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Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： Qian Yin Fan Wen Zhigang Tao Hai pu Tianci Deng Yaoyao Meng Qingbin Meng Hongwen Jing Bo Meng jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

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传统食品源乳酸菌对酸面团面包风味的影响

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粮油食品科技 2024年第2期32卷 65-73页

作者：杨海莺卢玉张春强姚倩儒李佳璞牛兴和李慧中粮营养健康研究院有限公司老年营养食品研究北京市工程实验室营养健康与食品安全北京市重点实验室北京102209 南京财经大学食品科学与工程学院/江苏省现代粮食流通与安全协同创新中心江苏南京210023 中粮麦芽(大连)有限公司辽宁大连116200 北京农学院北京100020

乳酸菌在酸面团制作中扮演着重要角色,对其风味等品质有显著影响。不同种类的乳酸菌在性能上存在差异,为了选育特色酸面团用乳酸菌发酵剂,开发差异化酸面团面包,本研究对来自不同种类传统发酵食品中的乳酸菌,进行糖代谢能力、产有机酸... 详细信息

乳酸菌在酸面团制作中扮演着重要角色,对其风味等品质有显著影响。不同种类的乳酸菌在性能上存在差异,为了选育特色酸面团用乳酸菌发酵剂,开发差异化酸面团面包,本研究对来自不同种类传统发酵食品中的乳酸菌,进行糖代谢能力、产有机酸能力及风味特征评估,并验证其对酸面团和面包风味的影响。结果显示,有6株乳酸菌具有较强的糖代谢能力和产酸性能,风味特征优良。其产生的挥发性风味物质主要包括醇类、酯类、酮类、醛类、酸类和其他类化合物。其中有2株植物乳杆菌可为酸面团面包贡献酸味、果味和酒酿味等特殊风味。这些筛选出的菌株为开发具有特征性香气成分的酸面团发酵剂提供了资源,具有工业应用潜力。

关键词：乳酸菌酸面团风味物质糖代谢能力产有机酸能力面包

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可降解药物控释系统的药物扩散系数表征

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西安科技大学学报 2018年第6期38卷 1021-1026页

作者：高扬李佳璞杨来侠徐超董贵荣西安科技大学机械工程学院陕西西安710054 西安理工大学高等技术学院陕西西安710082

为实现药物的长期稳定释放并提高药物利用率,提出了一种以聚乳酸-聚羟基乙酸(PLGA)为载药基体的新型植入式药物控释系统。该药物控释系统可埋植在病灶附近进行长期释药,在药物释放结束后药物载体自然降解。为研究该药物控释系统的释药性... 详细信息

为实现药物的长期稳定释放并提高药物利用率,提出了一种以聚乳酸-聚羟基乙酸(PLGA)为载药基体的新型植入式药物控释系统。该药物控释系统可埋植在病灶附近进行长期释药,在药物释放结束后药物载体自然降解。为研究该药物控释系统的释药性能,建立其药物释放模型、模拟释药过程是有效方法之一,但在建立药物释放模型过程中,不断降解的PLGA材料特性难以量化。文中提出了一种使用扩散系数来表征PLGA材料的降解溶蚀程度的方法,在37℃下使用生理盐水模拟体液,对50/50、65/35及75/25三种单体比例的PLGA材料进行吸水实验和降解实验,并制备全封装药物控释系统进行了体外释药实验。通过实验结果的对比并基于物质守恒与传递定理,推导了封装药物在PLGA载药基体中释放时扩散系数的分段表达函数。基于该扩散系数表达函数,建立了药物通过该给药系统释放的有限元模型;使用有限元模型模拟药物的释放过程,并将有限元模拟结果与该药物控释系统体外释药实验结果进行了对比。结果表明,药物控释系统累积释药量呈线性变化,有限元模型模拟结果与体外释药实验结果基本吻合,验证了药物在PLGA材料中扩散系数分段表达式及有限元释药模型的正确性。该研究为后期建立药物释放的解析模型提供了一定的理论基础。

关键词：机械工程可降解材料给药系统体外释药扩散系数

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng li Hai-Wei pu Xin-Yian Guo jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao lin Changzhou Ying Xiaoli Si Naijia Xue Yi liu Ran Zheng Ying Chen jiali pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

