检索结果-南通市图书馆

Insufficient MIRO1 contributes to declined oocyte quality during reproductive aging

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年

作者： Zhen-Nan pan Hao-Lin Zhang Kun-huan Zhang jia-Qian Ju jing-Cai Liu Shao-Chen Sun College of Animal Science and Technology Nanjing Agricultural University Reproductive Medicine Centre The Affiliated Yantai Yuhuangding Hospital of Qingdao University

Mitochondrial Rho-GTPase 1 (MIRO1) is an outer mitochondrial membrane protein which regulates mitochondrial transport and mitophagy in mitosis. In present study, we reported the crucial roles of MIRO1 in mammalian oocyte meiosis and its potential relationship with aging. We found that MIRO1 expressed in mouse and porcine oocytes, and its expression decreased in aged mice. MIRO1 deficiency caused the failure of meiotic resumption and polar body extrusion in both mouse and porcine oocytes, which could be rescued by exogenous MIRO1supplementation. Mass spectrometry data indicated that MIRO1 associated with several cytoskeleton and cell cycle-related proteins, and MIRO1 regulated motor protein Dynein for microtubule-organizing centers (MTOCs) dynamics at germinal vesicle (GV) stage, which determined meiotic resumption. Furthermore, we found that MIRO1 regulated Aurora A and kinesin family member 11 (KIF11) for meiotic spindle assembly in oocytes. Besides, MIRO1 associated with several mitochondria-related proteins dynamic-related protein 1 (DRP1),Parkin and lysosomal-associated membrane protein 2 (LAMP2) for mitochondrial dynamics and mitophagy during oocyte meiosis. Taken together, our results suggested that MIRO1 played pivotal roles in meiotic resumption, spindle assembly and mitochondrial function in mouse and porcine oocytes, and its insufficiency might contribute to the oocyte maturation defects during aging.

关键词：

Self-assembled carbon monoxide nanoprodrug for chemiexcitationtriggered synergistic chemotherapy against breast cancer

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Shunfei Cui Yiyao pan Chenzhe Ma Bin Qi Qingqiang Min Ming Li Huabing Chen Hengte Ke Xingyue ji jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development College of Pharmaceutical ScienceSoochow University

Carbon monoxide（CO） has recently been well-established as a promising therapeutic modality against cancer. The development of transition-metal-free and tumor-targeted delivery platforms for CO is highly demanded but remains very sporadic. Herein, we developed a polyprodrug system for the co-delivery of CO and a chemotherapeutic agent combretastin A-4（CA-4） to the tumor site based on a chemiexcitation mechanism. Such a poly-prodrug successfully achieved the co-activation of CO and CA-4 in response to H2O2at the tumor site both in vitro and in vivo. Importantly, a synergist effect between CO and CA-4 was observed in suppressing tumor growth in a mouse tumor model. It is anticipated that such a poly-prodrug system could be potentially adapted for the co-delivery of CO and another drug payload for combinational therapy for other indications.

关键词：

Upsilon Photo-Production off Proton in QCD Inspired Model

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2009年第7期52卷 108-114页

作者： pan ji-huan MA Wei-Xing GU Yun-Ting LUO Liang-Zi Department of Physics Guangxi University Nanning 530004 China Department of Physics and Electronic Engineering Hechi College Yizhou 546300 China Institute of High Energy Physics the Chinese Academy of Sciences Box 918 Beijing 100049 China

Based on the generalized vector meson dominance model in QCD, we study photoproduction of vector meson T off the proton by use of the QCD inspired model in which the contributions from quark-quark, gluon-gluon, and quark-gluon interference term to observable are taken into consideration. Calculations are performed for total cross section σtot, differential cross section dσ/dt, ratio of the real part to imaginary part of forward scattering amplitude ρ, and nuclear slop parameter function β. The mediators of interactions between projectiles （the quark and antiquark pair fluctuated from the real the photon） and the proton target （three-quark system） are the tensor Glueball and Odderon instead of using the usual Pomeron exchange. The theoretical predictions for σtot （s） are consistent with the experimental data within error bars of the data. The data for dσ/dt, ρ, and β are urgently needed.

