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急性心肌梗死相关线粒体基因的生物信息学鉴定与验证

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中国组织工程研究 2025年第31期29卷 6697-6707页

作者：田宇诗付强李冀黑龙江中医药大学基础医学院黑龙江省哈尔滨市150040 黑龙江中医药大学黑龙江省哈尔滨市150040

背景:线粒体在急性心肌梗死损伤和修复中具有重要意义,因此基于线粒体基因探索急性心肌梗死发病进展具有重要的临床意义。目的:探究线粒体基因是否可以作为评估急性心肌梗死进展的可靠生物标志物。方法:从高通量基因表达数据库下载急性... 详细信息

背景:线粒体在急性心肌梗死损伤和修复中具有重要意义,因此基于线粒体基因探索急性心肌梗死发病进展具有重要的临床意义。目的:探究线粒体基因是否可以作为评估急性心肌梗死进展的可靠生物标志物。方法:从高通量基因表达数据库下载急性心肌梗死数据集GSE66360,GSE12288,在线粒体蛋白质数据库获取人类线粒体基因集;对急性心肌梗死数据集GSE66360进行差异基因分析及加权基因共表达网络分析,两者取交集后获得基因进行蛋白质-蛋白质相互作用分析、基因本体论和京都基因与基因组百科全书分析;将交集基因与人类线粒体基因取交集以获得差异线粒体基因,对差异线粒体基因进行基因集富集分析和免疫浸润分析,并在外部数据集GSE12288中进行受试者工作特征曲线分析,验证线粒体差异基因的表达特征。结果与结论:①获得急性心肌梗死差异基因548个,差异基因分析及加权基因共表达网络分析显示Blue模块包含基因最多(4992个),二者交集基因共有116个,其中肿瘤坏死因子、白细胞介素1B、白细胞介素6、Toll样受体4和白细胞介素10为核心基因;②基因本体论分析显示生物过程主要涉及炎症反应、肿瘤坏死因子产生的正调控及细胞表面受体信号通路,细胞组成主要涉及三级颗粒膜、质膜外层和质膜等,分子功能主要涉及免疫球蛋白G结合、跨膜信号受体活性及趋化因子活性等,京都基因与基因组百科全书分析显示,这些基因主要涉及肿瘤坏死因子、白细胞介素17及核转录因子κB通路;③共获得8个差异线粒体基因,经过最小绝对收缩和选择算子和比例风险回归模型分析后筛选出4个特征基因,包括佛波醇-12-肉豆酸酯-13-乙酰基诱导蛋白1、BCL2-相关蛋白A1、溶质载体家族25成员37和脱氧核糖核酸聚合酶β,并分别对应了肿瘤蛋白53、氧化磷酸化、硫代谢及甘油磷脂代谢通路;④受试者工作特征曲线分析显示4个特征基因均具有诊断意义,并与静息树突状细胞、幼稚B细胞呈显著负相关性;⑤提示佛波醇-12-肉豆酸酯-13-乙酰基诱导蛋白1、BCL2-相关蛋白A1、溶质载体家族25成员37和脱氧核糖核酸聚合酶β表达特征可作为预测急性心肌梗死中线粒体功能的潜在生物标志物,可进一步提高急性心肌梗死预测的准确性。

关键词：线粒体急性心肌梗死生物信息学机器学习免疫浸润分析氧化应激炎症凋亡

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Molecular simulation study of the microstructures and properties of pyridinium ionic liquid[HPy][BF_(4)]mixed with acetonitrile

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原子与分子物理学报 2025年第4期42卷 27-32页

作者： XU jian-qiang MA Zhao-Peng CHENG si LIU Zhi-Cong ZHU Guang-Lai Department of Physics School of Physics and Electronic InformationAnhui Normal UniversityWuhu 241002China

The microstructures and thermodynamic properties of mixed systems comprising pyridinium ionic liquid[HPy][BF_(4)]and acetonitrile at different mole fractions were studied using molecular dynamics simulation in this *** following properties were determined:density,self-diffusion coefficient,excess molar volume,and radial distribution *** results show that with an increase in the mole fraction of[HPy][BF_(4)],the self-diffusion coefficient ***,the excess molar volume initially decreases,reaches a minimum,and then *** rules of radial distribution functions(RDFs)of characteristic atoms are *** increasing the mole fraction of[HPy][BF_(4)],the first peak of the RDFs of HA1-F decreases,while that of CT6-CT6 rises at first and then *** indicates that the solvent molecules affect the polar and non-polar regions of[HPy][BF_(4)]differently.

