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Synthesis and biological evaluation of 3-amino-2-pyrones as selective cyclooxygenase-1(COX-1) inhibitors

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Chinese Chemical Letters 2013年第2期24卷 120-122页

作者： Xue-Ping Chu Qing-Fa Zhou Shen Zhao Fei-Fei Ge Mian Fu jia-peng chen Tao Lu Department of Organic Chemistry China Pharmaceutical University

Received 2 December 2012 Received in revised form 21 December 2012 Accepted 27 December 2012 Available online 4 February 2013

关键词： 3-Amino-2-pyroneBiological activityCOX-l-selective inhibitorSynthesis

Intrauterine Infections and Birth Defects

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Biomedical and Environmental Sciences 2004年第4期17卷 476-491页

作者： XIAO-YING ZHENG TING ZHANG YI-FEI WANG chen XU GONG chen RuO-LEI XIN jia-peng chen XU-MEI HU QING YANG XIN-MING SONG LI-HUA PANG YING JI HONG-MEI SUN LEI ZHANG JU-FEN LIU YAN-LING GUO YAN ZHANG Institute of Population Research／WHO Collaborating Centeron Reproductive Health and Population Science Beijing 100871China Department of Infection and Immunity Capitallnstimte of PediatricsBeijing 100020China Medical School of Shanghai jiatong University No.1954Huashan RoadShanghai 200030China Department of Embryology the Second Medical UniversityNo.280Chongqing NanluShanghai 200025China

Intrauterine infection is an important cause of some birth defects worldwide. The most common pathogens include rubella virus, cytomegaloviurs, ureaplasma urealyticum, toxoplasma, etc. General information about these pathogens in epidemiology, consequence of birth defects, and the possible mechanisms in the progress of birth defects, and the interventions to prevent or treat these pathogens?infections are described. The infections caused by rubella virus, cytomegaloviurs, ureaplasma urealyticum, toxoplasma, etc. are common, yet they are proved to be fatal during the pregnant period, especially during the first trimester. These infections may cause sterility, abortion, stillbirth, low birth weight, and affect multiple organs that may induce loss of hearing and vision, even fetal deformity and the long-term effects. These pathogens?infections may influence the microenvironment of placenta, including levels of enzymes and cytokines, and affect chondriosome that may induce the progress of birth defect. Early diagnosis of infections during pregnancy should be strengthened. There are still many things to be settled, such as the molecular mechanisms of birth defects, the effective vaccines to certain pathogens. Birth defect researches in terms of etiology and the development of applicable and sensitive pathogen detection technology and methods are imperative.

关键词： Pregnancy Complications Infectious Pregnancy Outcome Abnormalities Animals Female Humans Infant Newborn Placenta Diseases Pregnancy Pregnancy Trimester First Research Support Non-U.S. Gov't Rubella Toxoplasma Ureaplasma urealyticum

手法复位联合石膏固定治疗桡骨下端骨折的临床疗效观察

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现代预防医学 2011年第17期38卷 3579-3580+3582页

作者：彭笳宸遵义医学院附属医院关节外科

[目的]探讨手法复位联合石膏固定治疗桡骨下端骨折的临床疗效。[方法]选择某院2008年6月～2010年6月期间诊治的桡骨下端骨折患者88例,随机将患者分为研究组和对照组,每组44例。两组患者经相关检查和明确诊断后均行手法复位治疗,而研究... 详细信息

[目的]探讨手法复位联合石膏固定治疗桡骨下端骨折的临床疗效。[方法]选择某院2008年6月～2010年6月期间诊治的桡骨下端骨折患者88例,随机将患者分为研究组和对照组,每组44例。两组患者经相关检查和明确诊断后均行手法复位治疗,而研究组患者则在此基础上换用石膏固定治疗,并对两组患者的临床治疗效果等相关评价指标进行比较分析。[结果]与对照组患者相比,研究组患者临床治疗效果处于优的比率和总有效率均显著提高,分别高达79.55%和97.73%,而处于差的比率则显著降低,仅为2.27%,差异均具有统计学意义(P﹤0.05);与此同时,研究组患者的疼痛消失所需时间和肿胀消退所需时间以及骨折临床愈合所需时间均明显减少,差异均具有统计学意义(P﹤0.05)。[结论]手法复位与石膏固定联合治疗桡骨下端骨折,其疗效确切,效果显著,对于桡骨下端骨折具有十分重要的临床治疗价值,是桡骨下端骨折患者较为理想的综合治疗方法。

关键词：桡骨下端骨折手法复位石膏固定

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非内镜微创手术治疗青少年臀肌挛缩症

重庆医科大学学报 2011年第7期36卷 886-888页

作者：彭笳宸刘骏遵义医学院附属医院骨一科遵义563000

目的：探讨常规器械完成青少年臀肌挛缩症的微创治疗可能性、适应症和手术要点。方法：采用常规手术器械而不是内窥镜等现代手术器械来完成青少年臀肌挛缩症的微创手术治疗,单切口长5-10 mm,不进行皮下等组织间隙的剥离。结果：29例患者... 详细信息

目的：探讨常规器械完成青少年臀肌挛缩症的微创治疗可能性、适应症和手术要点。方法：采用常规手术器械而不是内窥镜等现代手术器械来完成青少年臀肌挛缩症的微创手术治疗,单切口长5-10 mm,不进行皮下等组织间隙的剥离。结果：29例患者,男21例,女8例,年龄14～21岁,平均16岁,其中Ⅰ型10例,Ⅱ型18例,Ⅲ型1例,优良率100%。结论：青少年臀肌挛缩症不采用内窥镜完成微创手术,简单、实用,疗效满意。

关键词：臀肌挛缩症非内窥镜微创外科手术

RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

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World Journal of Gastroenterology 2025年第2期31卷 113-127页

作者： peng-Yu chen Pei-Yao Wang Bang Liu Yang-Pu jia Zhao-Xiong Zhang Xin Liu Dao-Han Wang Yong-jia Yan Wei-Hua Fu Feng Zhu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of General Surgery Jincheng People’s HospitalJincheng 048000Shanxi ProvinceChina

BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G *** speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet *** To explore the role and underlying mechanisms of action of RGS4 in GC *** The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with *** assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in *** RGS4 was highly expressed in GC tissues compared with matched adjacent normal *** RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with *** experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and ***,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor ***,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated *** High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic ***4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.

