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Frequent ventricular premature beats increase blood pressure variability in rats

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Acta Pharmacologica Sinica 2004年第5期25卷 3-11页

作者： Chao-yu MIAO2, li-ping XU, jian-guo liU, He-hui XIE, Wen-jun YUAN, Ding-feng SU2department of Pharmacology, Second Military Medical university, Shanghai 200433, china department of Pharmacology Second Military Medical University

AIM: The present study was designed to test a hypothesis that nonfatal ventricular arrhythmia such as ventricularpremature beats (VPB) is a contributing factor in the elevation of blood pressure variability (BPV). METHODS:Blood pressure (BP) and electrocardiogram were continuously recorded. The relation between VPB and BPV wasobserved under conscious state in chronic myocardial infarction (MI) rats one month after ligation of the leftcoronary artery, and further verified under anesthetized state in rat model of ventricular arrhythmia produced byacute intravenous infusion of aconitine. RESULTS: MI rats exhibited a big difference in the count and pattern ofVPB, and were divided into no VPB, occasional VPB, and frequent VPB groups. Among the three groups, therewere no differences in BP, heart period (HP), and MI size. However, BPV was markedly higher in frequent notoccasional VPB rats, and HP variability (HPV) was larger in both frequent and occasional VPB rats, when comparedwith no VPB rats. In the whole population of MI rats, BPV was positively correlated with VPB and HPV, not withBP, HP and MI size. Infusion of aconitine had no effect on BP, HP, BPV, and HPV during the period without *** VPB after several minutes of aconitine infusion induced significant increase in BPV and HPV with nochange in BP and HP. BPV was also positively correlated with VPB and HPV, not with BP and HP. Hemodynamicsin aconitine-evoked ventricular tachycardia was characterized as lower BP, higher BPV, and higher ***: High BPV can be caused by frequent not occasional VPB in rats.

关键词： arrhythmia blood pressure variability heart period variability

Drift-wave fluctuation in an inviscid tokamak plasma

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Chinese Physics B 2013年第11期22卷 396-400页

作者：杨建荣毛杰健唐晓艳 department of Physics and Electronics Shangrao Normal University department of Physics Shanghai Jiao Tong University

In order to describe the characterization of resistive drift-wave nuctuauon in a [OKalnaK plasma, a coup^e~a lllVlbt;IU two-dimensional Hasegawa-Wakatani model is investigated. Two groups of new analytic solutions with and without phase shift between the fluctuant density and the ftuctuant potential are obtained by using the special function transformation method. It is demonstrated that the fluctuant potential shares similar spatio-temporal variations with the density. It is found from the solutions without phase shift that the effect of the diffusion and adiabaticity on the fluctuant density is quite complex, and that the fuctuation may be controlled through the adiabaticity and diffusion. By using the typical parameters in the quasi-adiabatic regime in the solutions with phase contours become dense toward the plasma edge and the distribution in the tokamak edge. shift, it is shown that the density gradient becomes larger as the contours have irregular structures, which reveal the nonuniform

关键词： tokamak plasma Hasegawa-Wakatani model drift-wave fluctuation

Testing local realism in P → VV decays

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Science china(Physics,Mechanics & Astronomy) 2010年第5期53卷 870-875页

作者： li Junli1 & QIAO CongFeng1,2 1department of Physics,Graduate university of Chinese Academy of Sciences,Beijing 100049,china 2Theoretical Physics Center for Science Facilities(TPCSF),Chinese Academy of Sciences,Beijing 100049,china 1. department of Physics Graduate University of Chinese Academy of Sciences Beijing 100049 China2. Theoretical Physics Center for Science Facilities (TPCSF) Chinese Academy of Sciences Beijing 100049 China

It was found that the vector meson pair from the pseudoscalar decays can form an entangled *** this work we give out detailed explanations on the polarization correlation of the two entangled vector *** is demonstrated that an experimental test of the Clauser-Horne inequality can be carried out through measuring the azimuthal distribution of four pseudoscalars in the cascade decay ηc→ VV →(PP)(PP),and the measurement of this process is feasible with the current running experiments in tau-charm ***,a brief discussion on the polarization correlation of the two vector mesons from B → VV decays is also presented.

