检索结果-南通市图书馆

维普期刊数据库

Disubstituted quinazoline derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA

在线全文

学校读者我要写书评

暂无评论

Disubstituted quinazoline derivatives as a new type of highl...

Temporal and spatial regulation of biomimetic vascularization in 3D-printed skeletal muscles

2011年全国药物化学学术会议——药物的源头创新

作者： Zeng Li,Tian-Miao Ou,jia-heng tan,Jin-Hui He,Yi Long,Ding Li,~* Lian-Quan Gu,Zhi-Shu Huang~* School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou University City,Waihuan East Road 132,Guangzhou 510006,People''s Republic of China.

＜正＞A series of 2,4-disubstituted quinazoline derivatives with one imitative tetracyclic aromatic plane formed through intramolecular hydrogen bond and two positively charged side chains found to be a new type of highly selective ligand to bind with telomeric G-quadruplex DNA,and their biological properties were reported for the first *** interactions with telomeric

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2024年第5期7卷 597-610页

作者： Minxuan jia Tingting Fan tan jia Xin Liu heng Liu Qi Gu Key Laboratory of Organ Regeneration and Reconstruction State Key Laboratory of Membrane BiologyInstitute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Orthopaedics Beijing Jishuitan HospitalCapital Medical UniversityBeijing 100035China

In the intricate skeletal muscle tissue,the symbiotic relationship between myotubes and their supporting vasculature is pivotal in delivering essential oxygen and *** study explored the complex interplay between skeletal muscle and endothelial cells in the vascularization ofmuscle *** harnessing the capabilities of three-dimensional(3D)bioprinting and modeling,we developed a novel approach involving the co-construction of endothelial and muscle cells,followed by their subsequent *** findings highlight the importance of the interaction dynamics between these two cell ***,introducing endothelial cells during the advanced phases of muscle differentiation enhanced myotube ***,it stimulated the development of the vascular network,paving the way for the early stages of vascularized skeletal muscle *** methodology proposed in this study indicates the potential for constructing large-scale,physiologically aligned skeletal ***,it highlights the need for exploring the delicate equilibrium and mutual interactions between muscle and endothelial *** on the multicell-type interaction model,we can predict promising pathways for constructing even more intricate tissues or organs.

关键词： Skeletal muscle Vascularization 3D bioprinting Cell interaction

维普期刊数据库

Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： Lei Xue Tong Shi Chenhui Han heng Zhang Fenrong Liu Haorun Li Yan Wang Xiaojun Gu Shanghong Zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Oxygen vacancy Hydrocarbon production Reaction mechanism

16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu Xu Shaocong Yan Ting Liang jia jia Shengjie Yuan Dongxing Kou Zhengji Zhou Wenhui Zhou Yafang Qi Yuena Meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： CIGS solar cells Solution-processed method Ag doping Crystal growth Defects engineering

C-5-methyl-cytosine stabilizing G-quadruplex DNA in bcl-2 promoter

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

C-5-methyl-cytosine stabilizing G-quadruplex DNA in bcl-2 pr...

Enhanced post-combustion CO2 capture and direct air capture by plasma surface functionalization of graphene adsorbent

2011年全国药物化学学术会议——药物的源头创新

作者： Jing Lin,Jin-qiang Hou,Han-dan Xiang,Yi-yong Yan,Yu-chao Gu,jia-heng tan,Ding Li,Lian-quan Gu, Tian-miao Ou,and Zhi-shu Huang~* Inistitute of Medicinal Chemistry,School of Pharmaceutical Sciences,Sun Yat-sen University, Guangzhou University City,Waihuan East Road 132,Guangzhou 510006

＜正＞The epigenetic modification of gene-5-C-methylation of cytosine plays significance roles in regulating gene transcription through DNA hypermethylation or ***,the molecular details on how DNA methylated state regulates gene expression is not well understood. In the present work,we hypothesized a potential molecular mechanism for explaining this question,which is associated with the G-quadruplex,a special DNA secondary structure,which in most cases,acts as an impediment to gene ***,we demonstrated that methylation induced a conformational transition of the G-quadruplex formed by the P1 promoter of bcl-2 and increased the stability of this ***,cytosine methylation enhanced G-quadruplex’s competition with duplex formation as well as the ability to arrest the polymerase in *** results suggested that one possible mechanism of cytosine methylation to suppress gene transcription is achieved through stabilizing the blockader-G-quadruplex in the promoters of human genes.

关键词： Cytosine DNA methylation G-quadruplex

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 653-664页

作者： Rahul Navik Eryu Wang Xiao Ding Huang Yunyi Yiyu Liu jia Li Guangdong-Hong Kong Joint Laboratory for Carbon Neutrality Jiangmen Laboratory of Carbon and Science and Technology Guangzhou HKUST Fok Ying Tung Research Institute The Hong Kong University of Science and Technology (Guangzhou) Carbon Neutrality and Climate Change Thrust Society Hub The Hong Kong University of Science and Technology (Guangzhou) Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University

Graphene has enormous potential to capture CO2due to its unique properties and ***,graphene-based adsorbents have drawbacks of lower CO2adsorption capacity and poor *** work demonstrates a one-step rapid and sustainable N2/H2plasma treatment process to prepare graphene-based sorbent material with enhanced CO2adsorption *** treatment directly enriches amine species,increases surface area,and improves textural *** CO2adsorption capacity increases from 1.6 to 3.3 mmol/g for capturing flue gas,and from 0.14 to 1.3 mmol/g for direct air capture （DAC）.Importantly,the electrothermal property of the plasma-modified aerogels has been significantly improved,resulting in faster heating rates and significantly reducing energy consumption compared to conventional external heating for regeneration of *** aerogels display improved selectivity of 42 and 87 after plasma modification for 5 and 10 min,*** plasma-treated aerogels display minimal loss between 17%and 19% in capacity after 40 adsorption/desorption cycles,rendering excellent *** N2/H2plasma treatment of adsorbent materials would lower energy expenses and prevent negative effects on the global economy caused by climate change.

