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Science China Chemistry 2024年第9期67卷 3012-3018页

作者： jia nie Huanfeng jiang Chuanle Zhu School of Chemistry and Chemical Engineering Key Lab of Functional Molecular Engineering of Guangdong ProvinceSouth China University of TechnologyGuangzhou 510640China Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing South China University of TechnologyGuangzhou 510640China

The chemoselective epoxidation of electron-deficient olefins in the presence of electron-rich alkene moieties is *** chemoselective epoxidation strategy undergoes a conjugated olefin epoxidation and BHT hydroxylation process to give various useful oxiranes in high yields,especially for the 2-substituted ***,this protocol features mild conditions,is transition-metal free,operationally simple,and gram-scalable,and tolerates diverse functional *** candidate HSD-16 is synthesized smoothly by this *** studies indicate molecular oxygen is the terminal oxidant and the O-source of the oxiranes.

关键词： chemoselective epoxidation alkene fluorine molecular oxygen

Downside of a carbon tax for environment:Impact of information sharing

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Advances in Climate Change Research 2020年第2期11卷 92-101页

作者： nie jia-jia SHI Chun-Lai XIONG Yu XIA Sen-Mao LIANG jia-Min School of Economics and Management Southwest Jiaotong UniversityChengdu610031China Surrey Business School University of SurreyGuilfordGU27XHUK Business School Coventry UniversityCoventryCV15FBUK Newcastle Business School Northumbria UniversityNewcastleNE18STUK

Motivated by the observation that firms invest in carbon emissions reduction to decrease the cost of carbon tax as governments in numerous countries increasingly implement carbon tax to improve the environment,and broad researcher and practitioner agreement that carbon tax implementation always benefits the ***,we find that a carbon tax may actually hurt the environment based on a stylized game model with a better-informed retailer(one who controls the demand information sharing with the manufacturer)and a *** particular,we find that the carbon emissions reduction may harm the environment if the carbon tax is moderate or both the carbon tax and the demand fluctuation are *** further reveal free-riding behavior by the retailer,who may enjoy more profit sharing from the supply chain in the presence of carbon emissions *** on these observations,we argue that a carbon tax does not always benefit the environment when a manufacturer who receives demand information from the retailer responds better to market uncertainty.

关键词： Supply chain management Carbon emissions reduction Carbon tax Information sharing

Cross-Domain Authentication Scheme Based on Blockchain and Consistent Hash Algorithm for System-Wide Information Management

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Computers, Materials & Continua 2023年第11期77卷 1467-1488页

作者： Lizhe Zhang Yongqiang Huang jia nie Kenian Wang Key Laboratory of Civil Aircraft Airworthiness Technology Civil Aviation University of ChinaTianjin300000China School of Safety Science and Engineering Civil Aviation University of ChinaTianjin300000China

System-wide information management(SWIM)is a complex distributed information transfer and sharing system for the next generation of Air Transportation System(ATS).In response to the growing volume of civil aviation air operations,users accessing different authentication domains in the SWIM system have problems with the validity,security,and privacy of SWIM-shared *** order to solve these problems,this paper proposes a SWIM crossdomain authentication scheme based on a consistent hashing algorithm on consortium blockchain and designs a blockchain certificate format for SWIM cross-domain *** scheme uses a consistent hash algorithm with virtual nodes in combination with a cluster of authentication centers in the SWIM consortium blockchain architecture to synchronize the user’s authentication mapping relationships between authentication *** virtual authentication nodes are mapped separately using different services provided by SWIM to guarantee the partitioning of the consistent hash ring on the consortium *** to the dynamic change of user’s authentication requests,the nodes of virtual service authentication can be added and deleted to realize the dynamic load balancing of cross-domain authentication of different *** analysis shows that this protocol can resist network attacks such as man-in-the-middle attacks,replay attacks,and Sybil *** show that this scheme can reduce the redundant authentication operations of identity information and solve the problems of traditional cross-domain authentication with single-point collapse,difficulty in expansion,and uneven *** the same time,it has better security of information storage and can realize the cross-domain authentication requirements of SWIM users with low communication costs and system *** System-wide information management(SWIM);consortium blockchain;consistent hash;cross-domain authentication;load balancing.