关键词： Pyridinium ionic liquids Thermodynamic properties Molecular dynamics simulation Radial distribution functions

Transverse Velocity Field Measurements in High-resolution Solar Images Based on Deep Learning

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Research in Astronomy and Astrophysics 2023年第6期23卷 86-97页

作者： Zhen-Hong Shang si-Yu Mu Kai-Fan ji Zhen-Ping qiang Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming 650500China Yunnan Key Laboratory of Artificial Intelligence Kunming University of Science and TechnologyKunming 650500China Yunnan Observatories Chinese Academy of SciencesKunming 650216China College of Big Data and Intelligent Engineering Southwest Forestry UniversityKunming 650224China

To address the problem of the low accuracy of transverse velocity field measurements for small targets in highresolution solar images,we proposed a novel velocity field measurement method for high-resolution solar images based on *** method transforms the transverse velocity field measurements into an optical flow field prediction *** evaluated the performance of the proposed method using the Hαand TiO data sets obtained from New Vacuum Solar Telescope *** experimental results show that our method effectively predicts the optical flow of small targets in images compared with several typical machine-and deeplearning *** the Hαdata set,the proposed method improves the image structure similarity from 0.9182 to0.9587 and reduces the mean of residuals from 24.9931 to 15.2818;on the TiO data set,the proposed method improves the image structure similarity from 0.9289 to 0.9628 and reduces the mean of residuals from 25.9908 *** optical flow predicted using the proposed method can provide accurate data for the atmospheric motion information of solar *** code implementing the proposed method is available on https://***/lygmsy123/transverse-velocity-field-measurement.

关键词： methods:data analysis techniques:image processing Sun:fundamental parameters

Robust secrecy beamforming for full-duplex two-way relay networks under imperfect channel state information

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Science China(Information Sciences) 2018年第2期61卷 115-124页

作者： si LI qiang LI Shihai SHAO National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of China School of Communication and Information Engineering University of Electronic Science and Technology of China

Consider a two-way amplify-and-forward(AF) relay network where two legitimate nodes communicate through a relay in the presence of an eavesdropper. Assuming full duplexity at the legitimate nodes and the relay, a robust artificial noise(AN)-aided AF scheme is proposed to maximize the worst-case sum secrecy rate under imperfect channel state information(Csi) of the eavesdropper. This robust sum secrecy rate maximization(SSRM) problem is formulated as a max-min semi-infinite problem and is tackled by the semidefinite relaxation(SDR) method. In particular, we first convert the max-min semi-infinite problem into a maximization problem with a finite number of constraints. Then, an efficient two-block alternating difference-of-concave(DC) programming approach is proposed to iteratively solve the SDR problem, with one of the blocks computed in closed form. In addition, a specific robust rank-one solution construction procedure is presented to extract a feasible solution for the original robust SSRM problem from the SDR solution. The efficacy of the proposed method is demonstrated by numerical simulations.

关键词： physical-layer security full-duplex relay difference-of-concave program semidefinite relaxation MIMO

The Defocusing Energy-supercritical Hartree Equation

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Acta Mathematica sinica,English Series 2014年第4期30卷 547-566页

作者： ji qiang ZHENG The Graduate School of China Academy of Engineering Physics

In this paper, we study the global well-posedness and scattering problem for the energy -supercritical Hartree equation iut ＋ △u - （｜χ｜^-r＊｜u｜^2）u = 0 with r〉 4 in dimension d 〉r. We prove that if the solution u is apriorily bounded in the critical Sobolev space, that is, u ∈ Lt^∞（I;Hx^sc（R^d）） with Sc ：= x/2 - 1 〉 1, then u is global and scatters. The impetus to consider this problem stems from a series of recent works for the energy-supercritical nonlinear wave equation （NLW） and nonlinear SchrSdinger equation （NLS）. We utilize the strategy derived from concentration compactness ideas to show that the proof of the global well-posedness and scattering is reduced to disprove the existence of three scenarios： finite time blowup; soliton-like solution and low to high frequency cascade. Making use of the No-waste Duhamel formula, we deduce that the energy of the finite time blow-up solution is zero and so get a contradiction. Finally, we adopt the double Duhamel trick, the interaction Morawetz estimate and interpolation to kill the last two scenarios.

关键词： Havtree equation scattering theory Strichartz estimate energy supercritical concentration compactness

Conducting network interface modulated rate performance in LiFePO_(4)/C cathode materials

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Rare Metals 2022年第3期41卷 951-959页

作者： ji-Ming Peng Zhi-qiang Chen Yu Li si-jiang Hu Qi-Chang Pan Feng-Hua Zheng Hong-qiang Wang Qing-Yu Li Guangxi Key Laboratory of Low Carbon Energy Materials School of Chemical and Pharmaceutical SciencesGuangxi New Energy Ship Battery Engineering Technology Research CenterGuangxi Normal UniversityGuilin 541004China Hubei Key Laboratory for Processing and Application of Catalytic Materials College of Chemical EngineeringHuanggang Normal UniversityHuanggang 438000China

