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Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning Li Yakun Gu Wei ma Yuying Guan Mengyuan Guo Qianqian Shao Xunming ji jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu ji-Chuan Liu Zi-Ling Shi Quan-Hong ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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Self-assembled carbon monoxide nanoprodrug for chemiexcitationtriggered synergistic chemotherapy against breast cancer

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Science China Chemistry 2025年

作者： Shunfei Cui Yiyao Pan Chenzhe ma Bin Qi Qingqiang Min Ming Li Huabing Chen Hengte Ke Xingyue ji jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development College of Pharmaceutical ScienceSoochow University

Carbon monoxide（CO） has recently been well-established as a promising therapeutic modality against cancer. The development of transition-metal-free and tumor-targeted delivery platforms for CO is highly demanded but remains very sporadic. Herein, we developed a polyprodrug system for the co-delivery of CO and a chemotherapeutic agent combretastin A-4（CA-4） to the tumor site based on a chemiexcitation mechanism. Such a poly-prodrug successfully achieved the co-activation of CO and CA-4 in response to H2O2at the tumor site both in vitro and in vivo. Importantly, a synergist effect between CO and CA-4 was observed in suppressing tumor growth in a mouse tumor model. It is anticipated that such a poly-prodrug system could be potentially adapted for the co-delivery of CO and another drug payload for combinational therapy for other indications.

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Nitrogen addition promotes soil carbon accumulation globally

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Science China Life Sciences 2025年第1期 284-293页

作者： Xuemei Yang Suhui ma Erhan Huang Danhua Zhang Guoping Chen jiangling Zhu Chengjun ji Biao Zhu Lingli Liu jingyun Fang Institute of Ecology College of Urban and Environmental Sciencesand Key Laboratory for Earth Surface Processes of the Ministry of EducationPeking University Ministry of Education Key Laboratory for Transboundary Ecosecurity of Southwest China School of Ecology and Environmental ScienceYunnan University State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of Sciences

Soil is the largest carbon(C) reservoir in terrestrial ecosystems and plays a crucial role in regulating the global C cycle and climate *** nitrogen(N) deposition has been widely considered as a critical factor affecting soil organic carbon(SOC) storage, but its effect on SOC components with different stability remains unclear. Here, we analyzed extensive empirical data from 304 sites worldwide to investigate how SOC and its components respond to N addition. Our analysis showed that N addition led to a significant increase in bulk SOC(6.7%), with greater increases in croplands(10.6%) and forests(6.0%) compared to grasslands(2.1%). Regarding SOC components, N addition promoted the accumulation of plant-derived C(9.7%–28.5%) over microbial-derived C(0.2%), as well as labile(5.7%) over recalcitrant components(–1.2%), resulting in a shift towards increased accumulation of plant-derived labile C. Consistently, N addition led to a greater increase in particulate organic C(11.9%) than mineral-associated organic C(3.6%), suggesting that N addition promotes C accumulation across all pools, with more increase in unstable than stable pools. The responses of SOC and its components were best predicted by the N addition rate and net primary productivity. Overall, our findings suggest that N enrichment could promote the accumulation of plant-derived and non-mineral associated C and a subsequent decrease in the overall stability of soil C pool, which underscores the importance of considering the effects of N enrichment on SOC components for a better understanding of C dynamics in soils.

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The law of barrel wear and its application

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Defence Technology（防务技术） 2018年第6期14卷 674-676页

作者： ji-sheng ma School of Mechanical Engineering Xijing University

A power function relation between number of rounds and barrel wear amount is created based on the test data from firing of large-caliber barrels. The function is optimized to fully fit the test data. A new concept of diameter change rate of bore is proposed and the law of barrel wear is put forward by means of comparing the diameter change rates for large-caliber barrels with different calibers. It is shown that the law of barrel wear is successful in barrel life prediction.

关键词： Barrel life Prediction model Law of barrel wear Curve fitting

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A versatile solution-phase, precursor route to surface-mazelike hierarchical structures

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Science China Chemistry 2015年第4期58卷 620-626页

作者： ji ma Lianchao Han Kezheng Chen Lab of Functional and Biomedical Nanomaterials College of materials Science and Engineering Qingdao University of Science and Technology

In this work, surface-mazelike Zn O, Cu, and Ni hierarchical structures were synthesized via a versatile ethylene glycol- mediated solvothermal method. The structure evolution of these materials bore striking similarities, including(1) initial formation of metal alkoxides precursors and(2) subsequent structural evolution of products from tiered plates to jigsaw puzzles; then to extrusion ridges, nests and spindles; and thereafter to final mazelike structures driven by persistent thermal decomposition of preformed precursors. Based on their unique surface morphologies in sinuous asymmetry, it is anticipated that such mazelike hierarchical structures may shed new light on the development of morphology-controlled adsorption and heterogeneous catalysts.

