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Radiofrequency ablation vs hepatic resection for solitary colorectal liver metastasis:A meta-analysis

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World Journal of Gastroenterology 2011年第36期17卷 4143-4148页

作者： Yun-Zi Wu Bin Li Tao Wang Shuang-jia Wang Yan-ming zhou Department of Hepato-Biliary-Pancreato-Vascular Surgery the First Affiliated Hospital of Xiamen UniversityXiamen 361003Fujian ProvinceChina

AIM:To evaluate the comparative therapeutic efficacy of radiofrequency ablation (RFA) and hepatic resection (HR) for solitary colorectal liver metastases (CLM).METHODS:A literature search was performed to identify comparative studies reporting outcomes for both RFA and HR for solitary *** odds ratios (OR) with 95% confidence intervals (95% CI) were calculated using either the fixed effects model or random effects ***:Seven nonrandomized controlled trials studies were included in this *** studies included a total of 847 patients:273 treated with RFA and 574 treated with *** 5 years overall survival rates in the HR group were significantly better than those in the RFA group (OR:0.41,95% CI:0.22-0.90,P=0.008).RFA had a higher rate of local intrahe-patic recurrence compared to HR (OR:4.89,95% CI:1.73-13.87,P=0.003).No differences were found between the two groups with respect to postoperative morbidity and ***:HR was superior to RFA in the treatment of patients with solitary ***,the findings have to be carefully interpreted due to the lower level of evidence.

关键词： Hepatic resection Colorectal liver metastases Radiofrequency ablation Efficacy Meta-analysis

Malignant atrophic papulosis:Two case reports

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World Journal of Clinical Cases 2022年第35期10卷 12971-12979页

作者： Zhi-Gui Li jia-ming zhou Li Li Xiao-Dong Wang Department of Gastrointestinal Surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Clinical Medicine West China School of MedicineSichuan UniversityChengdu 610207Sichuan ProvinceChina

BACKGROUND Malignant atrophic papulosis is a rare and potentially lethal thrombo-occlusive microvasculopathy characterized by cutaneous papules and gastrointestinal *** precise pathogenesis of this disease remains *** SUMMARY We describe the case of a 67-year-old male patient who initially presented with cutaneous aubergine papules and dull pain in the *** week after symptom onset,he was admitted to the hospital for worsening abdominal *** laparotomy showed patchy necrosis and subserosal white plaque lesions on the small intestinal wall,along with multiple *** examination of the small intestine showed extensive hyperemia,edema,necrosis with varying degrees of inflammatory reactions in the small bowel wall,small vasculitis with fibrinoid necrosis and intraluminal thrombosis in the *** on the mentioned evidence,a diagnosis of malignant atrophic papulosis was *** also present the case of a 46-year-old man with known cutaneous manifestations,abdominal pain,nausea and *** physical examination showed positive rebound tenderness.A computed tomography scan revealed free intraperitoneal *** required surgical intervention on admission and then developed an esophageal *** ultimately died of a massive *** In previously published cases of this disease,the cutaneous lesions initially appeared as small erythematous ***,the papules became porcelain-white atrophic depression lesions with a pink,telangiectatic peripheral *** one of the patients,the cutaneous lesions appeared as aubergine *** other patient developed multiple perforations in the gastrointestinal *** to malignant atrophic papulosis affecting multiple organs,many authors speculated that it is not a specific *** case series serves as additional evidence for our hypothesis.

关键词： Malignant atrophic papulosis Gastrointestinal perforation Papulosis Thrombo-occlusive microvasculopathy Case report

The pseudospectrum and spectrum(in)stability of quantum corrected Schwarzschild black hole

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 55-75页

作者： Li-ming Cao jia-Ning Chen Liang-Bi Wu Libo Xie Yu-Sen zhou School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUCASHangzhou 310024China Peng Huanwu Center for Fundamental Theory Hefei 230026China Interdisciplinary Center for Theoretical Study and Department of Modern Physics University of Science and Technology of ChinaHefei 230026China

