检索结果-南通市图书馆

Behavioral consequences of children with sleep-disordered breathing after adenotonsillectomy

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2018年第1期14卷 57-65页

作者： ji Yoon kim Chang Ho Lee Hyoung-Mi kim Otorhinolaryngology Department CHA UniversitySeongnamKorea Otorhinolaryngology Department CHA Bundang MedicalCenterCHA University351Yatap-dongBundang-guSeongnam-siGyeonggi-do463-712Korea

Background Adenotonsillectomy (AT) has been an effective treatment for sleep-disordered breathing (SDB) in children, and several studies described the risk of postoperative weight gain and obesity in children treated with AT. The present study aimed to evaluate behavioral improvements in children with SDB one year after adenotonsillectomy and to investigate an influence of postoperative weight gain on behaviors. Methods The study included 170 children aged 5–11 years who underwent adenotonsillectomy for SDB and 150 controls. Body mass index percentile was obtained for age and gender, and parental sleep-related breathing disorder (SRBD) question-naire was used to assess the severity of SDB. Psychological assessment was performed pre- and post-adenotonsillectomy using standardized questionnaires including strength and difficulties questionnaire, children's depression inventory and screen for child anxiety-related emotional disorder. Results The mean age of 170 patients was 7.7 ± 1.5 years with 73 (42.9%) girls and 97 (57.1%) boys. The mean follow-up period were 15.4 ± 2.7 months. The patients had shown significant improvements in SDB scores as well as in questionnaire-based behavioral problems after adenotonsillectomy. The odds of a child being overweight were significantly increased after adenotonsillectomy. Less improvements in hyperactivity and conduct problems were observed in the patients with older ages, higher SRBD scores, and overweight/obesity at 1-year follow-up after adenotonsillectomy. Conclusion These data suggest that abnormal behavioral outcomes should be evaluated postoperatively, which potentially could be reduced with the early adenotonsillectomy and adequate postoperative weight control.

关键词： Obesity Obstructive sleep apnea Pediatric Snoring Tonsillectomy

Extract from Zanthoxylum piperitum Induces Apoptosis of AGS Gastric Cancer Cells through Akt/MDM2/p53 Signaling Pathway

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2021年第10期27卷 752-759页

作者： Ye Seul Park Gun He Nam Kyung Jo Jo hye Won Kawk Sang Yung kim Young Min kim Department of Biological science and Biotechnology College of Life science and Nano TechnologyHannam University1646 Yuseong-daeroYuseong-guDaejeon 34054South Korea Department of Food Science&Bio Technology Shinansan UniversityDeahakro Danwon-guAnsan-CityGyenggi-doKorea

Objective:To determine the effect of Zanthoxylum piperitum extracet(ZPE)on apoptosis and analyze anticancer substances in ZPE,changes in proteins related to apoptosis,and pathological changes in tumors in ***:Fifteen 4-week-old female BALB/c nu/nu mice were divided into 3 groups depending on ZPE dose,with 5 in each *** gastric carcinoma cells(1 x 10^(6) cells/200 jxL)were subcutaneously injected into the flank of each *** week after the injection of AGS cells,ZPE was administered to the skin tissue[10 or 50 mg/(kg-d)]in the low-and high-dose groups,respectively for 20 *** animals were injected with vehicle *** 3 weeks,the tumor was extracted and carried out for immunohistochemistry,the tendency of apoptosis and p53 in the body was checked using TdT-mediated dUTP nick-end labeling(TUNEL)*** 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay,annexin V dead cell staining,cell cycle arrest and Western blotting,AGS gastric carcinoma cells were incubated with various concentrations of ZPE for 24 *** survival rates were analyzed by MTT *** was analyzed using annexin V dead cell staining and cell cycle arrest and measured using Muse cell ***:High performance liquid chromatography(HPLC)analysis showed that ZPE contained organic sulfur compounds such as alliin and *** assay results revealed that ZPE(10-85»xg/mL)could effectively inhibit the growth of AGS gastric cancer cells at higher concentrations(Pjig/mL)*** decreased the expression of anti-apoptotic proteins(p-Akt,p-MDM2,Bcl-2),while increased pro-apoptotic proteins(cleaved PARP,p53,pro-Caspase 3,Bax).TUNEL assays revealed an increase in cell *** staining confirmed the involvement of ***:ZPE decreases AGS cell