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Potassium ions and cyano group modified g-C3N4 for effective generation of H2O2 through two-electron oxygen reduction

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Science China Chemistry 2025年第1期68卷 192-200页

作者： Dongying Wang Shulan pu Yongmin Chen Ke Lei Yujie Duan linjiao Mao Xuhui Zeng Xi Luo Yuntao Zhang Yuqin Dong Jin Zhong Zhang Yan Sun School of Mechanical Engineering Chengdu University Department of Chemistry and Biochemistry University of California

Potassium ions （K+） doped graphitic carbon nitride （g-C3N4） was prepared by a thermal etching method using potassium hydroxide （KOH） as an ion *** transform infrared spectroscopy （FTIR） and X-ray photoelectron spectroscopy （XPS）results showed that the generation of the cyano group was detected while introducing K+.Under simulated sunlight irradiation,the sample with a K+doping amount of 10%showed the highest hydrogen peroxide （H2O2） generation rate of2,140.2μmol *** apparent quantum yield （AQY） at 400 nm and the solar-to-chemical conversion （SCC） are 4.35%and1.23%,respectively.K+acted as a bridge between g-C3N4layers,which enhanced charge transfer ***,the cyano group enhanced the adsorption capacity of protons （H+） and promoted the yield of *** catalyst exhibited excellent photocatalytic stability based on four-cycle *** addition,a mechanism study showed that superoxide radicals （·O2-）were the most important active species in the reaction *** production of H2O2was achieved through consecutive single-electron *** study deepens the understanding of the oxygen reduction reaction process and opens up a new venue for improving H2O2generation.

关键词： photocatalysis hydrogen peroxide oxygen reduction reaction potassium doping cyano group

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成人气管支气管异物2222例临床Meta分析

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中华肺部疾病杂志（电子版） 2018年第2期11卷 195-199页

作者：贾卫红李建英卜丽娜西安市第三医院呼吸内科陕西710083

目的探讨我国成人气管支气管异物患者的临床特点和支气管镜下治疗的有效性和安全性。方法将1986年6月至2016年6月治疗的2 222例成人气管支气管异物患者的临床资料进行回顾性分析。结果成人气管支气管异物2 222例,男性1 520例,女性702例... 详细信息

目的探讨我国成人气管支气管异物患者的临床特点和支气管镜下治疗的有效性和安全性。方法将1986年6月至2016年6月治疗的2 222例成人气管支气管异物患者的临床资料进行回顾性分析。结果成人气管支气管异物2 222例,男性1 520例,女性702例。1 318例患者否认异物坠积。1 950例患者无基础疾病。1 952例(87.84%)患者接受局部麻醉下支气管镜镜下治疗,成功取出气道异物。主要的临床症状为咳嗽1 625例(73.1%)。异物来源为动物骨骼1 036例(46.6%),果肉、果核类358例(16.1%),金属异物122例(5.49%),义齿和破损牙齿136例(6.12%)。异物引发的并发症有阻塞性肺炎740例(33.3%),肺不张340例(15.3%)。操作过程中及治疗完成后气道内出血143例(6.43%)。3例患者死于窒息。结论成人的气管支气管异物没有典型的临床症状;在表面麻醉下经支气管镜取出成人气管支气管异物是有效的、安全的。

关键词：气管支气管异物成年人支气管镜

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Constraint and Mobility Change Analysis of Rubik’s Cube-inspired Reconfigurable Joints and Corresponding Parallel Mechanisms

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Chinese Journal of Mechanical Engineering 2020年第5期33卷 51-61页

作者： Duanling li pu jia jiazhou li Dan Zhang Xianwen Kong School of Automation Beijing University of Posts and TelecommunicationsBeijing 100876China College of Mechanical and Electrical Engineering Shaanxi University of Science and TechnologyXi’an 712000China Beijing Post Intelligent Equipment Engineering Technology Research Center Beijing 100876China Department of Mechanical Engineering York UniversityTorontoCanada School of Engineering and Physical Sciences Heriot-Watt UniversityEdinburgh EH144ASUK.