In this study,we investigate the pseudospectrum and spectrum(in)stability of quantum corrected Schwarzschild black ***,we use the hyperboloidal framework to cast the quasinormal mode(QNM)problem into an eigenvalue problem associated with a non-selfadjoint operator,and then the spectrum and pseudospectrum are ***,the invariant subspace method is exploited to improve the computational efficiency for *** investigation into the spectrum(in)stability entails two main *** the one hand,we calculate the spectra of the quantum corrected black hole,then by the means of the migration ratio,the impact of the quantum correction effect on the Schwarzschild black hole has been *** results indicate that the so-called“migration ratio instability”will occur for small black holes with small angular momentum number *** the eikonal limit,the migration ratios remain the same for each *** the other hand,we study the spectrum(in)stability of the quantum corrected black hole by directly adding some particular perturbations into the effective potential,where perturbations are located at the event horizon and null infinity,*** are two interesting observations under the same perturbation energy ***,perturbations at infinity are more capable of generating spectrum instability than those at the event ***,we find that the peak distribution can lead to the instability of QNM spectrum more efficiently than the average distribution.

关键词： quasinormal modes pseudospectrum hyperboloidal coordinate

Effects of dietary intervention on human diseases:molecular mechanisms and therapeutic potential

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1389-1422页

作者： Yu-Ling Xiao Yue Gong Ying-jia Qi Zhi-ming Shao Yi-zhou jiang Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudanUniversityShanghai200032China

Diet,serving as a vital source of nutrients,exerts a profound influence on human health and disease ***,dietary interventions have emerged as promising adjunctive treatment strategies not only for cancer but also for neurodegenerative diseases,autoimmune diseases,cardiovascular diseases,and metabolic *** interventions have demonstrated substantial potential in modulating metabolism,disease trajectory,and therapeutic *** reprogramming is a hallmark of malignant progression,and a deeper understanding of this phenomenon in tumors and its effects on immune regulation is a significant challenge that impedes cancer *** intake,as a key environmental factor,can influence tumor *** evidence indicates that dietary interventions might affect the nutrient availability in tumors,thereby increasing the efficacy of cancer ***,the intricate interplay between dietary interventions and the pathogenesis of cancer and other diseases is *** encouraging results,the mechanisms underlying diet-based therapeutic strategies remain largely unexplored,often resulting in underutilization in disease *** this review,we aim to illuminate the potential effects of various dietary interventions,including calorie restriction,fasting-mimicking diet,ketogenic diet,protein restriction diet,high-salt diet,high-fat diet,and high-fiber diet,on cancer and the aforementioned *** explore the multifaceted impacts of these dietary interventions,encompassing their immunomodulatory effects,other biological impacts,and underlying molecular *** review offers valuable insights into the potential application of these dietary interventions as adjunctive therapies in disease management.

关键词： diseases metabolism potential

5-Fluorouracil upregulates the activity of Wnt signaling pathway in CD133-positive colon cancer stem-like cells

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Chinese Journal of Cancer 2010年第9期29卷 810-815页

作者： Yan-Hong Deng Xing-Xiang Pu Mei-Jin Huang jian Xiao jia-ming zhou Tong-Yu Lin Edward H. Lin Department of Medical Oncology the Sixth Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510655 P. R. China Department of Medical Oncology Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R China Department of Colorectal Surgery the Sixth Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510655 P. R. China Seattle Cancer Care Alliance Seattle Washington 98115 USA

