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Microsystems & Nanoengineering 2024年第2期10卷 91-99页

作者： Zhixian Zhu Hui Ren Dan Wu Zhonghua ni Nan Xiang School of Mechanical Engineering and Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical InstrumentsSoutheast University211189NanjingChina School of Mechanical Technology Wuxi Institute of TechnologyNo.1600 Gaolang West Road214129WuxiChina Department of Oncology Jiangyin People’s Hospital214400JiangyinChina

Tumor cell clusters are regarded as critical factors in cancer pathophysiology,and increasing evidence of their higher treatment resistance and metastasis compared to single tumor cells has been ***,existing cell separation methods that are designed for single tumor cells cannot be used to simultaneously purify tumor cell *** address this problem,we demonstrated a microfluidic approach for the high-throughput,continuous-flow ternary separation of single tumor cells,tumor cell clusters,and WBCs from clinical pleural or abdominal effusions by coupling slanted spiral channels and periodic contraction-expansion *** first systematically explored the influence of particle size and flow rate on particle *** separation performance indicated that 94.0%of WBCs were removed and more than 97%of MDA-MB-231 tumor cells were recovered at a high flow rate of 3500µL/***,more than 90%of tumor cell clusters were effectively preserved after ***,we successfully applied our device for the ternary separation of single tumor cells,tumor cell clusters,and WBCs from different malignant effusions collected from patients with metastatic ***,our spiral-contraction-expansion device has potential as a sample pretreatment tool for the cytological diagnosis of malignant effusions.

关键词： separation contraction removed

Improving IEC thermal model for oil natural air natural transformers using optimised parameters based on dynamic simulation

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High Voltage 2024年第1期9卷 217-229页

作者： Lijing Zhang Yingting Luo Gehao Sheng Zizhan ni Xiuchen jiang Department of Electrical Engineering Shanghai Jiao Tong UniversityShanghaiChina Electric Power Research Institute of Guangdong Power Grid Corporation GuangzhouChina

Accurate assessment of hot-spot temperature is essential for the safe operation of power *** dynamic thermal models cannot estimate hot-spot temperature accurately since some input parameters are roughly determined by transformer capacity and cooling mode while ignoring the effect of winding structure,tank dimensions,and material physical *** improve the accuracy of temperature assessment,empirical parameters of the IEC thermal model including thermal constants,winding and oil exponents are optimised with the help of numerical simulation in this *** on energy conservation and heat transfer theory,a computational fluid dynamic(CFD)model of a transformer in oil natural air natural(ONAN)cooling mode is *** CFD model simulates the entity's structure,sizes,and multi-stage heat dissipation processes realistically,so it can more precisely calculate the dynamic hot-spot *** to the simulated temperature curves at different operating conditions,the thermal constants and oil exponent are estimated using non-linear regression,and the winding exponent is optimised using linear regression.A case study is conducted on an ONAN *** shows the improved IEC model with optimised parameters can more accurately evaluate hot-spot temperature,and the absolute error is decreased by 2.4 K(38.7%)compared with traditional thermal models.

关键词： temperature properties. thermal

Metal-based inorganic nanocrystals for biological sonodynamic therapy applications:recent progress and perspectives

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Rare Metals 2024年第2期43卷 413-430页

作者： Dong Wang jia-Tao Zhang Institute of Medical-Industrial Integration Beijing Key Laboratory of Structurally Controllable Advanced Functional Materials and Green ApplicationsSchool of Materials Science and EngineeringBeijing Institute of TechnologyBeijing100081China Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Ministry of Industry and Information TechnologySchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing100081China

With the fast development of technology for the treatment of tumor and bacteria,photo-therapeutic strate-gies emerge as a kind of highly effective and common treatment,but the low tissue penetration depth of light limits their *** therapy(SDT),as an efficient and non-invasive treatment,attracts more people's attention due to the inherent property of high tissue *** soft tissue penetration depth of ultrasound(US)can even reach more than 10 cm,which has great advantage over that of ***,many sonosensitizers are studied and applied to SDT-based ***-based inorganic nanocrystals are able to generate more reactive oxygen species(ROS)due to the special composition and band *** representative achievements and the specific functions of the nanocrystals sonosensitizers are summarized in this work,and the relationship of structure/composition-SDT performance and the internally regulated composite is ***-gistic effects of SDT in combination with other therapeutic modalities are mainly *** the same time,the critical and potential issues and future perspectives are addressed.

