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Rare earth-based MOF@mesoporous silica nanoplatform for long-term and luminescence trackable chemotherapy

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Rare Metals 2022年第8期41卷 2701-2710页

作者： Lu-Min Wang Wen-Yan liu Ming-Liang Hu jia-Sai Yao Ping Wang jia-hao liu Miao He Yi Gao Zhen-Xing Li Gastroenterology Department The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710004China Digestive Diseases in Precision Medicine Institute The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710004China State Key Laboratory of Heavy Oil Processing College of New Energy and MaterialsChina University of Petroleum(Beijing)Beijing102249China

Developing the multifunctional nanocarriers for long-term drug release and luminescence traceability is a challenging *** this task,we designed a novel nanoplatform for long-term and luminescence trackable chemotherapy,which is prepared via a hollow ZIF-8(where ZIF is zeolitic imidazolate frameworks)coated by the Eu^(3+)-doped mesoporous silica(ZIF-8@mesoporous silica).The hollow ZIF-8 is used as a drug library for loading the anticancer drug,and the pH-sensitive properties of ZIF-8 can targeted-release drugs in the tumor and cut down the poisonousness of drugs to normal *** shell layer of mesoporous silica can achieve the long-term drug release,which solves the problem of short drug circulation time in the body,reduces the drug administration frequency,and improves the therapeutic ***,the ZIF-8@mesoporous+doxorubicin(DOX)is injected only once during the 14-day *** addition,Eu^(3+)doped in mesoporous silica ensures luminescence tracking and detection of drug pathways in living ***,this nanoplatform provides a whole new strategy for the longterm treatment of tumors.

关键词： Rare earth ZIF-8 Mesoporous silica Long-term chemotherapy Luminescence traceability Nanocarrier

Anderson Acceleration of Gradient Methods with Energy for Optimization Problems

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1299-1318页

作者： Hailiang liu jia-hao He Xuping Tian Department of Mathematics Iowa State UniversityAmesIAUSA Department of Agricultural and Biosystems Engineering Iowa State UniversityAmesIAUSA

Anderson acceleration(AA)is an extrapolation technique designed to speed up fixed-point *** optimization problems,we propose a novel algorithm by combining the AA with the energy adaptive gradient method(AEGD)[arXiv:2010.05109].The feasibility of our algorithm is ensured in light of the convergence theory for AEGD,though it is not a fixed-point *** provide rigorous convergence rates of AA for gradient descent(GD)by an acceleration factor of the gain at each implementation of *** experimental results show that the proposed AA-AEGD algorithm requires little tuning of hyperparameters and exhibits superior fast convergence.

关键词： Anderson acceleration(AA) Gradient descent(GD) Energy stability

Flow characterization of macroporous W-4.8 vol.%ZrO2 alloy during hot deformation with improved constitutive equation and processing maps

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Tungsten 2024年第3期6卷 610-620页

作者： jia-hao Ye liu-Jie Xu Ji-Kang Hu School of Materials Science and Engineering Henan University of Science and Technology National Joint Engineering Research Center for Abrasion Control and Molding of Metal Materials Henan University of Science and Technology

In this work,isothermal compression experiments of macroporous W-4.8 vol.%ZrO2（W-4.8ZrO2） at 1300-1600℃ and strain rate of 0.005-1 s-1were carried out on a Gleeble-1500D thermo-mechanical *** dynamic recovery of W-4.8ZrO2is the main "softening" *** the basis of Arrhenius model,the initial constitutive equation is established by exploring the influence of temperature,strain rate and rheological *** on Arrhenius model,the relationship between flow stress,strain rate and deformation temperature is *** the influence of strain,the improved constitutive equation and the law of material constant changing with the strain are *** that,the hot processing maps were drawn on the basis of the dynamic material model,which is used to analyze the instability mechanism of the W-4.8ZrO2,and determine the appropriate hot working process parameters(temperature:1350-1450℃,strain rate:0.1-1 s-1).

