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Hydrogel bioadhesives harnessing nanoscale phase separation for Achilles tendon repairing

Nano Research 2024年第2期17卷 778-787页

作者： jun Zhang Xingmei chen jingseng Lin Pei Zhang Iek Man Lei Yue Tao jiajun Zhang Tian Luo ji Liu Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055China Research and Innovation Center SKG Health TechnologyShenzhen 518000China SAFE(Shenzhen)Medical Technology Company Limited Shenzhen 518000China Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems Department of Mechanical and Energy EngineeringSouthern University of Science and TechnologyShenzhen 518055China Guangdong Provincial Key Laboratory of Human-Augmentation and Rehabilitation Robotics in Universities Southern University of Science and TechnologyShenzhen 518055China

Repairing Achilles tendon has emerged as a long-standing challenge in the orthopaedic *** suture is the gold standard for re-attaching and repairing the fractured Achilles tendons in clinical surgeries,it is still subjected to numerous adverse side-effects,including chronic inflammatory,tendon tissue re-rupture,scar formation,and post-surgical peritendinous *** this work,we develop a class of hydrogel bioadhesives with tailored nanoscale phase separation for Achilles tendon *** address the existing limitations of sutures,our hydrogel bioadhesives encompass three core functionalities:(i)instant and tough adhesion to Achilles tendon tissues,(ii)extraordinary long-term adhesion robustness under wet and dynamic in vivo conditions,and(iii)anti-postsurgical peritendinous *** our hydrogel bioadhesives with sutures,such kind of integrated approach enables a conformable yet robust biointerface with the tendon tissues,and prevents the fibroblast migration and formation of connective tissues,thus facilitating the tendon *** hydrogel bioadhesives reported here open up new opportunities for the repairing of fractured Achilles tendons in diverse and complicated clinical scenarios.

关键词： hydrogels phase separation bioadhesion robustness tendon repairing

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Chemical Constituents from Mentha haplocalyx Briq.(Mentha canadensis L.)and Theirα‑Glucosidase Inhibitory Activities

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Natural Products and Bioprospecting 2019年第3期9卷 223-229页

作者： Xiao-Feng He Chang-An Geng Xiao-Yan Huang Yun-Bao Ma Xue-Mei Zhang ji-jun chen State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China Yunnan Key Laboratory of Natural Medicinal Chemistry Kunming 650201China University of Chinese Academy of Sciences Beijing 100049China

Mentha haplocalyx(Mentha canadensis)is widely used as a medicinal plant in traditional Chinese medicine,and the extracts of its aerial parts are found to signifcantly inhibit the activity ofα-glucosidase with an IC_(50) value of 21.0μg/***-guided isolation of the extracts aforded two new compounds(1 and 2),together with 23 known ones(3-25).Their structures were established by extensive spectroscopic analyses(1D and 2D NMR,MS,IR and UV).Compounds 1-17 and 21-25 were evaluated for theirα-glucosidase inhibitory *** 11 was the most active ones with an IC_(50) values of 83.4μ*** results verify theα-glucosidase inhibitory activity of ***(***)and specify its active compounds for the frst time.

关键词： Mentha haplocalyx Briq.(Mentha canadensis L.) Lamiaceae α-Glucosidase inhibitor

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Monothetic and conductive network and mechanical stress releasing layer on micron-silicon anode enabling high-energy solid-state battery

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Rare Metals 2024年第3期43卷 1017-1029页

作者： Xiang Han Min Xu Lan-Hui Gu Chao-Fei Lan Min-Feng chen jun-jie Lu Bi-Fu Sheng Peng Wang Song-Yan chen ji-Zhang chen College of Materials Science and Engineering Co-Innovation Center of Efficient Processing and Utilization of Forestry ResourcesNanjing Forestry UniversityNanjing210037China Department of Physics Xiamen UniversityXiamen361005China Western Digital Corporation MilpitasCA95035USA

Silicon has ultrahigh capacity,dendrite-free alloy lithiation mechanism and low cost and has been regarded as a promising anode candidate for solid-state *** to the low infiltration of solid-state electrolyte(SSE),not the unstable solid-electrolyte interphase(SEI),but the huge stress during lithiation-and delithiation-induced particle fracture and conductivity lost tend to be the main *** this study,starting with micron-Si,a novel monothetic carbon conductive framework and a MgO coating layer are designed,which serve as electron pathway across the whole electrode and stress releasing layer,*** addition,the in situ reaction between Si and SSE helps to form a LiF-rich and mechanically stable SEI *** a result,the mechanical stability and charge transfer kinetics of the uniquely designed Si anode are significantly ***,high initial Coulombic efficiency,high capacity and durable cycling stability can be achieved by applying the Si@MgO@C anode in *** example,high specific capacity of 3224.6 mAh·g^(-1)and long cycling durability of 200 cycles are *** work provides a new concept for designing alloy-type anode that combines surface coating on particle and electrode structure design.