关键词： Metal-based inorganic nanocrystals Sonodynamic therapy(SDT) Tumor treatment Antibacteria

Charge regulation by ferromagnetic metal/LiF spin-polarized interface for high-performance Li metal anodes

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Rare Metals 2024年第3期43卷 995-1005页

作者： Ming-Yang Feng Shuang zhou Yi-Fang Zhang Ya-Ping Wang Chun-Yan Fu jian-Wen Li Yuan-Lang Wan Zhi-jia Zhang Yong jiang An-Qiang Pan State Key Laboratory of Powder Metallurgy School of Materials Science and EngineeringCentral South UniversityChangsha410083China State Key Laboratory of Separation Membranes and Membrane Processes Tianjin Key Laboratory of Advanced Fibers and Energy StorageSchool of Material Science and EngineeringTiangong UniversityTianjin300387China School of Materials Science and Engineering Hebei University of TechnologyTianjin300130China

The interfacial characteristics of the Li metal anode(LMA)play a crucial role in its overall *** various materials being applied to modify the interface,a comprehensive understanding of their specific mechanisms remains to be ***,we have prepared carbon cloth(CC)frameworks with their surfaces modified using ferromagnetic metal/LiF heterogeneous films(T^(M)-LiF-CC)as the substrate for LMA,which exhibit superior electrochemical *** ferromagnetic Co as a representative example,our study demonstrates that the enhanced performance of Co-LiF-CC,compared to bare CC,is attributed to the spinpolarized interface contributed by the Co/LiF *** and LiF play individual roles in redistributing electrons and Li^(+)to promote homogeneous Li *** nanoparticles play a crucial role in generating strong surface capacitance by storing electrons in spin-split bands,while LiF,with low surface diffusion barriers,ensures fast transportation of Li^(+).The Co-LiF-CC@Li electrodes deliver long lives of 7400 and 3600 h at 1 and 2 mA·cm^(-2)in symmetric cells,respectively;moreover,they enable full batteries with high and durable capacities,particularly when the N/P ratios are low(3.3 or even 1.7).

关键词： Lithium metal anode Interfacial charge Ferromagnetic metal Lithium fluoride Spin polarization

Normal sperm head morphometric reference values in fertile Asian males

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Asian Journal of Andrology 2024年第3期26卷 315-320页

作者： Ye-Lin jia Ying-Bi Wu Lin Yu Yan Zheng Ting-Ting Yang Yan-Yun Wang Bin zhou Lin Zhang Fu-Ping Li Laboratory of Andrology West China Second University Hospital Human Sperm BankChengdu 610000China Laboratory of Molecular Translational Medicine Center for Translational MedicineChengdu 610061China Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengdu 610061China NHC Key Laboratory of Chronobiology West China Second University HospitalSichuan UniversityChengdu 610000China

Sperm head morphology is crucial for male factor infertility diagnosis and assessment of male reproductive *** are available to analyze sperm head morphology,but they are limited by poor methodology comparability and *** study aimed to explore comprehensive and new normal morphometric reference values for spermatozoa heads infertile Asian *** automated sperm morphology analysis system captured 23152 stained spermatozoa from confirmed *** these samples,1856 sperm head images were annotated by three experienced laboratory technicians as“normal”.Weemployed 14 novel morphometric features to describe sperm head size(head length,head width,length/width ratio,and girth),shape(ellipse intersection over union,girth intersection over union,short-axis symmetry,and long-axis symmetry),area(head,acrosome,postacrosomal areas,and acrosome area ratio),and degrees of acrosome and nuclear *** straight-forwardmethod for the morphometric analysis of sperm by accurate visual measurements is clinically *** measured parameterspresent valuable information to establish morphometric reference intervals for normal sperm heads in fertile Asian *** detailed measurement data will be valuable for interlaboratory comparisons and technician *** vitro fertilizationand andrology laboratory technicians can use these parameters to perform objective morphology evaluation when assessing malefertilization potential.

