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International Journal of Minerals,Metallurgy and Materials 2017年第6期24卷 718-725页

作者： jia-xin wen Tian-bin Zhu Zhi-peng Xie wen-bin Cao Wei Liu School of Materials Science and Engineering University of Science and Technology Beijing Sate Key Laboratory of New Ceramics and Fine Processing Department of Materials Science and Engineering Tsinghua University School of Electromechanical Engineering Guangdong University of Technology

Despite its unique high efficiency and good environmental compatibility, the water-soluble binder system still encounters problems achieving a desired sintered part via ceramic injection molding because of the poor compatibility and the powder-binder segregation between ceramic powders and binders. The objective of this study was to obtain a sintered part with excellent properties by introducing a small quantity of oleic acid to the surface of zirconia powders before the mixing process. As opposed to many previous investigations that focused only on the rheological behavior and modification mechanism, the sintering behavior and densification process were systematically investigated in this study. With the modified powders, debound parts with a more homogeneous and smaller pore size distribution were fabricated. Also, a higher density and greater flexural strength were achieved in the sintered parts fabricated using the modified powders.

关键词： ceramic materials zirconia injection molding oleic acid sintering

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： xin Yang Yu-wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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白花败酱草的化学成分研究

中国药学杂志 2017年第3期52卷 185-187页

作者：项峥阎新佳温静刘伟哈尔滨商业大学生命科学与环境科学研究中心哈尔滨150076 哈尔滨商业大学药学部哈尔滨150076

目的对白花败酱草的化学成分进行研究。方法通过大孔吸附树脂、Sephadex LH-20、反相HPLC等多种色谱进行分离纯化,根据理化性质和波谱数据进行鉴定。结果从白花败酱草的体积分数70%乙醇提物中分离得到了9个化合物,分别为(E,4R)-4-hydrox... 详细信息

目的对白花败酱草的化学成分进行研究。方法通过大孔吸附树脂、Sephadex LH-20、反相HPLC等多种色谱进行分离纯化,根据理化性质和波谱数据进行鉴定。结果从白花败酱草的体积分数70%乙醇提物中分离得到了9个化合物,分别为(E,4R)-4-hydroxy-4,5,5-trimethyl-3-(3-oxobut-1-enyl)cyclohex-2-enone(1),vomifoliol(2),cis-4-hydroxymellein(3),dehydrovomifoliol(4),野鸦椿素A(5),黑麦草内酯(6),对甲氧基苯甲醇(7),sphenanthin A(8)和尿素(9)。结论化合物1~7为首次从败酱属中分离得到。

关键词：白花败酱草结构鉴定野鸦椿素A 黑麦草内酯对甲氧基苯甲醇

饮食干预管理和健康教育对小儿糖尿病酮症酸中毒效果及低血糖发生影响

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糖尿病新世界 2019年第2期22卷 18-19,60页

作者：贾文欣临沂市妇女儿童医院儿童康复科山东临沂276000

目的观察小儿糖尿病酮症酸中毒应用饮食干预管理与健康教育的效果及低血糖情况。方法临床资料采集该院2016年7月—2018年7月治疗的90例DKA患儿,分2组,每组45例,对照组行常规治疗,观察组在其基础展开饮食干预、健康教育,比较两组血糖及... 详细信息

目的观察小儿糖尿病酮症酸中毒应用饮食干预管理与健康教育的效果及低血糖情况。方法临床资料采集该院2016年7月—2018年7月治疗的90例DKA患儿,分2组,每组45例,对照组行常规治疗,观察组在其基础展开饮食干预、健康教育,比较两组血糖及健康知识掌握。结果观察组空腹血糖(10.33±1.21)mmol/L、餐后2 h血糖(14.30±2.33)mmol/L相较于对照组低(P<0.05),观察组血糖控制时间(6.23±1.21)d、酸中毒纠正时间(5.33±1.25)d相较于对照组均较短(P<0.05)。结论小儿糖尿病酮症酸中毒通过饮食干预管理、健康教育,能加快血糖改善,迅速纠正酸中毒,并提升家属掌握健康知识的程度,避免低血糖发生。