关键词： Tungsten alloy Flow characteristics Constitutive equation Hot processing maps

Emerging clinical relevance of microbiome in cancer:promising biomarkers and therapeutic targets

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Protein & Cell 2024年第4期15卷 239-260页

作者： jia-hao Dai Xi-Rong Tan Han Qiao Na liu State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510050China

The profound influence of microbiota in cancer initiation and progression has been under the spotlight for years,leading to numerous researches on cancer microbiome entering clinical *** promising biomarkers and therapeutic targets,the critical involvement of microbiota in cancer clinical practice has been increasingly ***,recent progress in this field is *** describe the potential of tumor-associated microbiota as effective diagnostic and prognostic biomarkers,*** addition,we highlight the relationship between microbiota and the therapeutic efficacy,toxicity,or side effects of commonly utilized treatments for cancer,including chemotherapy,radiotherapy,and *** that microbial factors influence the cancer treatment outcome,we further summarize some dominating microbial interventions and discuss the hidden risks of these *** review aims to provide an overview of the applications and advancements of microbes in cancer clinical relevance.

关键词： microbiome cancer diagnosis prognosis therapy

Skyrmion transport driven by pure voltage generated strain gradient

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Chinese Physics B 2022年第11期31卷 566-570页

作者： Shan Qiu jia-hao liu Ya-Bo Chen Yun-Ping Zhao Bo Wei Liang Fang Institute for Quantum Information&State Key Laboratory of High Performance Computing College of ComputerNational University of Defense TechnologyChangsha 410073China Hunan University of Humanities Science and Technology Loudi 417000China

The magnetic skyrmion transport driven by pure voltage-induced strain gradient is proposed and studied via micromagnetic *** combining the skyrmion with multiferroic heterojunction,a voltage-induced uniaxial strain gradient is adjusted to move *** the system,a pair of short-circuited trapezoidal top electrodes can generate the symmetric *** to the symmetry of strain,the magnetic skyrmion can be driven with a linear motion in the middle of the nanostrip without *** calculate the strain distribution generated by the trapezoidal top electrodes pair,and further investigate the influence of the strain intensity as well as the strain gradient on the skyrmion *** findings provide a stable and low-energy regulation method for skyrmion transport.

关键词： skyrmion strain gradient multiferroic heterojunction spintronics

Morphology and phylogenetic placement of Mallomonas vietnamica(Synurales,Chrysophyceae)from China

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Journal of Oceanology and Limnology 2024年第4期42卷 1325-1335页

作者： Junxue hao Fangru NAN Junping LÜ Qi liu Xudong liu Shulian XIE jia FENG School of Life Science Shanxi UniversityTaiyuan 030006China

The newly described chrysophyte,Mallomonas vietnamica,is reported for the first time in China from specimens collected in Guizhou Province,SW *** morphological characteristics were studied using light and scanning electron *** species was described based on morphological characteristics,including cell size,scale size,dome,V-rib,and ***,molecular sequencing of *** was conducted and a phylogenetic tree was constructed based on concatenated SSU,LSU,and rbc L *** phylogenetic tree led us to suggest raising a new section named Uncatusipedae for this *** study provides new molecular data from the genus Mallomonas and enriches our understanding of the species diversity and geographical distribution of the genus Mallomonas in China.

关键词： Chrysophyta Mallomonas vietnamica phylogenetic study taxonomy

Bimetallic CoNi single atoms supported on three-dimensionally ordered mesoporous chromia: highly active catalysts for n-hexane combustion

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Green Energy & Environment 2024年第7期9卷 1122-1137页

作者： Xiuqing hao Yuxi liu Jiguang Deng Lin Jing jia Wang Wenbo Pei Hongxing Dai Beijing Key Laboratory for Green Catalysis and Separation Key Laboratory of Beijing on Regional Air Pollution Control Key Laboratory of Advanced Functional Materials Education Ministry of China Laboratory of Catalysis Chemistry and Nanoscience Department of Chemical Engineering Faculty of Environment and Life Beijing University of Technology

