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Spectral domain optical coherence tomography crosssectional image of optic nerve head during intraocular pressure elevation

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International Journal of Ophthalmology(English edition) 2014年第6期7卷 1022-1029页

作者： ji young lee You Kyung lee Jung Il Moon Myoung Hee Park Department of Ophthalmology Yeouido St. Mary's HospitalCollege of Medicinethe Catholic University of Korea62Yeuido-dongYoungdeungpo-guSeoul 150-713Korea

AIM: To analyze changes of the optic nerve head(ONH) and peripapillary region during intraocular pressure(IOP) elevation in patients using spectral domain optical coherence tomography(SD-OCT).METHODS: Both an optic disc 200×200 cube scan and a high-definition 5-line raster scan were obtained from open angle glaucoma patients presented with monocular elevation of IOP(≥30 mm Hg) using SD-OCT. Additional baseline characteristics included age, gender, diagnosis,best-corrected visual acuity, refractive error, findings of slit lamp biomicroscopy, findings of dilated stereoscopic examination of the ONH and fundus, IOP, pachymetry findings, and the results of visual ***: The 24 patients were selected and divided into two groups: group 1 patients had no history of IOP elevation or glaucoma(n =14), and group 2 patients did have history of IOP elevation or glaucoma(n =10). In each patient, the study eye with elevated IOP was classified into group H(high), and the fellow eye was classified into group L(low). The mean deviation(MD)differed significantly between groups H and L when all eyes were considered(P =0.047) and in group 2(P =0.042), not in group 1(P =0.893). Retinal nerve fiber layer(RNFL) average thickness(P =0.050), rim area(P =0.015),vertical cup/disc ratio(P =0.011), cup volume(P =0.028),inferior quadrant RNFL thickness(P =0.017), and clockhour(1, 5, and 6) RNFL thicknesses(P =0.050, 0.012, and0.018, respectively), cup depth(P =0.008), central prelaminar layer thickness(P =0.023), mid-inferior prelaminar layer thickness(P =0.023), and nasal retinal slope(P =0.034)were significantly different between the eyes with groups H and ***:RNFLaveragethickness,rim area,vertical cup/disc ratio, cup volume, inferior quadrant RNFL thickness, and clock-hour(1, 5, and 6) RNFL thicknesses significantly changed during acute IOP elevation.

关键词： spectral domain optical coherence tomography optic nerve head elevated intraocular pressure open angle glaucoma retinal nerve fiver layer

Choroidal changes in eyes treated with high-dose systemic corticosteroids for optic neuritis

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1430-1435页

作者： Jun Hyuk lee ji young lee Ho Ra Nam Yeo Kang jiwon Baek Department of Ophthalmology Bucheon St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaGyeonggi-do 14647Republic of Korea Department of Ophthalmology Yeoeuido St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoul 06591Republic of Korea

AIM:To analyze the effect of systemic high-dose corticosteroid on the choroid in patients with unilateral optic ***:A retrospective comparative cohort ***-six eyes of 38 patients with unilateral optic neuritis that received systemic high-dose corticosteroid treatment were *** thickness(CT)and choroidal vascularity index(CVI)were measured in both affected and the fellow eyes at baseline,1 wk.1 and 3 *** in CT and CVI were analyzed in both eyes and compared between ***:The mean CT and CVI were 349μm and 0.70 in the affected eyes and 340μm and 0.69 in the fellow eyes at baseline(P=0.503 and 0.440,respectively).Decrement of CT and CVI at month 3 were significant in affected eyes(P=0.017 and P<0.001).Decreased CVI began 2 wk after treatment whereas CT decreased from 1 *** CVI also decreased significantly in fellow eyes at 3 mo compared to the baseline(P=0.001).CONCLUSION:A significant decrement in CT and CVI can appear after 3 mo in optic neuritis patients treated with high-dose systemic corticosteroid *** decrease in CVI appeared earlier than the decrease in CT,suggesting choroidal vasoconstriction caused by systemic steroid as a possible mechanism.

