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激光冲压钛板小曲率成形技术研究

中国石油大学学报（自然科学版） 2007年第5期31卷 95-98页

作者：于加洋潍坊学院机电工程学院山东潍坊261061

采用传统的工艺成形钛合金比较困难,因而探索钛合金板材成形的新工艺和新技术具有十分重要的意义。利用激光冲击波技术对钛合金板料进行了成形试验,所采用的激光波长为1.064μm,脉宽约23 ns,能量35 J左右,有效光斑直径为8 mm,脉冲的重... 详细信息

采用传统的工艺成形钛合金比较困难,因而探索钛合金板材成形的新工艺和新技术具有十分重要的意义。利用激光冲击波技术对钛合金板料进行了成形试验,所采用的激光波长为1.064μm,脉宽约23 ns,能量35 J左右,有效光斑直径为8 mm,脉冲的重复率为0.5 Hz。探讨了激光连续冲击条件下板料成形深度、成形轮廓与激光参数、约束边界条件和冲击路径之间的变化规律。研究结果表明,激光冲击路径不同,产生的最大变形量不同;受冲击区域表面光洁度有明显提高;随激光冲击次数的增加,板料塑性变形越大,成形深度越深。

关键词：纯钛板料激光冲压小曲率塑性成形

Amisulpride augmentation therapy improves cognitive performance and psychopathology in clozapine‑resistant treatment‑refractory schizophrenia:a 12‑week randomized,double‑blind,placebo‑controlled trial

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Military Medical Research 2023年第4期10卷 431-443页

作者： Ming‑Huan Zhu Zhen‑Jing Liu Qiong‑yue Hu jia‑yu yang Ying Jin Na Zhu Ying Huang Dian‑Hong Shi Min‑jia Liu Hong‑yang Tan Lei Zhao Qin‑yu Lv Zheng‑Hui Yi Feng‑Chun Wu Ze‑Zhi Li Clinical Research Center for Mental Disorders School of MedicineShanghai Pudong New Area Mental Health CenterTongji UniversityShanghai 200124China Qingdao Mental Health Center Qingdao 266034ShandongChina Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai 200030China Department of Psychiatry the Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510370China Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders Guangzhou 510370China

Background:Although clozapine is an effective option for treatment-resistant schizophrenia(TRS),there are still 1/3 to 1/2 of TRS patients who do not respond to *** main purpose of this randomized,double-blind,placebocontrolled trial was to explore the amisulpride augmentation efficacy on the psychopathological symptoms and cognitive function of clozapine-resistant treatment-refractory schizophrenia(CTRS)***:A total of 80 patients were recruited and randomly assigned to receive initial clozapine plus amisulpride(amisulpride group)or clozapine plus placebo(placebo group).Positive and Negative Syndrome Scale(PANSS),Scale for the Assessment of Negative Symptoms(SANS),Clinical Global Impression(CGI)scale scores,Repeatable Battery for the Assessment of Neuropsychological Status(RBANS),Treatment Emergent Symptom Scale(TESS),laboratory measurements,and electrocardiograms(ECG)were performed at baseline,week 6,and week ***:Compared with the placebo group,amisulpride group had a lower PANSS total score,positive subscore,and general psychopathology subscore at week 6 and week 12(PBonferroni<0.01).Furthermore,compared with the placebo group,the amisulpride group showed an improved RBANS language score at week 12(PBonferroni<0.001).Amisulpride group had a higher treatment response rate(P=0.04),lower scores of CGI severity and CGI efficacy at week 6 and week 12 than placebo group(PBonferroni<0.05).There were no differences between the groups in body mass index(BMI),corrected QT(QTc)intervals,and laboratory *** study demonstrates that amisulpride augmentation therapy can safely improve the psychiatric symptoms and cognitive performance of CTRS patients.

关键词： Schizophrenia Clozapine-resistant treatment-refractory schizophrenia Clozapine Amisulpride Augmentation

Transplantation of vascular endothelial growth factor-modified neural stem/progenitor cells promotes the recovery of neurological function following hypoxic-ischemic brain damage

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Neural Regeneration Research 2016年第9期11卷 1456-1463页

作者： yue Yao Xiang-rong Zheng Shan-shan Zhang Xia Wang Xiao-he yu Jie-lu Tan yu-jia yang Department of Pediatrics Xiangya HospitalCentral South University