关键词： fertile Asian males head morphometric reference value normal spermatozoa

Perenniality:From model plants to applications in agriculture

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Molecular Plant 2024年第1期17卷 141-157页

作者： Bo Zhao jia-Wei Wang National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant Sciences(CEMPS)Institute of Plant Physiology and Ecology(SIPPE)Chinese Academy of Sciences(CAS)Shanghai 200032China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Key Laboratory of Plant Carbon Capture CASShanghai 200032China New Cornerstone Science Laboratory Shanghai 200032China

To compensate for their sessile nature,plants have evolved sophisticated mechanisms enabling them to adapt to ever-changing *** such prominent feature is the evolution of diverse life history strategies,particularly such that annuals reproduce once followed by seasonal death,while perennials live longer by cycling growth *** intrinsic phenology is primarily genetic and can be altered by environmental *** evolutionary transitions between annual and perennial life history strategies are common,perennials account for most species in nature because they survive well under year-round *** proportion,however,is reversed in ***,perennial crops promise to likewise protect and enhance the resilience of agricultural ecosystems in response to climate *** significant endeavors that have been made to generate perennial crops,progress is slow because of barriers in studying perennials,and many developed species await further *** findings in model species have illustrated that simply rewiring existing genetic networks can lead to lifestyle *** implies that engineering plant life history strategy can be achieved by manipulating only a few key *** this review,we summarize our current understanding of genetic basis of perenniality and discuss major questions and challenges that remain to be addressed.

关键词： perenniality developmental plasticity flowering time poplar Arabis alpina perennial crops life history strategy

Enriched electrophilic oxygen species facilitate acidic oxygen evolution on Ru-Mo binary oxide catalysts

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Nano Research 2024年第3期17卷 1165-1172页

作者： Yaya Wang Yunzhou Wen Yumeng Cheng Xinhong Chen Mengjiao Zhuansun Tongbao Wang Jun Li Debora Meira Huarui Sun Jun Wei jia zhou Yuhang Wang Sisi He Shenzhen Key Laboratory of Flexible Printed Electronics Technology Harbin Institute of Technology(Shenzhen)University TownShenzhen 518055China School of Science Harbin Institute of Technology(Shenzhen)University TownShenzhen 518055China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory of Advanced Negative Carbon TechnologiesSoochow UniversitySuzhou 215123China Frontiers Science Center for Transformative Molecules Shanghai Jiao Tong UniversityShanghai 200240China Science Division Canadian Light SourceSaskatoonSKS7N 2V3Canada Photon Science Division Argonne National LaboratoryLemontIL60439USA School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)University TownShenzhen 518055China

The polymer electrolyte membrane(PEM)electrolyzers are burdened with costly iridium(Ir)-based catalysts and high operation overpotentials for the oxygen evolution reaction(OER).The development of earth-abundant,highly active,and durable electrocatalysts to replace Ir is a critical step in reducing the cost of green hydrogen *** we develop a Ru5Mo4Ox binary oxide catalyst that exhibits high activity and stability in acidic *** electron-withdrawing property of Mo enriches the electrophilic surface oxygen species,which promotes acidic OER to proceed via the adsorbate evolution *** a result,we achieve a 189 mV overpotential at 10 mA·cm^(-2) and a Tafel slope of 48.8 mV·dec^(-1).Our catalyst demonstrates a substantial 18-fold increase in intrinsic activity,as evaluated by turnover frequency,compared to commercially available RuO_(2) and IrO_(2) ***,we report a stable OER operation at 10 mA·cm^(-2) for 100 h with a low degradation rate of 2.05 mV·h^(-1).

