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Trace amounts of antibiotic altered metabolomic and microbial profiles of weaned pigs infected with a pathogenic ***

Journal of Animal Science and Biotechnology 2022年第5期13卷 1576-1590页

作者： Kwangwook kim Cynthia jinno Peng ji Yanhong Liu Department of Animal Science University of CaliforniaDavisCA 95616USA Department of Nutrition University of CaliforniaDavisCA 95616USA

Background:Our previous study has shown that supplementation of trace amounts of antibiotic exacerbated the detrimental effects of enterotoxigenic ***(ETEC)infection and delayed the recovery of pigs that may be associated with modified metabolites and metabolic ***,the objective of this study was to explore the impacts of trace levels of antibiotic(carbadox)on host metabolic profiles and colon microbiota of weaned pigs experimentally infected with ETEC ***:The multivariate analysis highlighted a distinct metabolomic profile of serum and colon digesta between trace amounts of antibiotic(TRA;0.5 mg/kg carbadox)and label-recommended dose antibiotic(REC;50 mg/kg carbadox)on d 5 post-inoculation(PI).The relative abundance of metabolomic markers of amino acids,carbohydrates,and purine metabolism were significantly differentiated between the TRA and REC groups(q<0.2).In addition,pigs in REC group had the highest(P<0.05)relative abundance of Lactobacillaceae and tended to have increased(P<0.10)relative abundance of Lachnospiraceae in the colon digesta on d 5 *** d 11 PI,pigs in REC had greater(P<0.05)relative abundance of Clostridiaceae compared with other groups,whereas had reduced(P<0.05)relative abundance of Prevotellaceae than pigs in control ***:Trace amounts of antibiotic resulted in differential metabolites and metabolic pathways that may be associated with its slow responses against ETEC F18 *** altered gut microbiota profiles by labelrecommended dose antibiotic may contribute to the promotion of disease resistance in weaned pigs.

关键词： Carbadox Colon microbiota Enterotoxigenic Escherichia coli Metabolomics Weaned pigs

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Reaction mechanism and additional lithium storage of mesoporous MnO_(2) anode in Li batteries

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Journal of Energy Chemistry 2021年第2期30卷 276-284,I0010页

作者： Jaesang Yoon Woosung Choi Taewhan kim Hyunwoo kim Yun Seok Choi ji Man kim Won-Sub Yoon Department of Energy Science Sungkyunkwan UniversitySuwon 16419South Korea Department of Chemistry Sungkyunkwan UniversitySuwon 16419South Korea

Nanostructured transition metal oxides,employed as anode materials for lithium-ion batteries,exhibit a higher capacity than the theoretical capacity based on the conversion *** date,the reasons behind this phenomenon are *** the one-step evolution of anode material for lithium-ion batteries,it is essential to understand the lithium storage reaction mechanism of the anode ***,we provide a detailed report on the lithium storage and release mechanism of MnO2,using synchrotron-based X-ray techniques.X-ray diffraction and X-ray absorption spectroscopy results indicate that during the first discharge,MnO2 is reduced in the order of MnO2→LixMnO2(1

关键词： Mesoporous MnO_(2) Reaction mechanism Electrolyte-derived surface layer Synchrotron-based X-ray techniques Anode Li battery

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Passivation engineering via silica‐encapsulated quantum dots for highly sensitive photodetection

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Carbon Energy 2023年第9期5卷 49-62页

作者： ji Yun Chun Byung Gi kim jin Young kim Woongsik Jang Dong Hwan Wang School of Integrative Engineering Chung‐Ang UniversitySeoulRepublic of Korea

Organometal halide perovskites are promising semiconducting materials for photodetectors because of their favorable optoelectrical *** nanoscale perovskite materials such as quantum dots(QDs)show novel behavior,they have intrinsic stability *** this study,an effectively silane barrier-capped quantum dot(QD@APDEMS)is thinly applied onto a bulk perovskite photosensitive layer for use in ***@APDEMS is synthesized with a silane ligand with hydrophobic CH_(3)-terminal groups,resulting in excellent dispersibility and durability to enable effective *** introduction of the QD@APDEMS layer results in the formation of a lowdefect perovskite film with enlarged *** is attributed to the grain boundary interconnection effect via interaction between the functional groups of QD@APDEMS and uncoordinated Pb^(2+)in grain *** passivating the grain boundaries,where various trap sites are distributed,hole chargecarrier injection and shunt leakage can be ***,from the energy point of view,the deep highest occupied molecular orbital(HOMO)level of QD@APDEMS can work as a hole charge injection *** charge dynamics(generation,transfer,and recombination properties)and reduced trap density of QD@APDEMS are *** this perovskite film is used in a photodetector,the device performance(especially the detectivity)stands out among existing perovskites evaluated for energy sensing device applications.