关键词： Gastric cancer Prognosis Regulator of G protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition

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椎间盘突出症复发原因初步研究

中国矫形外科杂志 2005年第15期13卷 1130-1131页

作者：彭笳宸张天宏遵义医学院第一附属医院骨科贵州遵义563003

[目的]检测突出椎间盘组织中免疫、炎症机理的代表产物表达情况,初步探索椎间盘突出症的复发原因及转归。[方法]以猪为实验动物,手术制作椎间盘突出的动物模型,采用免疫组化的方法对突出椎间盘组织中免疫复合物及巨噬细胞的浸润现象尤... 详细信息

[目的]检测突出椎间盘组织中免疫、炎症机理的代表产物表达情况,初步探索椎间盘突出症的复发原因及转归。[方法]以猪为实验动物,手术制作椎间盘突出的动物模型,采用免疫组化的方法对突出椎间盘组织中免疫复合物及巨噬细胞的浸润现象尤其是远期表现进行了观察。[结果]52例突出椎间盘组织中有22例出现免疫复合物的阳性表达,明显晚于巨噬细胞的出现;在晚期出现了局部巨噬细胞浸润减少后免疫复合物仍呈较高阳性表达的现象。[结论]突出的椎间盘组织中存在的免疫复合物是椎间盘突出症引起下腰痛及坐骨神经痛的重要病理生理基础之一,并很可能是椎间盘突出症复发或者保守治疗效果欠佳的关键因素。

关键词：椎间盘突出症复发病理生理学免疫复合物腰痛坐骨神经痛

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低温下半导体热电材料发电性能的初步研究

太阳能学报 2004年第4期25卷 443-446页

作者：贾磊胡芃陈则韶孙炜中国科学技术大学热科学和能源工程系合肥230027

为了对液化天然气(LNG)的冷能回收利用,对半导体热电材料在低温下的发电性能进行了实验研究,得到了这种热电材料的发电性能随冷端温度变化的关系,并发现在热端温度不变的情况下,冷端温度在特定温度下热电堆的输出电动势达到最大值。运... 详细信息

为了对液化天然气(LNG)的冷能回收利用,对半导体热电材料在低温下的发电性能进行了实验研究,得到了这种热电材料的发电性能随冷端温度变化的关系,并发现在热端温度不变的情况下,冷端温度在特定温度下热电堆的输出电动势达到最大值。运用数值方法理论计算了该热电堆在实验所处条件下的输出电动势,并将计算值与实验值进行了对比。

关键词：低温半导体热电材料发电

Unusual Patterns of Neural Tube Defects in a High Risk Region of Northern China

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Biomedical and Environmental Sciences 2009年第4期22卷 340-344页

作者： GONG chen LI-JUN PEI jiaN HUANG XIN-MING SONG LIANG-MING LIN XUE GU jiaN-XIN WU FANG WANG JI-LEI WU jia-peng chen JU-FEN LIU RUO-LEI XIN TING ZHANG XIAO-YING ZHENG Institute of Population Research Peking University Beijing 100871 China Institute of Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing 100050 China Capital Institute of Pediatrics Beijing 100020 China

Objective To study the prevalence of different types of neural tube defects （NTDs） in Luliang Prefecture, Shanxi province, where the prevalence of NTDs is unusually high and the correlation between NTDs prevalence and patterns. Methods A surveillance population-based birth defects was performed in Luliang Prefecture, Shanxi province. Results The results of our study showed that the prevalence of NTDs was 2-fold higher in Luliang Prefecture than in other areas of Shanxi province. Unusual patterns of NTDs were found, however, multiple NTDs were relatively common in Luliang Prefecture, accounting for over 13% of all NTDs cases in China. Conclusion The prevalence of NTDs is associated with its patterns.

关键词： Neural tube defects Epidemiology Geographic variation

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弯曲波导研究进展及其应用

中国光学 2017年第2期10卷 176-193页

作者：高峰秦莉陈泳屹贾鹏陈超梁磊陈红张星宁永强中国科学院长春光学精密机械与物理研究所发光学及应用国家重点实验室吉林长春130033 中国科学院大学北京100049

本文主要分析了弯曲波导损耗机理,包括传输损耗、辐射损耗、模式转换损耗。重点综述了设计低损耗弯曲波导的方法,包括波导材料、弯曲波导的曲线形状、波导种类、脊型波导的宽度、脊高、弯曲半径、模场分布、弯曲波导曲线形状和其他新型... 详细信息

本文主要分析了弯曲波导损耗机理,包括传输损耗、辐射损耗、模式转换损耗。重点综述了设计低损耗弯曲波导的方法,包括波导材料、弯曲波导的曲线形状、波导种类、脊型波导的宽度、脊高、弯曲半径、模场分布、弯曲波导曲线形状和其他新型波导结构等。简要概括了近年来设计和制备低损耗弯曲波导的代表性工作。介绍了弯曲波导在集成光学中的应用。通过对弯曲波导的损耗及耦合机制理论的不断完善,实现光在较小弯曲半径的低损耗传输,从而提高集成光学的集成度是弯曲波导今后的发展趋势。

关键词：弯曲波导集成光学 SOI 低损耗波导