Neural stem/progenitor cell （NSC） transplantation has been shown to effectively improve neurological function in rats with hypoxic-isch- emic brain damage. Vascular endothelial growth factor （VEGF） is a signaling protein that stimulates angiogenesis and improves neural regeneration. We hypothesized that transplantation of VEGF-transfected NSCs would alleviate hypoxic-ischemic brain damage in neo- natal rats. We produced and transfected a recombinant lentiviral vector containing the VEGF165gene into cultured NSCs. The transfected NSCs were transplanted into the left sensorimotor cortex of rats 3 days after hypoxic-ischemic brain damage. Compared with the NSCs group, VEGF mRNA and protein expression levels were increased in the transgene NSCs group, and learning and memory abilities were significantly improved at 30 days. Furthermore, histopathological changes were alleviated in these animals. Our findings indicate that transplantation of VEGF-transfected NSCs may facilitate the recovery of neurological function, and that its therapeutic effectiveness is better than that of unmodified NSCs.

关键词： nerve regeneration vascular endothelial growth factor transfection neural stem/progenitor cells transplantation hypoxic-ischemicbrain damage cerebral cortex animal model neuroprotection neural regeneration

Linking Lipid Metabolism with Cell Transformation and Tumor Progression

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Journal of Nutritional Oncology 2020年第4期5卷 153-161页

作者： Meng Si Zuo jia yu yang Pei yun Wang Hai Ou yang Yi Ba Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin 300060China

Carbohydrates,lipids,and proteins are the three major nutrients required by the human *** lipids,comprising triglycerides,phospholipids,and sterols,provide energy and essential fatty acids for the body,and are required for the growth and maintenance of human cells and tissues.A variety of lipid molecules and their intermediates are involved in cell signaling and inflammation,and have been reported to promote tumor transformation and *** acid biosynthetic enzymes are also involved in the lipid metabolism of *** is closely related to many solid tumors,and may both play a role in both tumorigenesis and be a consequence of tumor ***,abnormal lipid metabolism is strongly associated with tumor transformation and *** review discusses the signaling pathways,related genes,enzymes,and inflammatory cell factors involved in tumor lipid metabolism,as well as the roles of dyslipidemia in tumor transformation and *** believe the information provided will serve as valuable reference highlighting molecules that can be targeted to improve the treatment of tumors.

关键词： Tumor Lipid metabolism Lipid raft Tumor microenvironment

Are There Any Clinical and Radiographic Differences Between Quadriceps-sparing and Mini-medial Parapatellar Approaches in Total Knee Arthroplasty After a Minimum 5 Years of Follow-up？

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Chinese Medical Journal 2015年第14期128卷 1898-1904页

作者： Ai-Bing Huang Hai-Jun Wang jia-Kuo yu Bo yang Dong Ma Ji-Ying Zhang Institute of Sports Medicine Peking University Third Hospital Beijing 100191 China

Background： Although the early clinical outcomes of total knee arthroplasty （TKA） using minimally invasive surgery techniques have been widely described, data on the mid- to long-term outcomes are limited. We designed a retrospective study to compare the two most common TKA techniques - The modified quadriceps-sparing （m-QS） approach and the mini-medial parapatellar （MMP） approach - In terms of the clinical and radiographic parameters, over a minimum follow-up period of 5 years. Methods： The m-QS approach was used in 31 knees and the MMP approach, in 36 knees. Knees in both groups were compared for component position and alignment, knee alignment, length of the skin incision, range of motion, Visual Analog Scale score, muscle torques, Knee Society Score, Western Ontario and McMaster Universities Osteoarthritis Index, and number of complications. Results： There were no major intergroup differences in any of the clinical and radiographic outcomes assessed at the final follow-up examination. Conclusions： On the basis of numbers studied, the m-QS group, which requires more technique, showed equivalent results with the MMP group in the postoperative 5 years. Preservation of the extensor mechanism in the m-QS approach could not ensure any improvement in the clinical outcomes during the mid-term follow-up duration.

关键词： Minimally Invasive Surgery Quadriceps-sparing Total Knee Arthroplasty

RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

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World Journal of Gastroenterology 2025年第2期31卷 113-127页

作者： Peng-yu Chen Pei-Yao Wang Bang Liu yang-Pu jia Zhao-Xiong Zhang Xin Liu Dao-Han Wang Yong-jia Yan Wei-Hua Fu Feng Zhu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of General Surgery Jincheng People’s HospitalJincheng 048000Shanxi ProvinceChina

BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G *** speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet *** To explore the role and underlying mechanisms of action of RGS4 in GC *** The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with *** assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in *** RGS4 was highly expressed in GC tissues compared with matched adjacent normal *** RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with *** experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and ***,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor ***,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated *** High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic ***4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.