Background and Objective:CD133-positive colon cancer stem like cells (CSLCs) are resistant to the conventional cytotoxic drug 5-fluorouracil (5-FU).Wnt signaling pathway plays important roles in colon cancer carcinogenesis and metastasis, and regulates the self-renewal capacity of *** the present study, we explored the impact of 5-FU on Wnt signaling pathway of CD133-positive colon CSLCs, and the relation between Wnt signaling pathway and drug resistance of CD133-positive colon ***:Magnetic activation cell separation was used to collect CD133-positive cells from colon cancer cell line DLD1, which was transfected with luciferase reporter for Wnt signaling *** activity of Wnt signaling pathway was compared between CD133-positive and CD133-negative *** the treatment with 1 μg/mL of 5-FU, the cell proliferation rates of DLD1 cells, CD133-positive cells, and CD133-negative cells were *** the treatment with 1 μg/mL and 10 μg/mL of 5-FU for 48 h, Wnt activity was compared between CD133-positive and CD133-negative *** expression of CD133 and cell apoptosis of CD133-positive cells was detected after exposure to 50 ng/mL of dickkopf (DKK)-1, a Wnt pathway ***:After the treatment with 5-FU, the cell proliferation rate of CD133-positive cells was higher than that of CD133-negative cells and the sensitivity of CD133-positive cells to 5-FU *** activity was higher in CD133-positive cells than in CD133-negative cells [(46.3±0.3)% vs.(33.9±2.7)%, P=0.009].After the treatment with 1 μg/mL and 10 μg/mL of 5-FU, Wnt activity of CD133-positive cells was (90.1±10.0)% (P=0.012) and (52.9±2.5)% (P=0.047), respectively, whereas that of CD133-negative cells was (35.5±3.3)% (P=0.434) and (26.5±0.4)% (P=0.046), ***133 expression in CD133-positive cells decreased from (87.2±5.3)% to (60.6±3.1)% (P=0.022) after treatment with DKK-1, whereas the cell apoptosis rate increased from (11.8±0.2)% to (28.3±0.6)% (P=0.0

关键词： Wnt信号通路阳性细胞干细胞氟尿嘧啶活性比结肠癌细胞增殖率肿瘤

Bayesian inference of neutron-skin thickness and neutron-star observables based on effective nuclear interactions

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 97-105页

作者： jia zhou Jun Xu Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China School of Physics Science and Engineering Tongji UniversityShanghai 200092China

We have obtained the constraints on the density dependence of the symmetry energy from neutron-skin thickness data by parityviolating electron scatterings and neutron-star observables using a Bayesian approach,based on the standard Skyrme-HartreeFock(SHF)model and its extension as well as the relativistic mean-field(RMF)*** the neutron-skin thickness data(neutron-star observables)mostly constrain the symmetry energy at subsaturation(suprasaturation)densities,they may more or less constrain the behavior of the symmetry energy at suprasaturation(subsaturation)densities,depending on the energy-density functional *** showing the final posterior density dependence of the symmetry energy,we also compare the slope parameters of the symmetry energy at 0.10 fm-3as well as the values of the symmetry energy at twice saturation density from three effective nuclear *** present work serves as a comparison study based on relativistic and non-relativistic energy-density functionals,for constraining the nuclear symmetry energy from low to high densities using a Bayesian approach.

关键词： symmetry energy neutron skin neutron star

Numerical analysis of the correlation between fluid dynamic modes and hydrodynamic noise in flows around a three-dimensional circular cylinder

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Journal of Hydrodynamics 2024年第1期36卷 119-129页

作者： jia-jia Qin ming-xin Zou Yuan Zhuang De-cheng Wan Computational Marine Hydrodynamics Lab(CMHL) School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Wuhan Second Ship Design and Research Institute Wuhan430205China

The flow around a circular cylinder for Re=1000 is characterized by flow separation and Karman vortex *** typical flow features can be captured to study the correlation between fluid fields and sound *** this paper,the three-dimensional circular cylinder is taken as the research object,and the probes of surface fluctuating pressure and far field sound pressure are arranged every 10°.The directional diagram and the coherence of fluctuating pressure and sound pressure are *** relationship between the flow mode and hydrodynamic noise is studied by using dynamic mode decomposition(DMD).The characteristics of the dipole and quadrupole sound source term of a long span cylinder are *** results show that at the angles between 30°–120°and 190°–350°,the fluctuating pressure contributes more to the generation of dipole *** quadrupole sound source shows three-dimensional effects,which is more obvious in a cylinder with large spanwise length.