关键词： AGS gastric cancer cells Zanthoxylum piperitum apoptosis Akt/MDM2/p53 signaling pathway active compounds

Anti-obesity Effects of Ginsenosides in High-Fat Diet-Fed Rats

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2019年第12期25卷 895-901页

作者： Hyun-Jung Park ji Hyun kim Insop Shim Department of Physiology College of MedicineKyung Hee UniversitySeoul(130-701)Republic of Korea Department of Food Science&Biotechnology College of Science and EngineeringSuwon-si(16227)Republic of Korea

Objective: To examine the anti-obesity effects of ginsenosides in Korea Red Ginseng(KRG, Panax ginseng) in rats fed with a high-fat diet(HFD). Methods: Twenty-five 4-week-old obesity rats after receiving an HFD for 5 weeks;subsequently, they were additionally treated with ginsenosides Rb1, Rd, Rg1, or Re(10 mg/kg, intraperitoneal injection) for a further 3 weeks(n=5 in each group). The control rats were fed a normal diet. The food consumption, body weight, locomotor activity, serum lipids, adipose tissues, nitric oxide(NO) expression, leptin, neuropeptide Y(NPY), cholecystokinin(CCK) in the brains were measured. Results: In the HFD-fed rats, body weight, body fat mass, serum levels of leptin and NO were significantly higher than in the control rats(P<0.05 or P<0.01). However, the treatment of Rd, Re, and Rb1 markedly decreased body fat mass and body weight(P<0.05). The serum level of leptin and NO in ginsenoside-treated rats were markedly lower than the control group(P<0.01). The expression of NPY and CCK in the hypothalamic nuclei showed insignificant difference among groups. However, the expression of NPY immunoreactive neurons in the hypothalamus was significantly reduced in the Rb1-treated group(P<0.05). Conclusion: PD-type ginsenoside Rb1 from the crude saponins of KRG may be a useful compound for the treatment of obesity and related disorders through the modulation of peripheral and central appetite-regulating signals.

关键词： Panax ginseng ginsenosides hypothalamus obesity

Stand development patterns of forest cover types in the natural forests of northern Baekdudaegan in South Korea

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2015年第2期26卷 381-390页

作者： ji Hong kim Guangze jin Sang Hoon Chung Department of Forest Management College of Forest and Environmental SciencesKangwon National University School of Forestry Northeast Forestry University Forest Ecology Division Forest Conservation DepartmentKorea Forest Research Institute

The purpose of this study was to classify current forest cover types,and to investigate stand development patterns for natural forests in six areas in northern Baekdudaegan,South ***-eight independent forest communities were aggregated into eight forest cover types by species composition in the overstory of each forest *** forest cover types were of mixed mesophytic,‘‘others’ ’ deciduous,Quercus mongolica dominant,*** pure,Pinus densiflora–***,***,Betula ermanii,and ***–*** ecological information was organized by importance value and species diversity for each forest *** on the correlation between species diversity index and the abundance of *** plus *** for corresponding forest cover types,we compared the developmental process and approximate successional pathway between each cover *** *** forest cover type changes into the ***–*** cover type,followed by the *** dominant cover type through continuous invasion of the oak ***,the *** pure cover type would spread toward the *** dominant cover type with a mixture of various deciduous tree *** *** dominant cover type progresses through the other deciduous cover types to the mixed mesophytic cover type with diversified composition and *** the mid to lower slopes,with loamy soils and good moisture conditions,various deciduous forest types should progress,by ecological succession,toward the mixed mesophytic cover type without any further disturbance.

