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Perioperative complication incidence and risk factors for retroperitoneal neuroblastoma in children:analysis of 571 patients

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World Journal of Pediatrics 2024年第3期20卷 250-258页

作者： Min He jia-bin cai Xuan Wu Yin-bing Tang Jin-Yan Wang Jun-Qin Mao Ji-Jun Chen Li-Feng Zhang Zhong-Hai Guan Jie-Ni Xiong Wan-Xin Peng Jin-Hu Wang Ting Tao Pediatric Cancer Research Center National Clinical Research Center for Child HealthHangzhouChina Department of Surgical Oncology Children's HospitalZhejiang University School of MedicineHangzhouChina Cancer Center Zhejiang UniversityNo.3333 Binsheng RodeHangzhouChina

Background Surgery plays an important role in the treatment of *** complications may impact the course of neuroblastoma *** date,comprehensive analyses of complications and risk factors have been *** Patients with retroperitoneal neuroblastoma undergoing tumor resection were retrospectively analyzed between 2014 and *** data collected included clinical characteristics,operative details,operative complications and postopera-tive *** factors for perioperative complications of retroperitoneal neuroblastoma were *** A total of 571 patients were enrolled in this *** complications were observed in 255(44.7%)*** leakage(28.4%),diarrhea(13.5%),and injury(vascular,nerve and organ;7.5%)were the most frequent *** were three operation-related deaths(0.53%):massive hemorrhage(n=1),biliary tract perforation(n=1)and intestinal necrosis(n=1).The presence of image-defined risk factors(IDRFs)[odds ratio(OR)=2.09,P<0.01],high stage of the International Neuroblastoma Risk Group staging system(INRGSS)(OR=0.454,P=0.04),retroperitoneal lymph node metastasis(OR=2.433,P=0.026),superior mesenteric artery encasement(OR=3.346,P=0.003),and inferior mesenteric artery encasement(OR=2.218,P=0.019)were identified as independent risk factors for perioperative *** Despite the high incidence of perioperative complications,the associated mortality rate was quite ***-perative complications of retroperitoneal neuroblastoma were associated with IDRFs,INRGSS,retroperitoneal lymph node metastasis and vascular *** with high-risk factors should receive more serious attention during surgery but should not discourage the determination to pursue total resection of neuroblastoma.

关键词： Complication Neuroblastoma Risk factors Surgery

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Ferroptosis inhibitors reduce celastrol toxicity and preserve its insulin sensitizing effects in insulin resistant HepG2 cells

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Journal of Integrative Medicine 2024年第3期22卷 286-294页

作者： jia-jia Liu Xue Zhang Bang-lan cai Man-man Qi Yong-bin Chi bin Peng Deng-hai Zhang School of Medicine Shanghai UniversityShanghai 200444China Shanghai Health Commission Key Lab of Artificial Intelligence-Based Management of Inflammation and Chronic Diseases Shanghai Pudong Gongli HospitalSecondary Military Medical UniversityShanghai 200135China School of Basic Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

Objective:Research has shown that celastrol can effectively treat a variety of diseases,yet when passing a certain dosage threshold,celastrol becomes toxic,causing complications such as liver and kidney damage and erythrocytopenia,among *** this dichotomy in mind,it is extremely important to find ways to preserve celastrol’s efficacy while reducing or preventing its ***:In this study,insulin-resistant Hep G2(IR-Hep G2)cells were prepared using palmitic acid and used for in vitro ***-Hep G2 cells were treated with celastrol alone or in combination with Nacetylcysteine(NAC)or ferrostatin-1(Fer-1)for 12,24 or 48 h,at a range of *** counting kit-8assay,Western blotting,quantitative reverse transcription-polymerase chain reaction,glucose consumption assessment,and flow cytometry were performed to measure celastrol’s cytotoxicity and whether the cell death was linked to ***:Celastrol treatment increased lipid oxidation and decreased expression of anti-ferroptosis proteins in IR-Hep G2 *** downregulated glutathione peroxidase 4(GPX4)m *** docking models predicted that solute carrier family 7 member 11(SLC7A11)and GPX4 were covalently bound by ***,we found for the first time that the application of ferroptosis inhibitors(especially NAC)was able to reduce celastrol’s toxicity while preserving its ability to improve insulin sensitivity in IR-Hep G2 ***:One potential mechanism of celastrol’s cytotoxicity is the induction of ferroptosis,which can be alleviated by treatment with ferroptosis *** findings provide a new strategy to block celastrol’s toxicity while preserving its therapeutic effects.