Developing the alternative supported noble metal catalysts with low cost,high catalytic efficiency,and good resistance toward carbon dioxide and water vapor is critically demanded for the oxidative removal of volatile organic compounds （VOCs）.In this work,we prepared the mesoporous chromia-supported bimetallic Co and Ni single-atom （Co1Ni1/meso-Cr2O3） and bimetallic Co and Ni nanoparticle (CoNPNiNP/mesoCr2O3) catalysts adopting the one-pot polyvinyl pyrrolidone （PVP）-and polyvinyl alcohol （PVA）-protecting approaches,*** results indicate that the Co1Ni1/meso-Cr2O3catalyst exhibited the best catalytic activity for n-hexane (C6H14) combustion (T50%and T90%were 239 and 263℃ at a space velocity of 40,000 mL g-1h-1;apparent activation energy and specific reaction rate at 260℃ were 54.7 kJ mol-1and 4.3×10-7mol g-1cats-1,respectively),which was associated with its higher (Cr5++Cr6+) amount,large n-hexane adsorption capacity,and good lattice oxygen mobility that could enhance the deep oxidation of n-hexane,in which Ni1was beneficial for the enhancements in surface lattice oxygen mobility and low-temperature reducibility,while Co1preferred to generate higher contents of the high-valence states of chromium and surface oxygen species as well as adsorption and activation of n-hexane.n-Hexane combustion takes place via the Mars van Krevelen（MvK） mechanism,and its reaction pathways are as follows:n-hexane→olefins or 3-hexyl hydroperoxide→3-hexanone,2-hexanone or 2,5-dimethyltetrahydrofuran→2-methyloxirane or 2-ethyl-oxetane→acrylic acid→COx→CO2and H2O.

关键词： Three-dimensional ordered mesoporous chromium oxide Supported bimetallic single-atom catalyst Cobalt−nickel single atoms n -Hexane combustion Catalytic reaction mechanism

Fermi level tuning in Sn_(1-x)Pb_(x)Te/Pb heterostructure via changing interface roughness

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 118-125页

作者： Tengteng liu Zhaoxia Yi Bangjin Xie Weiyan Zheng Dandan Guan Shiyong Wang hao Zheng Canhua liu hao Yang Yaoyi Li Jinfeng jia Key Laboratory of Artificial Structures and Quantum Control(Ministry of Education) Tsung-Dao Lee InstituteSchool of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Research Center for Quantum Sciences Shanghai 201315China Hefei National Laboratory Hefei 230088China

Superconducting SnTe-type topological crystalline insulators(TCIs)are predicted to host multiple Majorana zero modes(MZMs)which can coexist in a single *** level(FL)close to the Dirac points of topological surface states is helpful for detecting ***,the TCI SnTe is a heavily p-type semiconductor which is very difficult to modify to n-type via doping or *** this work,we fabricate the atomically flat Sn_(1-x)Pb_(x)Te/Pb heterostructure by molecular beam epitaxy,and make the p-type Sn_(1-x)Pb_(x)Te become n-type through changing the interface *** scanning tunnelling microscope,we find the Dirac points of Sn_(1-x)Pb_(x)Te/Pb heterostructure are always above the FL due to the Fermi level pinning(FLP)induced by topological surface states at atomically flat *** increasing the interface roughness,the FLP effect is suppressed and then the Dirac points of p-type Sn_(1-x)Pb_(x)Te can be tuned very close to or even below the *** work provides a new method for tuning the FL of SnTe-type TCI which has potential application in novel topological superconductor device.

关键词： topological crystalline insulator superconductor heterostructure Fermi level pinning interface roughness

Rate transient analysis methods for water-producing gas wells in tight reservoirs with mobile water

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Energy Geoscience 2024年第1期5卷 311-320页

作者： Qingyan Yu Ying jia Pengcheng liu Xiangyang Hu Shengye hao Research Institute of Petroleum Exploration and Development of SINOPEC Beijing100083China School of Energy Resources China University of GeosciencesBeijing100083China

Tight gas reservoirs with mobile water exhibit multi-phase flow and high stress *** analyzing the reservoir and well parameters using conventional single-phase rate transient analysis methods proves *** study introduces novel rate transient analysis methods incorporating evaluation processes based on the conventional flowing material balance method and the Blasingame type-curve method to examine fractured gas wells producing *** positing a gas-water two-phase equivalent homogenous phase that considers characteristics of mobile water,gas,and high stress sensitivity,the conventional single-phase rate transient analysis methods can be applied by integrating the phase's characteristics and defining the phase's normalized parameters and material balance *** rate transient analysis methods based on the equivalent homogenous phase can be used to quantitatively assess the parameters of wells and gas reservoirs,such as original gas-in-place,fracture half-length,reservoir permeability,and well drainage *** facilitates the analysis of production dynamics of fractured wells and well-controlled areas,subsequently aiding in locating residual gas and guiding the configuration of well *** specific evaluation processes are ***,a numerical simulation mechanism model was constructed to verify the reliability of the developed *** methods introduced have been successfully implemented in field water-producing gas wells within tight gas reservoirs containing mobile water.

关键词： Gas reservoirs with mobile water Gas-water two phase flow High stress sensitivity Equivalent homogenous phase Rate transient analysis