关键词： Pressure coherence dynamic mode decomposition flow-sound correlation circular cylinder

Three-dimensional visualization of the functional fascicular groups of a long-segment peripheral nerve

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Neural Regeneration Research 2018年第8期13卷 1465-1470页

作者： jian Qi Wei-Ya Wang Ying-Chun Zhong jia-ming zhou Peng Luo Ping Tang Cai-Feng He Shuang Zhu Xiao-Lin Liu Yi Zhang Department of Orthopedics and Microsurgery First Affiliated Hospital of Sun Yat-sen University Department of Plastic Surgery Nanxishan Hospital of Guangxi Zhuang Autonomous Region Automation College Guangdong University of Technology Scientific Research Department Sixth Affiliated Hospital of Sun Yat-sen University Department of Orthopedics Shenzhen Nanshan People's Hospital Zhongshan University Medical Equipment Co. Ltd. Department of Joint and Orthopedics Orthopedic Center Zhujiang Hospital of Southern Medical University Department of Plastic Surgery First Affiliated Hospital of Sun Yat-sen University

The three-dimensional（3D） visualization of the functional bundles in the peripheral nerve provides direct and detailed intraneural spatial information. It is useful for selecting suitable surgical methods to repair nerve defects and in optimizing the construction of tissue-engineered nerve grafts. However, there remain major technical hurdles in obtaining, registering and interpreting 2D images, as well as in establishing 3D models. Moreover, the 3D models are plagued by poor accuracy and lack of detail and cannot completely reflect the stereoscopic microstructure inside the nerve. To explore and help resolve these key technical problems of 3D reconstruction, in the present study, we designed a novel method based on re-imaging techniques and computer image layer processing technology. A 20-cm ulnar nerve segment from the upper arm of a fresh adult cadaver was used for acetylcholinesterase（ACh E） staining. Then, 2D panoramic images were obtained before and after ACh E staining under the stereomicroscope. Using layer processing techniques in Photoshop, a space transformation method was used to fulfill automatic registration. The contours were outlined, and the 3D rendering of functional fascicular groups in the long-segment ulnar nerve was performed with Amira 4.1 software. The re-imaging technique based on layer processing in Photoshop produced an image that was detailed and accurate. The merging of images was accurate, and the whole procedure was simple and fast. The least square support vector machine was accurate, with an error rate of only 8.25%. The 3D reconstruction directly revealed changes in the fusion of different nerve functional fascicular groups. In conclusion. The technique is fast with satisfactory visual reconstruction.

关键词： nerve regeneration peripheral nerve ulnar nerve three-dimensional reconstruction functional fascicular group registration segmentation locating spots auto-registration acetylcholinesterase neural regeneration

Interplay between Microscopic Structures and Macroscopic Viscoelastic Properties of Polyampholyte Gels

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Chinese Journal of Polymer Science 2024年第9期42卷 1360-1367,I0008页

作者： You-Cai Xue Yi-ming Yang Di jia Beijing National Laboratory for Molecular Sciences Laboratory of Polymer Physics and ChemistryInstitute of ChemistryChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China

Polyampholyte gels,which have hierarchical structures,exhibit excellent self-healing properties and have great promise for biomaterials and *** investigated the relationship between microscopic structures and macroscopic viscoelastic properties of polyampholyte gels and found three factors influencing their viscoelastic properties,including the chemical crosslinking bonds,topological entanglements controlled by monomer concentration,and the ionic *** strength plays a major role on the strength of ionic bonds.A crossover point of elastic modulus and loss modulus was observed in the dynamic frequency sweeps at low monomer concentration or low chemical crosslinking density for gels with intermediate strength of ionic *** solid-liquid transition signaled by the crossover point is a typical feature of dynamic associated gels,representing the dynamical association-dissociation of the ionic bonds and full relaxation of the topological entanglements in the gel *** the crossover point disappears when the ionic bonds are too weak or too strong to form“permanent”***,in the non-linear yielding measurement,gels with intermediate strength of the ionic bonds are ductile and yield at very large shear strain due to the self-healing properties and the dynamic association-dissociation of the ionic *** the self-healing properties disappear when the ionic bond strength is too weak or too *** work reveals the mechanism of how the dynamic association-dissociation of ionic bonds influences both the linear and non-linear viscoelastic properties of the polyampholyte gels.

关键词： Polyampholyte gel Ionic bond Topological entanglement Self-healing Hierarchical structure