关键词： Upsilon production QCD inspired model vector meson dominance model

Synthesis and luminescence properties of Ca_2SiO_4-based red phosphors with Sm^(3+) doping for white LEDs

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2012年第7期19卷 663-667页

作者： jin-jun Cai huan-huan pan Yi Wang School of Applied Physics and Materials Wuyi University Jiangmen 529020 China

Sm3＋-activated Ca2SiO4 red phosphors were prepared by the conventional high-temperature solid-state reaction method, and the effects of sodium （Na＋） and samarium （Sm3＋） ions doping concentrations on their crystal structure and luminescent properties were investigated by X-ray diffraction （XRD） and fluorescent spectrofluorometer. XRD patterns demonstrate that a well-crystalline structure forms in the phosphors when they are treated by calcination at 1200~C for 4 h, and the excitation spectra exhibit good absorption in the range between 350 and 420 nm. Under the irradiation of 405 nm near-ultraviolet （NUV） light, the spectra of the phosphors show a main emission peak at 601 nm attributed to the 4G5/2→6H7/2 transition of Sm3＋ ions, and its intensity is greatly influenced by the concentrations of Sm3＋ and Na2CO3. When the concentrations of Sm3＋ ions and Na2CO3 are 2mol% and 6mol%, respectively, the optimal emission intensity can be obtained. From strong absorption in the near ultraviolet zone, the Na0.06Sm0.02Ca1.92SiO4 phosphor is a promising red-emitting phosphor for white light emitting diodes （W-LEDs）.

关键词： light emitting diodes phosphors photoluminescence doping samarium calcium silicate

The sex determination gene doublesex regulates expression and secretion of the basement membrane protein Collagen Ⅳ

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2022年第7期49卷 636-644页

作者： Qionglin Peng jiangtao Chen Rong Wang huan Zhu Caihong Han Xiaoxiao ji Yufeng pan The Key Laboratory of Developmental Genes and Human Disease School of Life Science and TechnologySoutheast UniversityNanjingJiangsu 210096China Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu 226019China

The highly conserved doublesex(dsx) and doublesex/mab-3 related(Dmrt) genes control sexually dimorphic traits across animals. The dsx gene encodes sex-specific transcription factors, Dsx^(M) in males and Dsx^(F) in females, which function differentially and often oppositely to establish sexual dimorphism. Here, we report that mutations in dsx, or overexpression of dsx, result in abnormal distribution of the basement membrane(BM) protein Collagen Ⅳ in the fat body. We find that Dsx isoforms regulate the expression of Collagen Ⅳ in the fat body and its secretion into the BM of other tissues. We identify the procollagen lysyl hydroxylase(dPlod) gene, which is involved in the biosynthesis of Collagen Ⅳ, as a direct target of Dsx. We further show that Dsx regulates Collagen Ⅳ through d Plod-dependent and independent pathways. These findings reveal how Dsx isoforms function in the secretory fat body to regulate Collagen Ⅳ and remotely establish sexual dimorphism.

关键词： Drosophila Sexual dimorphism doublesex Dmrt genes CollagenⅣ dPlod Fat body

SOME SYNCHRONIZATION CRITERIA FOR GENERAL COMPLEX NETWORKS WITH COUPLING DELAYS

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2011年第6期24卷 1057-1067页

作者： huan pan Xiaohong NIAN Weihua GUI School of Information Science and Engineering Central South University Changsha 410004 China

A general complex delayed dynamical network model with asymmetric coupling matrix is considered in this paper. For reducing the conservativeness of synchronization criteria, several novel synchronization stability conditions are presented by using delay decomposition methods. Numerical examples which are widely used to study delay-dependent synchronization stability are given to illustrate the effectiveness of the proposed methods.

关键词： Asymmetric coupling complex network linear matrix inequality synchronization timedelay.