关键词： Lithium-ion battery(LIB) Solid-state electrolyte(SSE) Silicon anode Stress relief Coating

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Copper-Catalyzed Enantioconvergent Radical C(sp^(3))−N Cross- Coupling to Access Chiral α-Amino-β-lactams

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Precision Chemistry 2023年第10期1卷 576-582页

作者： jing-jing Zheng Wei-Long Liu Qiang-Shuai Gu Zhong-Liang Li ji-jun chen Xin-Yuan Liu Shenzhen Key Laboratory of Cross-Coupling Reactions Southern University of Science and TechnologyShenzhen 518055China Shenzhen Grubbs Institute and Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China Academy for Advanced Interdisciplinary Studies and Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China

A copper-catalyzed enantioconvergent radical C-(sp^(3))-N cross-coupling of racemic tertiaryα-bromo-β-lactams with aromatic amines is developed under mild thermal reaction *** use of a sterically demanded oxazoline-derived sulfonamide N,N,N-ligand is crucial for the reaction initiation and effective enantio-discrimination of the azetidinone-derived cyclic alkyl *** strategy provides an attractive approach to access chiralα-amino-β-lactams,an important structural motif in many biologically active *** mechanistic studies support the formation of azetidinone-derived alkyl radicals from the L*Cu(I)-amido complex andα-bromo-β-lactams.

关键词： copper asymmetric radical reactions cross-coupling aromatic amines chiralα-amino-β-lactams

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Event-triggered adaptive output feedback control for hyperbolic PDEs: swapping-based design

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Science China(Information Sciences) 2024年第5期67卷 327-328页

作者： Chunting ji Zhengqiang ZHANG Xue-jun XIE School of Engineering Qufu Normal University Institute of Automation Qufu Normal University

Partial differential equations(PDEs) characterize transport phenomena and fluid flow, and common cases include heat exchangers and road traffic [1]. Recently, scholars have become enthusiastic about event-triggered control(ETC) of hyperbolic PDEs, primarily because it can help conserve computing and communication resources. For example,Ref. [2] presented an output feedback ETC scheme for 2 × 2hyperbolic PDEs.

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Catalytically generated noncovalent ammonium dienolate:a versatile platform for the development of organocatalytic asymmetric cascade reactions

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Science China Chemistry 2024年第8期67卷 2524-2546页

作者： jun-Bing Lin Dong-Sheng ji Peng-Fei Xu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China Shaanxi Key Laboratory of Chemical Reaction Engineering College of Chemistry and Chemical EngineeringYan’an UniversityYan’an 716000China

Organocatalytic cascade reactions represent a powerful strategy for the rapid construction of complex chiral molecules with multiple stereocenters from simple substrates under mild conditions. The intriguing structural feature and diverse reactivity of catalytically generated dienolate species render them competent and versatile intermediates for the development of practical and valuable cascade reactions. Over the past years, a plethora of innovative and pioneering noncovalent ammonium dienolatemediated cascade reactions have been designed and implemented under the catalysis of chiral organocatalysts, making dienolate activation a general, robust, and complementary method for the functionalization of unsaturated carbonyl compounds and related substances. This review illustrates the recent advances in organocatalytic noncovalent ammonium dienolate-mediated cascade reactions(mainly from 2010 to 2023), including the cascade transformations of ammonium dienolates directly generated from unsaturated ketone/aldehyde, ester/lactone/azlactone, amide/lactam/pyrazolone/oxindole, and alkylidene nitrile compounds. The contents are arranged based on the reaction types of the ammonium dienolates, with an emphasis on cascade 2,5-, 3,5-, and 4,5-difunctionalizations of these intermediates. Furthermore, other cascade reactions involving the 1,3-, 2,3-, and even more complex 3,4,5-reactivities of ammonium dienolates were also discussed. The reaction pathway, reaction stereoinduction, and synthetic applications of the ammonium dienolate-mediated cascade reactions were highlighted throughout the article. As a stimulating and ever-growing research area, the organocatalytic noncovalent ammonium dienolate-mediated cascade reactions are expected to continue demonstrating their magic power for constructing chiral targets in the future and further expanding the boundaries of asymmetric catalysis.