关键词： corticosteroid optic neuritis choroidal thickness prednisolone

Neuromuscular electrical stimulation for a dysphagic stroke patient with cardiac pacemaker using magnet mode change: A case report

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World Journal of Clinical Cases 2021年第19期9卷 5313-5318页

作者： Myeongkyu Kim jin-Kyu Park ji young lee Mi Jung Kim Department of Rehabilitation Medicine Hanyang University College of MedicineSeoul 04763South Korea Department of Internal Medicine-Cardiology Hanyang University College of MedicineSeoul 04763South Korea Department of Radiology Hanyang University College of MedicineSeoul 04763South Korea

BACKGROUND Electromagnetic interference(EMI),means disturbance to the operation of implanted electrical devices caused by external *** cardiac pacemaker is implanted into the body,the risk of EMI should be considered when performing neuromuscular electrical stimulation(NMES).So far,no case has been reported that clinical magnets are used to safely manage the EMI risk of patients with cardiac pacemaker in *** SUMMARY A 72-year-old male with swallowing disorder due to pure motor lacunar syndrome was transferred to rehabilitation department six days after the symptom *** risk needed be considered when implementing NMES on pharyngeal muscles,since cardiac pacemaker was implanted on his left chest due to the sick sinus *** the first NMES,the function of the pacemaker was directly monitored using telemetric *** the second day,by a simple method of placing a magnet on the pacemaker,we chose to move the pacemaker into a mode that the device was not influenced by external *** magnet method has been used repeatedly for a year for the safe NMES *** could remove Levin tube four months after the initial symptom and dysphagia related symptoms had not been noted during two-year follow-up *** This report is the first case of dysphagia rehabilitation that EMI risk was handled using mode change of pacemaker with *** method is unfamiliar to doctors,but safe and easy *** paper could be guidance for clinicians who need to treat patients with EMI risk.

关键词： Dysphagia rehabilitation Electromagnetic interference Neuromuscular electrical stimulation Pacemaker Magnet Case report

Epstein-Barr virus-associated lymphoepithelioma-like early gastric carcinomas and endoscopic submucosal dissection: Case series

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World Journal of Gastroenterology 2014年第5期20卷 1365-1370页

作者： ji young lee Kyoung-Mee Kim Byung-Hoon Min Jun Haeng lee Poong-Lyul Rhee Jae Jun Kim Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Department of Pathology Samsung Medical Center Sungkyunkwan University School of Medicine

Epstein-Barr virus (EBV)-associated lymphoepithelioma-like gastric carcinoma (LELC) is characterized by a lower lymph node (LN) metastasis rate and a higher survival rate than other forms of gastric cancer. Although current prognosis for LELC is favorable, the most common approach is radical gastrectomy involving an extensive D2 lymph node dissection. Here, we report four cases of EBV-associated early LELC that were treated by an alternative approach, endoscopic submucosal dissection (ESD). The long-term outcome of this procedure is discussed. All patients were treated by ESD en bloc, and all ESD specimens showed tumor-free lateral resection margins. None of the lesions showed lymphovascular invasion. A pathological examination of ESD specimens revealed submucosal invasion of more than 500 μm in all four cases. One patient underwent additional radical surgery post-ESD; no residual tumor or LN metastasis was noted in the surgical specimen. The other three patients did not undergo additional surgery, either because of severe comorbidity or their refusal to undergo operation, but were subjected to medical follow-up. None of the ESD-treated patients reported local recurrence or distant metastases during the 27-32 mo of follow-up after ESD.

