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Median arcuate ligamentum syndrome:Four case reports

World Journal of Clinical Cases 2022年第6期10卷 1991-1997页

作者： ji eun Kim Poong Lyul Rhee Division of Gastroenterology Samsung Medical CenterSeoul 06351South Korea

BACKGROUND Median arcuate ligamentum syndrome(MALS)is a disease entity with unclear *** it is not considered in advance,the clinical diagnosis of the disease is very difficult because patients complain of digestive discomfort including ***,this characteristic is not specific to *** have been no studies to assist in making a quick *** aim of this case series was to recognize that MALS must be considered as a differential factor in the cause of abdominal *** SUMMARY We described cases in which four patients complained of abdominal pain over a long period but in whom a diagnosis of MALS could not be *** the gastroenterologist does not take into account abdominal pain in advance,the patient is considered an asymptomatic gallstone patient and has their gallbladder removed despite imaging *** patient may also be considered a psychiatric patient and may be administered psychiatric drugs over a long *** all four cases in this report,the patients experienced abdominal *** three cases,the diagnosis was possible by the clinician’s judgment considering both clinical symptoms and imaging techniques shortly after the onset of ***,in one case that lasted over 20 years,a clear diagnosis was not *** after complaining of colicky pain and performing a cholecystectomy,the diagnosis was made only after the symptoms *** all four cases,the symptoms were relieved by *** MALS is a rare disease and it is easy to miss because it is not malignant,but patients can suffer from pain over a long *** the accurate diagnosis of a patient complaining of abdominal pain,the diagnosis must be *** addition,as there are asymptomatic patients,patients who need treatment should be carefully selected,and improvement with medical treatment can be ***-scale studies are also needed.

关键词： Median arcuate ligamentum syndrome Abdominal pain Missed diagnosis Neuromodulator Celiac artery compression Case report

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Various diagnostic possibilities for zygomatic arch pain:Seven case reports and review of literature

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World Journal of Clinical Cases 2020年第11期8卷 2294-2304页

作者： Seoeun park ji Woon park Department of Oral Medicine and Oral Diagnosis School of Dentistry and Dental Research InstituteSeoul National UniversitySeoul 03080South Korea

BACKGROUND Pain of the zygomatic arch region is common among patients with orofacial pain,especially in those with temporomandibular disorder-related pain of a myogenic *** zygomatic arch pain may occur due to various causes other than muscle pain,appropriate diagnosis and treatment planning is essential to ensure its successful ***,zygomatic arch pain has not been handled as an independent clinical feature until now,and studies have mainly focused on pain resulting from trauma and surgical *** SUMMARY We describe 7 independent cases,all of which presented with the identical chief complaint of pain in the zygomatic arch ***,the underlying causes were different for each,being myofascial pain,myositis,tooth crack,dental caries,sinusitis,neuropathic pain,and salivary gland tumor *** this case report,the clinical features of each case are investigated and diseases to be considered in the diagnostic process are suggested,along with the diagnostic modalities(including computed tomography and magnetic resonance imaging)that can lead to the appropriate final *** Zygomatic arch pain is a common complaint encountered in the orofacial pain clinic but may lead to *** must have in-depth knowledge of the possible differential diagnoses and evaluation tools.

关键词： Zygomatic arch Myositis Odontogenic pain Sinusitis Neuropathic pain Salivary gland tumor Case report

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Efficacy and safety of conversion of percutaneous cholecystostomy to endoscopic transpapillary gallbladder stenting in high-risk surgical patients

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Hepatobiliary & Pancreatic Diseases International 2021年第5期20卷 478-484页

作者： Hyung Ku Chon Chan park Dong eun park Tae Hyeon Kim Division of Biliopancreas Department of Internal MedicineWonkwang University College of Medicine and Hospital895 MuwangRoIksanSouth Korea Institute of Wonkwang Medical Science Wonkwang University College of Medicine and HospitalIksanSouth Korea Department of Surgery Wonkwang University College of Medicine and HospitalIksanSouth Korea