关键词： nonlocality test high energy experiment meson decays

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审美概念学习效应与迁移的逻辑线路探究

心理科学 2002年第1期25卷 60-63页

作者：赵伶俐西南师范大学心理系重庆400715

以 49名小学四年级学生和 30名大学教师及研究生为实验对象 ,采用SMSD模式进行审美概念学习 ,结果发现这两组被试的审美理解和感受水平都有显著提高。对大学教师研究生组再作前审美概念 (已学概念 )之于后审美概念 (未学概念 )各因素影... 详细信息

以 49名小学四年级学生和 30名大学教师及研究生为实验对象 ,采用SMSD模式进行审美概念学习 ,结果发现这两组被试的审美理解和感受水平都有显著提高。对大学教师研究生组再作前审美概念 (已学概念 )之于后审美概念 (未学概念 )各因素影响情况的回归分析 ,得到四个回归方程 ,据此绘制出SMSD模式审美概念学习迁移模型图 ,归纳出平行迁移、纵向迁移、交叉迁移、小巡回迁移、大巡回迁移等若干逻辑线路。

关键词：概念学习大学教师研究生小学四年级纵向迁移探究审美影响因素感受

THERMODYNAMICS OF V REDUCTION IN SMELTING REDUCTION SLAG FOR V-Ti-CONTAINING MAGNETITE

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Acta Metallurgica Sinica(English Letters) 1993年第12期6卷 4+400-404页

作者： ZHANG binhuai liU Qingcai li Changwei ZOU Deyu SUN jinbiao Chongqing university,Chongqing,china professor,department of Metallurgy and Materials Engineering,Chongqing university,Chongqing 630044,china

For slag system of CaO-SiO_2-Al_2O_3-MgO-V_2O_5,the time of V reduction to appro ch the dynamical equilibrium is about 6 h,the equilibrium time is not evidently influenced by the ratio CaO/SiO_2 and shortens with the increase of *** the ratio of the weight of slag to that of iron bath is 1/2,CaO/SiO_2 0.8 and tomperature 1773 *** maxium distribution coefficeent of V reduction is 32.4 and maxium recovery of V is 96.1%.

关键词： magnetite smelting reduction thermodynamics vanadium

Layered(C_(5)H_(6)ON)_(2)[Sb_(2)O(C_(2)O_(4))_(3)]with a large birefringence derived from the uniform arrangement of π-conjugated units

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Chinese Journal of Structural Chemistry 2024年第6期43卷 50-55页

作者： Dong-Xue jiao Hui-li Zhang Chao He Si-Yu Chen Ke Wang Xiao-Han Zhang li Wei Qi Wei College of Chemistry and Chemical Engineering Qingdao UniversityShandong266071PR China College of Science Hebei University of Science and TechnologyShijiazhuangHebei050018PR China

An organic-inorganic hybrid antimony(Ⅲ)oxalate(C_(5)H_(6)ON)_(2)[Sb_(2)O(C_(2)O_(4))_(3)]has been successfully obtained by simultaneous combination of a-conjugated 4-hydroxypyridine and(C_(2)O_(4))^(2-)group with stereochemical active Sb(Ⅲ)*** compound features a layered structure,and the equatorial planes of SbO6 units,π-conjugated(C_(2)O_(4))^(2-)and(C5H6ON)+groups are closer to a planar arrangement,representing strong structural anisotropy that favors a large *** expected,(C_(5)H_(6)ON)_(2)[Sb_(2)O(C_(2)O_(4))_(3)]exhibits a large birefringence of 0.279 at 546 *** and theoretical analyses indicate that the combination of multipleπ-conjugated units is a feasible approach for designing and exploring new superior birefringent materials.