关键词： grain boundary passivation perovskite quantum dots photodetectors photosensitive layers trap

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表面含磺酸基的介孔分子筛SBA-15-SO_3H的直接合成

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催化学报 2003年第2期24卷 83-86页

作者：袁兴东沈健李国辉周敬来 ji-Man kim Sang-eon Park 抚顺石油学院石油化工系辽宁抚顺113001 中国科学院山西煤炭化学研究所山西太原030001 韩国化学研究院分子工程催化中心

采用水热法直接合成了含磺酸基的介孔分子筛SBA 15 SO3H .XRD表征结果表明 ,该分子筛具有规则的、六方立柱形的中孔结构 ,通过酸碱滴定和XRD确定了正硅酸乙酯 /有机硅的最佳合成配比为 9(α =0 1) .2 9SiMASNMR固体核磁结果表明 ,含... 详细信息

采用水热法直接合成了含磺酸基的介孔分子筛SBA 15 SO3H .XRD表征结果表明 ,该分子筛具有规则的、六方立柱形的中孔结构 ,通过酸碱滴定和XRD确定了正硅酸乙酯 /有机硅的最佳合成配比为 9(α =0 1) .2 9SiMASNMR固体核磁结果表明 ,含磺酸基的有机基团Si (CH2 ) 3 SO3H中的硅与SBA 15骨架上的氧通过Si O键结合 ,形成稳定的有机 /无机组成 ,FT IR谱表明 :在SBA 15 SO3H表面含有质子酸中心 SO3H .N2 吸附脱附和TEM结果表明 ,SBA 15 SO3H具有较大的比表面积、孔容和孔径 ,孔大小是单一的 ,孔分布是高度有序的 .酯化反应结果表明 ,与后合成法相比 ,直接法合成的催化剂既具有较高的稳定性 ,又具有简便。

关键词：磺酸介孔分子筛 SBA-15-SO3H 直接合成 SBA-15分子筛固体酸表面改性多相催化剂

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Polyarteritis nodosa presenting as leg pain with resolution of positron emission tomography-images:A case report

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World Journal of Clinical Cases 2023年第4期11卷 918-921页

作者： ji-Hyoun Kang Jahae kim Division of Rheumatology Department of Internal MedicineChonnam National University Medical School&HospitalGwangju 61469South Korea Department of Nuclear Medicine Chonnam National University Hospital&Medical SchoolGwangju 61469South Korea

BACKGROUND Although fluorodeoxyglucose-positron emission tomography/computed tomography(FDG-PET/CT)is widely used for diagnosis and follow-up of large sized vessel vasculitis,it is still not widely used for small to medium sized vessel *** SUMMARY This is the case of a 68-year-old male who presented at the emergency department complaining of fever,myalgia,and bilateral leg pain of over two weeks duration,with elevated levels of C-reactive *** was subsequently admitted and despite the absence of clinically significant findings,the patient continued to exhibit recurrent fever.A fever of unknown origin workup,which included imaging studies using FDG-PET/CT,revealed vasculitis involving small to medium-sized vessels of both lower extremities,demonstrated by linear hypermetabolism throughout the leg *** patient was treated with methylprednisolone and methotrexate after diagnosis leading to the gradual resolution of the patient’s *** weeks later,a follow-up FDGPET/CT was *** hypermetabolic vessels were markedly *** Our case report demonstrated that FDG-PET/CT has tremendous potential to detect medium-sized vessel inflammation;it can also play a crucial role in prognosticating outcomes and monitoring therapeutic efficacy.

