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World Journal of Clinical Cases 2022年第8期10卷 2577-2583页

作者： Tae Woong Yang Seunghwan Song hye Won lee Byeong-Ju lee Department of Rehabilitation Medicine Biomedical Research InstitutePusan National University HospitalPusan 602-739South Korea Department of Thoracic and Cardiovascular Surgery Pusan National University School of MedicinePusan National University HospitalPusan 602-739South Korea Division of Cardiology Department of Internal MedicinePusan National University School of MedicinePusan National University HospitalPusan 602-739South Korea

BACKGROUND Insertion of a left ventricular assist device(LVAD)and heart transplantation(HT)improve the survival of patients with heart *** addition,cardiac rehabilitation(CR)further increases the functional *** case report describes a successful case of CR after LVAD insertion and subsequent *** SUMMARY In the present case,during the LVAD insertion period,peak oxygen consumption(VO2)increased by 12.16%after *** was performed 7 mo after the LVAD insertion,and the patient participated in phases I and II *** peak VO2 increased from 17.24 to 22.29 m L/kg/*** improvement was more significant than that reported in previous studies on CR after LVAD insertion or *** patient’s quality of life also *** total average score of the short form-36 questionnaire increased from 29.5 points at admission to 53.3 points 9 mo after *** A tailored CR program after LVAD insertion or HT may improve the patients’quality of life and increase survival.

关键词： Left ventricular assist device Heart transplantation Cardiac rehabilitation Case report

Exosome-guided direct reprogramming of tumor-associated macrophages from protumorigenic to antitumorigenic to fight cancer

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Bioactive Materials 2023年第7期25卷 527-540页

作者： Hyosuk Kim Hyun-Ju Park Hyo Won Chang ji Hyun Back Su jin lee Yae Eun Park Eun hye Kim Yeonsun Hong Gijung Kwak Ick Chan Kwon ji Eun lee Yoon Se lee Sang Yoon Kim Yoosoo Yang Sun Hwa Kim Medicinal Materials Research Center Biomedical Research InstituteKorea Institute of Science and TechnologySeoul02792Republic of Korea Department of Functional Genomics KRIBB School of BioscienceKorea University of Science and Technology(UST)Daejeon34141Republic of Korea Department of Otolaryngology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul05505Republic of Korea Chemical&Biological Integrative Research Center Biomedical Research InstituteKorea Institute of Science and TechnologySeoul02792Republic of Korea Department of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul02841Republic of Korea Department of Life Sciences Korea UniversitySeoul02841Republic of Korea

Highly immunosuppressive tumor microenvironment containing various protumoral immune cells accelerates malignant transformation and treatment *** particular,tumor-associated macrophages(TAMs),as the predominant infiltrated immune cells in a tumor,play a pivotal role in regulating the immunosuppressive tumor *** a potential therapeutic strategy to counteract TAMs,here we explore an exosome-guided in situ direct reprogramming of tumor-supportive M2-polarized TAMs into tumor-attacking M1-type *** derived from M1-type macrophages(M1-Exo)promote a phenotypic switch from anti-inflammatory M2-like TAMs toward pro-inflammatory M1-type macrophages with high conversion *** M1 macrophages possessing protein-expression profiles similar to those of classically activated M1 macrophages display significantly increased phagocytic function and robust cross-presentation ability,potentiating antitumor immunity surrounding the ***,these M1-Exo also lead to the conversion of human patient-derived TAMs into M1-like macrophages that highly express MHC class II,offering the clinical potential of autologous and allogeneic exosome-guided direct TAM reprogramming for arming macrophages to join the fight against cancer.