关键词： Celastrol Insulin resistance Ferroptosis N-Acetylcysteine Palmitic acid Molecular docking

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Pathway Planning of Nuclear Power Development Incorporating Assessment of Nuclear Event Risk

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 500-513页

作者： Xinxin Yang Yusheng Xue bin cai School of Electrical Engineering Southeast UniversityNanjingChinaand they are also with State Grid Electric Power Research Institute(NARI Group Corporation)NanjingChina State Key Laboratory of Smart Grid Protection and Operation Control NanjingChina State Grid Electric Power Research Institute(NARI Group Corporation) NanjingChina

The nuclear event risk(NER)is an important and disputed factor that should be reasonably considered when planning the pathway of nuclear power development(NPD)to assess the benefits and risks of developing nuclear power more *** paper aims to explore the impact of nuclear events on NPD pathway *** influence of nuclear events is quantified as a monetary risk component,and an optimization model that incorporates the NER in the objective function is *** optimize the pathway of NPD in the lowcarbon transition course of power supply structure evolution,a simulation model is built to deduce alternative NPD pathways and corresponding power supply evolution scenarios under the constraint of an exogenously assigned carbon emission pathway(CEP);moreover,a method is proposed to describe the CEP by superimposing the maximum carbon emission space and each carbon emission reduction(CER)component,and various CER components are clustered considering the emission reduction characteristics and resource endowments of different power generation technologies.A case study is conducted to explore the impact of NER and its risk valuation uncertainty on NPD pathway *** method presented in this paper allows the impact of nuclear events on NPD pathway planning to be quantified and improves the level of coordinated optimization of benefits and risks.

关键词： Low-carbon transition power supply structure evolution nuclear power development(NPD) quantitative analysis nuclear event risk evaluation

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Gear walk instability caused by brake-disc friction characteristics

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Chinese Journal of Aeronautics 2024年第2期37卷 343-359页

作者： Xiaoqiong DU bin LI Wen cai Linyin LUO School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Department of Mechanical Engineering University of MichiganAnn Arbor 48109USA AVIC General Huanan Aircraft Industry Co.Ltd. Zhuhai 519040China

A multi-body dynamic rigid-flexible coupling model of landing gear is established to study the gear walk instability caused by the friction characteristics of the brake *** validating the model with the experimental results,the influence of the landing gear structure and braking system parameters on gear walk is further *** the above factors,the slope of the graph for the friction coefficient of the brake disc and the relative velocity of brake stators and rotors is the most influential factor on gear walk *** trajectory analysis verifies that gear walk occurs when the coupling of multiple factors causes the system to exhibit an equivalent negative damping *** consider a more realistic braking case,a back propagation neural network method is employed to describe the nonlinear behavior of the friction coefficient of the brake *** the realistic nonlinear model of the friction coefficient,the maximum error in predicting the braking torque is less than 10%and the effect of the brake disc temperature on gear walk is *** results reveal that a more negative friction slope may contribute to a more severe unstable gear walk,and reducing the braking pressure is an effective approach to avoid gear walk,which provides help for future braking system design.

关键词： Gear walk Friction characteristics of brake disc Brake-induced vibration Negative damping Rigid-flexible coupling Negative slope of braking torque

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Disentangling distinct Cu surface sites for electrocatalytic CO_(2)-to-CO and CO-to-C_(2+)conversion

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Science China Chemistry 2024年第4期67卷 1047-1048页

作者： Kun jiang Wen-bin cai Interdisciplinary Science Research Centre School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Collaborative Innovation Center of Chemistry for Energy MaterialsDepartment of ChemistryFudan UniversityShanghai 200438China

Electrochemical CO_(2)reduction reaction(CO_(2)RR)is a promising strategy to curb anthropogenic carbon emissions,for which intermittent renewable electricity could be stored as chemical energy within carbon-based fuel... 详细信息

关键词： carbon Electrochemical surface

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Intracellular redox potential-driven live-cell synthesis of CdSe quantum dots in Staphylococcus aureus

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Science China Chemistry 2024年第3期67卷 990-999页

