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Baseline predictors of virological response for chronic hepatitis B patients

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World Journal of Gastroenterology 2009年第34期15卷 4311-4315页

作者： xue-jie wu Yan wang ji chen gui-qiang wang Department of Infectious Diseases Peking University First Hospital Beijing 100034 China

AIM： To determine which baseline factors of chronic hepatitis B patients are predictive of virological response to Peginterferon α-2b therapy. METHODS： A total of 21 HBeAg-positive chronic hepatitis B （CriB） patients treated with Peginterferon α-2b were recruited. They were treated with Peginterferon α-2b （0.5-1.0 μg/kg per week） for 24 wk and followed up for 24 wk. Clinical and laboratory data of the patients were determined at pretreatment and at week 12, at 24 during treatment, and at week 48 during follow up. RESULTS： Ten patients achieved a virological response at the end of treatment. Their baseline serum alanine aminotransferase （ALT）, thyroid-stimulating hormone （TSH）, and total thyroxin （TT4） levels were significantly different from those who failed treatment. The positive predictive values （PPV） and negative predictive values （NPV） of ALT, TSH, and TT4 were 75% and 89 %, 75% and 89 %, and 75% and 75%, respectively. Moreover, combinations of the baseline ALT and TT4, ALT and TSH, TT4 and TSH levels had much higher PPV and NPV （86% and 88%, 89% and 100%, 83% and 100%, respectively）.CONCLUSION： Baseline serum ALT, TSH, and TT4 levels, especially in combination, have high predictive values of virological response to Peginterferon α-2b in HBeAg-positive CriB patients.

关键词： Chronic hepatitis B Hepatitis B virus Predictors Virological response Peginterferon

Pegylated interferon α-2b up-regulates specific CD8+ T cells in patients with chronic hepatitis B

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World Journal of Gastroenterology 2010年第48期16卷 6145-6150页

作者： ji chen,Yan wang,xue-jie wu,Jun Li,Feng-Qin Hou,gui-qiang wang,Department of Infectious Diseases,Center for Liver Diseases,Peking University First Hospital,Beijing 100034,China Department of Infectious Diseases Center for Liver Diseases Peking University First Hospital No. 8 Xishiku Street Xicheng District Beijing 10034 China.

AIM:To investigate the effect of pegylated interferon (IFN) α-2b on specific CD8+ T lymphocytes in patients with chronic hepatitis B (CHB). METHODS:Twenty-one patients with CHB were treated with pegylated IFN α-2b. Periphery blood mononuclear cells were isolated from fresh heparinized blood by Ficoll-Hypaque density gradient centrifugation (density:1.077 g/L,Pharmingen) at weeks 0,4,8,12,and 24,respectively. Frequency of circulating hepatitis B virus (HBV) epitope-specific CD8 T cells was detected by flow cytometry. Cytokines were detected by cytometric bead assay. RESULTS:The frequency of circulating HBV core or env-specific CD8 T cells was higher (P < 0.05),the number of HBV core specific CD8 T cells was greater at week 24 (P < 0.05),the level of Th1-type cytokines [interleukin (IL)-12,tumor necrosis factor-α,and IFN-γ] was higher,while that of Th2-type cytokines (IL-4,IL-6,and IL-10) was lower in responders than in nonresponders (P < 0.05) after pegylated IFN α-2b treatment. The IL-6 level was correlated with HBV DNA (r = 0.597,P = 0.04),while the inducible protein-10 (IP-10) level was correlated with serum alanine aminotransferase (ALT) (r = 0.545,P = 0.005). The IP-10 level at week 8 after pegylated IFN α-2b treatment could predict the normalization of ALT in CHB patients (positive predict value = 56%,negative predict value = 92%). CONCLUSION:Pegylated IFN α-2b can enhance the immune response of CHB patients by increasing the frequency of HBV specific CD8+ T cells and regulating the Th1/Th2 cytokines.

