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Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming

Neural Regeneration Research 2025年第4期20卷 1178-1191页

作者： Wanxian Luo Chuanhui Xu Linxi Li Yunxiang ji yezhong Wang Yingjia Li Yongyi ye Department of Medicine Ultrasonics Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Institute of Neuroscience Department of NeurosurgeryThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina

Microglia,the primary immune cells within the brain,have gained recognition as a promising therapeutic target for managing neurodegenerative diseases within the central nervous system,including Parkinson’s *** perfluorocarbon droplets have been reported to not only possess a high oxygen-carrying capacity,but also exhibit remarkable anti-inflammatory ***,the role of perfluoropentane in microglia-mediated central inflammatory reactions remains poorly *** this study,we developed perfluoropentane-based oxygen-loaded nanodroplets(PFP-OLNDs)and found that pretreatment with these droplets suppressed the lipopolysaccharide-induced activation of M1-type microglia in vitro and in vivo,and suppressed microglial activation in a mouse model of Parkinson’s *** suppression led to a reduction in the inflammatory response,oxidative stress,and cell migration capacity in ***,the neurotoxic effects were mitigated,which alleviated neuronal ***,ultrahigh-performance liquid chromatography–tandem mass spectrometry showed that the anti-inflammatory effects of PFP-OLNDs mainly resulted from the modulation of microglial metabolic *** further showed that PFP-OLNDs regulated microglial metabolic reprogramming through the AKT-mTOR-HIF-1α***,our findings suggest that the novel PFP-OLNDs constructed in this study alleviate microglia-mediated central inflammatory reactions through metabolic reprogramming.

关键词： metabolic reprogramming microglia microglial migration nanotherapy neurodegenerative diseases neuroinflammation oxygen-loaded nanodroplets Parkinson’s disease perfluoropentane ultra-performance liquid chromatography–mass spectrometry

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Diverse species of Colletotrichum associated with grapevine anthracnose in China

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Fungal Diversity 2015年第2期71卷 233-246页

作者： ji-ye yan M.M.R.S.Jayawardena Ishani D.Goonasekara Yong Wang Wei Zhang Mei Liu jin-Bao Huang Zhong-Yue Wang jing-jing Shang You-Liang Peng Ali Bahkali Kevin D.Hyde Xing-Hong Li Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesBeijing 100097People’s Republic of China Institute of Excellence in Fungal Research School of ScienceMae Fah Luang UniversityChiang Rai 57100Thailand Department of Plant Pathology Agriculture CollegeGuizhou UniversityGuiyang 550025People’s Republic of China Institute of Plant Protection Chinese Academy of Agriculture SciencesBeijing 1000193People’s Republic of China Department of Plant Pathology China Agricultural UniversityBeijing 100193People’s Republic of China College of Science Botany and Microbiology DepartmentKing Saud UniversityRiyadhSaudi Arabia

Grapevine anthracnose is an important disease,responsible for mild to severe yield losses in grape production,and is also an important post harvest *** disease was studied in vineyards in six provinces in China,with 34 isolates obtained from diseased ***-gene(ACT,ITS,GAPDH,TUB2 and CHS)analysis coupled with morphology showed that Colletotrichum aenigma,*** *** *** were associated with grapevine anthracnose in *** aenigma is reported for the first time as associated with grapevine *** hebeiense is a new species introduced *** testing showed that all species can infect grapes,causing anthracnose however,virulence of species and isolates showed great *** analysis showed that *** is a cryptic species and its taxonomy needs to be resolved in the future.