Background:Endoscopic transpapillary gallbladder stenting(ETGBS)has been used as an alternative to percutaneous cholecystostomy in patients with acute cholecystitis who are considered unfit for ***,there are few data on the efficacy and safety of ETGBS replacement of percutaneous cholecystostomy in high-risk surgical *** study aimed to evaluate the feasibility,efficacy,and safety of ETGBS to replace percutaneous cholecystostomy in high-risk surgical ***:This single center retrospective study reviewed the data of patients who attempted ETGBS to replace percutaneous cholecystostomy between January 2017 and September *** technical success,clinical success,adverse events,and stent patency were ***:ETGBS was performed in 43 patients(24 male,mean age 80.7±7.4 years)to replace percutaneous cholecystostomy due to high surgical *** technical success rate and clinical success rate were 97.7%(42/43)and 90.5%(38/42),***-related adverse events and stent-related late adverse events occurred in 7.0%(3/43)and 11.6%(5/43),*** the patients who successfully underwent ETGBS(n=42),only one had recurrent acute cholecystitis during *** median stent patency was 415 days(interquartile range 240–528 days).Conclusions:ETGBS,as a secondary intervention for the purpose of internalizing gallbladder drainage in patients following placement of a percutaneous cholecystostomy,is safe,effective,and technically ***,conversion of percutaneous cholecystostomy to ETGBS may be considered as a viable option in high-risk surgical patients.

关键词： Cholecystitis Percutaneous cholecystostomy Endoscopic transpapillary gallbladder stenting High surgical risk

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Clinical efficacy of 0.05%cyclosporine nano-emulsion in the treatment of dry eye syndrome associated with meibomian gland dysfunction

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 1924-1931页

作者： Yeon ji Jo ji eun Lee Jong Soo Lee Efficacy of nano-cyclosporine to DES with MGD 1 Department of Ophthalmology Pusan National University School of Medicine&Medical Research InstitutePusan National University HospitalPusan 49241Republic of Korea Department of Ophthalmology Pusan National University School of Medicine&Medical Research CenterYangsan Pusan National University HospitalYangsan 626-770Republic of Korea

AIM:To evaluate the clinical efficacy of topical 0.05%cyclosporine nano-emulsion in the treatment of dry eye syndrome(DES)with meibomian gland dysfunction(MGD).METHODS:This prospective study included 64 patients with DES and MGD who were randomly assigned to three groups:Group 1(n=24,conventional cyclosporine),Group 2(n=21,nano-emulsion cyclosporine),and Group 3(n=19,control).Lid margin telangiectasia(LMT),meibomian gland secretion(MGS),conjunctival injection(CI),corneal staining(CS),tear break-up time(TBUT),Schirmer test I(STI),Ocular Surface Disease Index(OSDI),and lipid layer thickness(LLT)was evaluated at 4,8,and 12wk of ***:In Group 3(control),LMT,CS,and CI improved after 8wk,MGS,TBUT after 12wk of *** Group 1(conventional cyclosporine),LMT,MGS,and TBUT improved significantly after 4wk,whereas CS,CI,STI,and LLT improved significantly after 8wk,and OSDI at *** Group 2(nano-cyclosporine),LMT,MGS,CS,CI,TBUT,and OSDI significantly improved after 4wk,and STI after ***,LLT was significantly higher than other groups after ***:Cyclosporine and nano-cyclosporine shows significant improvement in DES with MGD than the control *** contrast,the nano-cyclosporine group shows more statistically improved CI and CS at 4wk,especially LLT at 4,8,and 12wk compared to the conventional cyclosporine group.

关键词： anti-inflammatory treatment cyclosporine dry eye disease meibomian gland dysfunction

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Hydrangeae Dulcis Folium Attenuates Physical Stress by Supressing ACTH-Induced Cortisol in Zebrafish

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Chinese Journal of Integrative Medicine 2020年第2期26卷 130-137页

作者： Junyoung Oh Dong Hyun Kim Gi-young Kim eun-jin park Jong Hoon Ryu ji Wook Jung Se jin park Gwang-Woo Kim Seungheon Lee Department of Marine Life Science College of Ocean ScienceJeju National UniversityJeju(63243)Republic of Korea Departme nt of Medicinal Biotech no logy College of Health SciencesDong-A UniversityBusan(604-714)Republic of Korea Department of Food Bioengineering Jeju National UniversityJeju(63243)Republic of Korea Institute of Convergence BioHealth Dong-A UniversityBusan(604-714)Republic of Korea Department of Oriental Pharmaceutical Science College of PharmacyKyung Hee UniversityHoeki-dongDongdaemoon・KuSeoul(130-701)Republic of Korea Kyung Hee East-West Pharmaceutical Research Institute College of PharmacyKyung Hee UniversityHoeki-dongDongdaemoorvKuSeoul(130-701)Republic of Korea Department of Herbal Medicinal Pharmacology College of Herbal Bio-industryDaegu Haany UniversityYugok-dongGyeongsan(712-715)Republic of Korea School of Natural Resources and Environmental Sciences Kangwon National UniversityChuncheon(24341)Republic of Korea Marine Bio Con verge nee Center Gangneung Science&In dustry Promotion AgencyGangneung(25440)Republic of Korea