关键词： Baekdudaegan Forest cover type Species composition Species diversity Stand development patterns

Genomic organization and transcriptional modulation in response to endocrine disrupting chemicals of three vitellogenin genes in the self-fertilizing fish Kryptolebias marmoratus

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2016年第4期28卷 187-195页

作者： Bo-Mi kim Min Chul Lee hye-Min Kang Jae-Sung Rhee Jae-Seong Lee Department of Biological Science College of ScienceSungkyunkwan University Department of Marine Science College of Natural SciencesIncheon National University

Vitellogenin（Vtg）is the precursor of egg yolk proteins,and its expression has been used as a reliable biomarker for estrogenic contamination in the aquatic *** examine the biomarker potential of the self-fertilizing killifish Kryptolebias marmoratus Vtgs（Km-Vtgs）,full genomic DNAs of Km-Vtgs-Aa,Km-Vtgs-Ab,and Km-Vtgs-C were cloned,sequenced,and *** Vtg genes in *** are tandemly placed in a550 kb section of the same *** silico analysis of promoter regions revealed that both the Km-Vtgs-Aa and Km-Vtgs-Ab genes had an estrogen response element（ERE）,but the Km-Vtgs-C gene did ***,all three Km-Vtgs genes had several ERE-half sites in their promoter *** analysis demonstrated that the three deduced amino acid residues were highly conserved with conventional Vtgs protein,forming distinctive clades within teleost *** tissue showed the highest expression of Km-Vtg transcripts in all tested tissues（brain/pituitary,eye,gonad,intestine,skin,and muscle）in response to endocrine disrupting chemical（EDC）-exposed ***-Vtg transcripts were significantly increased in response to 17β-estradiol（E2）,tamoxifen（TMX）,4-n-nonylphenol（NP）,bisphenol A（BPA）,and octylphenol（OP）over 24 hr *** Km-Vtg-A gene was highly expressed compared to the control in response to NP and ***-induced modulatory patterns of Km-Vtg gene expression were different depending on tissue,gender,and isoforms.

关键词： Kryptolebias marmoratus Vitellogenin Endocrine disrupting chemical

Efficacy of horse oil on lipopolysaccharide-induced inflammation in human keratinocytes

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2021年第3期41卷 355-359页

作者： In Wook kim Hyo-Soon Jeong hye-Young Yun Kwang jin Baek Nyoun Soo Kwon Dong-Seok kim Department of Biochemistry Chung-Ang University College of MedicineSeoul 06974Republic of Korea

OBJECTIVE: To investigate the efficacy of horse oil on lipopolysaccharide(LPS)-induced inflammation in human ***: Western blot analysis was performed to measure the expression of cyclooxygenase-2(COX-2) and IκBα. ELISA was used to analyze prostaglandin E2(PGE2) ***: Horse oil decreased LPS-induced COX-2 and PGE2 levels in a dose-dependent manner. Nuclear factor-kappa B(NF-κB) plays a key role in the expression of inflammatory cytokines and mediators. Therefore, we investigated the influence of horse oil on the NF-κB signaling pathways. Horse oil inhibited translocation of NF-κB from the cytosol to the nucleus. Furthermore, LPS-induced degradation of IκBα was recovered by horse oil. The activation of p38 mitogen-activated protein kinase(MAPK) reportedly induces degradation of IκBα In agreement with this, LPS activated p38 MAPK and caused IκBα degradation. Conversely, horse oil inhibited LPS-induced p38 MAPK activation and IκBαdegradation. In addition, a specific p38 MAPK inhibitor, SB203580, blocked IκBα ***: Horse oil decreased COX-2 and PGE2 by inhibiting p38 MAPK activation, IκBα degradation, and the translocation of NF-κB.

关键词： horse oil inflammation keratinocytes NF-kappa B cyclooxygenase 2 mitogen-activated protein kinase lipopolysaccharides dinoprostone

Roughness coefficient and its uncertainty in gravel-bed river

在线全文

学校读者我要写书评

暂无评论

Water Science and Engineering 2010年第2期3卷 217-232页

作者： ji-Sung kim Chan-Joo LEE Won kim Yong-Jeon kim River and Coastal Research Division Korea Institute of Construction Technology

Manning＇s roughness coefficient was estimated for a gravel-bed river reach using field measurements of water level and discharge, and the applicability of various methods used for estimation of the roughness coefficient was evaluated. Results show that the roughness coefficient tends to decrease with increasing discharge and water depth, and over a certain range it appears to remain constant. Comparison of roughness coefficients calculated by field measurement data with those estimated by other methods shows that, although the field-measured values provide approximate roughness coefficients for relatively large discharge, there seems to be rather high uncertainty due to the difference in resultant values. For this reason, uncertainty related to the roughness coefficient was analyzed in terms of change in computed variables. On average, a 20% increase of the roughness coefficient causes a 7% increase in the water depth and an 8% decrease in velocity, but there may be about a 15% increase in the water depth and an equivalent decrease in velocity for certain cross-sections in the study reach. Finally, the validity of estimated roughness coefficient based on field measurements was examined. A 10% error in discharge measurement may lead to more than 10% uncertainty in roughness coefficient estimation, but corresponding uncertainty in computed water depth and velocity is reduced to approximately 5%. Conversely, the necessity for roughness coefficient estimation by field measurement is confirmed.

