷 2678-2683页

作者：陈飞许澎乔祺樊冰童嘉毅范国峰复旦大学附属上海市第五人民医院心内科上海市200240 复旦大学附属中山医院心内科上海市200032 东南大学附属中大医院心内科江苏省南京市210007 南京大学医学院附属鼓楼医院急诊中心江苏省南京市210008

背景:多项实验研究发现,超声联合微泡干预能够增强干细胞移植治疗心肌梗死后心力衰竭的效果,具有良好的应用前景。但超声介导一氧化氮微泡经冠脉移植骨髓间充质干细胞治疗大型动物心肌梗死是否具有同样的效果仍不明确。目的:探讨超声介... 详细信息

背景:多项实验研究发现,超声联合微泡干预能够增强干细胞移植治疗心肌梗死后心力衰竭的效果,具有良好的应用前景。但超声介导一氧化氮微泡经冠脉移植骨髓间充质干细胞治疗大型动物心肌梗死是否具有同样的效果仍不明确。目的:探讨超声介导一氧化氮微泡与冠脉移植骨髓间充质干细胞治疗家猪心肌梗死的有效性及可能机制。方法:(1)密度梯度离心法分离、培养、鉴定家猪骨髓间充质干细胞,CM-Dil体外标记骨髓间充质干细胞;(2)经介入法球囊封堵猪左冠状动脉前降支成功建立24只家猪心肌梗死模型,随机分为PBS组、骨髓间充质干细胞组、超声介导声诺维微泡组、超声介导一氧化氮微泡组(n=6)。于造模后1周进行如下干预:PBS组经冠脉注射10 m L PBS,骨髓间充质干细胞组将骨髓间充质干细胞(约1×10~7)用10 m L PBS稀释后经冠脉缓慢注射;超声介导声诺维微泡组经冠脉注入声诺维微泡0.1 m L/kg,同时超声干预(1 MHz、2 W/cm^2)2 min,然后将骨髓间充质干细胞(约1×10~7)用10 m L PBS稀释后经冠脉缓慢注射;超声介导一氧化氮微泡组移植方法及条件同超声介导声诺维微泡组,仅将声诺维微泡换作一氧化氮微泡;(3)干预后48 h随机处死每组各3只家猪,取梗死区心肌组织作冰冻切片,计数比较各组缺血心肌内荧光标记阳性骨髓间充质干细胞。4周后对每组剩余家猪行M型心脏超声观察比较各组左心室收缩功能。心功能检测结束后处死所有家猪,取梗死区心肌组织行石蜡切片及苏木精-伊红染色,计数比较各组心肌缺血区的毛细血管密度。结果与结论:(1)与超声介导声诺维微泡组及骨髓间充质干细胞组比较,超声介导一氧化氮微泡组CM-Dil阳性骨髓间充质干细胞数增多,差异有显著性意义(P<0.05);(2)与超声介导声诺维微泡组、骨髓间充质干细胞组及PBS组比较,超声介导一氧化氮微泡组左室射血分数值有显著改善,差异有显著性意义(P<0.05);(3)与超声介导声诺维微泡组、骨髓间充质干细胞组及PBS组比较,超声介导一氧化氮微泡组平均毛细血管密度显著增多,差异有显著性意义(P<0.05);(4)结果表明,超声介导一氧化氮微泡与冠脉移植骨髓间充质干细胞联合治疗可以改善家猪急性心肌梗死后的左心收缩功能,可能与超声介导一氧化氮微泡促进骨髓间充质干细胞向心肌缺血区归巢以及局部血管生成有关。

关键词：干细胞移植骨髓间充质干细胞心肌梗死超声一氧化氮微泡国家自然科学基金

Clinical experience of Xiangxi Liu's infantile tuina for exogenous fever in children

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Journal of Acupuncture and Tuina Science 2018年第5期16卷 310-314页

作者：汤伟邵湘宁贾一凡 The First Hospital of Hunan University of Chinese Medicine Beijing China

Xiangxi (the western part of Hunan province) Liu's infantile tuina,as one main school of current infantile tuina in China,highlights the compatibility of the specific points of Wujing in children,the idea of treatment by syndrome differentiation,and produces unique efficacy in the treatment of common diseases in *** fever in children can be treated with this method with excellent *** on the clinical experience and effective cases treated by this tuina school,the authors elaborated the clinical thought and experience from the perspective view of tuina,for the promotion of Xiangxi Liu's infantile tuina in clinic.

