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Chinese Chemical Letters 2017年第5期28卷 935-942页

作者： Yong Zhang jia-yi zhu Hong-Bo Ren Yu-Tie Bi Lin Zhang Department of Physics University of Sdence and Technology of ChinaHefei 230026China Joint Laboratory for Extreme Conditions Matter Properties Southwest University of Science and Technology and Research Center of Laser FusionMianyang621010China Science and Technology on Plasma Physics Laboratory Research Center of Laser FusionChina Academy of Engineering PhysicsMianyang 621900China

Three-dimensional porous nitrogen-doped graphene aerogels（NGAs） were synthesized by using graphene oxide（GO） and chitosan via a self-assembly process by a rapid *** morphology and structure of the as-prepared aerogels were *** results showed that NGAs possesed the hierarchical pores with the wide size distribution ranging from mesopores to *** NGAs carbonized at different temperature all showed excellent electrochemical performance in 6 mol/L KOH electrolyte and the electrochemical performance of the NGA-900 was the *** working as a supercapacitor electrode,NGA-900 exhibited a high specific capacitance（244.4 F/g at a current density of 0.2 A/g）,superior rate capability（51.0% capacity retention） and excellent cycling life（96.2% capacitance retained after 5000 cycles）.

关键词： Nitrogen-doped graphene aerogels Hierarchical porous structure Carbonizing temperature Supercapacitors Energy storage and conversion

A Panel of Genes Identified as Targets for 8q24.13-24.3 Gain Contributing to Unfavorable Overall Survival in Patients with Hepatocellular Carcinoma

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Current Medical Science 2018年第4期38卷 590-596页

作者： Kun ZHAO Yu ZHAO jia-yi zhu Hui DONG Wen-ming CONG yi YU Hui WANG Zhong-Zheng zhu Qing XU Department of Oncology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai 200072 China Shanghai Clinical College of Anhui Medical University Shanghai 200072 China Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Pathology Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China

Copy number aberrations （CNAs） in chromosome arm 8q have been associated with unfavorable clinical outcomes of several cancers and progressive tumor characteristics of hepatocellular carcinoma （HCC）. This study was to identify correlation of CNAs in 8q with clinical outcomes of HCC patients, and further screen for differentially expressed genes in outcome-related CNAs. Array comparative genomic hybridization and expression arrays were performed to detect CNAs and expression levels, respectively. The correlations between CNAs in 8q and outcomes were analyzed in 66 patients, with a median follow-up time of 45.0 months （range, 2.6-108.6 months）. One hundred and nine cases were further evaluated to identify differentially expressed genes in the potential outcome-related CNAs. Copy number gain in 8q was observed in 22 （33.3%） of the 66 HCC cases. The most recurrent gains （with frequencies 〉20%） were 8q 13.3-21.3, 8q21.3-23.3, 8q23.3-24.13, 8q24.13-24.3, and 8q24.3. Survival analysis showed that 8q24.13-24.3 gain was significantly associated with reduced overall survival （P=0.010）. Multivariate Cox analysis identified 8q24.13- 24.3 gain as an independent prognostic factor for poor overall survival （HR=2.47; 95% CI=1.16-5.26; P=0.019）. A panel of 17 genes within the 8q24.13-24.3 region, including ATAD2, SQLE, PVT1, ASAP1, and NDRG1 were significantly upregulated in HCCs with 8q24.13-24.3 gain compared to those without. These results suggest that copy number gain at 8q24.13-24.3 is an unfavorable prognostic marker for HCC patients, and the potential oncogenes ATAD2, SQLE, PVT1, ASAP1, and NDRG1 within the regional gain, may contribute coordinately to the 8q24.13-24.3 gain-related poor prognosis.

