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Seven-years post allogeneic hematopoietic stem cell transplantation pure red cell aplastic anemia cured with daratumumab:A case report and review of literature

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World Journal of Clinical Cases 2024年第24期12卷 5604-5612页

作者： Bo Deng Rui Gao Bing Yang Wen-Bing Lei Ming-Fang Xue ji-shi wang Peng Zhao Department of Haematology Guizhou HospitalThe First Affiliated Hospital of Sun Yat-sen UniversityGuiyang 550001Guizhou ProvinceChina Department of Hematology The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550001Guizhou ProvinceChina School of Clinical Medicine Guizhou Medical UniversityGuiyang 550001Guizhou ProvinceChina Department of Hematology The Affiliated Hospital of Guizhou Medical UniversityHematological Institute of Guizhou ProvinceGuiyang 550001Guizhou ProvinceChina

BACKGROUND Allogeneic hematopoietic stem cell transplantation(Allo-HSCT)is currently the only viable method of curing patients with acute myeloid *** 30%to 50%of patients,donors and recipients have some level of ABO blood group *** blood group incompatibility can cause antibodies against the donor's red blood cells to persist in the recipient's body,resulting in a delay of several months in the recovery of red blood cells.A number of different treatments have been reported for post-transplant pure red cell aplastic anaemia(PRCA),such as plasmapheresis,donor lymphocyte infusions,anti-thymocyte globulin,rituximab and *** SUMMARY A 41-year-old female diagnosed with acute myeloid leukaemia underwent peripheral blood allogeneic haematopoietic stem cell transplantation in November 2013 from an HLA matched unrelated *** donor was AB-positive and the recipient was *** patient was diagnosed with PRCA three months after receiving the donor stem cell *** failing multiple lines of therapy,the patient applied for *** receiving three doses of daratumumab,the patient developed a reticulocyte response and no longer required CONCLUSION The use of daratumumab anti-CD38 for the remove of plasma cells is safe and effective and may be tried for refractory patients with PRCA after undergoing allo-HSCT for ABO incompatibility.

关键词： Transplantation PRCA Daratumumab Leukemia blood-group Case report

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Selective Permeation of CO_2 Through Modified PVSA/PS Composite Membrane

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Chinese Chemical Letters 2006年第2期17卷 277-280页

作者： Ying ZHANG Zhi wang Juan ZHAO ji Xiao wang shi Chang wang Chemical Engineering Research Center School of Chemical Engineering and Technology Tianjin University Tianjin 300072

A new fixed carder membrane material VSA-SA for CO2 separation was prepared through the chemical modification of PVSA. The selective permeation of CO2 through VSA-SA/PS composite membrane was performed with CO2/CH4 system. The VSA-SA/PS composite membranes possess better CO2 permselectivity than PVSA/PS composite membrane. Keywords： Fixed carder membrane, CO2 separation, PVSA, VSA-SA.

关键词： Fixed carder membrane CO2 separation PVSA VSA-SA.

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Loyal wingman task execution for future aerial combat:A hierarchical prior-based reinforcement learning approach

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Chinese Journal of Aeronautics 2024年第5期37卷 462-481页

作者： jiandong ZHANG Dinghan wang Qiming YANG Zhuoyong shi Longmeng ji Guoqing shi Yong WU School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710129China

In modern Beyond-Visual-Range(BVR)aerial combat,unmanned loyal wingmen are pivotal,yet their autonomous capabilities are *** study introduces an advanced control algorithm based on hierarchical reinforcement learning to enhance these capabilities for critical missions like target search,positioning,and relay *** on a dual-layer model,the algorithm’s lower layer manages basic aircraft maneuvers for optimal flight,while the upper layer processes battlefield dynamics,issuing precise navigational *** approach enables accurate navigation and effective reconnaissance for lead ***,our Hierarchical Prior-augmented Proximal Policy Optimization(HPE-PPO)algorithm employs a prior-based training,prior-free execution method,accelerating target positioning training and ensuring robust target *** paper also improves missile relay guidance and promotes the effective *** integrating this system with a human-piloted lead aircraft,this paper proposes a potent solution for cooperative aerial *** experiments demonstrate enhanced survivability and efficiency of loyal wingmen,marking a significant contribution to Unmanned Aerial Vehicles(UAV)formation control *** advancement is poised to drive substantial interest and progress in the related technological fields.

