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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu Wei Huang jiayi wen xin Xiong Ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

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Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo Shao Chao-Min Xu Ke Wang jia-Zhu wen Li-Kang Luo jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

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连翘的化学成分研究

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中草药 2017年第4期48卷 644-647页

作者：阎新佳温静项峥杨波吴健江培崔琳琳赵瑛哈尔滨商业大学药学部黑龙江哈尔滨150076 哈尔滨商业大学生命科学与环境科学研究中心黑龙江哈尔滨150076

目的对连翘Forsythia suspensa的化学成分进行研究。方法通过大孔吸附树脂、Sephadex LH-20、反相HPLC等多种色谱进行分离纯化,根据理化性质和波谱数据鉴定化合物结构。结果从连翘的50%乙醇提取物中分离得到了13个化合物,分别鉴定为毛柳... 详细信息

目的对连翘Forsythia suspensa的化学成分进行研究。方法通过大孔吸附树脂、Sephadex LH-20、反相HPLC等多种色谱进行分离纯化,根据理化性质和波谱数据鉴定化合物结构。结果从连翘的50%乙醇提取物中分离得到了13个化合物,分别鉴定为毛柳苷(1)、连翘酯苷E(2)、quinolacetic acid(3)、黄瑞烷酮(4)、千里光内酯(5)、cleroindicin C(6)、4-羟基-4-异丙基-1-环己烯甲酸(7)、oleuropeic acid(8)、rel-(1S,2S,4S)-trihydroxy-p-menthane(9)、壬二酸(10)、2-羟基-丁二酸-4-内酯(11)、glochidioboside(12)、(+)-异落叶松脂醇-9-O-β-D-葡萄糖苷(13)。结论化合物5~13为从连翘属中首次分离得到。

关键词：连翘千里光内酯 cleroindicin C 4-羟基-4-异丙基-1-环己烯甲酸 oleuropeic acid 2-羟基-丁二酸-4-内酯 glochidioboside

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Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma jia Liu Xiang Xia Ning Xu wen Sun jianjun Du jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu jia-Bao Liao Wei-Bo wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li wen‑Xia Su jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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The role of Debye mass in the chiral crossover in a strong magnetic field

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Communications in Theoretical Physics 2022年第10期74卷 68-75页

作者： jia Zhang xin-jian wen Institute of Theoretical Physics State Key Laboratory of Quantum Optics and Quantum Optics DevicesShanxi UniversityTaiyuanShanxi 030006China

In this paper,the Debye mass of quarks is investigated in the Nambu–Jona-Lasinio model at zero and nonzero chemical *** a uniform plasma,the Debye mass usually behaves as a monotonous increasing function of the temperature,the chemical potential and the magnetic *** the fixed coupling interaction G,we find that the magnetic catalysis(MC)on the occurrence of the chiral restoration could be revealed by the susceptibility of the Debye mass dmD/dT at low chemical potential and by the quantity TdmD/dT in the region of moderate ***,the inverse MC is realized under a thermomagnetic coupling constant G(B,T)by the behavior of the Debye mass at both zero and nonzero chemical potentials.

关键词： chiral restoration strong magnetic field Debye mass Nambu-Jona-Lasinio

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加强素质教育改革高等数学教学

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华北水利水电学院学报（社会科学版） 2001年第1期18卷 98-99页

作者：贾文新李亦芳陈宝娟华北水利水电学院信息工程系河南郑州450008

高等数学是自然科学的基础 ,有助于培养学生的科学思维能力。因此 ,应加强课程建设 ,改革教学方法 ,注重能力培养。

关键词：人才素质课程建设能力培养素质教育

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基于多波长光学系统结构的透射波前检测

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激光与红外 2022年第7期52卷 1064-1072页

作者：朱大勇张齐元王芳朱怀康贾文昕韩森上海理工大学光电信息与计算机工程学院上海200093 苏州慧利仪器有限责任公司江苏苏州215123 苏州科技大学物理科学与技术学院江苏苏州215009

基于多波长波前检测技术的实际需要,设计了多波长激光干涉仪光学结构。结构基于菲索干涉原理,使用分光棱镜集成5个波长的激光光源。通过笼式系统减小了光学结构各部分的同轴误差,采用消色差镜头作为干涉系统的准直系统和成像系统,缩短... 详细信息

基于多波长波前检测技术的实际需要,设计了多波长激光干涉仪光学结构。结构基于菲索干涉原理,使用分光棱镜集成5个波长的激光光源。通过笼式系统减小了光学结构各部分的同轴误差,采用消色差镜头作为干涉系统的准直系统和成像系统,缩短了调整准直系统行程的同时,也减小了系统内部光学系统的色差。使用该光学结构对光学系统进行测量,采用转换多项式法计算的Zernike系数-波长曲线符合预测结果。多波长激光干涉仪光学结构提高了多波长透射波前的检测效率,有利于多波长透射波前检测技术的工程化和推广,并为新仪器的开发提供了借鉴。

关键词：透射波前激光干涉仪光学系统 Zernike系数

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FDA医疗器械境外临床研究的监管要求及启示

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医疗卫生装备 2016年第10期37卷 124-127页

作者：田佳鑫何文俊侯倩国家食品药品监督管理总局医疗器械技术审评中心北京100044 解放军总医院附属第一医院创伤外科研究室北京100048 解放军总医院基础医学所北京100853

目的:探讨美国食品药品监督管理局(Food and Drug Administration,FDA)对医疗器械境外临床研究的监管要求,为我国相关从业人员提供参考和借鉴。方法:通过介绍美国法规中针对医疗器械境外临床研究的条款和FDA发布的涉及境外临床研究的指... 详细信息

目的:探讨美国食品药品监督管理局(Food and Drug Administration,FDA)对医疗器械境外临床研究的监管要求,为我国相关从业人员提供参考和借鉴。方法:通过介绍美国法规中针对医疗器械境外临床研究的条款和FDA发布的涉及境外临床研究的指导原则,了解FDA对医疗器械境外临床研究的监管要求,从而在此方面为我国相关监管部门提出启示。结果:相关监管部门在接受医疗器械境外临床研究资料时,需考虑临床医疗条件、临床研究人群、临床研究监管要求等多方面的差异。结论:我国相关监管部门可借鉴FDA接受境外临床研究结果的经验,结合我国相关法规要求和实际情况,在确保产品安全有效的前提下,细化接受进口医疗器械提交境外临床试验资料的接受标准和要求。

关键词：医疗器械境外临床研究监管要求

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