关键词： chromosome 8 copy number aberration hepatocellular carcinoma prognosis gene expression

Copy Number Aberrations of Multiple Genes Identified as Prognostic Markers for Extrahepatic Metastasis-free Survival of Patients with Hepatocellular Carcinoma

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Current Medical Science 2019年第5期39卷 759-765页

作者： Zhong-zheng zhu Ling-ling BAO Kun ZHAO Qing XU jia-yi zhu Ke-xuan zhu Bing-ji WEN ying-quan YE Xiao-xi WAN Liang-liang WANG Song-qin HE Wen-ming CONG Department of Oncology Shanghai Tenth People fs HospitalTongji University School of MedicineShanghai 200072China Department of Oncology No.113 Hospital of People's Liberation ArmyAnhui Medical UniversityNingbo 315040China Department of Education The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030China Department of Burns and Plastic Surgery General Hospital of Liaoning Provincial Armed Police Force of PLAShenyang 110034China Department of Pathology Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China

Extrahepatic metastasis confers unfavorable patient prognosis in patients with hepatocellular carcinoma(HCC),however,reliable markers allowing prediction of extrahepatic metastasis at the time of initial diagnosis are still *** study was to identify gene-level copy number aberrations(CNAs)related to extrahepatic metastasis-free survival of HCC patients,and further examine the associations between CNAs and gene *** comparative genomic hybridization(aCGH)and expression array were used to analyze gene CNAs and expression levels,*** associations between CNAs of a panel of 20 genes and extrahepatic metastasis-free survival were analyzed in 66 patients with follow-up period of 1.6-90.5 *** gene expression levels between HCCs with and without gene CNA were compared in 109 patients with *** observed that gains at MDM4 and BCL2L1,and losses at APC and FBXW7 were independent prognostic markers for extrahepatic metastasis-free survival of HCC *** analysis of aCGH and expression data showed that MDM4 and BCL2L1 were significantly upregulated in HCCs with gene gain,while APC and FBXW7 were significantly downregulated in HCCs with gene *** concluded that gene gains at MDM4 and BCL2L1,and losses at APC and FBXW7,with concordant expression changes,were associated with extrahepatic metastasis-free survival of HCC patients and have potential to act as novel prognostic markers.

关键词： hepatocellular carcinoma extrahepatic metastasis-free survival gene copy number aberration expression

Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway

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World Journal of Gastroenterology 2024年第20期30卷 2709-2725页

作者： Kai-Di Chen Kui-Ling Wang Chen Chen yi-jia zhu Wen-Wen Tang Yu-Ji Wang Ze-Peng Chen Lin-Hai He Yu-Gen Chen Wei Zhang jiangsu Province Hospital of Chinese Medicine The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina The No.1 Clinical Medical College Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Colorectal Surgery Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina jiangsu Province Key Laboratory of Tumor Systems Biology and Chinese Medicine The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina jiangsu Collaborative Innovation Center of Chinese Medicine in Prevention and Treatment of Tumor The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina

BACKGROUND Constipation,a highly prevalent functional gastrointestinal disorder,induces a significant burden on the quality of patients'life and is associated with substantial healthcare ***,identifying efficient therapeutic modalities for constipation is of paramount *** stress is a pivotal contributor to colonic dysmotility and is the underlying pathology responsible for constipation ***,we postulate that hydrogen therapy,an emerging and promising intervention,can serve as a safe and efficacious treatment for *** To determine whether hydrogen-rich water(HRW)alleviates constipation and its potential *** Constipation models were established by orally loperamide to Sprague-Dawley *** freely consumed HRW,and were recorded their 24 h total stool weight,fecal water content,and charcoal propulsion *** samples were subjected to 16S rDNA gene *** non-targeted metabolomic analysis,malondialdehyde,and superoxide dismutase levels were *** tissues were stained with hematoxylin and eosin,Alcian blue-periodic acid-Schiff,reactive oxygen species(ROS)immunofluorescence,and immunohistochemistry for cell growth factor receptor kit(c-kit),PGP 9.5,sirtuin1(SIRT1),nuclear factor-erythroid-2-related factor 2(Nrf2),and heme oxygenase-1(HO-1).Quantitative real-time PCR and western blot analysis were conducted to determine the expression level of SIRT1,Nrf2 and HO-1.A rescue experiment was conducted by intraperitoneally injecting the SIRT1 inhibitor,EX527,into constipated ***460 cells were induced with H2O2 and treated with the metabolites to evaluate ROS and SIRT1 *** HRW alleviated constipation symptoms by improving the total amount of stool over 24 h,fecal water content,charcoal propulsion rate,thickness of the intestinal mucus layer,c-kit expression,and the number of intestinal *** modulated intestinal microbiota imbalance and abnormaliti