关键词： Chronic hepatitis B Pegylated interferon α-2b therapy Immune response Cytokine

Erlotinib versus gemcitabine plus cisplatin as neoadjuvant treatment of stage IIIA-N2 EGFR-mutant non-small-cell lung cancer:final overall survival analysis of the EMERGING-CTONG 1103 randomised phase II trial

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1310-1317页

作者： Wen-Zhao Zhong Hong-Hong Yan Ke-Neng chen Chun chen Chun-Dong Gu Jun wang xue-Ning Yang Wei-Min Mao Qun wang gui-Bin Qiao Ying cheng Lin Xu Chang-Li wang Ming-Wei chen Xiao-Zheng Kang Wan-Pu Yan Ri-qiang Liao jin-ji Yang Xu-Chao Zhang Si-Yang Liu Qing Zhou Yi-Long wu Guangdong Provincial People’s Hospital Guangdong Academy of Medical Sciences510080 GuangzhouChina Peking University Cancer Hospital and Institute 100142 BeijingChina Fujian Medical University Union Hospital 350001 FuzhouChina First Affiliated Hospital of Dalian Medical University 116011 DalianChina Peking University People’s Hospital 100044 BeijingChina Zhejiang Cancer Hospital 310022 HangzhouChina Zhongshan Hospital 200032 ShanghaiChina Guangzhou Liuhuaqiao Hospital 510000 GuangzhouChina jilin Provincial Tumor Hospital 130012 ChangchunChina jiangsu Cancer Institute and Hospital 210009 NanjingChina Tianjin Medical University Cancer Institute and Hospital 300060 TianjinChina First Affiliated Hospital of Xi’an jiaotong University 710061 Xi’anChina

EMERGING-CTONG 1103 showed improved progression-free survival(PFS)with neoadjuvant erlotinib *** for patients harbouring EGFR sensibility mutations and R0 resected stage IIIA-N2 non-small cell lung cancer(NSCLC)(NCT01407822).Herein,we report the final *** patients were randomly allocated 1:1 to the erlotinib group(150 mg/day orally;neoadjuvant phase for 42 days and adjuvant phase to 12 months)or to the GC group(gemcitabine 1250 mg/m2 plus cisplatin 75 mg/m2 intravenously;2 cycles in neoadjuvant phase and 2 cycles in adjuvant phase).Objective response rate(ORR),complete pathologic response(pCR),PFS,and overall survival(OS)were assessed along with *** hoc analysis was performed for subsequent treatments after disease *** investigated 72 patients(erlotinib,n=37;GC,n=35),the median follow-up was 62.5 *** median OS was 42.2 months(erlotinib)and 36.9 months(GC)(hazard ratio[HR],0.83;95%confidence interval[CI],0.47-1.47;p=0.513).The 3-and_(5-y)ear OS rates were 58.6%and 40.8%with erlotinib and 55.9%and 27.6%with GC(p_(3-y)=0.819,p_(5-y)=0.252).Subsequent treatment was administered in 71.9%and 81.8%of patients receiving erlotinib and GC,respectively;targeted therapy contributed mostly to OS(HR,0.35;95%CI,0.18-0.70).After disease progression,the ORR was 53.3%,and the median PFS was 10.9 months during the EGFR-TKI *** postoperative therapy,grade 3 or 4 adverse events(AEs)were 13.5%in the erlotinib group and 29.4%in the GC *** serious adverse events were *** exhibited clinical feasibility for resectable IIIA-N2 NSCLC over chemotherapy in the neoadjuvant setting.

