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The influence of admission glucose on epicardial and microvascular flow after primary angioplasty

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Chinese Medical Journal 2006年第2期119卷 95-102页

作者： SHEN Xu-hua jia San-qing li Hong-wei Department of Cardiology Beijing Friendship Hospital Beijing 100050 China

Background Patients with elevated admission glucose levels may be at increased risk of death after myocardial infarction, independent of other baseline risk factors and more severe coronary artery disease. However, data regarding admission glucose and epicardial and microvascular flow after primary angioplasty is limited. Methods Angioplasty was performed in 308 ST-segment elevated myocardial infarction patients. Patients were divided into 3 groups on the basis of admission glucose level： group 1, 〈7.8 mmol/L; group 2, （7.8 - 11.0） mmol/L; and group 3, ≥ 11.0 mmol/L. Results Compared with group 1, patients in group 2 and group 3 were more often female and older. Triglycerides （TG） in group 3 were significantly higher than group 1. At angiography, they more frequently had 2-vessel or 3-vessel disease. In the infarct-related artery, there was no relationship between hyperglycemia and thrombolysis in myocardial infarction （TIMI） 3 flow after percutaneous coronary intervention （PCI）（89.7%, 86.0% and 86.3%, P=NS）. However, corrected TIMI frame count （CTFC） in group 2 and group 3 were more than group 1. TIMI myocardial perfusion grade （TMPG） 0-1 grade among patients with hyperglycemia after PCI were more frequent （30.9% and 29.0% vs 17.3%, P〈0.05）. There was less frequent complete ST-segment resolution （STR） and early T wave inversion among patients with hyperglycemia after PCI. Conclusion Elevated admission glucose levels in ST-segment elevation myocardial infarction patients treated with primary PCI are independently associated with impaired microvascular flow. Abnormal microvascular flow may contribute at least in part to the poor outcomes observed in patients with elevated admission glucose.

关键词： myocardial infarction glucose percutaneous transluminal coronary angioplasty

Modular assembly of Co4-thiacalix[4]arene units and Keggin-type SiW12O40 for visible-light photothermal conversion

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Tungsten 2025年第1期7卷 112-119页

作者： jia-Hui li qing Zhao Dong-Ao Mao Kun Zhou Bao-Kuan Chen Yan-Feng Bi School of Petrochemical Engineering Liaoning Petrochemical University

The construction of metal-organic coordination clusters（MCCs） using modular secondary building units is an important method for preparing functional *** this study,two new MCCs modularly assembled from Keggin-type {SiW12O40}H4TC4A=p-tert-Butylthiacalix[4]arene(SiW12) units and thiacalixarene-supported Co4-thiacalix[4]arene(Co4-TC4A polynuclear second-building units（PSBUs,H4TC4A=p-tert-Butylthiacalix[4]arene） are *** two MCCs,abbreviated as Co4-SiW12and Co8-SiW12,were structurally characterized by single-crystal X-ray *** Co4-SiW12is a supramolecular structure involving cation-anion interactions between Co4-TC4A PSBUs and ***8-SiW12features "barbell-like" shapes with two Co4-TC4A coordinatively linked to a Keggin-type SiW12unit on opposite via W-O_t-Co *** coordination of Co4-TC4A to SiW12in Co8-SiW12resulted in significantly improved photothermal conversion performances compared with Co4-SiW12and pure SiW12or ***-gap determination and photophysical analysis combined with density functional theory calculations indicated the binding mode between Co4-TC4A PSBUs and SiW12,which considerably influences the way of electron transport and the conversion ability of visible light to heat.

关键词： Modular construction Photothermal conversion Polyoxometalate Thiacalixarene

Molecular mechanisms of Buqing granule for the treatment of diabetic retinopathy:Network pharmacology analysis and experimental validation

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World Journal of Diabetes 2024年第9期15卷 1942-1961页

作者： Yi-Fan Yang ling Yuan Xiang-Yang li Qian liu Wen-Jie jiang Tai-Qiang jiao jia-qing li Meng-Yi Ye Yang Niu Yi Nan Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Diabetic retinopathy(DR)is a common microvascular complication of diabetes *** blindness rate is high;therefore,finding a reasonable and safe treatment plan to prevent and control DR is ***,there are abundant and diverse research results on the treatment of DR by Chinese medicine Traditional Chinese medicine compounds are potentially advantageous for DR prevention and treatment because of its safe and effective therapeutic *** To investigate the effects of Buqing granule(BQKL)on DR and its mechanism from a systemic perspective and at the molecular level by combining network pharmacology and in vivo *** This study collected information on the drug targets of BQKL and the therapeutic targets of DR for intersecting target gene analysis and protein-protein interactions(PPI),identified various biological pathways related to DR treatment by BQKL through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses,and preliminarily validated the screened core targets by molecular ***,we constructed a diabetic rat model with a high-fat and high-sugar diet and intraperitoneal streptozotocin injection,and administered the appropriate drugs for 12 weeks after the model was successfully *** mass and fasting blood glucose and lipid levels were measured,and pathological changes in retinal tissue were detected by hematoxylin and eosin *** was used to detect the oxidative stress index expression in serum and retinal tissue,and immunohistochemistry,real-time quantitative reverse transcription PCR,and western blotting were used to verify the changes in the expression of core *** Six potential therapeutic targets of BQKL for DR treatment,including Caspase-3,c-Jun,TP53,AKT1,MAPK1,and MAPK3,were screened using *** analysis indicated that the MAPK signaling pathway might be the core target pathway of BQKL in DR *** docking prediction indica