关键词： Positron emission tomography-computed tomography Polyarteritis nodosa Case report

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Design of 1 kbit antifuse one time programmable memory IP using dual program voltage

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Journal of Central South University 2011年第1期18卷 125-132页

作者：金丽妍 JANG ji-Hye kim Du-Hwi kim Young-Hee Department of Electronic Engineering Changwon National University9 Sarim-DongChangwon 641-773Korea

A 1 kbit antifuse one time programmable(OTP) memory IP,which is one of the non-volatile memory IPs,was designed and used for power management integrated circuits(ICs).A conventional antifuse OTP cell using a single positive program voltage(VPP) has a problem when applying a higher voltage than the breakdown voltage of the thin gate oxides and at the same time,securing the reliability of medium voltage(VM) devices that are thick gate transistors.A new antifuse OTP cell using a dual program voltage was proposed to prevent the possibility for failures in a qualification test or the yield *** the newly proposed cell,a stable sensing is secured from the post-program resistances of several ten thousand ohms or below due to the voltage higher than the hard breakdown voltage applied to the terminals of the *** layout size of the designed 1 kbit antifuse OTP memory IP with Dongbu HiTek's 0.18 μm Bipolar-CMOS-DMOS(BCD) process is 567.9 μm×205.135 μm and the post-program resistance of an antifuse is predicted to be several ten thousand ohms.

关键词： one time programmable memory IP antifuse hard breakdown dual program voltage post-program resistance

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Effects of PWHT on Microstructure and Mechanical Properties of Weld Metals of Ni-Based Superalloy 617 and 263 for Hyper-Supercritical Power Plants

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Acta Metallurgica Sinica(English Letters) 2016年第12期29卷 1107-1118页

作者： Jeong Kil kim Hae ji Park Deog Nam Shim Doosan Heavy Industries and Construction ChangwonGeongnam Korea

It is well known that solid solution-strengthened alloy 617 and γ′ precipitation-strengthened alloy 263 have excellent mechanical properties and corrosion resistance at high temperatures. Hyper-supercritical power plants work at temperatures above 700 ℃, and these superalloys are considered candidate materials for steam turbines components of these power plants. In this study, gas tungsten arc weldability of these superalloys was evaluated, and the effects of post- weld heat treatment （PWHT） on the microstructural characteristics and the mechanical properties of their weld metals were investigated. Scanning transmission electron microscopy, energy-dispersive spectroscopy and electron probe microanalysis were utilized for the investigation. The experimental results confirmed that these weld metals had different characteristics in microstructure and mechanical properties. PWHT resulted in the precipitation of intergranular carbides, γ′ particles and an increase in tensile strength of these superalloy weld metals. Furthermore, fine γ′ particles, which were not detected in the as-welded metal of alloy 263, were precipitated after PWHT and those particles were the reason for the drastic increase in tensile strength.

关键词： Superalloy Welding Precipitation Segregation

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Median arcuate ligamentum syndrome:Four case reports

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World Journal of Clinical Cases 2022年第6期10卷 1991-1997页

作者： ji Eun kim Poong Lyul Rhee Division of Gastroenterology Samsung Medical CenterSeoul 06351South Korea

BACKGROUND Median arcuate ligamentum syndrome(MALS)is a disease entity with unclear *** it is not considered in advance,the clinical diagnosis of the disease is very difficult because patients complain of digestive discomfort including ***,this characteristic is not specific to *** have been no studies to assist in making a quick *** aim of this case series was to recognize that MALS must be considered as a differential factor in the cause of abdominal *** SUMMARY We described cases in which four patients complained of abdominal pain over a long period but in whom a diagnosis of MALS could not be *** the gastroenterologist does not take into account abdominal pain in advance,the patient is considered an asymptomatic gallstone patient and has their gallbladder removed despite imaging *** patient may also be considered a psychiatric patient and may be administered psychiatric drugs over a long *** all four cases in this report,the patients experienced abdominal *** three cases,the diagnosis was possible by the clinician’s judgment considering both clinical symptoms and imaging techniques shortly after the onset of ***,in one case that lasted over 20 years,a clear diagnosis was not *** after complaining of colicky pain and performing a cholecystectomy,the diagnosis was made only after the symptoms *** all four cases,the symptoms were relieved by *** MALS is a rare disease and it is easy to miss because it is not malignant,but patients can suffer from pain over a long *** the accurate diagnosis of a patient complaining of abdominal pain,the diagnosis must be *** addition,as there are asymptomatic patients,patients who need treatment should be carefully selected,and improvement with medical treatment can be ***-scale studies are also needed.