关键词： System-wide information management(SWIM) consortium blockchain consistent hash cross-domain authentication load balancing

Thymine DNA glycosylase promotes transactivation of β-catenin/TCFs by cooperating with CBP

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Journal of Molecular Cell Biology 2014年第3期8卷 231-239页

作者： Yingying jia Fen nie Aiying Du Zhangcheng Chen Yuanbo Qin Tao Huang Xiaomin Song Lin Li State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of SciencesShanghai 200031 China

Thymine DNA glycosylase CrDG）, an enzyme that initiates the repair of G/T and G/U mismatches, has been lately found crucial in em- bryonic development to maintain epigenetic stability and facilitate the active DNA demethylation. Here we report a novel role of TDG in Wnt signaling as a transcriptional coactivator of β-catenin/TCFs complex. Our data show that TDG binds to the transcriptional factor family LEF1/TCFs and potentiates β-catenin/TCFs transactivation, while TDG depletion suppresses Wnt3a-stimulated reporter activity or target gene transcription. Next, we show that CBP, a known coactivator, is also required for TDG function through forming a coopera- tive complex on target promoters. Moreover, there is an elevation of TDG levels in human colon cancer tissue, and knockdown of TDG inhibits proliferation of the colon cells. Overall, our results reveal that TDG, as a new coactivator, promotes β-catenin/TCFs transacti- vation and functionally cooperates with CBP in canonical Wnt signaUng.

关键词： TDG TCF CBP Wnt signaling transactivation

WGCNA Reveals Key Roles of IL8 and MMP-9 in Progression of Involvement Area in Colon of Patients with Ulcerative Colitis

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Current Medical Science 2018年第2期38卷 252-258页

作者： Xue LIN Jin LI Qiu ZHAO Jue-rong FENG Qian GAO jia-yan nie Department of Gastroenterology Zhongnan Hospital of Wuhan University Hubei Clinical Center & Key Lab of Intestinal& Colorectal Diseases Wuhan 430071 China

Ulcerative colitis （UC） is a chronic inflammatory disease and its involvement area in colon is influenced by a complex network of gene interactions. We analyzed the weighted gene co-expression networks in mieroarray dataset from colonic mucosa of patients with UC and identified one gene co-expression module that was highly associated with the progression of involved area in UC colon （Pearson coefficient=0.81, P〈0.0001）. In total, 523 hub genes in this module were found to be involved in immune system process after enrichment analysis in Gene Ontology. By the STRING and Cytoscape analysis, we observed that interleukin-8 （IL- 8） and matrix metalloproteinase-9 （MMP-9） were centered in the network of hub genes. We then detected the expression of IL-8 and MMP-9 in mucosa from left-sided colon of patients using quantitative PCR and immunofluorescence assay respectively. Both quantitative PCR and immunofluorescence assay revealed the expression levels of IL-8 and MMP-9 were significantly different among the healthy controls, left-sided colitis group and pancolitis group （P〈0.05）. IL-8 and MMP-9 were detected with an enhanced expression in pancolitis as compared with leftsided colitis and healthy controls, respectively （P〈0.05）. This study demonstrates that immune system process is indispensable in the progression of disease in colon, and identifies that IL-8 and MMP-9 play potential critical roles for the progression.

关键词： ulcerative colitis weighted gene co-expression network analysis interleukin-8 matrix metalloproteinase-9

Alterations of gut microbiota diversity, composition and metabonomics in testosterone-induced benign prostatic hyperplasia rats

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Military Medical Research 2023年第1期10卷 1-16页

作者： Lu-Yao Li Jie Han Lan Wu Cheng Fang Wei-Guang Li jia-Min Gu Tong Deng Chang-jiang Qin jia-Yan nie Xian-Tao Zeng Center for Evidence‑Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Gastrointestinal Surgery Huaihe Hospital of Henan UniversityKaifeng 475000HenanChina Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Stomatology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Urology Zhong‑nan Hospital of Wuhan UniversityWuhan 430071China

Background: Studies had shown many diseases affect the stability of human microbiota, but how this relates to benign prostatic hyperplasia(BPH) has not been well understood. Hence, this study aimed to investigate the regulation of BPH on gut microbiota composition and ***: We analyzed gut samples from rats with BPH and healthy control rats, the gut microbiota composition and metabonomics were detected by 16S rDNA sequencing and liquid chromatography tandem mass spectrometry(LC–MS/MS).Results: High-throughput sequencing results showed that gut microbiota beta-diversity increased(P0.05), Bacteroidetes(46.54% vs. 41.64%,P>0.05), Clostridia(50.89% vs. 54.66%, P>0.05), Ruminococcaceae(25.67% vs. 20.56%, P>0.05). LC–MS/MS of intestinal contents revealed that differential metabolites were mainly involved in cellular processes, environmental information processing, metabolism and organismal systems. The most important pathways were global and overview maps, lipid metabolism, amino acid metabolism, digestive system and endocrine system. Through enrichment analysis, we found that the differential metabolites were significantly enriched in metabolic pathways, steroid hormone biosynthesis,ovarian steroidogenesis, biosynthesis of unsaturated fatty acids and bile secretion. Pearson correlation analysis(R=0.94) showed that there was a strong correlation between Prevotellaceae, Corynebacteriaceae, Turicibacteraceae,Bifid