关键词： Gastric cancer Prognosis Regulator of G protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition

Bo’s abdominal acupuncture treatment for adult-onset Still's disease:A case report

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World Journal of Clinical Cases 2025年第8期13卷 41-48页

作者： jia-Min yang yu Wang yu-Qing Zhang Hong-Lin Zhang Zhi-yun Bo College for People's Livelihood and Well-being Beijing Vocational College of Labor and Social SecurityBeijing 100029China College of Acupuncture and Moxibustion Beijing University of Chinese MedicineBeijing 100029China Guang'Anmen Hospital China Academy of Traditional Chinese MedicineBeijing 100053China Beijing Zhiyuntang Traditional Chinese Medicine Clinic Beijing Bo’s Abdominal Acupuncture Research InstituteBeijing 100122China

BACKGROUND Adult-onset Still's disease(AOSD)is a rare autoinflammatory disease charac-terized by nonspecific symptoms such as fever,rash,sore throat and *** paper reports a clinical case of AOSD successfully treated with Bo’s abdo-minal acupuncture(BAA).CASE SUMMARY We report a 20-year-old man who suffered from cold exposure,presenting with high fever,rash,sore throat,arthralgia,and elevated erythrocyte sedimentation rate,leukocytosis with neutrophilic predominance,elevated ferritin,elevated C-reactive protein,and negative rheumatoid *** was diagnosed with AOSD based on the Yamaguchi *** treatment with traditional Chinese medi-cine(TCM)decoction and prednisone acetate tablets,there was some alleviation of sore throat,joint and muscle pain,and fever,but he still had persistent low-grade fever,rash,sore throat and *** went to the TCM acupuncture outpatient department to receive *** acupoints Zhongwan(CV12),Xiawan(CV10),0.5 cm below Xiawan(CV10),Qihai(CV6),Guanyuan(CV4),bilateral Qixue(KI13),bilateral Huaroumen(ST24),bilateral Shangfengshidian(AB1)and bilateral Daheng(SP15)were *** 3 months treatment,all symptoms disappeared,and the laboratory examination returned to normal *** did not take glucocorticoids or nonsteroidal anti-inflammatory drugs afterwards,and no relapse was observed during the 3-year follow-up *** BAA can be used as a complementary medical approach for treatment of AOSD.

关键词： Adult-onset Still’s disease Bo’s abdominal acupuncture Traditional Chinese medicine Complementary medicine Case report

基于人体免疫系统RBF网络的数控机床热误差建模

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上海交通大学学报 2009年第1期43卷 148-152页

作者：闫嘉钰杨建国上海交通大学机械与动力工程学院上海200240

针对现有误差预测模型无法实现结构自适应调整和在线训练的不足,通过对比人体免疫系统和人工神经网络,提出人工免疫RBF(AIRBF)网络,实现了网络结构的动态调整和在线学习.通过数控车削中心进行的实验验证,并将预测结果同传统RBF网络预测... 详细信息

针对现有误差预测模型无法实现结构自适应调整和在线训练的不足,通过对比人体免疫系统和人工神经网络,提出人工免疫RBF(AIRBF)网络,实现了网络结构的动态调整和在线学习.通过数控车削中心进行的实验验证,并将预测结果同传统RBF网络预测结果进行比较.结果表明,该网络结构简单,能够很好适应热弹性变形的非线性时变特性,并能获得更高的热误差预测精度和更好的对突变数据点的跟随性.

关键词： RBF网络人工免疫系统热误差数控机床建模

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数控机床热误差的最优线性组合建模

上海交通大学学报 2009年第4期43卷 633-637页

作者：闫嘉钰杨建国上海交通大学机械与动力工程学院上海200240

提出数控机床热误差的最优线性组合建模方法及其相关算法.该方法通过线性和的方式对基于不同数学理论所建立的热误差模型进行综合,并以不同拓扑结构及训练算法的反向传播神经网络为例,建立了最优线性组合神经网络.通过对一台CNC机床的... 详细信息

提出数控机床热误差的最优线性组合建模方法及其相关算法.该方法通过线性和的方式对基于不同数学理论所建立的热误差模型进行综合,并以不同拓扑结构及训练算法的反向传播神经网络为例,建立了最优线性组合神经网络.通过对一台CNC机床的实际加工数据进行分析,对该建模方法进行验证,并探讨了该方法的最佳使用条件及其原因.建模结果表明,所提出的方法能够在节省建模时间的同时大幅提高所建立模型的预测精度,是一种高性价比的建模方法.

关键词：数控机床热误差线性组合建模神经网络