关键词： Carbon neutrality CO 2 capture Climate change Plasma treatment Graphene aerogel

数字赋能乡村教育现代化的实然困境与优化路径

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

教学与管理 2025年第1期 6-11页

作者：王倩吴家华胡恒钊安徽大学马克思主义学院合肥230601 江西农业大学马克思主义学院南昌330045

以数字赋能为发展契机,推进乡村教育现代化是中国式教育现代化的必然要求,也是乡村全面振兴的重要依托。在教育领域,数字技术蕴含着驱动乡村教育现代化发展的重要价值,能够有效扩大优质教育资源的覆盖范围、变革乡村教育形态、推动乡土... 详细信息

以数字赋能为发展契机,推进乡村教育现代化是中国式教育现代化的必然要求,也是乡村全面振兴的重要依托。在教育领域,数字技术蕴含着驱动乡村教育现代化发展的重要价值,能够有效扩大优质教育资源的覆盖范围、变革乡村教育形态、推动乡土文化的交流传播。但在推动数字赋能乡村教育现代化的实践中,面临着数字教育观念淡薄、数字基础条件不足、师生数字素养薄弱等现实阻碍,迫切需要从重塑价值观念、完善数字设施、培养师生数字素养、加强体制建设入手,为数字赋能乡村教育现代化发展注入新动力,以适应中国式教育现代化发展的新生态。

关键词：数字赋能乡村教育中国式教育现代化乡土文化

Natural products and their derivatives as G-quadruplex binding ligands

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2013年第10期56卷 1351-1363页

作者： SHAN Chan tan jia-heng OU Tian-Miao HUANG Zhi-Shu School of Pharmaceutical Sciences Sun Yat-sen University

G-quadruplexes comprise a class of secondary structures that are formed in guanine-rich sequences in eukaryotic genomes and play a crucial role in the regulation of many biological events.G-quadruplexes have become targets for anticancer drugs with high selectivity *** DNA and low cytotoxicity against normal *** products and their derivatives display polymorphism,structural complexity,and potent *** is,therefore,reasonable to seek ligands targeting G-quadruplexes from natural ***,many successful examples have been reported,showing ligands with excellent anticancer *** this review,we summarized the development of research on natural products and derivatives that target G-quadruplex structures in an effort to guide future studies.

关键词： G-quadruplex binding ligands natural products derivatives

维普期刊数据库

Laparoscopic liver resection utilizing the ventral avascular area of the inferior vena cava:A retrospective cohort study

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第1期31卷 42-57页

作者： Kun Huang Zhu Chen heng Xiao Hai-Yang Hu Xing-Yu Chen Cheng-You Du Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400000China Department of General Surgery Mianyang Hospital of Traditional Chinese MedicineMianyang 621000Sichuan ProvinceChina

BACKGROUND Laparoscopic liver resection(LLR)can be challenging due to the difficulty of establishing a retrohepatic tunnel under *** the third hepatic hilum before parenchymal transection often leads to significant liver mobilization,tumor compression,and bleeding from the short hepatic veins(SHVs).This study introduces a novel technique utilizing the ventral avascular area of the inferior vena cava(IVC),allowing SHVs to be addressed after parenchymal transection,thereby reducing surgical complexity and improving outcomes in in situ *** To introduce and evaluate a novel LLR technique using the ventral avascular area of the IVC and compare its short-term outcomes with conventional *** The clinical cohort data of patients with pathologically confirmed hepatocellular carcinoma or intrahepatic cholangiocarcinoma who underwent conventional LLR and novel LLR between July 2021 and July 2023 at the First Affiliated Hospital of Chongqing Medical University were retrospectively *** novel LLR,we initially separated the caudate lobe from the IVC using dissecting forceps along the ventral avascular area of the ***,we transected the parenchyma of the left and right caudate lobes from the caudal side to the cephalic side using the avascular area as a ***,we addressed the SHVs and finally dissected the root of the right hepatic vein or left hepatic *** short-term postoperative outcomes and oncological results of the two approaches were evaluated and *** A total of 256 patients were included,with 150(58.59%)undergoing conventional LLR and 106(41.41%)undergoing novel *** novel technique resulted in significantly larger tumor resections(6.47±2.96 cm vs 4.01±2.33 cm,P<0.001),shorter operative times(199.57±60.37 minutes vs 262.33±83.90 minutes,P<0.001),less intraoperative blood loss(206.92±37.09 mL vs 363.34±131.27 mL,P<0.001),and greater resection volume(345.11±31.40 mL vs 264.38±31.98 mL,P<0.001)comp

关键词： Laparoscopic liver resection Inferior vena cava Retrohepatic tunnel Short hepatic veins Complex liver tumors Intraoperative bleeding control