关键词： electrocatalysis oxygen evolution reaction(OER) ruthenium(Ru)-based oxide molybdenum electrophilic oxygen

A prognostic four-gene signature and a therapeutic strategy for hepatocellular carcinoma:Construction and analysis of a circRNA-mediated competing endogenous RNA network

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 272-287页

作者： Hai-Yan Zhang jia-Jie Zhu Zong-Ming Liu Yu-Xuan Zhang jia-jia Chen Ke-Da Chen Zhejiang Chinese Medical University Hangzhou 310053China Shulan International Medical College Zhejiang Shuren UniversityHangzhou 310015China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China

Background:Hepatocellular carcinoma(HCC)has a poor long-term *** competition of circular RNAs(circRNAs)with endogenous RNA is a novel tool for predicting HCC *** on the alterations of circRNA regulatory networks,the analysis of gene modules related to HCC is ***:Multiple expression datasets and RNA element targeting prediction tools were used to construct a circRNA-microRNA-mRNA network in *** function,pathway,and protein interaction analyses were performed for the differentially expressed genes(DEGs)in this regulatory *** the proteinprotein interaction network,hub genes were identified and subjected to regression analysis,producing an optimized four-gene signature for prognostic risk stratification in HCC ***-HCC drugs were excavated by assessing the DEGs between the low-and high-risk groups.A circRNA-microRNA-hub gene subnetwork was constructed,in which three hallmark genes,KIF4A,CCNA2,and PBK,were subjected to functional enrichment ***:A four-gene signature(KIF4A,CCNA2,PBK,and ZWINT)that effectively estimated the overall survival and aided in prognostic risk assessment in the The Cancer Genome Atlas(TCGA)cohort and International Cancer Genome Consortium(ICGC)cohort was *** inhibitors,PI3K inhibitors,HDAC inhibitors,and EGFR inhibitors were predicted as four potential mechanisms of drug action(MOA)in high-risk HCC *** analysis has revealed that PBK,CCNA2,and KIF4A play a crucial role in regulating the tumor microenvironment by promoting immune cell invasion,regulating microsatellite instability(MSI),and exerting an impact on HCC ***:The present study highlights the role of the circRNA-related regulatory network,identifies a four-gene prognostic signature and biomarkers,and further identifies novel therapy for HCC.

关键词： Hepatocellular carcinoma circRNA-related ceRNA network Biomarker Least absolute shrinkage and selection operator Bioinformatics

Rogue wave solutions and rogue-breather solutions to the focusing nonlinear Schr?dinger equation

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Communications in Theoretical Physics 2024年第3期76卷 33-41页

作者： Si-jia Chen Xing Lü College of Science Tianjin University of TechnologyTianjin 300384People's Republic of China Department of Mathematics Beijing Jiaotong UniversityBeijing 100044People's Republic of China Beijing Laboratory of National Economic Security Early-warning Engineering Beijing Jiaotong UniversityBeijing 100044People's Republic of China

Based on the long wave limit method,the general form of the second-order and third-order rogue wave solutions to the focusing nonlinear Schr?dinger equation are given by introducing some arbitrary *** interaction solutions between the first-order rogue wave and one-breather wave are constructed by taking a long wave limit on the two-breather *** applying the same method to the three-breather solutions,two types of interaction solutions are obtained,namely the first-order rogue wave and two breather waves,the second-order rogue wave and one-breather wave,*** influence of the parameters related to the phase on the interaction phenomena is graphically *** occur among the rogue waves and breather *** the collisions,the shape of them remains *** abundant interaction phenomena in this paper will contribute to a better understanding of the propagation and control of nonlinear waves.

关键词： nonlinear Schrodinger equation rogue wave solutions interaction solutions

Big Theta Equals Small Theta Generically

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Acta Mathematica Sinica,English Series 2024年第3期40卷 717-730页

作者： Rui CHEN jia Liang ZOU Institute for Advanced Study in Mathmatics Zhejiang UniversityHangzhou 310058P.R.China Department of Mathematics University of Michigan530 Church StAnn ArborMI 48109USA

In this paper we consider the theta correspondence over a non-Archimedean local *** the homological method and the theory of derivatives,we show that under a mild condition the bigtheta lift is irreducible.

关键词： Theta correspondence derivatives