Objective:To determine the effects of Hydrangeae Dulcis Folium(EHDF)on physical stress,changes in the whole-body cortisol level and behaviour in zebrafish(Danio rerio).Methods:One hundred and seventy-four fish were randomly divided into 4[adrenocorticotropin hormone(ACTH)challenge test:4 fish per group]or 6 groups(behavioural test:10–12 fish per group,whole-body cortisol:4 fish per group).Net handling stress(NHS)was used to induce physical *** were treated with vehicle or EHDF(5–20 mg/L)for 6 min before they were exposed to *** then,fish were sacrificed for collecting body fluid from whole-body or conducted behavioural tests,including novel tank test and open field test,and were evaluated to observe anxiety-like behaviours and *** addition,to elucidate the mode of action of the anti-stress effects of EHDF,ACTH(0.2 IU/g,i.p.)challenge test was ***:The increased anxiety-like behaviours in novel tank test and open field test under stress were prevented by treatment with EHDF at 5–20 mg/L(P<0.05).Moreover,compared with the unstressed group,which was not treated with NHS,the whole-body cortisol level was significantly increased by treatment with NHS(P<0.05).Compared with the NHS-treated stressed control group,pre-treatment with EHDF at concentrations of 5–20 mg/L for 6 min significantly prevented the NHS-increased whole-body cortisol level(P<0.05).In addition,ACTH challenge test showed that EHDF completely blocked the effects of ACTH on cortisol secretion(P<0.05).Conclusion:EHDF may be a good antistress candidate and its mechanism of action may be related to its positive effects on cortisol release.

关键词： net handling stress zebrafish Hydrangeae Dulcis Folium whole-body cortisol behavioural tests

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THE PHYSICAL PROPERTIES OF POLY(2-HYDROXYETHYL METHACRYLATE)COPOLYMER HYDROGELS USED AS INTRAVAGINAL RINGS

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Chinese Journal of Polymer Science 2009年第3期27卷 359-366页

作者： Young A Han eun Mi Lee Byung Chul ji Department of Textile System Engineering Kyungpook National UniversityDaegu 702-701Korea Department of Advanced Organic Materials Science and Engineering Kyungpook National UniversityDaegu 702-701Korea

Poly(2-hydroxyethyl methacrylate)(PHEMA)and poly(2-hydroxyethyl methacrylate-co-sodium methacrylate) [P(HEMA-co-SMA)]hydrogels with different compositions were prepared to be used as intravaginal rings,and their gelation time,water content,mechanical properties and morphology were *** water content of PHEMA and P(HEMA-co-SMA) hydrogels decreased as the concentration of the monomer and the degree of crosslinking increased,while the water content significantly increased as the content of SMA,the hydrophilic monomer,*** increasing of the concentration of the crosslinking agent affected the tensile and flexural properties *** presence of a proper small amount of SMA also led the tensile and flexural modulus to move to a higher *** results showed that P(HEMA-co-SMA) hydrogel with high drug load and good mechanical properties at optimum preparation conditions can be prepared for intravaginal rings to deliver nonhormonal *** results may be applied to prepare better intravaginal drug delivery devices.

关键词： PHEMA and P(HEMA-co-SMA)hydrogels Tensile and flexural properties High drug load Intravaginal drug delivery devices.

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Influence of the preparation method on the catalytic activity of Mg-Al hydrotalcites as solid base catalysts

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Green Energy & Environment 2019年第3期4卷 287-292页

作者： Sungjae park Dahye Kwon ji Yeon Kang ji Chul Jung Department of Chemical Engineering Myongji University

Mg-Al hydrotalcites were synthesized using different preparation methods(a co-precipitation method, a urea method, and a simple one) to analyze their effect on the catalytic activity of these solid base catalysts. The method strongly affected the structure of their layers(e.g., the growth and stacking of the layers, and the type of intercalated anions) and, accordingly, their catalytic activity. The Mg-Al hydrotalcite prepared by co-precipitation showed the best catalytic performance in the isomerization of glucose into fructose, due to the small crystallite size and sand rose morphology enhancing the exposure of surface active sites to reactants.