考虑场地效应的多点地震动作用下边坡永久位移分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

岩土工程学报 2025年第1期47卷 65-75页

作者：宋健潘驭航陆朱汐姬建张飞高玉峰河海大学岩土力学与堤坝工程教育部重点实验室江苏南京210024 河海大学土木与交通学院江苏南京210024

地震动引起的边坡土层非线性动力响应可能导致坡体不同位置的地震动加速度时程不一致,从而对整个滑动体的极限平衡状态及之后的地震累积永久位移产生影响。为了研究场地效应对边坡地震永久位移的影响,基于极限平衡条分法,通过对不同土... 详细信息

地震动引起的边坡土层非线性动力响应可能导致坡体不同位置的地震动加速度时程不一致,从而对整个滑动体的极限平衡状态及之后的地震累积永久位移产生影响。为了研究场地效应对边坡地震永久位移的影响,基于极限平衡条分法,通过对不同土条赋予不同的水平和竖向地震动时程,推导出一种考虑场地效应的圆弧和任意形状滑面的多点地震作用下边坡永久位移分析方法。通过与有限差分软件FLAC的数值模拟结果进行对比,验证了该方法能够合理考虑地震动的场地效应。通过研究不同分布形式的多点地震动及竖向地震动对边坡永久位移的影响,结果表明:场地效应引起的水平地震动放大以及多点地震动不同分布模式会导致整个滑体平均地震惯性力作用位置发生改变,从而影响地震作用下滑动体沿滑面的永久变形量,竖向地震动对边坡地震位移影响较小。将方法应用于Lexington土石坝震后变形案例分析,计算得到的坝坡地震永久位移与实际震后观测值相吻合,证明了考虑场地效应的重要性及本文方法的合理性。

关键词：地震边坡稳定性场地效应永久位移极限平衡条分法多点地震动

Non-perturbative Aspects of QCD and Parameterized Quark Propagator

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2008年第1期49卷 181-188页

作者： ZHOU Li-Juan GU Yun-Ting MA Wei-Xing MENG Cheng-Ju pan ji-huan Collaboration Group of Hadron Physics and Non-perturbative QCD Study Guangxi University of Technology Liuzhou545006 China Department of Physics Guangxi University Nanning 530004 China Institute of High Energy Physics the Chinese Academy of Sciences Beijing 100049 China Department of Physics Hechi College Yizhou 546300 Guangxi China

Based on the Global Color Symmetry Model, the non-perturbative Q, CD vacuum is investigated in the parameterized fully dressed quark propagator. Our theoretical predictions for various quantities characterized the QCD vacuum are in agreement with those predicted by many other phenomenologieal QCD inspired models. The successful predictions clearly indicate the extensive validity of our parameterized quark propagator used here. A detailed discussion on the arbitrariness in determining the integration cut-off parameter ofμ in calculating QCD vacuum condensates and a good method, which avoided the dependence of calculating results on the cut-off parameter is also strongly recommended to readers.

关键词： global color symmetry model parameterized quark propagator non-perturbative QCD vacuumand vacuum condensate

Photoproduction of Vector Meson φ off Deuteron in QCD Inspired Model

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2009年第8期52卷 295-301页

作者： MENG Cheng-Ju pan ji-huan PENG jin-Song MA Wei-Xing YUAN Tong-Quan Department of Physics and Electronic Engineering Hechi College Yizhou 546300 China Institute of High Energy Physics the Chinese Academy of Sciences Beijing 100049 China

Based on the quark-gluon contents of nucleon and strongly believing that the force mediators,Pomeronand its counterpart in the conventional approach of Regge theory,for high energy diffractive process would be the tensorglueball and Odderon respectively,we discuss photo-production of vector meson φ off the deuteron at energy less than 3GeV in the QCD inspired model in which the quark gluon degrees of freedom and glueball,Odderon exchange are takeninto account.A calculation is performed for γ + D →φ + D,and the theoretical predictions of the differential crosssection dσ^(γD)) /dt,are presented and compared with available experimental *** QCD inspired model reproducesdata quite well in the whole range of the experimental measurements up to |t| ■0.4 *** results can be used toextract γn→φn data,which cannot be measured in experiment.

关键词： photoproduction of vector meson QCD generalized vector meson dominance model QCD