关键词： Exosome Cancer therapy Tumor microenvironment Tumor-associated macrophage Direct conversion

Application of Cellulose Nanofibril as a Wet-end Additive in Papermaking:A Brief Review

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Paper And Biomaterials 2020年第2期5卷 76-84页

作者： Guihua Yang Guangrui Ma Ming He Xinxiang ji hye Jung Youn Hak Lae lee jiachuan Chen State Key Laboratory of Biobased Material and Green Papermaking Qilu University of Technology(Shandong Academy of Sciences)Ji'nanShangdong Province250353China Department of Forest Sciences Research Institute of Agriculture and Life SciencesCollege of Agriculture and Life SciencesSeoul National University1 Gwanak-roGwanak-guSeoul08826South Korea

Recently,cellulose nanofibril(CNF)has emerged as a promising,sustainable reinforcement with outstanding potential in material *** to the properties of CNF,it has been explored in food,cosmetic,and pharmaceutical applications,as well as in industrial applications such as paints,drill muds,packaging,and *** application of CNF in papermaking is expected to be implemented in the near future to broaden the commercial market of *** studies and patents have reported on the manufacturing,properties,and applications of *** present paper focuses on the recent progresses in the application of CNF as a wet-end additive in papermaking.

关键词： cellulose nanofibril papermaking wet-end additive dewatering

Phase-controlled synthesis of thermally stable nitrogen-doped carbon supported iron catalysts for highly efficient Fischer-Tropsch synthesis

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Nano Research 2019年第10期12卷 2568-2575页

作者： jin Hee lee Hack-Keun lee Dong Hyun Chun Hyunkyung Choi Geun Bae Rhim Min hye Youn Heondo Jeong Shin Wook Kang Jung-ll Yang Heon Jung Chui Sung Kim ji Chan Park Clean Fuel Laboratory Korea Institute of Energy ResearchDaejeon 34129Republic of Korea Department of Chemical Engineering University of SeoulSeoul 02504Republic of Korea Advanced Energy and System Technology University of Science and TechnologyDaejeon 34113Republic of Korea Department of Physics Kookmin UniversitySeoul 02707Republic of Korea

Iron-based nan oparticles with un iform and high particle dispersi on,which are supported on carb on structures,have been used for various ***,their preparation still suffers from complicated synthesis involving multiple steps and from the high price of precursors and solve *** the prese nt work,a new carbon en capsulated iron-carbide nano particle supported on n itroge rvdoped porous carbon(Fe5C2@C/NPC)structure was *** was made using a simple solid-state reaction with sequential thermal ***5C2@C/NPC is a highly active and stable catalyst for the high-temperature Fischer-Tropsch synthesis *** showed very high hydrocarbon productivity(4.71 gHc gcat^-1·h^-1)with high CO conversions(up to 96%).

关键词： iron-carbide one-pot synthesis nitrogen-doped graphene Fischer-Tropsch synthesis Mdssbauer spectroscopy

Factors affecting length of stay according to bronchopulmonary dysplasia severity:a nationwide cohort study in Korea

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World Journal of Pediatrics 2024年第5期20卷 470-480页

作者： hye Mi lee Jeongmin Shin Sae Yun Kim So Young Kim Department of Pediatrics College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea Department of Pediatrics Yeouido St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea1063-roYeongdeungpo-guSeoul07345Republic of Korea

Background Longer hospitalizations for preterm infants with bronchopulmonary dysplasia(BPD)delay developmental outcomes,increase the risk for hospital-acquired complications,and exert a substantial socioeconomic *** study aimed to identify factors associated with an extended length of stay(LOS)at different levels of severity of *** A cohort study was conducted using the Korean Neonatal Network registry of very low birth weight infants with BPD between 2013 and 2017 through retrospective *** A total of 4263 infants were diagnosed with *** mild BPD,infants requiring surgical treatment for patent ductus arteriosus needed a longer LOS[eadjustedβcoefficients(adjβ)1.041;95%confidence interval(CI):0.01–0.08]and hydrocephalus(eadjβ1.094;95%CI 0.01–0.17).In moderate BPD,infants administered steroids or with intraventricular hemorrhage required a longer LOS(eadjβ1.041;95%CI 0.00–0.07 and eadjβ1.271;95%CI 0.11–0.38,respectively).In severe BPD,infants with comorbidities required a longer LOS:pulmonary hypertension(eadjβ1.174;95%CI 0.09–0.23),administrated steroid for BPD(eadjβ1.116;95%CI 0.07–0.14),sepsis(eadjβ1.062;95%CI 0.01–0.11),patent ductus arteriosus requiring surgical ligation(eadjβ1.041;95%CI 0.00–0.08),and intraventricular hemorrhage(eadjβ1.016;95%CI 0.05–0.26).Additionally,the higher the clinical risk index score,the longer the LOS needed for infants in all *** The factors affecting LOS differed according to the severity of *** approaches to reducing LOS may be devised using knowledge of the various risk factors affecting LOS by BPD severity.

