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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka Lu Ju-song Yang Fu-Min Zhang Ai-jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi jiali song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

Accuracy and Consistency of the Explicit-Invariant Energy Quadratization Approach for the Cahn-Hilliard Equation

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Journal of Mathematical Research with Applications 2025年第1期 84-104页

作者： jun ZHANG Fangying song Yu ZHANG Computational Mathematics Research Center Guizhou University of Finance and Economics School of mathematics and statistics Guizhou University of Finance and Economics School of Mathematics and Stastistics Fuzhou University

It is well known that the explicit-invariant energy quadratization (EIEQ) approach can generate fully decoupled, linear and unconditionally energy-stable numerical schemes, so it is favored by many researchers. However, the undeniable fact is that the numerical method obtained by EIEQ approach preserves the “modified” energy law instead of the original *** is mainly due to the introduction of some auxiliary variables in EIEQ scheme, and the truncation error will make the auxiliary variables deviate from the original definition in the process of numerical calculation. The primary objective of this paper is to address this gap by providing the accuracy and consistency of the EIEQ method in the context of the CahnHilliard equation. We introduce a relaxation technique for auxiliary variables and construct two numerical schemes based on EIEQ. The analysis results show that the newly constructed schemes are not only unconditionally energy stable, linear and fully decoupled, but also can effectively correct the errors introduced by auxiliary variables and follow the original energy ***, several 2D and 3D numerical examples illustrate the accuracy and efficiency of the newly constructed numerical schemes.

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A Method of Non-textured Regions Matching

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Chinese Journal of Electronics 2019年第3期28卷 598-603页

作者： jia Di ZHAO Mingyuan CAO jun song Weidong School of Electronic and Information Engineering Liaoning Technical University School of Computing Informatics Decision System Engineering Arizona State University School of Geomatics Liaoning Technical University

It is difficult for existing dense or quasidense matching algorithms to obtain accurate matching results due to the lack of effective feature information in non-textured regions. This may affect the quality of subsequent 3 D reconstruction and super-resolution reconstruction. We propose a method of non-textured regions matching. To reduce the impact of noise and illumination, vector sampling normalized cross correlation is proposed to directly measure coherence between two colour images by the effective information of multi-channel features. Three mathematical properties are used in affine transformation: 1) Centroid location is not affected by affine transformation; 2) Affine transformation transforms a straight line into another straight line; 3) Affine transformation maintains the linear relation invariant. In non-textured regions, we can construct texture regions which have affine invariant properties to improve the accuracy of template matching. This could provide more information for the diffusion of dense or quasi-dense matching. In experiments, we demonstrate that the method has high accuracy in cases where there is no big distortion between the two viewing angles from two aspects of simulated images and photographic images.

关键词： Stereo matching Dense matching Nontextured region Affine transformation

108例老年人晚期非小细胞肺癌三维适形放射治疗的疗效分析

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中华老年医学杂志 2007年第10期26卷 762-764页

作者：侯友贤石卫民李工贾峻嵩李志强陈海扬麟伍军锋广州军区总医院放射肿瘤中心广州市510010

目的分析三维适形放射治疗（3D-CRT）在老年人非小细胞肺癌（NSCLC）的临床应用效果和放射损伤情况。方法接受3D-CRT的108例老年人晚期NSCLC中,男性102例,女性6例,中位年龄72岁。适形放疗单次剂量5～8Gy,隔日1次,总剂量68～82Gy。结果10... 详细信息

目的分析三维适形放射治疗（3D-CRT）在老年人非小细胞肺癌（NSCLC）的临床应用效果和放射损伤情况。方法接受3D-CRT的108例老年人晚期NSCLC中,男性102例,女性6例,中位年龄72岁。适形放疗单次剂量5～8Gy,隔日1次,总剂量68～82Gy。结果108例全部完成了放射治疗计划,完全缓解21例（19.4%）,部分缓解73例（67.6%）,无变化12例（11.1%）,恶化2例（1.9%）,总有效率87.0%。1、2、3年总生存率分别为65%、33%、28%。急性放射性肺炎2级8例,3级2例;晚期放射性肺炎2级11例,3级5例。结论采用3D-CRT技术治疗老年人晚期NSCLC有比较好的近期疗效,无严重的不良反应,有助于提高肿瘤的局部控制率,改善患者生存质量,减少并发症。

关键词：癌,非小细胞肺放射疗法,适形辐射性肺炎

Effect of order–disorder transition on thermodynamic and electronic properties of σ and χ phases in W–Re alloy: the first-principles calculation

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Tungsten 2025年第1期 195-213页

作者： Zhi-Peng Zhu Dian jia William Yi Wang jun-Lei Yin Xing-Yu Gao Shu-Feng Yang Hai-Feng song Jin-Shan Li State Key Laboratory of Solidification Processing Northwestern Polytechnical University Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