关键词： Beyond-visual-range Loyal wingmen Hierarchical prior-augmented proximal policy optimization Unmanned aerial vehicles Warfare

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Effect of intestinal function-recovering decoction on treatment of multiple organ dysfunction syndrome in rats

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Asian Pacific Journal of Tropical Medicine 2013年第11期6卷 889-892页

作者： Shu-jie Zhao Dong Zhang shi-ji wang Ying Chen jin-Feng Han Yu-Shan wang Intensive Care Unit First HospitalJilin University

Objective:To analyze the effect of intestinal function-recovering decoction on multiple organ dysfunction syndrome in rats,and to investigate a novel solution to multiple organ dysfunction ***:Multiple organ dysfunction syndrome was induced in 60 Sprague-Dawley rats by intestinal ischemia-reperfusion combined with cecal ligation and *** these rats were intragastrically administered physiological saline(group Ⅰ,n=20),ampicillin(group Ⅱ,n=20) or intestinal function-recovering decoction(group Ⅲ,n=20).After treatment, serum malondialdehyde and superoxide dismutase levels were compared among three groups. Simultaneously,bacterial culture of various organ tissues was performed and bacterial and endotoxin translocation were ***:Compared with group 1,serum malondialdehyde, alanine aminotransferase and aspartate aminotransferase levels were significantly decreased(all P0.05). The rate of bacterial translocation in the groups Ⅱ and Ⅲ was significantly lower than in the group Ⅰ(P0.05). Conclusions:Intestinal function-recovering decoction can significantly reduce endotoxin and bacterial translocation and stabilize enteral oxidative-antioxidative balance.

关键词： Multiple organ dysfunction syndrome Intestinal function-recovering decoction Malondialdehyde Superoxide dismutase

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Research progress of quantum artificial intelligence in smart city

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Intelligent and Converged Networks 2024年第2期5卷 116-133页

作者： Sumin wang Ning wang Tongyu ji Yiyun shi Chao wang the Joint International Research Laboratory of Specialty Fiber Optics and Advanced Communication Shanghai UniversityShanghai 200444China School of Information Engineering Ganzhou Key Laboratory of Cloud Computing and Big Data ResearchGannan University of Science and TechnologyGanzhou 341000China

The rapid accumulation of big data in the Internet era has gradually decelerated the progress of Artificial Intelligence(AI).As Moore’s Law approaches its limit,it is imperative to break the constraints that are holding back artificial *** computing and artificial intelligence have been advancing along the highway of human civilization for many years,emerging as new engines driving economic and social *** article delves into the integration of quantum computing and artificial intelligence in both research and *** introduces the capabilities of both universal quantum computers and special-purpose quantum computers that leverage quantum *** discussion further explores how quantum computing enhances classical artificial intelligence from four perspectives:quantum supervised learning,quantum unsupervised learning,quantum reinforcement learning,and quantum deep *** an effort to address the limitations of smart cities,this article explores the formidable potential of quantum artificial intelligence in the realm of smart *** does so by examining aspects such as intelligent transportation,urban operation assurance,urban planning,and information communication,showcasing a plethora of practical achievements in the *** the foreseeable future,Quantum Artificial Intelligence(QAI)is poised to bring about revolutionary development to smart *** urgency lies in developing quantum artificial intelligence algorithms that are compatible with quantum computers,constructing an efficient,stable,and adaptive hybrid computing architecture that integrates quantum and classical computing,preparing quantum data as needed,and advancing controllable qubit hardware equipment to meet actual *** ultimate goal is to shape the next generation of artificial intelligence that possesses common sense cognitive abilities,robustness,excellent generalization capabilities,and interpretability.