关键词： Colletotrichum aenigma Disease symptoms Virulence Grape ripe rot Multi-gene

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Species of Botryosphaeriaceae involved in grapevine dieback in China

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Fungal Diversity 2013年第4期61卷 221-236页

作者： ji-ye yan Yue Xie Wei Zhang Yong Wang jian-Kui Liu Kevin D.Hyde Robert C.Seem Guo-Zhen Zhang Zhong-Yue Wang Sheng-Wei Yao Xian-jin Bai Asha J.Dissanayake You-Liang Peng Xing-Hong Li Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesBeijing 100097People’s Republic of China Department of Plant Pathology China Agricultural UniversityBeijing 100193People’s Republic of China Department of Plant Pathology Agriculture CollegeGuizhou UniversityGuiyang 550025People’s Republic of China Institute of Excellence in Fungal Research School of ScienceMae Fah Luang UniversityChiang Rai 57100Thailand Department of Plant Pathology New York State Agricultural Experiment StationCornell UniversityGenevaNY 14456USA Institute of Plant Protection Chinese Academy of Agricultural SciencesBeijing 100193People’s Republic of China Guangxi Fruit and Vegetable Research Institute Guilin 541004People’s Republic of China

Botryosphaeria dieback is a serious disease problem for table and grape wine production *** disease however,has been less well-studied in *** this study,we surveyed Botryosphaeria dieback in 72 vineyards of 20 grape-growing regions in China and found that Botryosphaeria dieback occurs in 18 out of 20 *** and multi-gene phylogenetic analyses confirmed that Botryosphaeria dothidea,Diplodia seriata,Lasiodiplodia theobromae and Neofusicoccum parvum are associated with different grapevine dieback *** study also revealed considerable differences in the geographical distribution of Botryosphaeriaceae species in China with Lasiodiplodia theobromae and Neofusicoccum parvum occurring only in subtropical monsoon climate regions,Diplodia seriata occurring only in temperate monsoon climate regions,and Botryosphaeria dothidea occurring in both temperate and subtropical monsoon climate *** of 26 isolates showed that there is little genetic variation within ***’s postulates were satisfied for all species,and pathogenicity testing showed that among the 25 major cultivars growing in China,none was resistant to the four *** current paper represents the first detailed report on Botryosphaeria dieback of grapevines in China.

关键词： Botryosphaeria dieback Botryosphaeriaceae Grapevine Pathogenicity

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Manufacture the conducting polymer with light

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Science China Chemistry 2025年第01期 8-9页

作者： yang Li Tianyu Li yan ji Baoguang Liu College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology) Nanjing University of Posts & Telecommunications

Poly(3,4-ethylenedioxythiophene) (PEDOT), heralded as the “king” of conducting polymers, is esteemed in bioelectronics for its mixed electronic and ionic conductivity, mechanical properties compatible with biological tissues, tunable healing ability and stability in diverse environments [1]. Based on additive manufacturing of three-dimensional structures,PEDOT realizes the implementation in the efficient production of flexible bioelectronics, the construction of intricate electrode-neural implantations, and the development of smart brain-computer-interfaces [2].

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Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi ji Chaoyi yang Xuerui Pang Yibing yan Yue Wu Zhi Geng Wenjie Hu Panpan Hu Xingqi Wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

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Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo ji jianhua Zhuang yan Liu jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

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InNi alloy-induced interface effect promoting the parallel electron transfer: improved photothermal catalytic CO2 hydrogenation

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Science China Chemistry 2025年

作者： Haoyu Zhang Yuhang Li Yu Nie Xinyu Dou Haodong ji Xin Tan jinhua ye Tao Yu School of Chemical Engineering and Technology Tianjin University Eco-environment and Resource Efficiency Research Laboratory School of Environment and Energy Peking University Shenzhen Graduate School School of Environmental Science and Engineering Tianjin University Advanced Catalytic Materials Research Center School of Materials Science and Engineering Tianjin University Research Center for Solar Driven Carbon Neutrality Hebei University

Photothermal catalytic CO2hydrogenation is an effective means of utilizing carbon ***,it is severely limited in terms of kinetics and ***,it is necessary to meticulously design catalysts to solve this ***,a sandwich structured NiO@InNi/In2O3is designed to intrinsically regulate the direction of photogenerated carriers transfer,resulting in a CO yield of 42.97 mmol g-1h-1(1290.3μmol h-1) with a selectivity near to 100%.InNi alloy favors the collection of photogenerated carriers by the parallel way and enhancement of the adsorption and activation of *** grown on the surface of InNi alloy not only improves the adsorption of H2and provides sufficient H+for the reaction,but also makes InNi alloy more stable during the reaction *** photothermal effect caused by In2O3accelerates the transfer of photogenerated carriers and increases the surface temperature of the catalyst,thereby synergistically promoting the reaction from a kinetic *** work ameliorates the kinetic and thermodynamic limitations of the photothermal catalytic CO2hydrogenation process through rationally designing the electron transfer direction of the sandwich structured catalysts to parallel way.