关键词： Bronchopulmonary dysplasia Length of stay Very low birth weight

Design of 512-bit logic process-based single poly EEPROM IP

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Journal of Central South University 2011年第6期18卷 2036-2044页

作者：金丽妍 JANG ji-hye 余忆宁 HA Pan-Bong KIM Young-Hee Department of Electronic Engineering Changwon National University

A single poly EEPROM cell circuit sharing the deep N-well of a cell array was designed using the logic process. The proposed cell is written by the FN tunneling scheme and the cell size is 41.26 μm2, about 37% smaller than the conventional cell. Also, a small-area and low-power 512-bit EEPROM IP was designed using the proposed cells which was used for a 900 MHz passive UHF RFID tag chip. To secure the operation of the cell proposed with 3.3 V devices and the reliability of the used devices, an EEPROM core circuit and a DC-DC converter were proposed. Simulation results for the designed EEPROM IP based on the 0.18μm logic process show that the power consumptions in read mode, program mode and erase mode are 11.82, 25.15, and 24.08 ~tW, respectively, and the EEPROM size is 0.12 mm2.

关键词： single poly EEPROM cell Fowler-Nordheim tunneling logic process radio frequency identification small area

Inverse relationship between bioavailable testosterone and subclinical coronary artery calcification in non-obese Korean men

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Asian Journal of Andrology 2012年第4期14卷 612-615页

作者： Byoung-jin Park Jae-Yong Shim Yong-Jae lee Jung-Hyun lee hye-Ree lee Department of Family Medicine Yonsei University College of Medicine Seou1135-720 Korea Department of Health Promotion Center Gangnam Severance Hospita Yonsei University College of Medicine Seou1135-720 Korea

Although low testosterone levels in men have been associated with high risk for cardiovascular disease, little is known about the association between male sex hormones and subclinical coronary disease in men with apparently low cardiometabolic risk. This study was performed to investigate the association between male sex hormones and subclinical coronary artery calcification measured as coronary calcium score in non-obese Korean men. We examined the relationship of total testosterone, sex hormone-binding globulin, bioavai lable testosterone and free testosterone with coronary calcium score in 291 non-obese Korean men （mean age： 52.8--- 9.3 years） not having a history of cardiovascular disease. Using multiple linear regression, we evaluated associations between log （sex hormone） levels and log （coronary calcium score） after adjusting for confounding variables in 105 men with some degree of coronary calcification defined as coronary calcium score ~〉 1. In multiple linear regression analysis, bioavailable testosterone was inversely associated with coronary calcium score （P=0.046） after adjusting for age, body mass index, smoking status, alcohol consumption, regular exercise, mean blood pressure, resting heart rate, C-reactive protein, fasting plasma glucose, total cholesterol, triglyceride, high-density lipoprotein （HDL） cholesterol, hypertension medication and hyperlipidernia medication, whereas total testosterone, sex hormone-binding globulin and free testosterone were not （P=0.674, P=O. 121 and P=O. 102, respectively）. Our findings indicate that bioavailable testosterone is inversely associated with the degree of subclinical coronary artery calcification in non-obese men.