关键词： Benign prostatic hyperplasia Gut microbiota Intestinal metabolites Microbial diversity

Three New Polyoxometalates Derivatives Decorated by Phenanthroline and Transition-metal Cations(M=Zn~ⅡI , Co~Ⅱ , Ni~Ⅱ)

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Chemical Research in Chinese Universities 2010年第5期26卷 683-686页

作者： ZHANG Yong-feng jia Yan-yan nie Hai-liang YAN Xing-juan WANG Li HUANG Ru-dan Department of Chemistry Beijing Institute of Technology Beijing 100081 P. R. China

Three new Keggin polyoxometalates, [Zn（phen）3]2[SiW12O40]＇5H2O（1）, [Co（phen）3]2[SiW12O40]（2） and [Ni（phen）3]2[SiW12O40].2H2O（3）（phen=1,10＇-phenanthroline） have been hydrothermally synthesized and characterized by elemental analysis, IR, crystal X-ray diffraction, thermogravimetric analyses（TGA） and fluorescence tech- niques. Complex 1, crystallized in the triclinic space group Pi, consists of one [SiW12O40]4 anion, two discrete [Zn（phen）3]^2＋ cations and five crystal water molecules. Complexes 2 and 3 have the similar configuration to complex 1, but they crystallized in the monoclinic space group C2/c. Variable-temperature magnetic susceptibilities of complexess 2 and 3 reveal antiferromagnetism and ferromagnetism, respectively.

关键词： Polyoxometalate Phen Organic-inorganic compound Hydrothermal synthesis

A Study on Current Situation and Strategies of Oral English Teaching in Nanguan Middle School in Huyi District

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西安翻译学院学报 2019年第2期26卷 67-73页

作者： nie jia 任芳(指导) Xi'an Fanyi University Xi'an Shaanxi 710105 不详

With the development of society and the deepening of economic globalization,as a common language in today's world,the role of English is inereasingly *** recent years,with the advent of the Chinese Dream and the establishment of the Economic Belt of the Belt and Road,there is no doubt that China needs a large number of proficient people speaking English fluently to tell the world the stories of China,to spread the brilliant history of Chinese cultures and to play an important role in the inereasingly colse international exchanges and ***,as we all know,oral English teaching has always been quite weak in Chinese junior high *** district,located in the central and western regions of China,not only has the commonalities of the western regions but also has its own unique personalities in oral English *** it has made great progress,some problems in teaching should be *** on this,the thesis mainly aims to find out the problems that exist in oral English teaching of Nanguan Middle School by questionnaire and put forward corresponding countermeasures for these problems in order to promote the development of oral English teaching in middle schools in Huyi district.

关键词： Nanguan Middle School oral English teaching strategies

Therapeutic effects of Lingguizhugan decoction in a rat model of high-fat diet-induced insulin resistance

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World Journal of Diabetes 2024年第6期15卷 1291-1298页

作者： Xiao-Ming Liu Shi-Qing Yuan Ying Ning Shi-jia nie Xu-Qiong Wang Hong-Yi jia Xiu-Li Zheng Department of Basic Medicine School of Basic Medicine Chengdu University of Traditional Chinese MedicineChengdu 611137Sichuan ProvinceChina Department of Clinical Medicine Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina

BACKGROUND Lingguizhugan(LGZG)decoction is a widely used classic Chinese medicine formula that was recently shown to improve high-fat diet(HFD)-induced insulin resistance(IR)in animal *** To assess the therapeutic effect of LGZG decoction on HFD-induced IR and explore the potential underlying *** To establish an IR rat model,a 12-wk HFD was administered,followed by a 4-wk treatment with *** determination of IR status was achieved through the use of biochemical tests and oral glucose tolerance *** a targeted metabolomics platform to analyze changes in serum metabolites,quantitative real-time PCR(qRT-PCR)was used to assess the gene expression of the ribosomal protein S6 kinase beta 1(S6K1).RESULTS In IR rats,LGZG decreased body weight and indices of hepatic *** effectively controlled blood glucose and food intake while protecting islet *** analysis revealed significant differences between the HFD and HFDLGZG *** intervention reduced branched-chain amino acid *** of IR-related metabolites such as tryptophan,alanine,taurine,and asparagine decreased *** may be linked to amino acids due to the contemporaneous increase in S6K1 expression,as shown by *** Our study strongly suggests that LGZG decoction reduces HFD-induced *** may activate S6K1 via metabolic *** findings lay the groundwork for the potential of LGZG as an IR treatment.

关键词： Lingguizhugan decoction High-fat diet-induced insulin resistance Amino acid metabolism S6K1

Possible Unconventional Pairing Mechanism at Superconducting LaAlO3/SrTiO3(110) Interface

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Possible Unconventional Pairing Mechanism at Superconducting...