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Impact of Fusobacterium nucleatum in the gastrointestinal tract on natural killer cells

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World Journal of Gastroenterology 2021年第29期27卷 4879-4889页

作者： Yeon ji kim Bu Kyung kim Seun Ja Park Jae Hyun kim Institute of Gastroenterology Kosin University College of MedicineBusan 49267Spain Department of Internal Medicine Kosin University College of MedicineBusan 49267South Korea

BACKGROUND Gut microbial dysbiosis contributes to the development and progression of colorectal cancer(CRC).Natural killer(NK)cells are involved in early defense mechanisms to kill infective pathogens and tumor cells by releasing chemokines and *** better understand the relationship between the gut microbiome and CRC,it was hypothesized here that a high abundance of Fusobacterium nucleatum(***)in the gastrointestinal tract could cause reduced NK cell *** To identify associations between gastrointestinal tract *** levels and NK cell *** In vitro experiments were performed on NK cells treated with ***,Peptostreptococcus anaerobius,and Parvimonas micra to identify the effects of gut microbiome species on NK *** 24 and 48 h of treatment,NK cell counts were *** parallel studies,C57BL/6 mice were given broadspectrum antibiotics in their drinking water to reduce resident gut *** 3 wk,the mice received the various bacterial species or phosphate-buffered saline(PBS)via oral gavage every 2 d for 6 *** the study end,blood samples were acquired to perform NK cell activity assessment and cytokine *** tissues were collected and analyzed via immunohistochemistry(IHC).RESULTS The data show that after 3 wk of broad-spectrum antibiotic treatment,levels of total bacteria and *** were markedly decreased in *** of *** significantly decreased NK cell activity relative to the activities of cells from mice treated with antibiotics only and *** administration of *** decreased the proportion of NK46+cells based on IHC staining and increased the production of interleukin-1βand tumor necrosis factor-α.CONCLUSION High levels of *** in the gastrointestinal tract reduced NK cell activity in mice,and the decrease in NK cell activity might be affected by increased proinflammatory cytokines after *** treatment.

关键词： Fusobacterium nucleatum Natural killer cells Colorectal cancer

Cystic metastasis from a mucinous adenocarcinoma of duodenum mimicking type Ⅱ choledochal cyst: A case report

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World Journal of Gastrointestinal Oncology 2017年第12期9卷 492-496页

作者： Yo Na kim ji Soo Song Department of Pathology Chonbuk National University Medical School Research Institute for Endocrine Sciences Department of Radiology Chonbuk National University Medical School and Hospital Research Institute of Clinical Medicine of Chonbuk National University Biomedical Research Institute of Chonbuk National University Hospital

A 51-year-old male patient was referred to our hospital because of an incidentally detected cystic mass near the common bile duct(CBD). Imaging studies demonstrated a cystic mass that was suspected to communicate with the CBD. Gastroscopy showed irregular mucosal thickening with hyperemic change in the second portion of the duodenum. A type Ⅱ choledochal cyst combined with duodenal malignancy was suspected. The patient underwent surgical resection and the histological diagnosis was mucinous adenocarcinoma of the duodenum with cystic metastasis. Although its incidence is extremely rare, care should be taken to check for other sites of malignancy when a pericholedochal cystic mass is detected.

关键词： Duodenal cancer Choledochal cyst Cystic metastasis Mucinous adenocarcinoma

Stable Zn Metal Anodes with Limited Zn-Doping in MgF_(2) Interphase for Fast and Uniformly Ionic Flux

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Nano-Micro Letters 2022年第3期14卷 169-183页

作者： ji Young kim Guicheng Liu Ryanda Enggar Anugrah Ardhi jihun Park Hansung kim Joong Kee Lee Energy Storage Research Center Korea Institute of Science and TechnologyHwarang‑ro 14‑gil 5Seongbuk‑guSeoul 02792Republic of Korea Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei‑roSeodaemun‑guSeoul 03722Republic of Korea Department of Physics Dongguk UniversitySeoul 04620Republic of Korea APC Technology 10868 Gangbyeonyeok‑ro‑4‑gilGwangjin‑guSeoul 05116Republic of Korea Department of Energy and Environmental Engineering KIST SchoolKorea University of Science and TechnologyHwarang‑ro 14‑gil 5Seongbuk‑guSeoul 02792Republic of Korea