关键词： Mg-Al hydrotalcite Preparation method Base catalyst Glucose isomerization Fructose

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Induction of vascular endothelial growth factor receptor expression in human umbilical vein endothelial cells after repeated bevacizumab treatment in vitro

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1064-1068页

作者： ji eun Lee jin Young Kim Jae Ho Jung Dong Hoon Shin Sung Who park Department of Ophthalmology School of MedicinePusan National University Medical Research Institute Pusan National University Hospital Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Department of Pathology School of MedicinePusan National University

AIM： To investigate the mechanism underlying the loss of responsiveness to anti-vascular endothelial growth factor（VEGF） treatment after repeated injections for choroidal neovascularization, VEGF and VEGF receptor（VEGFR） expressions were evaluated following repeated bevacizumab treatments in hypoxic human umbilical vein endothelial cells（HUVECs） in ***： HUVECs were incubated under hypoxic conditions in two media of different bevacizumab concentrations（1.0 or 2.5 mg/m L） for 17 h, and then in a new medium without bevacizumab for 7h. This procedure was repeated twice more. A culture with an identical volume of excipients served as the control. Cytotoxicity and cell proliferation were assessed using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide and Ki-67 assays, respectively. Levels of VEGF and VEGFR were assessed using enzyme-linked immunosorbent assay and Western blot ***： Cytotoxic effects were not reported for either bevacizumab concentration. Cell proliferation was not reduced after anti-VEGF treatments. VEGF level after single treatment was significantly higher than that of the control and after repeated treatments. Phosphorylated VEGFR-2 expression increased significantly after singleand repeated bevacizumab treatments compared with the control. The 1.0 mg/m L bevacizumab induced significantly higher expressions of VEGFR-2 than the 2.5 mg/m L in single and repeated treatment ***： Bevacizumab treatment of HUVECs elevated VEGFR expression in both single and repeated treatments, indicating a mechanism for the reduced efficacy of anti-VEGF therapy in ocular neovascular disorders.

关键词： vascular endothelial growth factor vascular endothelial growth factor receptor choroidal neovascularization bevacizumab repeated treatments

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Metal@Silica Yolk-Shell Nanostructures as Versatile Bifunctional Nanocatalysts

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Nano Research 2011年第1期4卷 33-49页

作者： ji Chan park Hyunjoon Song Department of Chemistry Korea Advanced Institute of Science and Technology （KAIST） Daejeon 305-701 Republic of Korea

Recent developments in nanochemistry offer precise morphology control of nanomaterials, which has significant impacts in the field of heterogeneous catalysis. Rational design of bifunctional catalysts can influence various aspects of catalytic properties. In this review, a new class of bifunctional catalysts with a metal@silica yolk-shell nanostructure is introduced. This structure has many advantages as a heterogeneous catalyst since it ensures a homogeneous environment around each metal core, and particle sintering is effectively eliminated during high temperature reactions. The catalysts exhibit high activity and recyclability in gas- and solution-phase reactions. It is anticipated that appropriate selection of bifunctional components and optimal structural control will significantly further enhance the catalytic properties, and enable target reaction-oriented development of new catalysts.

关键词： Yolk-shell nanostructure nanocatalyst bifunctionality metal nanoparticles heterogeneous catalytic reactions

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Submerged arc plasma system combined with ozone oxidation for the treatment of wastewater containing non-degradable organic compounds

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Frontiers of Environmental Science & Engineering 2021年第5期15卷 155-163页

作者： Byungjin Lee eun Seo Jo Dong-Wha park jinsub Choi Department of Chemistry and Chemical Engineering and Regional Innovation Center for Environmental Technology of Thermal Plasma(RIC-ETTP) INHA UniversityIncheon402-751Republic of Korea

Submerged arc plasma technology was assessed for the removal of phenols from *** OH radicals generated from the boundary between the plasma and waste solution were considered as a significant factor on the degradation *** this study,the effects of highly energetic electrons released from the submerged arc plasma were mainly *** highly energetic electrons directly broke the strong chemical bond and locally increased the reaction temperatures in *** effects of the submerged-arc plasma on the decomposition of phenol are discussed in terms of the input energy and initial *** single use of submerged arc plasma easily decomposed the phenol but did not increase the mineralization ***,the submerged arc plasma,coupled with the ozone injection,was *** submerged arc plasma combined with ozone injection had a synergic effect,which led to significant improvements in mineralization with only a small increase in input *** decomposition mechanism of phenol by the submerged arc plasma with the ozone was analyzed.

关键词： Thermal plasma Submerged arc plasma Wastewater Ozone Phenol Highly energetic electron

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