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Folfirinox chemotherapy prolongs stent patency in patients with malignant biliary obstruction due to unresectable pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 590-595页

作者： jinwoo Kang Sang Hyub Lee jin Ho Choi woo Hyun Paik Dong-Won Ahn ji Bong jeong ji Kon Ryu Yong-Tae Kim Department of Internal Medicine and Liver Research Institute Seoul National University HospitalSeoul National University College of MedicineSeoulKorea Department of Internal Medicine SMG-SNU Boramae Medical CenterSeoulKorea

Background:Stent insertion for biliary decompression to relieve jaundice and subsequent biliary infection is necessary for patients with biliary obstruction caused by pancreatic cancer,and it is important to keep the stent patent as long as ***,few studies have compared stent patency in terms of chemotherapy in patients with pancreatic *** study aimed to evaluate the differences in stent patency in terms of recently evolving ***:Between January 2015 and May 2017,161 patients with pancreatic cancer who had undergone biliary stent insertion with a metal stent were retrospectively *** relationship between chemotherapy and stent patency was ***,overall survival according to the treatment,risk factors for stent patency,and long-term adverse events were ***:Median stent patency was 42 days for patients with the best supportive care and 217 days for patients with chemotherapy(conventional gemcitabine-based chemotherapy and folfirinox)(P<0.001).Furthermore,the folfirinox group showed the longest median stent patency and overall survival,with 283 days and 466 days,respectively(P<0.001)despite higher adverse events *** who underwent folfirinox chemotherapy after stent insertion had better stent patency in multivariate analysis(HR=0.26;95%CI:0.12–0.60;P=0.001).Conclusions:Compared with patients who received best supportive care only,patients who underwent chemotherapy after stent insertion had better stent *** prolonged stent patency can be expected for patients with folfirinox than conventional gemcitabine-based chemotherapy.

关键词： Stent patency Malignant distal biliary obstruction Pancreatic cancer Folfirinox Chemotherapy

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Alveolar macrophage phagocytosis-evading inhaled microgels incorporating nintedanib-PLGA nanoparticles and pirfenidone-liposomes for improved treatment of pulmonary fibrosis

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Bioactive Materials 2024年第3期33卷 262-278页

作者： woo Tak Lee Hyunjun Lee Juho Kim Yujin Jung Eojin Choi ji Hoon jeong Jee-Heon jeong Jung Heon Lee Yu Seok Youn School of Pharmacy Sungkyunkwan University2066 Seobu-roJangan-guSuwonGyeonggi-do16419Republic of Korea Department of Precision Medicine School of MedicineSungkyunkwan University2066 Seobu-roJangan-guSuwon16419Republic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan University2066 Seobu-roJangan-guSuwon16419Republic of Korea

Idiopathic pulmonary fibrosis(IPF)is a chronic inflammatory and fibrotic response-driven lung disease that is difficult to cure because it manifests excessive profibrotic cytokines(e.g.,TGF-β),activated myofibroblasts,and accumulated extracellular matrix(ECM).In an attempt to develop an inhalation formulation with enhanced antifibrotic efficacy,we sought to fabricate unique aerosolizable inhaled microgels(μGel)that contain nintedanib-poly(lactic-co-glycolic acid)(PLGA)nanoparticles(NPs;n-PN)and pirfenidone-liposomes(p-LP).The aero-μGel was~12μm,resisted phagocytosis by alveolar macrophages in vitro and in vivo,and protected inner-entrapped n-PN and *** n-PN/p-LP@aero-μGel caused enhanced/extended antifibrotic efficacy in a bleomycin-induced pulmonary fibrosis mouse presumably due to prolonged lung ***,the results obtained by intratracheal aerosol insufflation of our n-PN/p-LP@aero-μGel twice a week were much better than those by as many as seven doses of single or mixed applications of n-PN or *** antifibrotic/pharmacokinetic results for the n-PN/p-LP@aero-μGel included reduced fibrosis progression,restored lung physiological functions,deactivated myofibroblasts,inhibited TGF-βprogression,and suppressed ECM component production(collagen I andα-SMA)along with prolonged lung retention *** believe that our n-PN/p-LP@aero-μGel increased the local availability of both nintedanib and pirfenidone due to evasion of alveolar macrophage phagocytosis and prolonged lung retention with reduced systemic *** this approach,our inhalation formulation subsequently attenuated fibrosis progression and improved lung ***,these results hold profound implications in the therapeutic potential of our n-PN/p-LP@aero-μGel to serve as a clinically promising platform,providing significant advancements for improved treatment of many respiratory diseases including IFP.