Carbon can play a critical role in electrode,especially for LiFePO_(4)cathode,not only serving as con-tinuous conducting network for electron pathway,but also boosting Li^(+) diffusion through providing sufficient ***,we report the modulation of electrode/elec-trolyte interface to yield excellent rate performance by creating cross-linked conducting carbon network in LiFePO_(4)/C cathode *** conducting networks inhibit agglomeration and growth of LiFePO_(4)/C primary particles and hence lead to a short Li^(+)diffusion ***,it also offers fast electron transmission rate and efficient electron for Li storage in the LiFePO_(4)*** LiFePO_(4)/C with carbon nanotubes(CNTs)delivers a discharge capacity of 150.9 mAh·g^(-1) at 0.1C(initial Coulombic efficiency of 96.4%)and an enhanced rate capability(97.2 mAh·g^(-1) at 20.0C).Importantly,it exhi-bits a high cycle stability with a capacity retention of 90.3%even after 800 cycles at 5.0C(0.85 A·g^(-1)).This proposed interface design can be applied to a variety of battery electrodes that face challenges in electrical contact and ion transport.

关键词： Lithium-ion battery Cathode material LiFePO_(4) Rate performance

TWO-STEP SCHEME FOR BACKWARD STOCHASTIC DIFFERENTIAL EQUATIONS

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Journal of Computational Mathematics 2023年第2期41卷 287-304页

作者： qiang Han Shaolin ji Zhongtai Securities Institute for Financial Studies Shandong UniversityJinan 250100China

In this paper,a stochastic linear two-step scheme has been presented to approximate backward stochastic differential equations(BSDEs).A necessary and sufficient condition is given to judge the L 2-stability of our numerical *** stochastic linear two-step method possesses a family of 3-order convergence schemes in the sense of strong *** coefficients in the numerical methods are inferred based on the constraints of strong stability and n-order accuracy(n∈N^(+)).Numerical experiments illustrate that the scheme is an efficient probabilistic numerical method.

关键词： Backward stochastic differential equation Stochastic linear two-step scheme Local truncation error Stability and convergence

jinfengopteryx Compared to Archaeopteryx,with Comments on the Mosaic Evolution of Long-tailed Avialan Birds

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Acta Geologica sinica(English Edition) 2007年第3期81卷 337-343页

作者： ji Shu＇an ji qiang Institute of Geology Chinese Academy of Geological Sciences Beijing 100037

jinfengopteryx is a newly uncovered Archaeopteryx-like avialan bird outside Germany, which was found from the Jehol Biota of northern Hebei in northeastern China. It shares many characters only with Archaeopteryx by the possession of three fenestrae in the antorbital cavity, 23 caudal vertebrae and long tail feathers attached to all the caudal vertebrae. But the former differs from the latter in the relatively short and high preorbital region of skull, more and closely packed teeth, much shorter forelimb compared to hindlimb. Such differences indicate jinfengopteryx is even slightly more primitive than Archaeopteryx, although both birds can be placed at the root position of the avialan tree based on cladistic analysis. Shenzhouraptor is suggested to be slightly more advanced than jinfengopteryx ＋ Archaeopteryx, supported by some derived features in teeth, shoulder girdles and forelimbs such as the reduction of tooth number, dorsolaterally directed glenoid facet, very long forelimb and comparatively short manus. Meanwhile, the tail of Shenzhouraptor shows more primitive characters than those of jinfengopteryx and Archaeopteryx, e.g., the strikingly longer tail composed of more caudal vertebrae and the long tail feathers attached only to distal caudal segments. The mixed primitive and advanced characters reveal the evident mosaic evolution among long-tailed avialan birds.

关键词： jinfengopteryx Archaeopteryx long-tailed avialans mosaic evolution Mesozoic

Fermi Blazars in the Zwicky Transient Facility Survey:Properties of Large Optical Variations

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Research in Astronomy and Astrophysics 2024年第10期24卷 104-115页

作者： si-si Sun Zhong-Xiang Wang Shun-Hao ji Department of Astronomy School of Physics and AstronomyYunnan UniversityKunming 650091China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China

We analyze the optical light curve data,obtained with the Zwicky Transient Facility(ZTF)survey,for 47 γ-ray blazars monitored by the Large Area Telescope onboard the Fermi Gamma-ray Space Telescope(Fermi).These 47sources are selected because they are among the Fermi blazars with the largest optical variations in the ZTF *** color-magnitude variation patterns are seen in them,with one being redder-to-stable-when-brighter(RSWB;in 31 sources)and the other being stable when brighter(in 16 sources).The patterns fit with the results recently reported in several similar studies with different ***,we find that the colors in the stable state of the sources share similar values,for which(after being corrected for the Galactic extinction)most sources are in a range of 0.4–*** feature could be intrinsic and may be applied in,for example,study of the intragalactic *** also determine the turning points for the sources showing the RSWB pattern,after which the color changes saturate and become *** find a correlation between optical fluxes and γ-ray fluxes at the turning *** physical implications of the correlation remain to be investigated,probably better with a sample of high-qualityγ-ray flux measurements.

关键词： (galaxies:)BL Lacertae objects:general (galaxies:)quasars:general gamma-rays:galaxies