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Clinical indices and mortality of hospitalized avian influenza A (H7N9) patients in Guangdong, China

Chinese Medical Journal 2019年第3期132卷 302-310页

作者： Yang Yang Xue Li Guthrie S.Birkhead Zhe Zheng jia-hai lu Department of Medical Statistics and Epidemiology School of Public HealthSun Yat-sen UniversityGuangzhouGuangdong 510080China Department of Epidemiology and Biostatistics School of Public HealthUniversity at AlbanyNY 12222USA Key Laboratory of Tropical Disease Control Sun Yat-sen UniversityMinistry of EducationGuangzhouGuangdong 510080China One Health Center of Excellence for Research &Training Sun Yat-sen UniversityGuangzhouGuangdong 510080China

Background:Six epidemic waves of human infection with avian influenza A (H7N9) virus have emerged in China with high mortality. However, study on quantitative relationship between clinical indices in ill persons and H7N9 outcome (fatal and nonfatal) is still unclear. A retrospective cohort study was conducted to collect laboratory-confirmed cases with H7N9 viral infection from 2013 to 2015 in 23 hospitals across 13 cities in Guangdong Province, ***:Multivariable logistic regression model and classification tree model analyses were used to detect the threshold of selected clinical indices and risk factors for H7N9 death. The receiver operating characteristic curve (ROC) and analyses were used to compare survival and death distributions and differences between indices. A total of 143 cases with 90 survivors and 53 deaths were ***:Average age (Odds Ratio (OR)=1.036, 95% Confidence Interval (CI)=1.016-1.057), interval days between dates of onset and confirmation (OR=1.078, 95% CI=1.004-1.157), interval days between onset and oseltamivir treatment (OR=5.923, 95% CI=1.877-18.687), body temperature (BT) (OR=3.612, 95% CI=1.914-6.815), white blood cell count (WBC) (OR=1.212, 95% CI=1.092-1.346) were significantly associated with H7N9 death after adjusting for confounders. The chance of death from H7N9 infection was 80.0% if BT was over 38.1 °C, and chance of death is 67.4% if WBC count was higher than 9.5 (109/L). Only 27.1% of patients who began oseltamivir treatment less than 9.5 days after disease onset died, compared to 68.8% of those who started treatment more than 15.5 days after ***:The intervals between date of onset and confirmation of diagnosis, between date of onset to oseltamivir treatment, age, BT and WBC are found to be the best predictors of H7N9 mortality.

关键词： Clinical markers Hospitalization Influenza A virus H7N9 subtype

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奥尼尔《奇异的插曲》与《悲悼》中的女性观

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山东大学学报（哲学社会科学版） 2009年第2期 147-152页

作者：甲鲁海山东大学外国语学院

在《奇异的插曲》与《悲悼》中,尤金.奥尼尔通过一系列女性形象表达了对充满母性情怀和奉献精神的女性的赞赏,同时就两性关系表达了自己的看法。他不满父权社会男性对女性的控制和压迫,但并不主张女性为反抗压迫而凌驾于男性之上,他所... 详细信息

在《奇异的插曲》与《悲悼》中,尤金.奥尼尔通过一系列女性形象表达了对充满母性情怀和奉献精神的女性的赞赏,同时就两性关系表达了自己的看法。他不满父权社会男性对女性的控制和压迫,但并不主张女性为反抗压迫而凌驾于男性之上,他所期望和欣赏的是和谐的两性关系。奥尼尔虽受父权社会集体无意识的影响,以传统的妇女观来评价女性,但他关注女性的内心世界,揭示了女性的生存现状,对女性的不幸境遇充满同情和理解,因此仍属难能可贵。

关键词：奥尼尔《奇异的插曲》《悲悼》母性奉献两性冲突

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Risk assessment and genomic characterization of Zika virus in China and its surrounding areas

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Chinese Medical Journal 2019年第14期132卷 1645-1653页