关键词： Aerosolizable microgel Lung retention Extracellular matrix Pro-inflammatory cytokines Idiopathic pulmonary fibrosis

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Antioxidant and anti-inflammatory roles of tea polyphenols in inflammatory bowel diseases

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Food Science and Human Wellness 2022年第3期11卷 502-511页

作者： Van-Long Truong woo-Sik jeong Food and Bio-industry Research Institute School of Food Science&BiotechnologyCollege of Agriculture and Life SciencesKyungpook National UniversityDaegu 41566Korea

Polyphenols,including phenolic acids,flavonoids,and procyanidins,are abundant in food and beverage derived from ***(Camellia sinensis)is particularly rich in polyphenols(e.g.,catechins,theaflavins,thearubigins,gallic acid,and flavonols),which are thought to contribute to the health benefits of *** intake of tea polyphenols has been described to prevent and/or attenuate a variety of chronic pathological conditions like cardiovascular diseases,neurodegenerative diseases,diabetes,and *** review focuses on established antioxidant and anti-inflammatory properties of tea polyphenols and underlying mechanisms of their involvement in inflammatory bowel diseases(IBD).Tea polyphenols act as efficient antioxidants by inducing an endogenous antioxidant defense system and maintaining intracellular redox *** polyphenols also regulate signaling pathways such as nuclear factor-κB,activator protein 1,signal transducer and activator of transcriptions,and nuclear factor E2-related factor 2,which are associated with IBD *** pieces of evidence have indicated that tea polyphenols enhance epithelial barrier function and improve gut microbial dysbiosis,contributing to the management of inflammatory ***,this study suggests that supplementation of tea polyphenols could prevent inflammatory conditions and improve the outcome of patients with IBD.

关键词： Antioxidant Anti-inflammation Epithelial barrier function Inflammatory bowel diseases Gut microbiota Tea polyphenols

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Managing portal hypertension in patients with liver cirrhosis and hepatocellular carcinoma:non-invasive diagnosis and systemic treatment considerations

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 960-962页

作者： woo Kyoung jeong Department of Radiology and Center for Imaging Sciences Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea

Portal hypertension(PH)represents a crucial complication of liver cirrhosis that significantly impacts a patient’s *** portal venous pressure requires a combination of medical and interventional ***,it’s important to note that the presence of other conditions in patients,such as hepatocellular carcinoma(HCC),can influence the treatment approaches for PH and subsequently affect the overall *** should consider that condition when developing treatment strategies to enhance patient outcomes(1).

关键词： Portal hypertension(PH) hepatocellular carcinoma(HCC) elastography bevacizumab variceal bleeding

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Strategies to overcome resistance to epidermal growth factor receptor monoclonal antibody therapy in metastatic colorectal cancer

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World Journal of Gastroenterology 2014年第29期20卷 9862-9871页

作者： woo-jeong jeong Pu-Hyeon Cha Kang-Yell Choi Translational Research Center for Protein Function Control Department of BiotechnologyCollege of Life Science and BiotechnologyYonsei University

Administration of monoclonal antibodies(mAbs)against epidermal growth factor receptor(EGFR)such as cetuximab and panitumumab in combination with conventional chemotherapy substantially prolongs survival of patients with metastatic colorectal cancer(mCRC).However,the efficacy of these mAbs is limited due to genetic variation among patients,in particular K-ras *** discovery of K-ras mutation as a predictor of non-responsiveness to EGFR mAb therapy has caused a major change in the treatment of *** that inhibit transformation caused by oncogenic alterations of Ras and its downstream components such as BRAF,MEK and AKT seem to be promising cancer therapeutics as single agents or when given with EGFR *** multiple therapeutic strategies to overcome EGFR mAb-resistance are under investigation,our understanding of their mode of action is *** drug development based on stringent preclinical data,biomarker validation,and proper selection of patients is of paramount importance in the treatment of *** this review,we will discuss diverse approaches to overcome the problem of resistance to existing anti-EGFR therapies and potential future directions for cancer therapies related to the mutational status of genes associated with EGFRRas-ERK and PI3K signalings.