关键词： hierarchical structure versatile precursor route mazelike solvothermal adsorption

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Surface coating of electrocatalysts boosts battery performance

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Rare Metals 2020年第6期39卷 613-615页

作者： ji-Zhen ma jin-Tao Zhang Key Laboratory for Colloid and Interface Chemistry(Ministry of Education) School of Chemistry and Chemical EngineeringShandong UniversityJinan 250100China

Bifunctional electrocatalyst is crucial to boost the performance of a zinc-air *** electrocatalysts beyond noble metals are highly desirable to lower the energy barriers for oxygen reduction and evolution reactions in... 详细信息

关键词： battery boost alkaline

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Dislocation behavior in Cu single crystal joints under the ultrasonically excited high-strain-rate deformation

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Journal of materials Science & Technology 2023年第10期141卷 66-77页

作者： Qiuchen ma jingyuan ma jianli Zhou Xiaoxiong Zheng Hongjun ji The State Key Laboratory of Advanced Welding and Joining School of Materials Science and EngineeringHarbin Institute of Technology at ShenzhenShenzhen 518055China Sauvage Laboratory for Smart materials Shenzhen Key Laboratory of Flexible Printed Electronics TechnologySchool of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China School of Science Harbin Institute of Technology at ShenzhenShenzhen 518055China

The coupling effects of ultrasonic excitation and high-strain-rate deformation are the core factors for weld formation during ultrasonic ***,interfacial deformation behavior still shrouds in uncer-tainty because of the contradictory features between mutual dislocation retardation caused by severely frictional deformation and ultrasonic-accelerated dislocation motion.[101]and[111]-oriented Cu single crystals which tended to form geometrically necessary boundaries(GNBs)were selected as the welding substrates to trace the uniquely acoustoplastic effects in the interfacial region under the ultrasonically excited high-strain-rate *** was indicated that for a low energy input,micro-welds localized at the specific interface region,and equiaxed dislocation cells substituting for GNBs dominated in the ini-tial single crystal rotation *** the welding energy increased,continuous shear deformation drove the dynamic recrystallization region covered by equiaxed grains to spread *** discrete dislocations inside the recrystallized grains and nascent dislocation cells at the grain boundaries were ob-served in[101]and[111]joints simultaneously,suggesting that the ultrasonic excitation promoted motion of intragranular dislocation and pile-up along the sub-grain *** interfacial morphology be-fore and after expansion of recrystallization region all exhibited the weakening of orientation constraint on dislocation motion,which was also confirmed by the similar micro-hardness in joint *** first-principle calculation and applied strain-rate analysis further revealed that ultrasonic excitation en-hanced dislocation slipping,and enabled dislocation motion to accommodate severe plastic deformation at a high-strain-rate.

关键词： Acoustoplasticity Ultrasonic welding Cu single crystal Dynamic recrystallization Dislocation cell High-strain-rate deformation

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Nickel-carbonate nanowire array： An efficient and durable electrocatalyst for water oxidation under nearly neutral conditions

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Frontiers of Chemical Science and Engineering 2018年第3期12卷 467-472页

作者： Yuyao ji Min ma Xuqiang ji Xiaoli Xiong Xuping Sun College of Chemistry and materials Science Sichuan Normal University Chengdu 610068 China College of Chemistry Sichuan University Chengdu 610064 China Key Lab of Process Analysis and Cont ol of Sichuan Universities Yibin University Yibin 644000 China

It is highly attractive but still remains a great challenge to develop an efficient electrocatalyst for oxygen evolution reaction under nearly neutral conditions. In this work, we report the transformation of Ni3S2 nanowire array on nickel foam into the amorphous nickel carbonate nanowire array on nickel foam （NiCO3/NF）. The resulting NiCO3/NF shows high electrocatalytic activity towards water oxidation and affords current density of 50 ma. cm-2 at overpotential of 395 mV in 1.0 mol·L^-1 KHCO3. Moreover, this NiCO3/NF is also durable with a long-term electrochemical durability of 60 h. This catalyst electrode achieves a high turnover frequency of 0.21 mol O2·s^-1 at the overpotential of 500 mV.

关键词： water oxidation NiCO3/NF nearly neutral conditions superior activity electocatalyst

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A Separation Theorem for Stochastic Singular Linear Quadratic Control Problem with Partial Information

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Acta mathematicae Applicatae Sinica 2013年第2期29卷 303-314页

作者： Hong-ji ma Ting HOU College of Science Shandong University of Science and Technology Department of Systems and Control Beijing University of Aeronautics and Astronautics

In this paper, we provide a separation theorem for the singular linear quadratic （LQ） control problem of ItS-type linear systems in the case of the state being partially observable. Above all, the Kalmam Bucy filtering of the dynamics is given by means of Girsanov transformation, by which the suboptimal feedback control of the LQ problem is determined. Furthermore, it is shown that the well-posedness of the LQ problem is equivalent to the solvability of a generalized differential Riccati equation （GDRE）.

关键词： singular optimal control Kalman-Bucy filtering separation theorem linear systems generalizeddifferential Riccati equation

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