关键词： organocatalysis asymmetric catalysis ammonium dienolate cascade reaction difunctionalization

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Degradation of warm permafrost and talik formation on the Qinghai-Tibet Plateau in 2006-2021

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Advances in Climate Change Research 2024年第2期15卷 275-284页

作者： Qi-Hang MEI ji chen You-Qian LIU Shou-Hong ZHANG jing-Yi ZHAO Tian-Chun DONG jun-cheng WANG Yao-jun ZHAO Beiluhe Observation and Research Station of Frozen Soil Engineering and Environment Key Laboratory of Cryospheric Science and Frozen Soil EngineeringNorthwest Institute of Eco-Environmental and ResourcesChinese Academy of SciencesLanzhou 730000China China Railway Qinghai-Tibet Group Co.Ltd Xining 810007China University of Chinese Academy of Sciences Beijing 100049China

Permafrost is degrading globally,particularly those with low thermal stability on the Qinghai-Tibet Plateau,owing to climate ***,the inadequacy of direct research on permafrost degradation based on in-situ monitoring limits the prediction of permafrost degradation and engineering *** study explored the processes and modes of permafrost degradation into talik by analyzing ground temperature data from five points in the hinterland of the Qinghai-Tibet Plateau from 2006 to *** results showed that the degradation of the warm permafrost layer with a geothermal gradient of zero occurred simultaneously in the top and bottom *** rate of permafrost degradation from the top down and bottom up increase during the degradation process,but the increase of the former is more drastic after the formation of thawed ***,the construction of the Qinghai-Tibet Railway changed the degradation modes of the permafrost in adjacent natural sites through horizontal heat transfer,particularly after through talik formation under the *** findings suggest that taking countermeasures before or immediately after forming thawed interlayer is more *** evaluating the thermal impact of projects in warm permafrost regions,special attention should be given to the horizontal heat transfer process that may result from the formation of a through talik.

关键词： Warm permafrost Degradation Talik Qinghai-Tibet Plateau Climate change

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Guaiane-type Sesquiterpenoid Dimers from Artemisia zhongdianensis and Antihepatoma Carcinoma Activity via the p38MAPK Pathway

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Chinese Journal of Chemistry 2023年第19期41卷 2453-2468页

作者： Wei Dong Wen-jing Ma Yun-Bao Ma Feng-jiao Li Tian-Ze Li Yong-Cui Wang Xiao-Feng He Chang-An Geng Xue-Mei Zhang ji-jun chen State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan650201 China University of Chinese Academy of Sciences Beijing100049 China

17 new guaiane-type sesquiterpenoid dimers(GSDs),artemzhongdianolides B1—B17(1—17),were isolated from Artemisia zhongdianensis under the guidance of bioassay,and elucidated by spectral analyses(HRESIMS,1D and 2D NMR,IR,ECD).The absolute configuration of compounds 1,3,7,9,10,and 13 was determined by single-crystal X-ray diffraction ***,artemzhongdianolides B1(1)and B2(2)were the first example of the GSDs fused via a C-13/C-13'single bond,and artemzhongdianolides B3—B17 were[4+2]Diels–Alder adducts of two monomeric *** of the compounds showed antihepatoma cytotoxicity with IC_(50) values ranging from 9.9 to 170.1μmol/***,artemzhongdianolide B9(9)was the most active one against three hepatoma cell lines with IC_(50) values of 13.1μmol/L(HepG2),19.5μmol/L(Huh7),and 19.5μmol/L(SK-Hep-1),and dose-dependently inhibited cell migration and invasion,induced G1 cell cycle arrest and cell apoptosis in HepG2 *** 9 might suppress HepG2 cells via affecting the p38MAPK signaling pathway suggested by machine learning approach,and significantly upregulated expression of phosphorylated p38 validated by Western blot assay.