关键词： Endoscopic submucosal dissection Epstein-Barr virus Lymph node Lymphoepithelioma-like gastric carcinoma Prognosis

Designed fabrication of mesoporous silica-templated self-assembled theranostic nanomedicines

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Science China Chemistry 2021年第2期64卷 204-217页

作者： Fangyuan Li&Daishun Ling Yang Du Zheng Chen ji young lee Peihua Lin Fan Xia Yunan Guan Fangyuan Li Daishun Ling Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Biomedical Engineering of the Ministry of Education College of Biomedical Engineering&Instrument ScienceZhejiang UniversityHangzhou 310027China Hangzhou Institute of Innovative Medicine College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Hangzhou 310009China

Theranostic nanosystems that integrate diagnosis and therapy have garnered increasing attention for personalized *** integration of the versatile nanoparticles to fabricate self-assembled theranostic nanomedicines becomes increasingly important in current medical *** silica nanoparticles(MSN)with their highly attractive physicochemical properties and favorable morphological attributes represent ideal templates for the controlled assembly and integration of functional nanomaterials to fabricate self-assembled theranostic *** rationally designed combination strategy and heterostructure will improve the overall bioavailability and preserve the unique property of each *** this review,the cutting-edge strategies for the designed fabrication of MSN-templated self-assembled nanomedicines are *** categorize MSN-based nanomedicines by their unique heterostructures,including core-shell,yolk-shell,core-satellite,heterodimer and core-shell-satellite structures,and discuss the controlled assembly approaches as well as the intriguing applications for disease ***,a perspective on the challenges in the clinical translation of self-assembled theranostic nanomedicines is highlighted.

关键词： self-assembly theranostics heterostructure mesoporous silica nanomedicines

Pathologic etiology and predictors of malignancy in children with cervical lymphadenopathy

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World Journal of Pediatrics 2023年第3期19卷 283-287页

作者： Jee Woo Kim Jee Yeon Baek ji young lee Sung Min Lim ji-Man Kang Won Kee Ahn Seung Min Hahn Jung Woo Han Chuh Joo Lyu Jong Gyun Ahn Department of Pediatrics Severance Children's HospitalYonsei University College of Medicine50-1 Yonsei-RoSeodaemun-guSeoul 03722South Korea Institute for Immunology and Immunological Diseases Yonsei University College of MedicineSeoulSouth Korea Division of Pediatric Hematology and Oncology Department of PediatricsYonsei University College of MedicineYonsei University Health SystemSeoulSouth Korea Department of Pediatric Hemato-Oncology Yonsei Cancer CenterYonsei University Health SystemSeoulSouth Korea

Cervical lymphadenopathy in children is a common disease entity that is accompanied by a variety of processes,ranging from benign disease to *** the cause of cer-vical lymphadenopathy in children is often benign[1-4],the presence of enlarged lymph nodes can cause anxiety to parents because of its association with *** should be considered for the histologic diagnosis of persistent or unex-plained cervical lymphadenopathy in ***,biopsy is an invasive examination method,and it is difficult to clinically determine whether biopsy is needed in children with unexplained cervical ***,clini-cians should be aware of the differential diagnosis of lymph node enlargement in children and should identify situations in which malignancy may be *** this study,we aimed to identify the etiology of pediatric cervical lymphadenopathy using biopsy and to analyze the risk factors associated with malignancy in children with cervical lymphadenopathy.

关键词： malignancy cervical diagnosis

A Study on Smart Home Design Incorporating Ubiquitous Healthcare Services

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Computer Technology and Application 2013年第7期4卷 374-379页

作者： ji-Eun lee young-Ho Yoon Dong-Suk Yang Department of Architecture Land and Housing Institute Daejeon Korea

The smart home using ubiquitous technology can effectively provide services to the elderly and the physically impaired. However, such services are accompanied by high initial cost of installation and the operating inefficiency due to the absence of design guidelines. To solve these, the integrated management of the process by supplying the public service like voucher schemes to the dwelling is needed. This paper mainly proposes a research about the healthcare service in a residential environment, which includes medical service and safety service and so on, by surveying the voucher program and the in-house infra status. Finally, the house planning elements for healthcare-based smart home are drawn and the planning directions through expert survey are suggested. Therefore, this study surveyed on voucher program and in-house infra status, and drew the house planning elements for health-based care smart home. In addition, this study suggested the planning direction through expert survey. This study can be used as a guideline for constructing a smart home, which supplies healthcare service.