作者： cai-Qin Wu An-An Liu Xu Li jia-Wei Tu Juan Kong Ling-Ling Yang jian-Hong jia Chuan Wang bin Hu Zhi-Xiong Xie Dai-Wen Pang The Institute for Advanced Studies College of Chemistry and Molecular SciencesCollege of Life SciencesHubei Key Laboratory of Cell HomeostasisWuhan UniversityWuhan 430072China Research Center for Analytical Sciences College of ChemistryState Key Laboratory of Medicinal Chemical BiologyTianjin Key Laboratory of Biosensing and Molecular RecognitionFrontiers Science Center for New Organic MatterFrontiers Science Center for Cell Responsesand Haihe Laboratory of Sustainable Chemical TransformationsNankai UniversityTianjin 300071China

Biosynthesized semiconductor quantum dots(QDs) have bright fluorescence,adjustable particle sizes,and environmental friendliness,endowing them with convenience and potential for biological *** to the unclear mechanism of the cellular environment on the live-cell synthesis of QDs,it is still difficult to regulate their optical ***,the critical role of the intracellular redox environment in regulating the fluorescence properties of biosynthesized CdSe QDs in Staphylococcus aureus(***) has been *** glutathione peroxidase(GPx) activity directly affects the intracellular H_(2)O_(2) produced in the SeO_(3)^(2-) reduction,which further manipulates the glutathione redox cycle to determine the content of low-valence *** a result,the fluorescence intensity of the synthesized CdSe QDs increases by 60% in the GPx overexpressed *** cellular redox potential that is controlled by the GSH redox cycle provides the driving force for the reduction of SeO_(3)^(2-),facilitating the synthesis of CdSe QDs in *** *** proposed mechanism of the cellular redox state provides a new perspective for regulating the synthesis of semiconductor nanomaterials in live cells.

关键词： redox H_(2)O_(2) peroxidase quantum dot Staphylococcus aureus

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Neoadjuvant transcatheter arterial chemoembolization and systemic chemotherapy for the treatment of undifferentiated embryonal sarcoma of the liver in children

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World Journal of Clinical Cases 2022年第19期10卷 6437-6445页

作者： Min He jia-bin cai Can Lai Jun-Qing Mao Jie-Ni Xiong Zhong-Hai Guan Lin-Jie Li Qiang Shu Mei-Dan Ying Jin-Hu Wang Department of Surgical Oncology The Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052Zhejiang ProvinceChina Department of Radiology The Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052Zhejiang ProvinceChina Cancer Center Zhejiang UniversityHangzhou 310058Zhejiang ProvinceChina

BACKGROUND Undifferentiated embryonal sarcoma of the liver(UESL)is a rare and aggressive mesenchymal tumor in ***,we describe our experience in neoadjuvant therapy(NAT)and subsequent surgery for the treatment of UESL in *** To evaluate the efficacy of NAT and explore a new choice for successful operation of UESL in *** We retrospectively analyzed six patients newly diagnosed with unresectable UESL who received NAT and then surgery at our center between January 2004 and December *** tumor was considered unresectable if it involved a large part of both lobes of the liver or had invaded the main hepatic vessels or inferior vena *** NAT included preoperative transcatheter arterial chemoembol ization(TACE)and systemic *** patients were 4 boys and 2 girls with a mean age of 7 *** longest tumor at presentation ranged from 8.6 to 14.8 cm(mean,12 cm).Extrahepatic metastases were present in 2 *** systemic chemotherapy was administered 3 wk after *** resection was performed 3 wk after one or two cycles of *** patients received systemic chemotherapy after *** All patients successfully underwent NAT and complete *** tumor volumes decreased by 18.2%–68.7%,with a mean decrease of 36%after 1 cycle of NAT(t=3.524,P=0.017).According to the Response Evaluation Criteria In Solid Tumors criteria,4 patients had a partial response and underwent surgery,while 2 had stable disease and received another cycle of NAT before *** tumor necrosis was seen on pathological examination of the surgical specimen:>90%necrosis in two,>50%necrosis in three,and 25%necrosis in 1,with an average of 71.8%.Post-NAT complications included fever,nausea and vomiting,and mild bone marrow *** alanine transaminase levels occurred in all patients,which returned to normal within 7–10 d after *** cardiac or renal toxicity,severe hepatic dysfunction,bleeding and nontarget e

关键词： Undifferentiated embryonal sarcoma of the liver Unresectable Neoadjuvant therapy Transcatheter arterial chemoembolization Systemic chemotherapy

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One-step construction of strongly coupled Co_(3)V_(2)O_(8)/Co_(3)O_(4)/MXene heterostructure via in-situ Co-F bonds for high performance all-solid-state asymmetric supercapacitors

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Rare Metals 2024年第2期43卷 682-691页