关键词： Hydrogen-rich water Constipation Sirtuin1 Oxidative stress Gut microbiota Serum metabolites

利用相干制备的三能级原子介质实现低噪声弱光相位操控

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物理学报 2017年第2期66卷 159-167页

作者：关佳顾翊晟朱成杰羊亚平同济大学物理科学与工程学院上海200092

我们发现利用相干制备的三能级原子介质可实现低噪声弱光相位操控.基于两波混频效应,相干制备的原子系统在弱光相位操控方面有许多新特性,例如宽频范围内无损常数相位的实现以及无附加相位的吸收与放大等.通过同时锁定抽运光的光强和双... 详细信息

我们发现利用相干制备的三能级原子介质可实现低噪声弱光相位操控.基于两波混频效应,相干制备的原子系统在弱光相位操控方面有许多新特性,例如宽频范围内无损常数相位的实现以及无附加相位的吸收与放大等.通过同时锁定抽运光的光强和双光子失谐,我们发现探测光的吸收为零,且探测光的相位对于频率的变化十分缓慢,因而可以通过选择适当的系统参数在很宽的频率范围内实现无损π相位操控.同时,利用该系统我们可以在单光子水平下实现低噪声、无损的量子相位门,这个系统在光通信和信息处理领域有着重要的应用价值.

关键词：非线性光学相干光学效应量子噪声

Leonurine(4-guanidino-n-butyl Syringate)protects the middle cerebral artery occluded rats through antioxidant mechanisms and regulation of mitochondrial function

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Leonurine(4-guanidino-n-butyl Syringate)protects the middle ...

A Theoretical Study on the Gold Nanostructures on TiOx/Mo（112） Thin Films

中国药理学会第十次全国学术会议

作者： jia Qi,yi-zhun zhu (Department of Pharmacology,School of Pharmacy and Institute of Biomedical Sciences,Fudan University,Shanghai,China)

Oxidative stress is known to be involved in ischemic *** interest is drawn to the therapeutic potential of Chinese herbs on ischemic stroke as many of them contain antioxidant *** recently reported that purified Herba Leonuri(pHL) could be cerebral protective for ischemic ***,one of the key active compounds from pHL was further studied to evaluate its possible therapeutic effects on ischemic *** was pretreated with Leonurine orally for 7 days before the middle cerebral artery occlusion(MCAO) was *** day after surgery,Leonurine pretreatment could significantly reduce 40%of infarct volume from 40%,improve neurological deficit from stroke groups,increase activities of antioxidant enzymes SOD and GPx to 131%and 154%,respectively as compared to vehicle,and decrease 50%in level of lipid peroxidation marker MDA from(P<0.05).Leonurine also inhibited mitiochondrial ROS production and ATP biosynthesis dose-dependently in isolated *** studies demonstrated that the mitochondrial function(mitochondrial oxygen consumption and respiratory control ratio) was restored by Leonurine ***,Leonurine has neuroprotective effects and carries a therapeutic potential for treatment of stroke.

关键词： Ischemic stroke MCAO Leonurine antioxidant mitochondrial modulation

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A Theoretical Study on the Gold Nanostructures on TiOx/Mo（1...

芍药苷通过抑制脊髓Akt-NF-kB信号通路及小胶质细胞激活缓解炎症性疼痛

中国化学会第五届全国结构化学学术会议

作者： Yongfan Zhang~* jia zhu yi Li Junqian Li Department of Chemistry,Fuzhou University,Fuzhou,Fujian,350002,China

＜正＞The unusual catalytic activity of nanodispersed gold on oxide surfaces has stimulated a constantly increasing number of model studies based on surface science *** the large set of data and information available,...