关键词： Colorectal cancer Epidermal growth factor receptor Resistance K-ras mutation Combinational therapy

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Observational Study Evaluation of clinical application of Korean medicine standard clinical pathway in a public hospital

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World Journal of Clinical Cases 2025年第17期13卷 16-26页

作者： Seung-Jae Shin jin-Won Kim ji-Cheon jeong Department of Korean Medicine The Graduate SchoolDongguk UniversityGyeonggi-do 10326South Korea Department of Internal Medicine of Korean Medicine National Medical CenterSeoul 04564South Korea Department of Internal Medicine College of Korean MedicineDongguk UniversityGyeonggi-do 10326South Korea

BACKGROUND Clinical pathways(CPs)are structured guidelines introduced to improve healthcare quality and *** South Korea,CPs for Korean medicine have been developed since 2016 under the 3rd Comprehensive Plan for Korean Medicine Promotion,with limited studies on their clinical *** and shoulder pain are common conditions frequently treated at Korean medicine clinics,often by patients dissatisfied with conventional *** demand for Korean medicine treatments for neck and shoulder pain is on the *** To evaluate the clinical applicability and effectiveness of Korean medicine CPs for neck pain and shoulder pain in public healthcare institutions in South *** We collected and analyzed data from patients aged 19 years and older who visited the outpatient clinic of the Department of Korean Medicine at the National Medical Center in Korea from March 1,2023 to August 31,*** completion rates,along with patient satisfaction,clinical outcomes,and economic outcomes between the CP-implemented and non-CP groups were *** The CP completion rates were 93.3%for neck pain and 96.8%for shoulder *** satisfaction scores showed an improvement of 17.7%for neck pain and 18.0%for shoulder pain in the CP-implemented group compared to the non-CP *** neck pain,significant improvements were observed in the numerical rating scale(NRS)and the neck disability index,while for shoulder pain,only the University of California-Los Angeles shoulder rating scale showed notable progress,with no substantial change in NRS *** This study partially confirms the clinical applicability and effectiveness of the Korean medicine CPs for neck pain and shoulder *** research is required to enhance and validate these findings.

关键词： Clinical pathways Korean medicine Public healthcare Neck pain Shoulder pain

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Simply Fine-Tuned Deep Learning-Based Classification for Breast Cancer with Mammograms

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Computers, Materials & Continua 2022年第12期73卷 4677-4693页

作者： Vicky Mudeng jin-woo jeong Se-woon Choe Department of Medical IT Convergence Engineering Kumoh National Institute of TechnologyGumi39253Korea Department of Electrical Engineering Institut Teknologi KalimantanBalikpapan76127Indonesia Department of Data Science Seoul National University of Science and TechnologySeoul01811Korea Department of IT Convergence Engineering Kumoh National Institute of TechnologyGumi39253Korea

A lump growing in the breast may be referred to as a breast mass related to the ***,not all tumors are cancerous or *** masses can cause discomfort and pain,depending on the size and texture of the *** an appropriate diagnosis,non-cancerous breast masses can be diagnosed earlier to prevent their cultivation from being *** the development of the artificial neural network,the deep discriminative model,such as a convolutional neural network,may evaluate the breast lesion to distinguish benign and malignant cancers frommammogram breast masses *** work accomplished breastmasses classification relative to benign and malignant cancers using a digital database for screening mammography image datasets.A residual neural network 50(ResNet50)model along with an adaptive gradient algorithm,adaptive moment estimation,and stochastic gradient descent optimizers,as well as data augmentations and fine-tuning methods,were *** addition,a learning rate scheduler and 5-fold cross-validation were applied with 60 training procedures to determine the best *** results of training accuracy,p-value,test accuracy,area under the curve,sensitivity,precision,F1-score,specificity,and kappa for adaptive gradient algorithm 25%,75%,100%,and stochastic gradient descent 100%fine-tunings indicate that the classifier is feasible for categorizing breast cancer into benign and malignant from the mammographic breast masses images.