The current research of reconfigurable parallel mechanism mainly focuses on the construction of reconfigurable *** with the method of changing the mobility by physical locking joints,the geometric constraint has good controllability,and the constructed parallel mechanism has more configurations and wider application *** paper presents a reconfigurable axis(rA)joint inspired and evolved from Rubik’s Cubes,which have a unique feature of geometric and physical constraint of axes of *** effectiveness of the rA joint in the construction of the limb is analyzed,resulting in a change in mobility and topology of the parallel *** rA joint makes the angle among the three axes inside the groove changed *** change in mobility is completed by the case illustrated by a 3(rA)P(rA)reconfigurable parallel mechanism having variable mobility from 1 to 6 and having various special configurations including pure translations,pure *** underlying principle of the metamorphosis of this rA joint is shown by investigating the dependence of the corresponding screw system comprising of line vectors,leading to evolution of the rA joint from two types of spherical joints to three types of variable Hooke joints and one revolute *** reconfigurable parallel mechanism alters its topology by rotating or locking the axis of rA joint to turn all limbs into different *** prototype of reconfigurable parallel mechanism is manufactured and all configurations are enumerated to verify the validity of the theoretical method by physical experiments.

关键词： Reciprocal screws Reconfigurable-axis(rA)joint Metamorphic parallel mechanism Constraint analysis

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机械插秧密度和氮肥运筹对两优1528群体动态和产量的影响

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杂交水稻 2011年第6期26卷 69-73页

作者：程建平张再君赵锋汪光友杨如辉李家普王启均湖北省农业科学院粮食作物研究所湖北武汉430064 南漳县农业局湖北南漳441500 湖北省农业机械管理局湖北武汉430070 南漳县农业机械管理局湖北南漳441500 贵州省烟草公司遵义市公司贵州遵义563000

研究了机插条件下不同的栽植密度、氮肥使用量和氮肥中基、蘖、穗肥不同的用量比例对两系杂交水稻两优1528群体动态、产量构成以及生育进程。结果表明,两优1528分别在机插密度为24.0万穴/hm2、氮肥用量247.5 kg/hm2以及基、蘖、穗肥比例... 详细信息

研究了机插条件下不同的栽植密度、氮肥使用量和氮肥中基、蘖、穗肥不同的用量比例对两系杂交水稻两优1528群体动态、产量构成以及生育进程。结果表明,两优1528分别在机插密度为24.0万穴/hm2、氮肥用量247.5 kg/hm2以及基、蘖、穗肥比例为5∶3∶2时产量最高。栽植密度过大,无效分蘖增多,每穗总粒数减少,密度过小则群体总量较小,有效穗不足;氮肥用量达247.5 kg/hm2时虽然产量最高,但氮肥偏生产力(PPN)较低,而氮肥用量202.5 kg/hm2可获得较高的产量和氮肥偏生产力。

关键词：两系杂交水稻两优1528 机械插秧栽植密度氮肥运筹群体动态产量

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Distributionally robust optimization model of active distribution network considering uncertainties of source and load

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Journal of Modern Power Systems and Clean Energy 2019年第6期7卷 1585-1595页

作者： Lei DONG jia li Tianjiao pu Naishi CHEN Power System Research Institute North China Electric Power UniversityBeijing 102206China China Electric Power Research Institute Beijing 100192China

To ensure the safety and reliability of the distribution network and adapt to the uncertain development of renewable energy sources and loads,a two-stage distributionally robust optimization model is proposed for the active distribution network(ADN)optimization problem considering the uncertainties of the source and load in this *** establishing an ambiguity set to capture the uncertainties of the photovoltaic(PV)power,wind power and load,the piecewise-linear function and auxiliary parameters are introduced to help characterize the probability distribution of uncertain *** optimization goal of the model is to minimize the total expected cost under the worst-case distribution in the ambiguity *** first-stage expected cost is obtained based on the predicted value of the uncertainty *** second-stage expected cost is based on the actual value of the uncertainty variable to solve the first-stage *** generalized linear decision rule approximates the two-stage optimization model,and the affine function is introduced to provide a closer approximation to the second-stage optimization ***,the improved IEEE 33-node and IEEE 118-node systems are simulated and analyzed with deterministic methods,stochastic programming,and robust optimization methods to verify the feasibility and superiority of the proposed model and algorithm.

关键词： Active distribution network(ADN) Source-load uncertainty Two-stage distributionally robust optimization Ambiguity set Generalized linear decision rule

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