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中国生物化学与分子生物学报 2018年第3期34卷 325-333页

作者：洪嘉琪史家欣敖欢章鉴东翁依佳朱佳嘉兴学院医学院微生物学与免疫学教研室浙江嘉兴314000

芍药苷具有抑制炎症和镇痛的作用,在治疗炎症疼痛方面具有重要价值,但其作用机制尚不明确。本研究发现,弗氏完全佐剂诱导小鼠炎症疼痛模型,用80 mg/kg芍药苷腹腔注射能有效缓解疼痛。检测发现芍药苷治疗后,小鼠机械性痛阈与热板痛阈均... 详细信息

芍药苷具有抑制炎症和镇痛的作用,在治疗炎症疼痛方面具有重要价值,但其作用机制尚不明确。本研究发现,弗氏完全佐剂诱导小鼠炎症疼痛模型,用80 mg/kg芍药苷腹腔注射能有效缓解疼痛。检测发现芍药苷治疗后,小鼠机械性痛阈与热板痛阈均明显升高(机械性痛阈值:由6.38±1.00 g提高至8.31±0.81 g;热板痛阈值:由5.78±0.76 s提高至9.90±1.58 s);同时抑制外周炎症因子TNF-α等的释放(由708.71±46.55 pg/m L降低至588.65±16.02 pg/m L);免疫组织化学检测发现,芍药苷能有效抑制脊髓背角小胶质细胞的激活;NO检测结果发现,脊髓部位NO合成降低(3.55±0.28μmol/L·g-1Pro降至2.25±0.71μmol/L·g-1Pro);Western印迹检测证实,脊髓部位i NOS在使用芍药苷后,表达恢复正常水平。同时发现,Akt-NF-κB信号可能参与芍药苷的镇痛作用。上述结果提示,芍药苷缓解慢性炎症疼痛可通过抑制炎症因子释放,也通过抑制脊髓小胶质细胞的激活,而此过程依赖抑制Akt-NF-κB信号的激活。

关键词：芍药苷弗氏完全佐剂疼痛小胶质细胞炎症核因子κB

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li jianhua Huang Di Zhao Lemei zhu Zheyu Zhang Min yi Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

Surface embedded binary Co-Cu hydroxy phosphate over surface of oxy/hydroxides for efficient nitrate reduction to ammonia

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Nano Research 2025年第1期18卷 195-207页

作者： Chun zhu yifei Yang yike Jing Zhen Zeng Xuesong yi Wei Sun Fei Yang Key Laboratory of Agro-Forestry Environmental Processes and Ecological Regulation of Hainan Province School of Environmental Science and EngineeringHainan UniversityHaikou 570228China

Electrochemical nitrate reduction reaction(NO3RR)to ammonia is a promising approach to address excess Ncontamination in aqueous environment but suffers from a limited ammonia yield and selectivity due to the low concentration and sluggish *** work reports a three-dimensional porous electrode with binary Co_(2)Cu_(1)hydroxy phosphate embedded into the surface of Ni_(3)Co_(1)oxy/hydroxides(CoCu-PH@NiCo/Ni,“PH”means phosphate-hydroxide),which delivers a yield of 4.13 mg·h^(-1)·cm^(-2)with a high Faraday efficiency of 92.6%under a low nitrate concentration of 40 mM and provide an impressive *** embedded structure of the as-prepared catalyst exhibits unique metal coordination ligands and valence states different from the unitary *** electrochemical in situ infrared spectra and theoretical calculations revealed that the Co sites with the ability to dissociate water molecular to form adsorbed OH*can effectively provide the required protons for the deoxygenation and hydrogenation steps during NO3-conversion,thereby,effectively reducing the energy barrier of the key transition states in the NO3RR process to improve the intrinsic *** demonstrate that the rational design of binary components with the appropriate ability to activate water molecules as well as the threedimensional porous skeletal structure are expected to promote effectively the low-concentration nitrates conversion to ammonia.

关键词： nitrate reduction hydroxy phosphate surface embedded water dissociation active hydroxy adsorbed