作者： Rong-Fei Liu Zhen-jian He Peng Mei jia-Cheng Xi Xu-Dong Cao Li-Hong Yuan jia-hai lu School of Public Health Sun Yat-sen UniversityGuangzhouGuangdong 510080China Key Laboratory of Tropical Disease Control(Sun Yat-sen University) Ministry of EducationGuangzhouGuangdong 510080China Department of Chemical and Biological Engineering University of OttawaOttawaOntarioCanada School of Life Sciences and Biopharmaceutics Guangdong Pharmaceutical UniversityGuangzhouGuangdong 510006China One Health Center of Excellence for Research & Training Sun Yat-sen UniversityGuangzhouGuangdong 510080China

Background:Zika virus (ZIKV) has emerged as a global pathogen causing significant public health *** has reported several imported cases where ZIKV were carried by travelers who frequently travel between China and ZIKV-endemic *** fully characterize the ZIKV strains isolated from the cases reported in China and assess the risk of ZIKV transmission in China,comprehensive phylogenetic and genetic analyses were performed both on all ZIKV sequences of China and on a group of scientifically selected ZIKV sequences reported in some of the top interested destinations for Chinese ***:ZIKV genomic sequences were retrieved from the National Center for Biotechnology Information database through stratified *** event detection,maximum likelihood (ML) phylogenetic analysis,molecular clock analysis,selection pressure analysis,and amino acid substitution analysis were used to reconstruct the epidemiology and molecular transmission of ***:The present study investigated 18 ZIKV sequences from China and 70 sequences from 16 selected *** events rarely happens in all ZIKV Asian *** genomes were generally undergone episodic positive selection (17 sites),and only one site was under pervasive positive *** ZIKV imported into China were Asian lineage and were assigned into two clusters:Venezuela-origin (cluster A) and Samoa-origin cluster (cluster B) with common ancestor from French *** time of most recent common ancestors of Cluster A dated to approximately 2013/11 (95% highest posterior density [HPD] 2013/06,2014/ 03) and cluster B dated to 2014/08 (95% HPD 2014/02,2015/01).Cluster B is more variable than Cluster A in comparison with other clusters,but no varied site of biological significance was *** strains in Southeast Asia countries are independent from strains in America ***:The genetic evolution of ZIKV is *** are two independent intro

关键词： Zika virus China Phylogeny Genetic evolution Risk assessment

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Distribution of the COVID-19 epidemic and correlation with population emigration from Wuhan,China

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Chinese Medical Journal 2020年第9期133卷 1044-1050页

作者： Ze-Liang Chen Qi Zhang Yi lu Zhong-Min Guo Xi Zhang Wen-Jun Zhang Cheng Guo Cong-Hui Liao Qian-Lin Li Xiao-Hu Han jia-hai lu One Health Center School of Public HealthSun Yat-sen UniversityGuangzhouGuangdong 510080China Key Laboratory of Livestock Infectious Diseases in Northeast China Ministry of EducationShenyang Agricultural UniversityShenyangLiaoning 110866China College of Animal Science and Veterinary Medicine Shenyang Agricultural UniversityShenyangLiaoning 110866China Department of Health Law Policy and ManagementSchool of Public HealthBoston UniversityBostonMA 02215USA Animal Experiment Center Sun Yat-sen UniversityGuangzhouGuangdong 510080China Department of Biological Science and Technology School of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510080China Center for Infection and Immunity Mailman School of Public HealthColumbia UniversityNew YorkNY 10032USA

