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Applied Mathematics and Mechanics(English Edition) 2001年第10期22卷 1192-1197页

作者： LIU qi-lin(刘其林) MO jia-qi(莫嘉琪) Department of Mathematics Nanjing University Nanjing 210093 P R China Department of Mathematics Huzhou Teachers CollegeHuzhou 313000 P R China

A class of singularly perturbed initial boundary value problems for the reaction diffusion equations in a part of domain are considered. Using the operator theory the asymptotic behavior of solution for the problems i... 详细信息

关键词： singular perturbation reaction diffusion equation initial boundary value problem

Comprehensive Utilization of Ludwigite Ore Based on Metallizing Reduction and Magnetic Separation

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Journal of Iron and Steel Research International 2015年第8期22卷 672-680页

作者： Xiao-jiao FU jia-qi ZHAO Shuang-yin CHEN Zheng-gen LIU Tong-lai GUO Man-sheng chu School of Materials and Metallurgy Northeastern University

With the aim of high-efficiency utilization of Dandong ludwigite ore, a new process of metallizing reduction and mag- netic separation was proposed, and the effects of reduction temperature, reduction time, carbon ratio, ore size and coal size on the efficiency of the process were investigated in details, and relevant mechanisms were elucidated by SEM and EDS. The optimum technological parameters for metallizing reduction and magnetic separation on ludwigite ore were obtained as reduction tempera- ture of 1 250 ℃, reduction time of 60 min, carbon ratio of 1.4, ore size of 0.500-2.000 mm, and coal size of 0.50-1.50 mm. After adopting the optimum parameters, the iron content and recovery ratio of iron in magnetic substance are 87.78% and 88.02%, re- spectively, while the recovery ratios of boron, magnesium and silicon in non-magnetic substance are 88.86%, 94.60% and 98.66%, respectively. After metallizing reduction and magnetic separation, valuable elements of ludwigite ore could be separated and uti- lized in subsequent steelmaking process and hydrometallurgy process.

关键词： ludwigite ore metallizing reduction magnetic separation valuable element comprehensive utilization

Solar cycle prediction using a long short-term memory deep learning model

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Research in Astronomy and Astrophysics 2021年第1期21卷 119-126页

作者： qi-Jie Wang jia-Chen Li Liang-qi Guo School of Geosciences and Info-Physics Central South UniversityChangsha 410083China

In this paper,we propose a long short-term memory(LSTM)deep learning model to deal with the smoothed monthly sunspot number(SSN),aiming to address the problem whereby the prediction results of the existing sunspot prediction methods are not uniform and have large *** method optimizes the number of hidden nodes and batch sizes of the LSTM network structures to 19 and 20,*** best length of time series and the value of the timesteps were then determined for the network training,and one-step and multi-step predictions for Cycle 22 to Cycle 24 were made using the well-established *** results showed that the maximum root-mean-square error(RMSE)of the one-step prediction model was6.12 and the minimum was only *** maximum amplitude prediction error of the multi-step prediction was 17.2%and the minimum was only 3.0%.Finally,the next solar cycles(Cycle 25)peak amplitude was predicted to occur around 2023,with a peak value of about *** accuracy of this prediction method is better than that of the other commonly used methods,and the method has high applicability.

关键词： Sun:solar activity Sun:sunspot number techniques:deep learning techniques:long short-term memory

Application of magnetic solid phase extraction in separation and enrichment of glycoproteins and glycopeptides

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Chinese Chemical Letters 2021年第9期32卷 2629-2636页

作者： He qi Liyan jiang qiong jia College of Chemistry Jilin UniversityChangchun 130012China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education School of Life SciencesJilin UniversityChangchun 130012China

The analysis of endogenous glycoproteins and glycopeptides in human body fluids is of great importance for screening and discovering disease biomarkers with clinical ***,the presence of interfering substances makes the direct quantitative detection of low-abundance glycoproteins and glycopeptides in human body fluids one of the great challenges in analytical *** solid phase extraction(MSPE)has the advantages of easy preparation,low cost and good magnetic *** adsorbents are the core of MSPE technology,and magnetic adsorbents based on different functional materials are widely used in the quantitative analysis of glycoproteins and glycopeptides in human body fluids,making it possible to analyze glycoproteins and glycopeptides with low abundance as well as multiple types,which provides a technical platform for screening and evaluating glycoproteins and glycopeptides in body fluids as disease *** this paper,we focus on the recent advances in the application of MSPE technology and magnetic adsorbents for the separation and enrichment of glycoproteins and glycopeptides in human body fluids,and the future trends and application prospects in this field are also presented.