关键词： neoadjuvant cisplatin chemotherapy

The clinical and immunological features of pediatric COVID-19 patients in China

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Genes & Diseases 2020年第4期7卷 535-541页

作者： Juan chen Zhen-Zhen Zhang Yao-Kai chen Quan-Xin Long Wen-Guang Tian Hai-Jun Deng jie-Li Hu Xian-Xiang Zhang Pu-Liao jiang-Lin Xiang Dao-Xin wang Peng Hu Fa-Chun Zhou Zhi-jie Li Hong-Mei Xu xue-Fei Cai De-qiang wang Yuan Hu Ni Tang Bei-Zhong Liu gui-cheng wu Ai-Long Huang The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education Department of Infectious DiseasesThe Second Affiliated HospitalChongqing Medical UniversityChongqingChina Department of Infectious Diseases National Clinical Research Center for Child Health and DisordersThe Children’s Hospital of Chongqing Medical UniversityChongqingChina Division of Infectious Diseases Chonqging Public Health Medical CenterChongqingChina Department of Infectious Diseases Yongchuan Hospital Affiliated to Chongqing Medical UniversityChongqingChina Department of Endocrinology Chongqing Three Gorges Central HospitalChongqingChina Department of Clinical Laboratory Chongqing People’s HospitalChongqingChina Department of Infectious Diseases Chongqing Three Gorges Central HospitalChongqingChina Department of Respiration The First Affiliated HospitalChongqing Medical UniversityChongqingChina Department of Emergency The First Affiliated HospitalChongqing Medical UniversityChongqingChina Department of Clinical Laboratory Yongchuan Hospital Affiliated to Chongqing Medical UniversityChongqingChina Department of Liver Disease Chongqing Three Gorges Central HospitalChongqingChina

In December 2019,the corona virus disease 2019(COVID-19)caused by novel coronavirus(SARS-CoV-2)emerged in wuhan,China and rapidly spread *** information on clinical features and immunological profile of COVID-19 in *** clinical features and treatment outcomes of twelve paediatric patients confirmed as COVID-19 were *** immunological features of children patients was investigated and compared with twenty adult *** median age was 14.5-years(range from 0.64 to 17),and six of the patients were *** average incubation period was 8 ***,cough(9/12,75%)and fever(7/12,58.3%)were the most common *** patients(33.3%)had diarrhea during the *** to the immune profile,children had higher amount of total T cell,CD8t T cell and B cell but lower CRP levels than adults(P<0.05).Ground-glass opacity(GGO)and local patchy shadowing were the typical radiological findings on chest CT *** patients received antiviral and symptomatic treatment and the symptom relieved in 3e4 days after admitted to *** paediatric patients showed mild symptom but with longer incubation *** infected with SARS-CoV-2 had different immune profile with higher T cell amount and low inflammatory factors level,which might ascribed to the mild clinical *** advise that nucleic acid test or examination of serum IgM/IgG antibodies against SARS-CoV-2 should be taken for children with exposure history regardless of clinical symptom.

关键词： Clinical features COVID-19 Immune Paediatrics SARS-CoV-2

Overproduction of OsRACK1A,an effector-targeted scaffold protein promoting OsRBOHB-mediated ROS production,confers rice floral resistance to false smut disease without yield penalty

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Molecular Plant 2022年第11期15卷 1790-1806页

作者： Guo-Bang Li jia-xue He jin-Long wu He wang Xin Zhang jie Liu Xiao-Hong Hu Yong Zhu Shuai Shen Yi-Fei Bai Zong-Lin Yao Xin-Xian Liu jing-Hao Zhao De-qiang Li Yan Li Fu Huang Yan-Yan Huang Zhi-xue Zhao ji-Wei Zhang Shi-Xin Zhou Yun-Peng ji Mei Pu Peng Qin Shigui Li xuewei chen jing wang Min He Weitao Li Xian-Jun wu Zheng-Jun Xu Wen-Ming wang jing Fan State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130China Rice Research Institute Sichuan Agricultural UniversityChengdu 611130China