The Tungsten-Rhenium(W-Re) alloys,celebrated for their high melting point,strength at elevated temperatures,electrical resistivity,and radiation resistance,have been widely utilized in high-temperature components,aerospace,electronics,and nuclear *** constituents of the topologically close-packed(TCP) phases,the sigma phase(σ) and chi phase(χ) formed within W-Re alloys wield considerable influence on the mechanical properties and the stability of the *** calculations were utilized in the present work to explore the structural,thermodynamic,and electronic properties of both ordered and disordered configurations within the σ and χ phases,culminating in a systematic elucidation of the higher phase stability exhibited by the ordered *** is found that the bulk modulus of these two phases is directly proportional to the concentration of Re in the alloy,while the equilibrium volume is inversely *** thermodynamic parameters of the σ and χ phases are calculated via the mean-field potential *** similar trends observed in the isobaric heat capacity,enthalpy increment,and entropy change curves for these two phases suggest they possess comparable thermodynamic *** is noteworthy that the contribution of ionic vibrations predominantly affects the isobaric heat capacity,while the contribution of thermal electronic excitations increases linearly with *** the structure and thermodynamic properties of TCP phases in W-Re alloys at low temperatures has profound significance for optimizing material performance,microstructures features,establishing theoretical foundations,and predicting material behavior.

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The Spin Measurement of MAXI J0637-430:a Black Hole Candidate with High Disk Density

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Research in Astronomy and Astrophysics 2023年第7期23卷 277-287页

作者： Nan jia Ye Feng Yu-jia song jun Yang Jieun Yuh Pei-jun Huang Li-jun Gou Key Laboratory for Computational Astrophysics National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China Shanghai American School Puxi Campus Shanghai 201107China Shenzhen Yaohua Experimental School Shenzhen 518034China

The Galactic black hole candidate MAXI J0637-430 was first discovered by MAXI/GSC on 2019 November *** study the spectral properties of MAXI J0637-430 by using the archived NuSTAR data and Swift/XRT *** fitting the eight spectra by using a disk component and a powerlaw component model with absorption,we select the spectra with relatively strong reflection components for detailed X-ray reflection *** the most state-of-art reflection model,relxillCp,the spectral fitting measures a black hole spin a_(*)>0.72 and the inclination angle of the accretion disk i=46.1_(-5.3)^(+4.0)degrees,at a 90%confidence *** addition,the fitting results show an extreme supersolar iron *** with the fitting results of reflection model reflionx_hd,we consider that this unphysical iron abundance may be caused by a very high-density accretion disk(n_(e)>2.34×10^(21)cm^(-3))or a strong Fe K_(α) emission *** soft excess is found in the soft state spectral fitting results,which may be an extra free-free heating effect caused by high density of the accretion ***,we discuss the robustness of black hole spin obtained by X-ray reflection *** result of relatively high spin is self-consistent with broadened Fe K_(α) *** abundance and disk density have no effect on the spin results.

关键词： black hole physics X-rays:binaries accretion accretion disks

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给水管网现状分析中存在的问题及其解决方法

江西科学 2005年第6期23卷 807-810页

作者：贾俊松詹健马永生杨谱南昌大学建筑工程学院江西南昌330029 南昌大学计算中心江西南昌330029 南昌大学理学院江西南昌330047

给水管网现状分析是供水行业的一项重要课题,该文总结了人们对其研究的一些经验和成果,尤其遗传算法的应用,指出了其中的不足,指明了今后解决这些问题应努力的方向。

关键词：给水管网现状分析遗传算法问题

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Information Processing in Agriculture 2023年第2期10卷 149-163页

作者： Yang Zhang jun Yue Aihuan song Shixiang jia Zhenbo Li School of Information and Electrical Engineering Ludong UniversityYantai 264025PR China Marine Biology Institute of Shandong Province Qingdao 266104PR China School of Information and Electrical Engineering China Agricultural UniversityBeijing 100193PR China

The high similarity of shellfish images and unbalanced samples are key factors affecting the accuracy of shellfish *** study proposes a new shellfish recognition method FL_Net based on a Convolutional Neural Network(CNN).We first establish the shellfish image(SI)dataset with 68 species and 93574 images,and then propose a filter pruning and repairing model driven by an output entropy and orthogonality measurement for the recognition of shellfish with high similarity features to improve the feature expression ability of valid *** the shellfish recognition with unbalanced samples,a hybrid loss function,including regularization term and focus loss term,is employed to reduce the weight of easily classified samples by controlling the shared weight of each sample species to the total *** experimental results show that the accuracy of shell-fish recognition of the proposed method is 93.95%,13.68%higher than the benchmark network(VGG16),and the accuracy of shellfish recognition is improved by 0.46%,17.41%,17.36%,4.46%,1.67%,and 1.03%respectively compared with AlexNet,GoogLeNet,ResNet50,SN_Net,MutualNet,and ResNeSt,which are used to verify the efficiency of the proposed method.

关键词： Shellfish recognition High similarity Unbalanced samples Convolutional Neural Network Filter pruning and repairing Hybrid loss function