关键词： Diabetic retinopathy Network pharmacology Animal models Oxidative stress Inflammatory

Ideal Bi‑Based Hybrid Anode Material for Ultrafast Charging of Sodium‑Ion Batteries at Extremely Low Temperatures

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Nano-Micro Letters 2025年第3期17卷 152-167页

作者： Jie Bai jian Hui jia Yu Wang Chun Cheng Yang qing jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022People’s Republic of China

Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at−20°C or ***,the key capability of ultrafast charging at ultralow temperature for SIBs is rarely ***,a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue,which is synthesized via a high temperature shock *** a hybrid shows an unprecedented rate performance(237.9 mAh g^(−1)at 2 A g^(−1))at−60℃,outperforming all reported SIB anode *** with a Na_(3)V_(2)(PO_(4))_(3)cathode,the energy density of the full cell can reach to 181.9 Wh kg^(−1)at−40°*** on this work,a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

Thickness and sp3 bond modulation of（Ti/tetrahedral amorphous carbon）_n multilayer coatings

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Tungsten 2025年第1期7卷 152-160页

作者： Zhi-Jun Xie jia-lin li ling Gong Xiang-li Zhong Hong-jia Song Jin-Bin Wang National-Provincial Laboratory of Special Function Thin Film Materials School of Materials Science and Engineering Xiangtan University

The durability of wear-resistant tetrahedral amorphous carbon（ta-C） coatings is intimately linked to their thickness and the concentration of *** enhance the lifespan of the coatings,we have prepared a multilayer coating consisting of alternating layers of Ti and ta-C,denoted as（Ti/ta-C）_n,using arc ion plating.A multi-layer structure in conjunction with stage cooling is employed to enhance the thickness and promote *** results indicate that the ID/IGvalue,representing the ratio of the intensity of the D peak to that of the G peak in Raman spectroscopy,decreases from 0.85 when no stage cooling is applied to 0.35 when stage cooling is employed,suggesting an enhancement in the fraction of sp3bonds within the *** obtained（Ti/ta-C）_n multilayer coating without peeling off has a maximum thickness of 1.14 μm,which is almost double that of the ta-C coating single layer *** the same time,the coating has a low coefficient of friction,down to 0.069,and maintains excellent friction properties with a wear rate of 3.4×10-6mm3·N-1·*** results conclusively show that the preparation technology can enhance both thickness and sp3bonding in ta-C coatings,significantly expanding their utility across tools,molds,and precision engineering components.

关键词： Arc ion plating Multilayer structure sp3 bond Ta-C coating Wear resistance

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水厂膜处理过程中阻垢剂的典型种类及应用

中国给水排水 2024年第12期40卷 57-62页

作者：贾丽晴刘成河海大学浅水湖泊综合治理与资源开发教育部重点实验室江苏南京210098 河海大学环境学院江苏南京210098

膜结垢会降低膜的渗透通量,影响膜的使用寿命,是水厂膜处理过程的重要限制因素之一。投加阻垢剂是阻止膜结垢的一种方便、有效的方法,分别从阻垢机理、阻垢剂的种类和阻垢剂的应用三方面介绍了水厂膜处理过程中含磷阻垢剂、聚合物阻垢... 详细信息

膜结垢会降低膜的渗透通量,影响膜的使用寿命,是水厂膜处理过程的重要限制因素之一。投加阻垢剂是阻止膜结垢的一种方便、有效的方法,分别从阻垢机理、阻垢剂的种类和阻垢剂的应用三方面介绍了水厂膜处理过程中含磷阻垢剂、聚合物阻垢剂和环保阻垢剂的特点及合成方法,阐述了阻垢剂在水厂膜处理过程中的应用形式和阻垢性能。在此基础上,总结了阻垢剂应用过程中仍存在的问题,并对阻垢剂的未来发展和应用进行了展望。

关键词：阻垢剂膜结垢反渗透纳滤饮用水

Effect of pyrite content on chalcopyrite flotation under different regrinding conditions

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 49-57页

作者： Zejun Wang qing Shi Guofan Zhang Yuxuan Zhu Binbin li School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources Central South UniversityChangsha 410083China

This study aimed to investigate the effect of varying pyrite(Py)content on copper(Cu)in the presence of different regrinding conditions,which were altered using different types of grinding media:iron,ceramic balls,and their mixture,followed by flotation in the cleaner *** flotation performance of rough Cu concentrate can be improved by changing the regrinding conditions based on the Py *** electron microscopy,X-ray spectrometry,ethylenediaminetetraacetic acid disodium salt extraction,and X-ray photoelectron spectroscopy studies illustrated that when the Py content was high,the use of iron media in regrinding promoted the generation of hydrophilic Fe OOH on the surface of Py and improved the Cu *** ceramic medium with a low Py content prevented excessive Fe OOH from covering the surface of chalcopyrite(Cpy).Electrochemical studies further showed that the galvanic corrosion current of Cpy-Py increased with the addition of Py and became stronger with the participation of iron media.