关键词： Smart home ubiquitous healthcare services voucher program.

Synthesis and Characterization of Poly (Methyl Methacrylate)/Polyethylenimine Grafting Core-Shell Nanoparticles for CO₂ Adsorption Using Soap-Free Emulsion Copolymerization

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Advances in Materials Physics and Chemistry 2016年第7期6卷 220-229页

作者： Jun-Won Kook ji young lee Ki Seob Hwang In Park Jung Hyun Kim Jun-young lee Department of Chemical and Biomolecular Engineering Yonsei University Seoul Republic of Korea IT Convergence Materials Group Korea Institute of Industrial Technology Cheonan Republic of Korea

Unlike previous emulsion polymerization, we used grafting reactions in soap-free emulsion systems. In this study, we synthesized grafted PMMA/PEI core-shell nanoparticles by varying the MMA/PEI content and molecular weight of PEI (Mn = 600, 8000, and 10,000). The size and morphology of the core-shell nanoparticles were characterized by a particle size analyzer and scanning electron microscopy. The nanoparticles were 178 - 408 nm in diameter and swelled in water or methanol by 30 - 75 nm. The size of the nanoparticles increased with MMA contents, whereas the size distribution progressively became homogeneous with increasing molecular weight of PEI. Lastly, we measured CO2 adsorption capacity of the grafted PMMA/PEI core-shell nanoparticles, and we found the capacity to be limited at a level of 0.69 mg, which occurred for nanoparticles prepared from emulsions at a pH value of 11.

关键词： Polyethylenimine Core-Shell Nanoparticle CO2 Adsorption Grafting Reaction Soap-Free Emulsion

White luminescence of Ho^(3+)/Tm^(3+)/Yb^(3+)-codoped CaWO_4 synthesized via citrate complex route assisted by microwave irradiation

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Transactions of Nonferrous Metals Society of China 2014年第S1期24卷 134-140页

作者： Hyun CHO Seok Min HWANG Jae Bin lee Dong Hyun KA Tae Wan KIM Bo Seul lee ji young lee Jung-Il lee Jeong Ho RYU Department of Nanomechatronics Engineering Pusan National University50 Cheonghak-ri Miryang Gyeongnam 627-706 Korea Department of Materials Science and Engineering Korea National University of Transportation Chungju Chungbuk 380-702 Korea

The nanocrystalline Ho3+/Tm3+/Yb3+ co-doped CaWO4 upconversion(UC) phosphors were successfully synthesized by a modified citrate complex method using microwave irradiation. The citrate complex precursors were heat-treated at temperature ranging from 300 to 700 °C for 3 h. Crystallization of the Ho3+/Tm3+/Yb3+ co-doped CaWO4 was detected at 400 °C, and entirely completed at 600 °C. The Ho3+/Tm3+/Yb3+ co-doped CaWO4 heat-treated at 600 °C showed primarily spherical and homogeneous morphology. Under the laser excitation of 980 nm, Ho3+/Tm3+/Yb3+ co-doped CaWO4 shows the bright white upconversion(UC) emission visible to the naked eye, which is composed of a blue emission at 475 nm from Tm3+, and green and red emissions at 543 and 651 nm respectively from Ho3+. The coordinates of Ho3+/Tm3+/Yb3+ co-doped CaWO4 in the Commission International De'eclairage(CIE) chromaticity diagram could be controlled from a cool to a warm white color depending on the Tm3+ and Ho3+ concentrations. The UC luminescent properties on Tm3+ and Ho3+ concentrations and related mechanism based on laser pump power were discussed in detail.

关键词： upconversion CaWO4 microwave irradiation white luminescence