关键词： Artemzhongdianolides B1-B17 Artemisia zhongdianensis Guaiane-type sesquiter penoid dimers Antihepatoma activity p38MAPK pathway Cancer NMR spectroscopy X-ray diffraction

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Discovery of the choristodere Hyphalosaurus baitaigouensis from the Lower Cretaceous jiufotang Formation of western Liaoning,China and its paleobiogeographic significance

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Journal of Palaeogeography 2024年第3期13卷 547-562页

作者： Li-jun Zhang Shu-An ji Hai-Chun Zhang South China Sea Culture Museum Hainan Tropical Ocean UniversitySanya 572022Hainan ProvinceChina Key Laboratory of Stratigraphy and Paleontology Ministry of Natural ResourcesInstitute of GeologyChinese Academy of Geological SciencesBeijing 100037China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of SciencesNanjing 210008Jiangsu ProvinceChina

The water-living reptile genus Hyphalosaurus was previously discovered in the Lower Cretaceous Yixian Formation bearing the middle Jehol Biota in western Liaoning,*** complete skeletons of Hyphalosaurus are reported for the first time from the jiufotang Formation bearing the late Jehol Biota at two sites in western *** show the typical characteristics of Hyphalosaurus baitaigouensis in terms of the contact between some cranial bones and the number of cervical and dorsal vertebrae,and therefore are assigned to *** discovery extends the stratigraphic range of this species from the Yixian Formation to the overlying jiufotang *** paper further briefly compares the main characteristics of the two skeletons,summarizes the temporal and spatial distribution of Hyphalosaurus,and discusses the palaeogeographic evolution of western Liaoning at the middle and late Jehol Biota stages based on the aquatic habits of Hyphalosaurus and the geological background of western *** analytical results show that the volcanic downwarped lakes,with distinct geographical divisions in western Liaoning during the deposition of the Yixian Formation,had not completely disappeared till the deposition of the jiufotang *** palaeo-lake in the Fuxin-Yixian Basin underwent the process of generation,expansion and shrinkage during the depositional period of the Yixian Formation and finally merged into a large *** palaeo-Dalinghe River,which connected the main basins in western Liaoning during the depositional period of the jiufotang Formation,was formed simultaneously.

关键词： Western liaoning Jehol biota jiufotang formation Hyphalosaurus baitaigouensis Palaeobiogeography

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A robust viscoelastic surfactant tolerating 20% HCl up to 150℃ for oil well stimulation

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Petroleum Science 2024年第3期21卷 1865-1874页

作者： ji Wang Ning Qi Hong-Yao Yin Yu-jun Feng Polymer Research Institute State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu610065SichuanPR.China Tianfu Yongxing Laboratory New Theory and Technology of CO_(2) Capture Research CenterChengdu610065SichuanPR China School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China

Viscoelastic surfactants(VES)are often used as viscous diverters in acidizing stimulation to prolong the acid consumption time and maximize zonal coverage of the acid for improving well ***,the ceiling temperature of commercial VES cannot exceed 120℃in practical use because of the poor thermal stability and fragile molecular structure,hindering their implementation in hightemperature oil reservoirs,i.e.,≥150℃.Here we synthesized a novel C22-tailed diamine,N-erucaminopropyl-N,N-dimethylamine(EDPA),and examined comparatively its rheological behavior,assemblies morphology and molecular stability in 20 wt%HCl with a commercial VES,erucyl dimethyl amidopropyl betaine(EDAB).The feasibility of EDPA for acidizing stimulation was assessed by acid etching of carbonate rock with its HCl solution at 150℃.Rheological results showed that the 2.5 wt%EDPA—20 wt%HCl solution maintains stable viscosity of 90 m Pa s at 150℃for 60 min,while that of 2.0 wt%EDAB HCl solution is just 1 m Pa s under identical conditions.1H NMR spectra and cryo-TEM observations revealed that the chemical structure and self-assembled architectures of EDPA remained intact in such context,but the EDAB suffered from degradation due to the hydrolysis of the amide group,accounting for the poor heat-resistance and *** reaction rate of 2.5 wt%EDPA HCl solution with carbonate rock was one order of magnitude lower than that of 20 wt%HCl solution at 150℃,underpinning the potential of EDPA to be used in the high-temperature reservoirs *** work improved the thermal tolerance of VES in highly concentrated HCl solution,paving a feasible way for the acidization of high-temperature reservoir environments(~150℃).

关键词： Viscoelastic surfactants Thermal stability Self-diverting acid Wormlike micelles Acidizing stimulation

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