关键词： Glycoproteins Glycopeptides Magnetic solid phase extraction(MSPE) Separation Enrichment Human body fluids

Disparities in the Levels of Whole-Blood Epstein-Barr Virus between the Cancer and Non-Cancer Populations in Zhejiang,China

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Biomedical and Environmental Sciences 2024年第9期37卷 993-1002页

作者： qingjun jia Meichun Zeng qi Chen Hangzhou Center for Disease Control and Prevention(Hangzhou Health Supervision Institution) Hangzhou 310021ZhejiangChina Department of Pathology The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003ZhejiangChina

Objective This study aimed to investigate the prevalence of Epstein-Barr virus(EBV)infection in patients with and without *** A total of 26,648 participants who underwent whole-blood EBV DNA(WBEBV)assays between January 1,2020,and August 31,2023,were *** chi-square test was used for categorical data analysis,and R software was used to analyze the differences in EBV DNA load levels and the diagnostic capabilities of *** Positive rates were 10.2%and 25.4%for healthy controls(HC)and patients,*** positivity rate for EBV-associated neoplasms(EN)was the highest at 7.53%,followed by leukemia(Le)at 5.49%.The subgroup analysis showed that the positivity rate for abnormal proliferation or hyperplasia(APH)was 31.9%,followed by 30.5%for *** WBEBV of patients with transplants(TP),especially living-related transplants(LT),was the highest among all *** at diagnosis was used to differentiate between infectious mononucleosis(IM)and chronic active Epstein-Barr virus(CAEBV),with a sensitivity of 67.4%(95%confidence interval[CI]:57.6-75.8)and specificity of 72%(95%CI:63.3-79.3).We conclude that the prevalence of EBV infection is low in the healthy population in this region and that a high EBV load at baseline is more common in LT,IM,and Lymphocyte Leukemia(LL).Conclusion This study used a large-sample survey to characterize the prevalence of whole-blood EBV levels in various diseases,including the stages and *** EBV detection rate was higher in patients with malignant disease than in those with benign *** study provides clinicians with baseline information regarding EBV-associated diseases.

关键词： Epstein-Barr virus Epstein-Barr virus DNA Whole blood Epstein-Barr virus DNA Viral load

A Physics-Informed Structure-Preserving Numerical Scheme for the Phase-Field Hydrodynamic Model of Ternary Fluid Flows

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Numerical Mathematics(Theory,Methods and Applications) 2023年第3期16卷 565-596页

作者： qi Hong Yuezheng Gong jia Zhao School of Mathematics Nanjing University of Aeronautics and Astronautics/Key Laboratory of Mathematical Modelling and High Performance Computing of Air Vehicles(NUAA)MIITNanjing 211106China Department of Mathematics and Statistics Utah State UniversityLoganUT84322USA

Phase-field models are widely used in studying multiphase flow *** the complexity and strong nonlinearity,designing accurate,efficient,and stable numerical algorithms to solve these models has been an active research field for *** paper proposes a novel numerical scheme to solve a highly cited and used phase field hydrodynamic model for simulating ternary phase fluid *** main novelty is the introduction of a supplementary variable to reformulate the original problem into a constrained optimization *** reformulation leads to several advantages for our proposed numerical algorithms compared with many existing numerical techniques for solving this ***,the developed schemes allow more straightforward calculations for the hydrodynamic phase-field models by solving a few decoupled Helmholtz or Poisson-type systems with a constant precomputable coefficient matrix,remarkably reducing the computational ***,the numerical schemes can maintain mass conservation and energy dissipation at the discrete ***,the developed scheme based on the secondorder backward difference formula respects the original energy dissipation law that differs from many existing schemes,such as the IEQ,SAV,and Lagrange multiplier approaches for which a modified energy dissipation law is ***,rigorous proof of energy stability and practical implementation strategies are *** conduct adequate 2D and 3D numerical tests to demonstrate the proposed schemes’accuracy and effectiveness.

关键词： Energy stable phase field Cahn-Hilliard-Navier-Stokes supplementary variable method

Recent Advances of Catalytic Enantioselective Heck Reactions and Reductive-Heck Reactions

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Chinese Journal of Chemistry 2021年第3期39卷 710-728页

作者： jia-qi Xie Ren-Xiao Liang Yi-Xia jia College of Chemical Engineering State Key Laboratory Breeding Base of Green-Chemical Synthesis TechnologyZhejiang University of TechnologyHangzhouZhejiang 310014China

Heck reaction is one of the most important carbon-carbon bond forming reactions with wide applications in organic *** advances of enantioselective Heck reaction have been achieved in the past *** review focuses on recent development of catalytic asymmetric Heck reaction and reductive Heck reaction,which covers intermolecular and intramolecular versions since *** article is organized in terms of the cat-alysts and olefin substrates.