关键词： chalcopyrite regrinding media pyrite galvanic corrosion flotation

Direct measurement of the break-out ^(19)F(p,γ)^(20)Ne reaction in the China Jinping underground laboratory(CJPL)

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Nuclear Science and Techniques 2024年第8期35卷 142-152页

作者： Yin‑Ji Chen Hao Zhang li‑Yong Zhang jian‑Jun He Richard James deBoer Michael Wiescher Alexander Heger David Kahl Jun Su Daniel Odell Xin‑Yue li jian‑Guo Wang Long Zhang Fu‑Qiang Cao Zhi‑Cheng Zhang Xin‑Zhi jiang Luo‑Huan Wang Zi‑Ming li Lu‑Yang Song liang‑Ting Sun Qi Wu jia‑qing li Bao‑Qun Cui li‑Hua Chen Rui‑Gang Ma Er‑Tao li Gang lian Yao‑De Sheng Zhi‑Hong li Bing Guo Wei‑Ping liu Key Laboratory of Beam Technology of the Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Department of Physics and Astronomy The Joint Institute for Nuclear AstrophysicsUniversity of Notre DameNotre DameIN 46556USA School of Physics and Astronomy Monash UniversityClaytonVIC 3800Australia Facility for Rare Isotope Beams Michigan State UniversityEast LansingMI 48824USA Institute of Nuclear and Particle Physics and Department of Physics and Astronomy Ohio UniversityAthensOH 45701USA Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China China Institute of Atomic Energy Beijing 102413China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China College of Science Southern University of Science and TechnologyShenzhen 518055China Institute of Radiation Technology Beijing Academy of Science and TechnologyBeijing 100875China Key Laboratory of Nuclear Physics and Ion‑Beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Mathematics and Physics Handan UniversityHandan 056005China

Calcium production and the stellar evolution of first-generation stars remain fascinating mysteries in *** one possible nucleosynthesis scenario,break-out from the hot carbon–nitrogen–oxygen(HCNO)cycle was thought to be the source of the calcium observed in these oldest ***,according to the stellar modeling,a nearly tenfold increase in the thermonuclear rate ratio of the break-out ^(19)F(p,γ)^(20) Ne reaction with respect to the competing ^(19)F(p,α)^(16) O back-processing reaction is required to reproduce the observed calcium *** performed a direct measurement of this break-out reaction at the China Jinping underground *** measurement was performed down to the low-energy limit of E_(c.m.)=186 keV in the center-of-mass *** key resonance was observed at 225.2 keV for the first *** a temperature of approximately 0.1 GK,this new resonance enhanced the thermonuclear ^(19)F(p,γ)^(20) Ne rate by up to a factor of≈7.4,compared with the previously recommended NACRE *** is of particular interest to the study of the evolution of the first stars and implies a stronger breakdown in their“warm”CNO cycle through the ^(19)F(p,γ)^(20) Ne reaction than previously *** break-out resulted in the production of the calcium observed in the oldest stars,enhancing our understanding of the evolution of the first stars.

关键词： Nuclear astrophysics First stars Abundance of calcium Reaction cross section Reaction rate China Jinping underground laboratory(CJPL) JUNA

长链非编码RNA在结直肠癌中的作用及临床价值

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世界华人消化杂志 2017年第25期25卷 2261-2267页

作者：李佳茜孙青潍坊医学院临床医学院病理与病理生理学系山东省潍坊市261000 山东省千佛山医院病理科山东省济南市250014

结直肠癌是常见的消化系恶性肿瘤之一,其发生和发展是一个涉及多因素、多步骤的复杂过程.长链非编码RNA(long non-coding RNA,LncRNA)是一类长度大于200个核苷酸,缺乏开放阅读框,无蛋白质编码功能的RNA.通过诱饵分子、信号分子、支架分... 详细信息

结直肠癌是常见的消化系恶性肿瘤之一,其发生和发展是一个涉及多因素、多步骤的复杂过程.长链非编码RNA(long non-coding RNA,LncRNA)是一类长度大于200个核苷酸,缺乏开放阅读框,无蛋白质编码功能的RNA.通过诱饵分子、信号分子、支架分子、引导分子等4种形式在转录、转录后和表观遗传学多个水平调控基因的表达,参与了多种疾病的发生发展.同时,LncRNA在结直肠癌的临床应用中也有重大价值,参与结直肠癌的诊断、预防、治疗与预后.本文就近年来人们对于LncRNA与结直肠癌关系的研究进展作一综述,并探讨通过LncRNA治疗结直肠癌的现状和前景.

关键词：长链非编码RNA 结直肠癌转录