关键词：小儿糖尿病酮症酸中毒饮食干预管理健康教育

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浅谈工程预结算编制中存在的问题和对策

山西建筑 2009年第15期35卷 228-229页

作者：贾新文浙江省宁波市宁波德威工程造价投资咨询有限公司

重点探讨了目前建筑行业工程预结算编制中存在的问题和原因,针对这些问题提出了加强预结算管理的措施和建议,从而进一步提高工程预结算管理水平,降低工程造价,有效地控制工程成本。

关键词：工程预结算定额管理成本

Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu wen-jia Chen xin-Ning Yu Hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

基于3S技术的垃圾焚烧气体监测与扩散模型的研究与建立

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电子设计工程 2017年第18期25卷 161-163,167页

作者：刘佳丽温馨国土资源部地学空间信息技术重点实验室四川成都610059 成都理工大学地球科学学院四川成都610059

针对"垃圾围城"现象中垃圾焚烧产生的气体的污染问题,文中基于时下流行的3S技术,采集焚烧气体信息,建立了污染性气体的监测与扩散模型。本模型实现了污染物性气体的实时监测与扩散预测,保证了污染气体浓度达标,维护了垃圾焚烧厂的周边... 详细信息

针对"垃圾围城"现象中垃圾焚烧产生的气体的污染问题,文中基于时下流行的3S技术,采集焚烧气体信息,建立了污染性气体的监测与扩散模型。本模型实现了污染物性气体的实时监测与扩散预测,保证了污染气体浓度达标,维护了垃圾焚烧厂的周边生态环境。

关键词：垃圾焚烧 3S技术数学模型气体扩散污染监测

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第01期 201-208页

作者： Hui-Feng Wang wen-Jie Shi Yu-xin Yang Bao-Xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

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无穷区间上的分数阶微分方程边值问题的正解

山西师范大学学报（自然科学版） 2018年第2期32卷 1-10页

作者：姚佳欣王文霞贾建梅太原师范学院数学系山西晋中030619

利用Leggett-Williams不动点定理以及范数形式下的锥压缩-锥拉伸定理研究了一类无穷区间上的高阶分数阶微分方程边值问题,获得了该边值问题至少存在三个正解和一个正解的充分条件.最后给出了两个例子作为所获结果的应用.

关键词：分数阶微分方程边值问题正解

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比值辐射计空间环境适应性设计及验证

光子学报 2016年第11期45卷 160-166页

作者：李孟凡邹鹏孙真金洁曹兴家黄文薪洪津司孝龙乔延利中国科学院安徽光学精密机械研究所合肥230031 中国科学技术大学合肥230026 中国科学院通用光学定标与表征技术重点实验室合肥230031

结合卫星发射以及在轨运行过程中所处的环境条件,对"积分球+匀光板+电磁光开关"形式的比值辐射计进行空间环境适应性设计.对结构薄弱环节进行强化加固设计,通过降低器件功耗、表面热处理等方式保持比值辐射计在真空热环境下的温度稳定,... 详细信息

结合卫星发射以及在轨运行过程中所处的环境条件,对"积分球+匀光板+电磁光开关"形式的比值辐射计进行空间环境适应性设计.对结构薄弱环节进行强化加固设计,通过降低器件功耗、表面热处理等方式保持比值辐射计在真空热环境下的温度稳定,采用航天级光学涂层辅以结构屏蔽设计保证抗辐照能力.通过力学试验、热真空试验以及积分球光学涂层辐照试验进行验证.力学试验结果显示比值辐射计基频约为540Hz,振动前后比值辐射计辐射比变化小于0.31%,证明比值辐射计具有良好的结构稳定性,空间力学条件下的结构强度和刚度均满足基频大于100 Hz的设计要求.热真空试验过程中比值辐射计遥测输出稳定,各功能模块均工作正常.辐照试验后,比值辐射计光学涂层方向-半球反射比在485nm波段的最大衰变小于2%,红外波段无明显变化,该衰变对定标器在轨应用性能的影响可以忽略.研究结果表明,比值辐射计具有良好的空间环境适应性,可在复杂空间环境下进行稳定、可靠的工作,满足航天应用需求.

关键词：光学遥感星上定标环境试验比值辐射计力学热真空空间辐照