关键词： Medical image analysis convolutional neural network mammogram breast masses breast cancer

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Bone-targeted lipoplex-loaded three-dimensional bioprinting bilayer scaffold enhanced bone regeneration

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Regenerative Biomaterials 2024年第4期3卷 138-148页

作者： woo-jin Kim jeong-Hyun Ryu ji Won Kim Ki-Tae Kim Hye-Rim Shin Heein Yoon Hyun-Mo Ryoo Young-Dan Cho Department of Molecular Genetics School of Dentistry and Dental Research InstituteSeoul National UniversitySeoul03080Republic of Korea Department of Periodontology School of Dentistry and Dental Research InstituteSeoul National University and Seoul National University Dental HospitalSeoul03080Republic of Korea

Clinical bone-morphogenetic protein 2(BMP2)treatment for bone regeneration,often resulting in complications like soft tissue inflammation and ectopic ossification due to high dosages and non-specific delivery systems,necessitates research into improved biomaterials for better BMP2 stability and *** tackle this challenge,we introduced a groundbreaking bone-targeted,lipoplex-loaded,three-dimensional bioprinted bilayer scaffold,termed the polycaprolactone-bioink-nanoparticle(PBN)scaffold,aimed at boosting bone *** encapsulated BMP2 within the fibroin nanoparticle based lipoplex(Fibroplex)and functionalized it with DSS6 for bone tissue-specific targeting.3D printing technology enables customized,porous PCL scaffolds for bone healing and soft tissue growth,with a two-step bioprinting process creating a cellular lattice structure and a bioink grid using gelatin-alginate hydrogel and DSS6-Fibroplex,shown to support effective nutrient exchange and cell growth at specific pore *** PBN scaffold is predicted through in silico analysis to exhibit biased BMP2 release between bone and soft tissue,a finding validated by in vitro osteogenic differentiation *** PBN scaffold was evaluated for critical calvarial defects,focusing on sustained BMP2 delivery,prevention of soft tissue cell infiltration and controlled fiber membrane pore size in *** PBN scaffold demonstrated a more than eight times longer BMP2 release time than that of the collagen sponge,promoting osteogenic differentiation and bone regeneration in a calvarial defect *** findings suggest that the PBN scaffold enhanced the local concentration of BMP2 in bone defects through sustained release and improved the spatial arrangement of bone formation,thereby reducing the risk of heterotopic ossification.

关键词： 3D bioprinting bone-targeting lipoplex BMP2 bone regeneration

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Effective parameters on diameter of carbon nanotubes by plasma enhanced chemical vapor deposition

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中国有色金属学会会刊：英文版 2012年第S3期22卷 712-716页

作者： Kang Young jeong Hyun Kyung JUNG Hyung woo LEE National Core Research Center for Hybrid Materials Solution Hybrid Graduate SchoolPusan National University Department of Diagnostic Radiology Inje University College of MedicineHaeundae Paik Hospital

The effective parameters on the diameter of carbon nanotubes (CNTs) by plasma enhanced chemical vapor deposition (PECVD) were *** lots of influential parameters,the effects of the catalytic film thickness and the pretreatment plasma power on the growth of CNTs were *** results show that the size of catalytic islands increases by increasing the thickness of catalytic layer,but the density of CNTs *** pretreatment duration time of 30 s is the optimal condition for growing CNTs with about 50 nm in *** increasing the pretreatment plasma power,the diameter of CNTs decreases ***,the diameter of CNTs does not change drastically from 80 to 120 *** uniformly grown CNTs with the diameter of 50 nm are obtained at the pretreatment plasma power of 100 W.

关键词： carbon nanotubes catalytic film thickness pretreatment plasma power plasma enhanced chemical vapor deposition

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Attaching single carbon nanotube on tip's apex using dielectrophoresis of DC-pulse voltage

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中国有色金属学会会刊：英文版 2009年第B9期19卷 280-283页

作者： Hee-jin jeong Yoong-Ho JUNG Deug-woo LEE Gyeongbuk Hybrid Technology Institute School of Mechanical Engineering Pusan National University Department of Nanosystem and Nanoprocess Engineering Pusan National University

Single carbon nanotubes (CNTs) are candidates for a number of electronics and sensing applications, provided that single CNTs can be separated from a bundle of CNTs in suspension. Dielectrophoresis has recently been demonstrated as one route for the extraction of desired CNTs. However, previous methods using dielectrophoresis have found it difficult to extract single nanotubes from bundles of CNTs in solution. Here, we show that this restriction can be overcome by using pulsed DC voltage of an electric field, instead of regular AC and DC voltages.

关键词：碳纳米管直流脉冲脉冲电压介电顶点消息电子号码 CNTs

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