关键词： bioavailable testosterone cardiovascular disease coronary calcium score male sex hormone subclinical coronary arterydisease testosterone

Significance of adverse outcome pathways in biomarker-based environmental risk assessment in aquatic organisms

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Journal of Environmental Sciences 2015年第9期27卷 115-127页

作者： jin Wuk lee Eun-ji Won Sheikh Raisuddin Jae-Seong lee Department of Biological Science College of Science Sungkyunkwan University Department of Medical Elementology and Toxicology Hamdard University

In environmental risk assessments（ERA）, biomarkers have been widely used as an early warning signal of environmental contamination. However, biomarker responses have limitation due to its low relevance to adverse outcomes（e.g., fluctuations in community structure, decreases in population size, and other similar ecobiologically relevant indicators of community structure and function）. To mitigate these limitations, the concept of adverse outcome pathways（AOPs） was developed. An AOP is an analytical, sequentially progressive pathway that links a molecular initiating event（MIE） to an adverse outcome. Recently, AOPs have been recognized as a potential informational tool by which the implications of molecular biomarkers in ERA can be better understood. To demonstrate the utility of AOPs in biomarker-based ERA, here we discuss a series of three different biological repercussions caused by exposure to benzo（a）pyrene（Ba P）, silver nanoparticles（Ag NPs）, and selenium（Se）. Using mainly aquatic invertebrates and selected vertebrates as model species, we focus on the development of the AOP concept. Aquatic organisms are suitable bioindicator species whose entire lifespans can be observed over a short period; moreover, these species can be studied on the molecular and population ***, interspecific differences between aquatic organisms are important to consider in an AOP framework, since these differences are an integral part of the natural *** development of an environmental pollutant-mediated AOP may enable a better understanding of the effects of environmental pollutants in different scenarios in the diverse community of an ecosystem.

关键词： Adverse outcome pathway Biomarker Omics Environmental risk assessment Aquatic organisms Interspecific difference

Molecular Sensors of Temperature,Pressure,and Pain with Special Focus on TRPV1,TRPM8,and PIEZO2 Ion Channels

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Neuroscience Bulletin 2021年第12期37卷 1745-1749页

作者： Ru-Rong ji Seok-Yong lee Department of Anesthesissology Center for Translation Pain MedicineDuke University Medical CenterDurhamNC 27710USA Departments of Neurobiology and Cell Biology Duke University Medical CenterDurhamNC 27710USA Department of Biochemistry Duke University Medical CenterDurhamNC 27710USA

The 2021 Nobel Prize in Physiology or Medicine was awarded to two sensory neurobiologists and pain researchers,*** at the University of California in San Francisco and Ardem Patapoutian at Scripps Research in San Diego,for their discoveries of thermal and mechanical transducers[1](https://***/prizes/medicine/2021/advanced-infor mation/).As the Nobel Committee stated,“the question of how we sense the physical world through somatic sensation has fascinated humankind for millennia,however,the identity of the molecular transducers responsible for detecting and converting heat.

关键词： Sensors Focus stated

Characteristics of Sea Breeze Front Development with Various Synoptic Conditions and Its Impact on Lower Troposphere Ozone Formation

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Advances in Atmospheric Sciences 2013年第5期30卷 1461-1478页

作者： Hyo-Eun ji Soon-Hwan lee Hwa-Woon lee Division of Earth Environmental System Pusan National University Department of Earth Science Education Pusan National University

To examine the correlation between the sizes of sea breeze fronts and pollutants under the influence of synoptic fields, a numerical simulation was conducted in the southeast coastal area of the Korean Peninsula, where relatively high concentrations of pollutants occur because of the presence of various kinds of industrial developments. Sea breeze and sea breeze front days during the period 2005 09 were identified using wind profiler data and, according to the results, the number of days were 72 and 53, respectively. When synoptic forcing was weak, sea breeze fronts moved fast both in horizontal fields and in terms of wind velocity, while in the case of strong synoptic forcing, sea breeze fronts remained at the coast or moved slowly due to strong opposing flows. In this case, the sea breeze front development function and horizontal potential temperature difference were larger than with weak synoptic forcing. The ozone concentration that moves together with sea breeze fronts was also formed along the frontal surfaces. Ozone advection and diffusion in the case of strong synoptic forcing was suppressed at the frontal surface and the concentration gradient was large. The vertical distribution of ozone was very low due to the Thermal Internal Boundary Layer （TIBL） being low.

关键词： sea breeze front synoptic opposing flow wind profiler ozone numerical simulation