Background:The ongoing new coronavirus pneumonia(Corona Virus Disease 2019,COVID-19)outbreak is spreading in China,but it has not yet reached its *** million people emigrated from Wuhan before lockdown,potentially representing a source of virus *** case distribution and its correlation with population emigration from Wuhan in the early stage of the epidemic is of great importance for early warning and for the prevention of future ***:The official case report on the COVID-19 epidemic was collected as of January 30,*** and location information on COVID-19 cases was extracted and analyzed using ArcGIS and WinBUGS *** on population migration from Wuhan city and Hubei province were extracted from Baidu Qianxi,and their correlation with the number of cases was ***:The COVID-19 confirmed and death cases in Hubei province accounted for 59.91%(5806/9692)and 95.77%(204/213)of the total cases in China,*** spot provinces included Sichuan and Yunnan,which are adjacent to *** time risk of Hubei province on the following day was 1.960 times that on the previous *** number of cases in some cities was relatively low,but the time risk appeared to be continuously *** correlation coefficient between the provincial number of cases and emigration from Wuhan was up to *** lockdown of 17 cities in Hubei province and the implementation of nationwide control measures efficiently prevented an exponential growth in the number of ***:The population that emigrated from Wuhan was the main infection source in other cities and *** cities with a low number of cases showed a rapid increase in case *** to the upcoming Spring Festival return wave,understanding the risk trends in different regions is crucial to ensure preparedness at both the individual and organization levels and to prevent new outbreaks.

关键词： Corona Virus Disease 2019 Temporal Spatial Distribution Outbreak

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Immune Responses and Histopathological Changes in Rabbits Immunized with Inactivated SARS Coronavirus

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中国病毒学 2007年第5期22卷 360-365页

作者： Chuan-hai ZHANG Xin-jian LIU Yi-fei WANG jia-hai lu Huan-ying ZHENG Sheng XIONG Mei-ying ZHANG Qiu-ying LIU Biomedicine Research ＆ Development Center Jinan University Guangzhou 510630 China Department of Chemistry and Biology West Anhui University Lu-an 237012 China The First People＇s Hospital Shanghai jiaotong University Shanghai 200080 China School of Public Health Sun Yat-sen University Guangzhou 510080 China Center for Diseases Control and Prevention of Guangdong Province Guangzhou 510300 China

To evaluate the immunogenicity of inactivated SARS coronavirus(SARS-CoV),three groups of rabbits were immunized three times at 2-week intervals with inactivated vaccine + adjuvant,adjuvant,and normal saline *** batchs of serum were sampled from the auricular vein at day 7 to day 51,and specific IgG antibody titers and neutralizing antibody titers were detected by indirect ELISA and micro-cytopathic effect neutralizing *** specificity was identified by proteinchip *** changes were detected by H&E *** results showed that,rabbits in the experimental group immunized with inactivated SARS-CoV all generated specific IgG antibodies with neutralizing activity,which suggested the inactivated SARS-CoV could preserve its antigenicity well and elicit an effective humoral immune *** peak titer value of specific IgG antibody and neutralizing antibody reached 1:40960 and 1:2560 *** the experimental group,no obvious histopathological changes was detected in the H&E stained slides of heart,spleen,kidney and testis samples,but the livers had slight histopathological changes,and the lungs presented remarkable histopathological *** findings are of importance for SARS-CoV inactivated vaccine development.

关键词：免疫反应组织病理学兔急性呼吸综合症冠状病毒 SARS 疫苗

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From severe acute respiratory syndrome-associated coronavirus to 2019 novel coronavirus outbreak:similarities in the early epidemics and prediction of future trends

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Chinese Medical Journal 2020年第9期133卷 1112-1114页

作者： Ze-Liang Chen Wen-Jun Zhang Yi lu Cheng Guo Zhong-Min Guo Cong-Hui Liao Xi Zhang Yi Zhang Xiao-Hu Han Qian-Lin Li jia-hai lu One Health Center School of Public HealthSun Yat-sen UniversityGuangzhouGuangdong 510080China Key Laboratory of Livestock Infectious Diseases in Northeast China Ministry of EducationShenyang Agricultural UniversityShenyangLiaoning 110866China Department of Biological Science and Technology School of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510080China Department of Health Law Policy and ManagementSchool of Public HealthBoston UniversityBostonMA 02215USA Center for Infection and Immunity Mailman School of Public HealthColumbia UniversityNew YorkNY 10032USA Animal Experiment Center Sun Yat-sen UniversityGuangzhouGuangdong 510080China