The practical applications of aqueous Zn metal batteries are currently restricted by the inherent drawbacks of Zn such as the hydrogen evolution reaction,sluggish kinetics,and dendrite *** address these problems,herein,a limitedly Zn-doped MgF_(2)interphase comprising an upper region of pure,porous MgF_(2)and a lower region of gradient Zn-doped MgF_(2)is achieved via radio frequency sputtering *** porous MgF_(2)region is a polar insulator whose high corrosion resistance facilitates the de-solvation of the solvated Zn ions and suppression of hydrogen evolution,resulting in Zn metal electrodes with a low interfacial *** Zn-doped MgF_(2)region facilitates fast transfer kinetics and homogeneous deposition of Zn ions owing to the interfacial polarization between the Zn dopant and MgF_(2)matrix,and the high concentration of the Zn dopant on the surface of the metal substrate as fine ***,a symmetric cell incorporating the proposed Zn metal exhibits low overpotentials of~27.2 and~99.7 mV without Zn dendrites over 250 to 8000 cycles at current densities of 1.0 and 10.0 mA cm−2,*** developed Zn/MnO2 full cell exhibits superior capacity retentions of 97.5%and 84.0%with average Coulombic efficiencies of 99.96%after 1000 and 3000 cycles,respectively.

关键词： Zinc metal battery MgF_(2)layer Limited zinc doping Ion-transfer kinetic Deposition guidance

Proton pump inhibitors as a risk factor for recurrence of Clostridium-difficile-associated diarrhea

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World Journal of Gastroenterology 2010年第28期16卷 3573-3577页

作者： ji Won kim Kook Lae Lee ji Bong Jeong Byeong Gwan kim Sue Shin Joo Sung kim Hyun Chae Jung In Sung Song Division of Gastroenterology and Hepatology Department of Internal MedicineSeoul National University Boramae Hospital Seoul National University College of Medicine Seoul 156-707South Korea Department of Laboratory Medicine Seoul National University Boramae Hospital Division of Gastroenterology and Hepatology Department of Internal MedicineSeoul National University Hospital Seoul National University College of Medicine Seoul 110-744South Korea

AIM:To investigate the risk factors for Clostridiumdifficile-associated diarrhea(CDAD)recurrence,and its relationship with proton pump inhibitors(PPIs). METHODS:Retrospective data of 125 consecutive hospitalized patients diagnosed with CDAD between January 2006 and December 2007 were collected by medical chart *** data included patient characteristics at baseline,underlying medical disease, antibiotic history before receiving a diagnosis of CDAD, duration of hospital stay,severity of CDAD,concurrenttreatment with PPIs,laboratory parameters,response to CDAD therapy,and recurrence of disease within 90 d of successful *** clinical and laboratory parameters were compared in patients in whom CDAD did or did not recur. RESULTS:Of the 125 patients(mean age,67.6± 13.9 years)that developed CDAD,98(78.4%)did not experience recurrence(non-recurrent group)and 27 (21.6%)experienced one or more recurrences(recurrent group).Prior to the development of CDAD,96% of the 125 patients were prescribed antibiotics,and 56(44.8%)of the patients received *** older than 65 years(P=0.021),feeding via nasogastric tube(NGT)(P=0.045),low serum albumin level(P =0.025),and concurrent use of PPIs(P=0.014) were found to be risk factors for CDAD recurrence by univariate ***,sex,length of hospital stay,duration and type of antibiotics used,severity of disease,leukocyte count and C-reactive protein(CRP) were not associated with risk of CDAD *** multivariate analysis,the important risk factors were advanced age(>65 years,adjusted OR:1.32,95% CI:1.12-3.87,P=0.031),low serum albumin level(< 2.5 g/dL,adjusted OR:1.85,95%CI:1.35-4.91,P= 0.028),and concurrent use of PPIs(adjusted OR:3.48, 95%CI:1.64-7.69,P=0.016). CONCLUSION:Advanced age,serum albumin level< 2.5 g/dL,and concomitant use of PPIs were found to be significant risk factors for CDAD recurrence.