关键词： quantum artificial intelligence smart city D-Wave quantum computer

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Adaptive neural dynamic-based hybrid control strategy for stable retrieval of tethered satellite systems

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Astrodynamics 2024年第2期8卷 261-269页

作者： Zhixiong ji Gefei shi School of Aeronautics and Astronautics Sun Yat-sen UniversityGuangzhou 510275China Shenzhen Campus of Sun Yat-sen University Shenzhen 518107China Shenzhen Key Laboratory of Intelligent Microsatellite Constellation Shenzhen 518107China

This study proposes a novel adaptive neural dynamic-based hybrid control strategy for stable subsatellite retrieval of two-body tethered satellite *** retrieval speed is given analytically,ensuring a libration-free steady *** mitigate the potential libration motion,a general control input signal is generated by an adaptive neural-dynamic(AND)algorithm and executed by adjusting the retrieval speed and thruster on the *** address the limited retrieval speed and improve the control performance,the thruster controller is manipulated according to a novel advanced state fuzzy control law based on higher-order libration states,whereas the remaining control input is allocated to the speed *** Lyapunov stability of the control strategy is demonstrated *** simulations validate the proposed control strategy,demonstrating well-allocated control inputs for both controllers and good control performance.

关键词： tethered satellite system(TSS) stable retrieval hybrid control adaptive neural-dynamic (AND)control fuzzy control

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Light People: Professor Fanglin Bao and his cover story

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Light(Science & Applications) 2024年第6期13卷 1015-1020页

作者： ji wang School of Science Westlake UniversityHangzhouZhejiangPR China

Qu Yuan,a renowned ancient Chinese poet,once pondered in his work Heavenly Inquiry:“If the sun’s light is absent,from where does the radiance of the Hero Flower emanate?”The ability to see clearly in the darkest of nights has long been a sought-after magical power by *** holds not only immense technological significance for computer vision and remote sensing but also profound implications for transcending the dichotomy between day and night in our daily *** Fanglin Bao from Westlake University has made significant breakthroughs in this field,bringing us closer to a world where we can transform night into *** groundbreaking research on Heat-Assisted Detection and Ranging(HADAR)and night vision was featured as the cover story in Nature on July 26,2023.

关键词： bringing breakthrough holds

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In vitro performance of a biodegradable zinc alloy adjustable-loop cortical suspension fixation for anterior cruciate ligament reconstruction

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 887-898页

作者： Ting wang Zhangzhi shi Hongyong Zhong Xiangmin Li jinling Sun Wei Yin Xiaojing ji Qiang wang Anqi Zhao Luning wang School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China

Anterior cruciate ligament(ACL)injuries of the knee are one of the most common and serious athletic *** widely used cortical suspension fixation buttons for ligament reconstruction are permanent implants,particularly those made from conventional steel or titanium *** this study,a biodegradable Zn-0.45Mn-0.2Mg(ZMM42)alloy with the yield strength of 300.4 MPa and tensile strength of 329.8 MPa was prepared through hot *** use of zinc alloys in the preparation of cortical suspension fixation buttons was proposed for the first *** 35 d of immersion in simulated body fluids,the ZMM42 alloy fixation buttons were degraded at a rate of 44μm/a,and the fixation strength was retained(379.55 N)in the traction ***,the ZMM42 alloy fixation buttons exhibited an increase in MC3T3-E1 cell viability and high antibacterial activity against Escherichia coli and Staphylococcus *** results reveal the potential of biodegradable zinc alloys for use as ligament reconstruction materials and for developing diverse zinc alloy cortical suspension fixation devices.