关键词： roughness coefficient estimation field measurement gravel-bed river uncertainty

Assessing significant fibrosis using imaging-based elastography in chronic hepatitis B patients: Pilot study

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第25期25卷 3256-3267页

作者： Hee Sun Park Won hyeok Choe hye Seung Han Mi hye Yu Young Jun kim Sung Il Jung Jeong Han kim So Young Kwon Department of Radiology Konkuk University School of MedicineSeoul 05030South Korea Department of Internal Medicine Konkuk University School of MedicineSeoul 05030South Korea Department of Pathology Konkuk University School of MedicineSeoul 05030South Korea

BACKGROUND Accurate detection of significant fibrosis(fibrosis stage 2 or higher on the METAVIR scale)is important especially for chronic hepatitis B(CHB)patients with high viral loads but with normal or mildly elevated alanine aminotransferase(ALT)levels because the presence of significant fibrosis is accepted as the indication for antiviral *** biopsy is the reference standard for diagnosing significant fibrosis,but it is an invasive ***,noninvasive imaging-based measurements,such as magnetic resonance elastography(MRE)or two-dimensional shear-wave elastography(2DSWE),have been proposed for the quantitative assessment of liver *** To explore MRE and 2D-SWE to identify fibrosis stage,and to compare their performance with that of serum-based *** The study enrolled 63 treatment-na?ve CHB patients with high viral loads but with normal or mildly elevated ALT levels who underwent liver biopsy before a decision was made to initiate antiviral *** and 2D-SWE were performed,and serum-based indices,such as FIB-4 and aspartate transaminase to platelet ratio index(APRI),were *** diagnostic performances of MRE,2D-SWE,FIB-4,and APRI for assessing significant fibrosis(≥F2)and cirrhosis(F4)were evaluated with liver histology as the reference standard,using receiver operating characteristic *** The liver fibrosis stage was F0/F1 in 19,F2 in 14,F3 in 14,and F4 in 16 patients,*** significantly discriminated F2 from F0/1(P=0.022),whereas 2D-SWE showed a broad overlap in distinguishing those *** showed a higher correlation coefficient value with fibrosis stage than 2D-SWE with fibrosis stage(0.869 vs 0.649,Spearman test;P<0.001).Multivariate linear regression analyses showed that fibrosis stage was the only factor affecting the values of MRE(P<0.001),whereas body mass index(P=0.042)and fibrosis stage(P<0.001)were independent factors affecting 2D-SWE *** performance for diagnos

关键词： Antiviral therapy Chronic hepatitis B Liver fibrosis Magnetic resonance elastography Ultrasound elastography

Differential ligand binding/trafficking for distinct CTLA-4 fates: is it an expandable mechanism?

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2023年第1期20卷 1-2页

作者： ji Eon kim Eunmi kim Jung Weon Lee Department of Pharmacy Research Institute of Pharmaceutical SciencesCollege of PharmacySeoul National UniversitySeoul08826Republic of Korea

In a recent issue of Nature Immunology,Kennedy et *** that CTLA-4(CD152)differentially targets two distinct ligands,CD80 and CD86,on antigen-presenting cells(APCs)for destruction or recycling following transendocytosis(TE),resulting in separate fates for CTLA-4 on T_(reg) cells and thereby regulating ***,whereas CTLA-4 tightly binds CD80 for TE and causes ubiquitination and trafficking to late endosomes and lysosomes for degradation,CTLA-4 weakly binds CD86 for TE,resulting in dissociation under acidic conditions(pH<6)and recycling of CTLA-4 to the plasma membrane for further CD86 ***,CD86 targeting by CTLA-4 regulates T-cell function in autoimmunity[1]and presumably immune surveillance of cancer cells(Fig.1).

关键词： thereby traffic weakly