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从电子显微镜的象面和衍射面强度复原相位的计算实例

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物理学报 1983年第6期 762-769页

作者：西门纪业晏继文北京大学无线电电子学系

高分辨率电子显微学中相位复原问题是一个重要问题。本文的计算表明,对于振幅为常数或线性函数,相位为抛物型、正弦型或指数型的波函数,可以采用Gerchberg-Saxton迭代算法从已知的象面和衍射面上的强度分布来唯一地和精确地复原真实的... 详细信息

高分辨率电子显微学中相位复原问题是一个重要问题。本文的计算表明,对于振幅为常数或线性函数,相位为抛物型、正弦型或指数型的波函数,可以采用Gerchberg-Saxton迭代算法从已知的象面和衍射面上的强度分布来唯一地和精确地复原真实的相位。我们编制了计算机程序,对于给定的象面波函数,采用离散的快速傅里叶算法,可以计算其衍射面的波函数。输入数值在-π,+π间的初始相位后,按照G-S迭代算法,利用本程序可以复原相位。文中详细给出了若干个计算实例。所得的相位迭代解对于1弧度的初始相位扰动是稳定的。

关键词：相位分布抛物型指数型相位复原电子显微学电子显微镜电镜波函数波动力学迭代算法迭代结果计算实例单位振幅

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pH-controlled assembly of two supramolecular architectures based on Cu（Ⅱ）-metallacycle building blocks

pH-controlled assembly of two supramolecular architectures b...

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中国化学会第五届全国结构化学学术会议

作者： Lei Zhang jian Zhang Zhao-ji Li ye-yan Qin and Yuan-Gen Yao~*State Key Laboratory of Structural Chemistry,Fujian Institute of Research on the Structure of Matter,The Chinese Academy of Sciences,Fuzhou,Fujian 350002,People''s Republic of China.

＜正＞The design and construction of supramolecular architectures with coordination bonds and hydrogen bonds has attracted great attention in recent *** the various families of these supramolecular materials,the family of closed,ring-like coordination complexes such as metallacrowns and metallacycles is an important one,owing to their potential applications in

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存在球差和失焦下电子光学传递函数和脉冲响应函数

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物理学报 1985年第3期 348-358页

作者：西门纪业晏继文黄旭北京大学无线电电子学系

根据电子光学理论,球差和失焦引起附加相位移为γ,相干的振幅和相位衬度传递函数为cosγ和sinγ。它们的傅里叶逆变换给出脉冲响应函数的实部和虚部。本文讨论了cosγ和sinγ的零点和极值点,这些点将衍射平面划分为一系列环带。证明了... 详细信息

根据电子光学理论,球差和失焦引起附加相位移为γ,相干的振幅和相位衬度传递函数为cosγ和sinγ。它们的傅里叶逆变换给出脉冲响应函数的实部和虚部。本文讨论了cosγ和sinγ的零点和极值点,这些点将衍射平面划分为一系列环带。证明了当无量纲失焦量Δ=N1/2（N为正整数）时各环带上cosγ,sinγ的积分相同,即对脉冲响应函数中心值的贡献相同。本文讨论了使cosγ或sinγ的积分取极大值或极小值,亦即使脉冲响应函数中心值或中心强度取极大值或极小值的条件。本文还讨论了脉冲响应函数最佳均方逼近理想的Airy分布的条件。

关键词：光学传递函数零点实部光学转移函数点(数学) 脉冲响应函数极值点球差极小值点扩散函数极大值中心值傅里叶逆变换

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