作者： Ji Zhou bin-bin Liu Hu Zheng Wen-Qing Ma Qian Li cai-Xia Xu Institute for Advanced Interdisciplinary Research(iAIR) Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of ShandongSchool of Chemistry and Chemical EngineeringUniversity of JinanJinan250022China

Co_(3)V_(2)O_(8)/Co_(3)O_(4)/Ti_(3)C_(2)T_(x) composite was easily synthesized via one-step succinct-operated hydrothermal *** interconnected Co_(3)V_(2)O_(8)/Co_(3)O_(4) nanowires network can in-situ grow and anchor on the surface of Ti_(3)C_(2)T_(x) via the strong Co-F bonds and contribute tremendously to depress Ti_(3)C_(2)T_(x) *** from the synergistically interplayed effect among the multiple interfaces and high conductivity of Ti_(3)C_(2)T_(x) as well as outstanding stability of the as-designed nanostructure,the optimum Co_(3)V_(2)O_(8)/Co_(3)O_(4)/Ti_(3)C_(2)T_(x)electrode reaches a commendable specific capacitance(up to 3800 mF·cm^(−2)),great rate capability(80%capacitance retention after 20-times current increasing),and preeminent cycling stability(95.4%/85.5%retention at 7000th/20,000th cycle).Moreover,the all-solid-state asymmetric supercapacitor based on Co_(3)V_(2)O_(8)/Co_(3)O_(4)/Ti_(3)C_(2)T_(x) and active carbon can deliver a high energy density of 84.0μWh·cm^(−2) at the power energy of 3.2 mW·cm^(−2),and excellent cycling durability with 87.0%of initial capacitance retention upon 20,000 *** work provides a practicable pathway to tailor MXene-based composites for high-performance supercapacitor.

关键词： Ti_(3)C_(2)T_(x) Co_(3)V_(2)O_(8)/Co_(3)O_(4) Heterostructure Cathode Supercapacitor

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基于事件驱动的无人机吊挂系统在线自适应轨迹规划

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控制理论与应用 2024年第5期41卷 817-828页

作者：蔡佳明鲜斌天津大学电气自动化与信息工程学院天津300072

本文针对四旋翼无人机吊挂系统空运过程中负载摆角的非线性最优调节问题,提出了一种基于事件驱动的在线自适应轨迹规划策略.在事件驱动的自适应评价网框架下,利用神经网络的逼近学习能力得到吊挂负载摆动抑制的折现最优控制律.同时结合... 详细信息

本文针对四旋翼无人机吊挂系统空运过程中负载摆角的非线性最优调节问题,提出了一种基于事件驱动的在线自适应轨迹规划策略.在事件驱动的自适应评价网框架下,利用神经网络的逼近学习能力得到吊挂负载摆动抑制的折现最优控制律.同时结合该控制律进一步规划四旋翼无人机的飞行轨迹,实现了对无人机位置的精确调节和吊挂负载摆动的快速抑制,并且显著降低了无人机机载处理器的计算负担.然后采用基于Lyapunov稳定性的分析方法,证明了神经网络输出权值估计误差一致最终有界,并证明了无人机位置跟踪误差和吊挂负载摆动运动的收敛.最后,通过飞行对比实验验证了所提出的轨迹规划策略的有效性.

关键词：轨迹规划事件驱动无人机吊挂系统摆动抑制

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Clinical experience in the treatment of children who swallowed multiple magnetic foreign bodies: A report of five cases

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World Journal of Pediatrics 2017年第3期13卷 274-277页

作者： Yue-bin Zhang Zhi-Gang Gao Qi-Xing Xiong Li-Feng Zhang Dou-Te cai jia-bin cai Department of General Surgery Children's Hospital Zhejiang University School of MedicineHangzhouChina

Background:Several clinical reports have been published on complications resulting from swallowing multiple magnetic foreign *** study aimed to summarize the clinical experience of managing children who swallowed multiple magnetic foreign ***:We reviewed the clinical records of five children who swallowed multiple magnetic foreign bodies and were admitted to our hospital during June 2012 to June *** of the patients' presentation,imaging studies,complications and treatment were ***:All five children suffered from gastrointestinal perforation and intestinal *** magnetic foreign bodies caused local bowel wall tissue ischemia necrosis and perforation as well as other complications associated with fistula *** magnets were finally removed by laparotomy ***:If magnetic foreign bodies cannot be removed by endoscopy,an operation is suggested as soon as possible to avoid serious complications.

关键词： children gastrointestinal perforation intestinal obstruction magnetic foreign bodies

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