关键词： Heck reaction Asymmetric catalysis Palladium Nickel Reductive Heck reaction

Determining the geographic origin of the brown planthopper, Nilaparvata lugens, using trace element content

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Insect Science 2012年第1期19卷 21-29页

作者： qi Peng qi-Yi Tang jia-Lun Wu qing-Ling Miao jia-An Cheng State Key Laboratory of Rice Biology Institute of Insect SciencesZhejiang UniversityHangzhouChina

bstract A chemometric study using pattern recognition technology was carried out to characterize the geographic origins of the brown planthopper, Nilaparvata lugens. The concentrations of 23 trace elements （Mn, Mo, Cd, Ce, V, Th, Cs, Be, T1, Fe, Nd, Pr, Se, Tm, Lu, Eu, Ho, Br, Dy, Gd, U, Sm and Er） in 53 samples from seven regions in southern China were determined using inductively coupled plasma mass spectrometry. The data obtained were successively evaluated using a multivariate statistical approach, namely, linear discriminant analysis, which allowed classification and discrimination of the N. lugens samples from Fuqing, Shaoguan, Hepu, Yongfu, Hengnan, Wan-an and Yongkang with high accuracy and a clear separation among the seven regions. The results show that pattern identification on the basis of trace elements in the bodies ofN. lugens is feasible for determining the geographic origins of individuals.

关键词： brown planthopper discriminant analysis forecasting geographic origin trace element

A constrained particle dynamics for continuum-particle hybrid method in micro- and nano-fluidics

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Acta Mechanica Sinica 2006年第6期22卷 503-508页

作者： jia Cui Guo Wei He Dewei qi LNM Institute of Mechanics Chinese Academy of SciencesBeijing 100080 China Department of Paper and Chemical Engineering Western Michigan University Kalamazoo MI 49008 USA

A hybrid method of continuum and particle dynamics is developed for micro- and nano-fluidics, where fluids are described by a molecular dynamics （MD） in one domain and by the Navier-Stokes （NS） equations in another domain. In order to ensure the continuity of momentum flux, the continuum and molecular dynamics in the overlap domain are coupled through a constrained particle dynamics. The constrained particle dynamics is constructed with a virtual damping force and a virtual added mass force. The sudden-start Couette flows with either non-slip or slip boundary condition are used to test the hybrid method. It is shown that the results obtained are quantitatively in agreement with the analytical solutions under the non-slip boundary conditions and the full MD simulations under the slip bound- ary conditions.

关键词： Hybrid method Molecular dynamicsimulation Navier-Stokes equation Microfluidics

B-cell-specific signatures reveal novel immunophenotyping and therapeutic targets for hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第34期30卷 3894-3925页

作者： Ke-Quan Xu Zheng Gong jia-Ling Yang chu-qi Xia jian-Yi Zhao Xi Chen Department of Hepatobiliary and Pancreatic Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina Department of Pharmacy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina School of Basic Medical Sciences Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina Department of Gastrointestinal Surgery The Second Affiliated Hospital of Kunming Medical UniversityKunming 650101Yunnan ProvinceChina Department of General Surgery Second People’s Hospital of Jiaozuo CityJiaozuo 454001Henan ProvinceChina

BACKGROUND Immunotherapy presents both promises and challenges in treating hepatocellular carcinoma(HCC)due to its complex immunological *** role of B cells,a key part of the immune system,remains uncertain in *** To identify B-cell-specific signatures and reveal novel immunophenotyping and therapeutic targets for *** Using the Tumor Immune Single-cell Hub 2 database,we identified B-cell-related genes(BRGs)in *** enrichment analysis was performed to explore the possible collaboration between B cells and T cells in *** conducted univariate Cox regression analysis using The Cancer Genome Atlas liver HCC collection dataset to find BRGs linked to HCC ***,least absolute shrinkage and selection operator regression was utilized to develop a prognostic model with 11 *** model was validated using the International Cancer Genome Consortium dataset and *** The risk score derived from the prognostic model emerged as an independent prognostic factor for *** of the immune microenvironment and cell infiltration revealed the immune status of various risk groups,supporting the cooperation of B and T cells in suppressing *** BRGs model identified new molecular subtypes of HCC,each with distinct immune *** sensitivity analysis identified targeted drugs effective for each HCC subtype,enabling precision therapy and guiding clinical *** We clarified the role of B cells in HCC and propose that the BRGs model offers promising targets for personalized immunotherapy.

关键词： B cell Hepatocellular carcinoma Immune microenvironment Immunotherapy Molecular subtype