关键词： anterior cruciate ligament reconstruction zinc alloy fixation buttons mechanical property corrosion behavior biocompatibility

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Protection effect of Emodin pretreatment on intestinal I-RI damage of intestinal mucosa in ratsa

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Asian Pacific Journal of Tropical Medicine 2014年第9期7卷 749-753页

作者： Shu-jie Zhao shi-ji wang Hong-Xiang Li Li-Hua Dong Huai-jiang He Zhong-Min Liu Yu-Shan wang ICU First Hospital of Jilin University

Objective:To linvestigate the protective effect and mechanism of emodin pretreatment on intestinal mucosa of rats with intestinal ischemia-reperfusion ***:A total of 50SD rats were randomly divided into control group,model group,emodin groups of low,medium and high dose,with 10 in each ***-reperfusion injury(I-RI)mode was established by using noninvasive clamp on superior mesentericartery(SMA).Control group and model group were pretreated with 0.5%sodium carboxymethyl cellulose solution lavage 2 h before operation,emodin groups of low,medium and high dose were given emodin lavage with 20,40,60 mg/kg pretreatment,femoral venous blood before the lavage pretreatment(TO)and 1 h ischemia(Tl),and inferior vena venous blood after 1 h of reperfusion(T2)were extracted from each group of rats for detection of serun level of intestinal fatty acid binding protein(I-FABP),tumor necrosis factor(TNF-α),endotoxin,interleukin 6(IL-6),and die content of diamine oxidase(DAO);Mter model establishment,the rats were sacrificed,intestine homogenate was prepared by using blind intestinal tissue to detect intestinal tissue myeloperoxidase(MPO],malondialdehyde(MDA)and superoxide dismutase(SOD)*** upper small intestine tissue was retrieved,followed by fixation and conventional HE staining to observe intestinal tissue morphology under light ***:In emodin groups of low,medium and high dose at T1 and T2,I-FABP,TNF-α,***,-6 and DAO level were significandy lower than that of model group(P<0.05);in emodin group of low,medium and high dose,MPO and MDA content in intestinal tissue homogenate was significantly lower than that in model group(P<0.05),SOD level was significantly higher than that of model group(P<0.05).Intestinal damage of emodin low,medium and high dose groups were significandy lighter than model ***:Emodin pretreatment has certain protective effect on intestinal mucosa in ischemia reperfusion injury.

关键词： Emodin Ischemia-reperfusion injury Intestinal mucosa barrier Protection

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Role of catalyst surface-active sites in the hydrogenation ofα,β-unsaturated aldehyde

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Frontiers of Chemical Science and Engineering 2024年第6期18卷 41-69页

作者： Haixiang shi Tongming Su Zuzeng Qin Hongbing ji School of Chemistry and Chemical Engineering Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification TechnologyGuangxi UniversityNanning 530004China Zhejiang Green Petrochemical and Light Hydrocarbon Transformation Research Institute Zhejiang University of TechnologyHangzhou 310014China

As an important technology in fine chemical production,the selective hydrogenation ofα,β-unsaturated aldehydes has attracted much attention in recent *** the process ofα,β-unsaturated aldehyde hydrogenation,a conjugated system is formed between>C=CC=O,leading to hydrogenation at both ends of the conjugated system,which competes with each other and results in more complex ***,improving the reaction selectivity is also difficult in industrial ***,many researchers have reported that surface-active sites on catalysts play a crucial role inα,β-unsaturated aldehyde *** review attempts to summarize recent advances in understanding the effects of surface-active sites(SASs)over metal catalysts for enhancing the process of *** construction strategies and roles of SASs for hydrogenation catalysts are *** attention has been given to the adsorption configuration and transformation mechanism ofα,β-unsaturated aldehydes on catalysts,which contributes to understanding the relationship between SASs and hydrogenation *** addition,recent advances in metal-supported catalysts for the selective hydrogenation ofα,β-unsaturated aldehydes to understand the role of SASs in hydrogenation are briefly ***,the opportunities and challenges will be highlighted for the future development of the precise construction of SASs.

关键词： α,β-unsaturatedd aldehydes hydrogenation active site cinnamaldehyde

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