关键词： Clostridium difficile Diarrhea Recurrence Risk factors Proton pump inhibitors

Numerical modeling of sedimentation control scenarios in the approach channel of the Nakdong River Estuary Barrage,South Korea

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International Journal of Sediment Research 2016年第3期31卷 257-263页

作者： Un ji Eun-Kyung Jang Gwonhan kim Hydro Science and Engineering Research Institute Korea Institute of Civil Engineering and Building Technology

The effects of sedimentation reduction at the Nakdong River Estuary Barrage(NREB) in Korea were quantitatively analyzed with respect to different sediment control methods using the calibrated and validated two-dimensional *** countermeasures of sediment dredging,sediment flushing,channel geometry change,and a combination of flushing and channel geometry change were examined for the approach channel of the *** flood event and channel geometries of the 3.8 km section upstream of the NREB surveyed before and after dredging in 2007 were used for modeling *** a result,the half of sediments dredged in 2007 could be eliminated naturally by floods without *** numerical simulation of sediment flushing indicated that the deposition height decreased in the entire simulation section with the minimum and maximum reductions from 0.3 in to1.3 m in deposition *** channel contraction method produced quantitatively the largest amount of sedimentation reduction and sediment flushing and dredging *** reduction by a combination of flushing and channel contraction was up 10%compared to the individual method of channel contraction.

关键词： Channel contraction Nakdong River Estuary Barrage Sediment dredging Sediment flushing Sedimentation reduction

Subcarrier BD with Cooperative Communication for MIMO-NOMA System

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Computers, Materials & Continua 2022年第9期72卷 5807-5821页

作者： Jung-In Baik ji-Hwan kim Beom-Sik Shin ji-Hye Oh Hyoung-Kyu Song Department of Information and Communication Engineering and Convergence for Intelligent DroneSejong UniversitySeoul05006Korea

With the rapid evolution of Internet of things(IoT),many edge devices require simultaneous connection in 5G communication *** afford massive data of IoT devices,multiple input multiple output non-orthogonal multiple access(MIMO-NOMA)method has been considered as a promising ***,there are numerous drawbacks due to error propagation and inter-user ***,proposed scheme aims to improve the reliability of the MIMO-NOMA system with digital beamforming and intracluster cooperative multi point(CoMP)to efficiently support IoT *** the conventional MIMO-NOMA system,user entities are grouped into *** diagonalization(BD)is applied to efficiently eliminate the inter-cluster interference of the MIMO-NOMA ***,since the channel path of the data stream from a single antenna to a single cluster doesn’t hold other cluster’s data,the system can’t fully utilize the selective subcarrier channel *** indicates that there can be better channel paths for a data stream at a certain subcarrier ***,proposed scheme allocates data streams to antennas adaptively considering selective channel ***,intra-cluster CoMP method is adjusted to enhance the reliability of the system in the *** simulation results show that the proposed scheme improves BER and throughput performance compared to the conventional MIMO-NOMA system.

关键词： 5G MIMO-NOMA CoMP BD interference

An armature structure for 3D shapes

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Applied Mathematics(A Journal of Chinese Universities) 2014年第4期29卷 422-437页

作者： ji Zhong-ping LIU Li-gang kim Deok-soo School of Computer Science and Technology Hangzhou Dianzi University Graphics Geometric Computing Laboratory School of Mathematical Sciences University of Science and Technology of China Department of Industrial Engineering Hanyang University

We present a novel armature structure for 3D articulated shapes, called SBall short for skeletal balls, which includes two parts： a one-dimensional skeleton and incident balls. Our algorithm mainly focuses on constructing the armature structure. This structure is based on an approximation skeleton which is homotopy equivalent to the shape. Each ball in the structure connects a skeletal joint and an interior region of the shape. The boundary vertices on the shape surface are attached onto the SBall using the power diagram of the ball set. A bilateral O^tering algorithm and a variational segmentation algorithm are proposed to enhance the quality of SBall. Finally, applications of this structure are discussed.