关键词： Organicπ-conjugated unit Birefringence Stereochemically active lone pair Layered structure

Structure of cis-[Pt(NH_(3))(2-picoline)]^(2+)and DNA adduct and its bonding characteristics

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Science china Chemistry 2004年第1期47卷 67-74页

作者： jiA Muxin, liU Kai, YANG Zuoyin & CHEN Guangjudepartment of Chemistry, Beijing normal university, Beijing 100875, china Beijing General Research Institute of Mining and Metullargy, Beijing 100044, china 1. department of Chemistry Beijing Normal University 100875 Beijing China 2. Beijing General Research Institute of Mining and Metullargy 100044 Beijing China

Several methods including molecular mechanics, molecular dynamics, ONIOM that combines quantum chemistry with molecular mechanics and standard quantum chemistry are used to study the configuration and electron structures of an adduct of the DNA segment d(ATACATG*G*TACATA)·d(TATGTACCATGTAT) with cis-[Pt(NH3)(2-Picoline)]2+. The investigation shows that the configuration optimized by ONIOM is similar to that determined by NMR. Strong chemical bonds between Pt of the complex and two N7s of neighboring guanines in the DNA duplex and hydrogen bond between the NH3 of the complex and O6 of a nearby guanine have a large impact on the configuration of the adduct. Chemical bonds, the aforementioned hydrogen bond, and the interaction between a methyl of the complex and a methyl of the base in close proximity are critical for the complex to specifically recognize DNA.

关键词： cis-[PtCl2(NH3)(2-Pic)], DNA segment, ONIOM, molecular mechanics, molecular dynamics.

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Heisenberg群上一类算子的有界性

数学学报（中文版） 2004年第4期47卷 629-640页

作者：刘明菊北京师范大学数学系北京100875

设 F是λ阶正则的齐次分布,-Q≤λ<0。作者研究了Heisenberg群上的算子g*F在加幂权的Lebesgue空间和Herz型 Hardy空间上的有界性,其中 g是一恰当的函数。而且,本文还得到了由BMO(H^n)函数和线性算子T所生成的交换子[b,T]在Herz空间上的... 详细信息

设 F是λ阶正则的齐次分布,-Q≤λ<0。作者研究了Heisenberg群上的算子g*F在加幂权的Lebesgue空间和Herz型 Hardy空间上的有界性,其中 g是一恰当的函数。而且,本文还得到了由BMO(H^n)函数和线性算子T所生成的交换子[b,T]在Herz空间上的有界性。

关键词： Heisenberg群 Herz型空间奇异积分

Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin

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Genes & Diseases 2024年第1期11卷 397-412页

作者： Zhe Chen Qian Guo Shichen Huang Lei li Feng Wu Zhilong liu Zhigang li Tao Chen Guanbin Song Shuangnian Xu jieping Chen Yu Hou department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Institute of life Sciences Chongqing Medical UniversityChongqing 400016China Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing Foreign Language School Chongqing 400039China

Therapeutic targeting FOxO3A(a forkhead transcription factor)represents a prom-ising strategy to suppress acute myeloid leukemia(AML).However,the effective inhibitors that target FOXO3A are lacking and the adaptive response signaling weakens the cytotoxic effect of FOxO3A depletion on AML ***,we show that FOxO3A deficiency induces a compensa-tory response involved in the reactive activation of mTOR that leads to signaling rebound and adaptive *** metabolism acts downstream of mTOR to provoke activa-tion of JNK/c-JUN via reactive oxygen species(ROS).At the molecular level,FOXO3A directly binds to the promoter of G protein gamma subunit 7(GNG7)and preserves its expression,while GNG7 interacts with mTOR and restricts phosphorylated activation of ***,combinatorial inhibition of FOXO3A and mTOR show a synergistic cytotoxic effect on AML cells and prolongs survival in a mouse model of *** a structure-based virtual screening,we report one potent small-molecule FOxO3A inhibitor(Gardenoside)that exhibits a strong effect of anti-FOXO3A DNA *** synergizes with rapamycin to substantially reduce tumor burden and extend survival in AML patient-derived xenograft *** results demonstrate that mTOR can mediate adaptive resistance to FOxO3A inhibition and validate a combinatorial approach for treating AML.

关键词： AML Combinatorial inhibition FOXO3A GNG7 mTOR