关键词： Tuina Massage Pediatric Tuina Common Cold Fever Infant Child,Preschool

基于开绕组电机的增程式电动车动力系统构型及其功率分配

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吉林大学学报（工学版） 2021年第1期51卷 72-82页

作者：初亮董力嘉许楠张立峰贾一帆杨志华吉林大学汽车仿真与控制国家重点实验室长春130022 上汽集团商用车技术中心上海200438

为利用开绕组永磁同步电机在双能量源间功率分配的灵活性,提出一种新型电动汽车动力系统构型,实现了从功率分配指令形成到指令跟随的过程。首先提出基于模糊控制的期望功率计算方法,使主能量源工作在高效区,并在电机控制层面基于双逆变... 详细信息

为利用开绕组永磁同步电机在双能量源间功率分配的灵活性,提出一种新型电动汽车动力系统构型,实现了从功率分配指令形成到指令跟随的过程。首先提出基于模糊控制的期望功率计算方法,使主能量源工作在高效区,并在电机控制层面基于双逆变器电压矢量模型,然后提出精确功率跟随、线性分配两种分配方法,实现主、次能量源期望功率的跟随。仿真结果表明:在电压矢量分配方法下,电机转速、转矩跟随效果良好,且转矩波动幅度限制在3 N·m以内。

关键词：增程式电动车辆开绕组电机模糊控制矢量控制功率分配

Effect of warm needling plus oral medication on blood lipids in cerebral infarction patients

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Journal of Acupuncture and Tuina Science 2017年第2期15卷 115-119页

作者：徐贞杰漆伟刘奕贾一凡(译) Rehabilitation Department Chongqing Three Gorges Central Hospital Chongqing 404100 China 不详

Objective：To observe the effect of warm needling plus oral administration of rosuvastatin calcium tablets on blood lipids in cerebral infarction patients. Methods：A total of 125 eligible cases were randomly allocated into group A （n=42）, group B （n=40） and group C （n=43）. Cases in group A received warm needling plus oral administration of rosuvastatin calcium tablets, cases in group B received warm needling, whereas cases in group C received oral administration of rosuvastatin calcium tablets. Results：After treatment, the total cholesterol （TC）, triglyceride （TG）, low-density lipoprotein cholesterol （LDL-C） all dropped obviously in the three groups, with significant differences （allP〈0.05）, modified Barthel index （BI） scores all significantly rise （allP〈0.05）, and high-density lipoprotein cholesterol （HDL-C） remained unchanged （allP〉0.05）. After treatment, the changes of TC, TG and LDL-C in group A were significantly different from those in group B and group C （allP〈0.05）, while the changes showed no statistical significance between group B and group C （P〉0.05）. There were no between-group differences in HDL-C among the three groups （allP〉0.05）; the modified BI scores in groupA and groupB were significantly higher than that in group C （bothP〈0.05）, while there was no significant difference between group A and group B （P〉0.05）.After treatment, the total effective rate was significantly higher in group A than that in group B and group C （bothP〈0.05）, there was no significant difference between group B and group C （P〉0.05）. Conclusion：Warm needling and oral administration of rosuvastatin calcium tablets both can adjust blood lipids effectively in cerebral infarction patients with a similar therapeutic efficacy, while the effect gets better based upon combining both methods; acupuncture-moxibustion plays an important role in the recovery of nerve functions in cerebral infarction patients.

关键词： Acupuncture Therapy Moxibustion Therapy Warm Needling Therapy Cerebral Infarction Blood Lipid Rosuvastatin Calcium Tablets