关键词： Median arcuate ligamentum syndrome Abdominal pain Missed diagnosis Neuromodulator Celiac artery compression Case report

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Behavioral consequences of children with sleep-disordered breathing after adenotonsillectomy

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World Journal of Pediatrics 2018年第1期14卷 57-65页

作者： ji Yoon kim Chang Ho Lee Hyoung-Mi kim Otorhinolaryngology Department CHA UniversitySeongnamKorea Otorhinolaryngology Department CHA Bundang MedicalCenterCHA University351Yatap-dongBundang-guSeongnam-siGyeonggi-do463-712Korea

Background Adenotonsillectomy (AT) has been an effective treatment for sleep-disordered breathing (SDB) in children, and several studies described the risk of postoperative weight gain and obesity in children treated with AT. The present study aimed to evaluate behavioral improvements in children with SDB one year after adenotonsillectomy and to investigate an influence of postoperative weight gain on behaviors. Methods The study included 170 children aged 5–11 years who underwent adenotonsillectomy for SDB and 150 controls. Body mass index percentile was obtained for age and gender, and parental sleep-related breathing disorder (SRBD) question-naire was used to assess the severity of SDB. Psychological assessment was performed pre- and post-adenotonsillectomy using standardized questionnaires including strength and difficulties questionnaire, children's depression inventory and screen for child anxiety-related emotional disorder. Results The mean age of 170 patients was 7.7 ± 1.5 years with 73 (42.9%) girls and 97 (57.1%) boys. The mean follow-up period were 15.4 ± 2.7 months. The patients had shown significant improvements in SDB scores as well as in questionnaire-based behavioral problems after adenotonsillectomy. The odds of a child being overweight were significantly increased after adenotonsillectomy. Less improvements in hyperactivity and conduct problems were observed in the patients with older ages, higher SRBD scores, and overweight/obesity at 1-year follow-up after adenotonsillectomy. Conclusion These data suggest that abnormal behavioral outcomes should be evaluated postoperatively, which potentially could be reduced with the early adenotonsillectomy and adequate postoperative weight control.

关键词： Obesity Obstructive sleep apnea Pediatric Snoring Tonsillectomy

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Anti-obesity Effects of Ginsenosides in High-Fat Diet-Fed Rats

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Chinese Journal of Integrative Medicine 2019年第12期25卷 895-901页

作者： Hyun-Jung Park ji Hyun kim Insop Shim Department of Physiology College of MedicineKyung Hee UniversitySeoul(130-701)Republic of Korea Department of Food Science&Biotechnology College of Science and EngineeringSuwon-si(16227)Republic of Korea

Objective: To examine the anti-obesity effects of ginsenosides in Korea Red Ginseng(KRG, Panax ginseng) in rats fed with a high-fat diet(HFD). Methods: Twenty-five 4-week-old obesity rats after receiving an HFD for 5 weeks;subsequently, they were additionally treated with ginsenosides Rb1, Rd, Rg1, or Re(10 mg/kg, intraperitoneal injection) for a further 3 weeks(n=5 in each group). The control rats were fed a normal diet. The food consumption, body weight, locomotor activity, serum lipids, adipose tissues, nitric oxide(NO) expression, leptin, neuropeptide Y(NPY), cholecystokinin(CCK) in the brains were measured. Results: In the HFD-fed rats, body weight, body fat mass, serum levels of leptin and NO were significantly higher than in the control rats(P<0.05 or P<0.01). However, the treatment of Rd, Re, and Rb1 markedly decreased body fat mass and body weight(P<0.05). The serum level of leptin and NO in ginsenoside-treated rats were markedly lower than the control group(P<0.01). The expression of NPY and CCK in the hypothalamic nuclei showed insignificant difference among groups. However, the expression of NPY immunoreactive neurons in the hypothalamus was significantly reduced in the Rb1-treated group(P<0.05). Conclusion: PD-type ginsenoside Rb1 from the crude saponins of KRG may be a useful compound for the treatment of obesity and related disorders through the modulation of peripheral and central appetite-regulating signals.

关键词： Panax ginseng ginsenosides hypothalamus obesity

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