Emerging infectious diseases represent a serious threat for human public health worldwide.[1,2]The 2019 novel coronavirus(2019-nCoV)caused a pneumonia outbreak,which is spreading around the country and has affected 32 provinces and regions of China as of January 27,2020.[3,4]Countries outside China,including Japan,the United States,Thailand,and South Korea,have also reported cases imported from other countries.[5]With the joint efforts of Chinese scientists,health workers,and related departments,the pathogen causing this epidemic was quickly identified as a new type of coronavirus,10 days after the first official *** confirming the pathogen,specific detection methods were rapidly developed,with improvement in etiological *** of January 22,2020,it has been confirmed that the new coronavirus came from wild bats and belonged to group 2b of the beta coronavirus,which includes severe acute respiratory syndrome-associated coronavirus(SARS-CoV).[6]Although 2019-nCoV and SARS-CoV belong to the same sub-group of beta coronaviruses,the similarity at the genome level is only 80%,[7,8]meaning that the new virus is genetically different from SARS-CoV[Supplementary Figure 1A,http://***/CM9/A209].Rapid discovery of the causative agent and development of diagnostic reagents demonstrated that technology has greatly improved in the 17 years since the SARS ***,no effective anti-viral medication or vaccines are available for this new virus,and many of its aspects remain to be *** to the SARS outbreak,this outbreak also occurred during the spring festival,the most important of the Chinese traditional festivals,when 3 billion people travel throughout the country.[9]This unexpectedly provides beneficial conditions for the transmission of this highly infectious disease and correspondingly poses great challenges for the prevention and control of the outbreak.

关键词： prevention prediction Figure

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Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： jia Zhao Taixi Feng Guimin lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

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Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

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Nano-Micro Letters 2025年第3期17卷 389-439页

作者： Xiao Wang jia Zeng Donglin Gan Kun Ling Mingfang He jianshu Li Yongping lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

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China's great wall, Israel's Bar Lev Line, and passive infectious disease surveillance

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Journal of Medical Colleges of PLA(China) 2014年第2期29卷 77-79页

作者： Maha A Elbadry Mary M Merrill Meng-Meng Ma Mai-Juan Ma jia-hai lu Wu-Chun Cao Gregory C Gray One Health Center of Excellence for Research and Training College of Public Health and Health Professions University of Florida P.O. Box 100188Gainesville FL 32610 USA School of Public Health Key Laboratory of Tropical Disease Control Research Ministry of Education Sun Yat-sen University State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology

Emerging infectious diseases are some of modern society's greatest threats. Like some great construction efforts designed to protect mankind, current public health measures against these emerging pathogens have not always been successful. This paper highlights the importance of embracing new interdisciplinary approaches towards emerging pathogen threats. One such approach, termed One Health, is quickly being embraced by professional organizations and public health institutions across the world as a way forward. This paper briefly discusses the above problems and preliminary steps taken by Chinese academic institutions to embrace the One Health approach.

关键词： zoonoses communicable diseases emerging epidemiology public health one health

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分散网络化制造模式下协调调度的遗传算法

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同济大学学报（自然科学版） 2001年第8期29卷 926-939页

作者：王家海卢洪波张曙同济大学机械工程系上海200092

讨论了在生产实际问题中利用遗传算法实现具有各制造单元间协调功能的生产计划与调度系统 .为了把遗传算法应用到生产实际的协调调度的环境中 ,提出了自已的编码方式 ,在此基础上实现了针对调度问题的遗传算法 .并通过Agent实现异地调... 详细信息

讨论了在生产实际问题中利用遗传算法实现具有各制造单元间协调功能的生产计划与调度系统 .为了把遗传算法应用到生产实际的协调调度的环境中 ,提出了自已的编码方式 ,在此基础上实现了针对调度问题的遗传算法 .并通过Agent实现异地调度系统之间的协调通信 .这一调度系统适合于分布式、自治的控制场合。

关键词：分散网络化制度网络联盟生产控制遗传算法协调调度

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