关键词： armature structure prong feature thinning variational segmentation.

gscaLCA in R: Fitting Fuzzy Clustering Analysis Incorporated with Generalized Structured Component Analysis

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Computer Modeling in Engineering & Sciences 2022年第9期132卷 801-822页

作者： ji Hoon Ryoo Seohee Park Seongeun kim Heungsun Hwang Department of Education College of Educational SciencesYonsei UniversitySeoul03722South Korea Psychometrics Department American Board of Internal MedicinePhiladelphia19016USA Department of Educational Research Methodology School of EducationUniversity of North Carolina at GreensboroGreensboro27412USA Department of Psychology McGill UniversityMontrealH3A 0G4Canada

Clustering analysis identifying unknown heterogenous subgroups of a population(or a sample)has become increasingly popular along with the popularity of machine learning *** there are many software packages running clustering analysis,there is a lack of packages conducting clustering analysis within a structural equation modeling *** package,gscaLCA which is implemented in the R statistical computing environment,was developed for conducting clustering analysis and has been extended to a latent variable *** specifically,by applying both fuzzy clustering(FC)algorithm and generalized structured component analysis(GSCA),the package gscaLCA computes membership prevalence and item response probabilities as posterior probabilities,which is applicable in mixture modeling such as latent class analysis in *** a hybrid model between data clustering in classifications and model-based mixture modeling approach,fuzzy clusterwise GSCA,denoted as gscaLCA,encompasses many advantages from both methods:(1)soft partitioning from FC and(2)efficiency in estimating model parameters with bootstrap method via resolution of global optimization problem from *** main function,gscaLCA,works for both binary and ordered categorical *** addition,gscaLCA can be used for latent class regression as *** of profiles of latent classes based on the posterior probabilities is also available in the package *** paper contributes to providing a methodological tool,gscaLCA that applied researchers such as social scientists and medical researchers can apply clustering analysis in their research.

关键词： Fuzzy clustering generalized structured component analysis gscaLCA latent class analysis

TP-MobNet: A Two-pass Mobile Network for Low-complexity Classification of Acoustic Scene

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Computers, Materials & Continua 2022年第11期73卷 3291-3303页

作者： Soonshin Seo Junseok Oh Eunsoo Cho Hosung Park Gyujin kim ji-Hwan kim NAVER Corporation Seongnam13561Korea Department of Computer Science and Engineering Sogang UniversitySeoul04107Korea

Acoustic scene classification(ASC)is a method of recognizing and classifying environments that employ acoustic *** ASC approaches based on deep learning have been developed,with convolutional neural networks(CNNs)proving to be the most reliable and commonly utilized in ASC systems due to their suitability for constructing lightweight *** using ASC systems in the real world,model complexity and device robustness are essential *** this paper,we propose a two-pass mobile network for low-complexity classification of the acoustic scene,named *** inverse residuals and linear bottlenecks,TPMobNet is based on MobileNetV2,and following mobile blocks,coordinate attention and two-pass fusion approaches are *** log-range dependencies and precise position information in feature maps can be trained via coordinate *** capturing more diverse feature resolutions at the network’s end sides,two-pass fusions can also train ***,the model size is reduced by applying weight quantization to the trained *** adding weight quantization to the trained model,the model size is also *** TAU Urban Acoustic Scenes 2020 Mobile development set was used for all of the *** has been confirmed that the proposed model,with a model size of 219.6 kB,achieves an accuracy of 73.94%.

关键词： Acoustic scene classification low-complexity device robustness two-pass mobile network coordinate attention weight quantization