Grain formation is fundamental for crop yield but is vulnerable to abiotic and biotic *** grain production is threatened by the false smut fungus Ustilaginoidea virens,which specifically infects rice floral organs,disrupting fertilization and seed ***,little is known about the molecular mechanisms of the ***-rice interaction and the genetic basis of floral ***,we report that *** secretes a cytoplasmic effector,UvCBP1,to facilitate infection of rice ***,UvCBP1 interacts with the rice scaffold protein OsRACK1A and competes its interaction with the reduced nicotinamide adenine dinucleotide phosphate oxidase OsRBOHB,leading to inhibition of reactive oxygen species(ROS)*** the analysis of natural variation revealed no OsRACK1A variants that could avoid being targeted by UvCBP1,expression levels of OsRACK1A are correlated with field resistance against *** in rice *** of OsRACK1A restores the OsRACK1A-OsRBOHB association and promotes OsRBOHB phosphorylation to enhance ROS production,conferring rice floral resistance to *** without yield *** together,our findings reveal a new pathogenic mechanism mediated by an essential effector from a flower-specific pathogen and provide a valuable genetic resource for balancing disease resistance and crop yield.

关键词： rice flower false smut fungal effector scaffold protein reactive oxygen species disease resistance

Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study

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Biomedical and Environmental Sciences 2021年第1期34卷 9-18页

作者： ZHU Yuan Yue ZHENG Rui Zhi wang gui Xia chen Li SHI Li Xin SU Qing XU Min XU Yu chen Yu Hong YU xue Feng YAN Li wang Tian Ge ZHAO Zhi Yun QIN gui Jun WAN Qin chen Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo jie QIN Ying Fen HUO Ya Nan LI qiang YE Zhen ZHANG Yin Fei LIU Chao wang You Min wu Sheng Li YANG Tao DENG Hua Cong ZHAO jia Jun chen Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying wang Wei Qing NING Guang LI Mian LU jie Li BI Yu Fang Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai National Center for Translational MedicineRuijin Hospital.Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China The First Hospital of jilin University Changchun 130021JinlinChina Qilu Hospital of Shandong University Jinan 250012ShandongChina Affiliated Hospital of guiyang Medical College Guiyang 550004GuizhouChina Xinhua Hospital Affiliated to Shanghai jiaotong University School of Medicine Shanghai 200092China Tongji Hospital.Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030HubeiChina Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510120GuangdongChina The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052HenanChina The Affiliated Hospital of Southwest Medical University Luzhou 646099SichuanChina Fujian Provincial Hospital Fujian Medical UniversityFuzhou 350001FujianChina Dalian Municipal Central Hospital Dalian 116003LiaoningChina The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000ZhejiangChina The First Affiliated Hospital of Guangxi Medical University Nanning 530021GuangxiChina jiangxi Provincial People's Hospital Affiliated to Nanchang University Nanchang 330006JiangxiChina The Second Affiliated Hospital of Harbin Medical University Harbin 150086HeilongjiangChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310051ZhejiangChina Central Hospital of Shanghai jiading District Shanghai 201800China jiangsu Province Hospital on Integration of Chinese and Western Medicine Nanjing 210028JiangsuChina The First Affiliated Hospital of Anhui Medical University Hefei 230022AnhuiChina Karamay Municipal

Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains *** aimed to explore the associations between glycemic indices and SUA levels in the general Chinese *** The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid *** nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive *** A total of 30,941 men and 62,361 women were eligible for the current *** additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and *** thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women.

关键词： Cross-sectional study Serum uric acid Glycemic index Glycemic status

Solar X-ray and EUV imager on board the FY-3E satellite

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Light(Science & Applications) 2022年第12期11卷 2939-2951页

作者： Bo chen Xiao-Xin Zhang Ling-Ping He Ke-Fei Song Shi-jie Liu Guang-Xing Ding jin-Ping Dun jia-Wei Li Zhao-Hui Li Quan-Feng Guo Hai-Feng wang Xiao-Dong wang Yun-Qi wang Hong-ji Zhang Guang Zhang Zhen-Wei Han Shuang Dai Pei-jie Zhang Liang Sun Yang Liu software engineer Peng wang Kun wu chen Tao Shi-Lei Mao gui Mei Liang Yang Li-Heng chen Chun-Yang Han Bin Huang Yang Liu mechanical engineer Shuai Ren Peng Zhou Ze-XiWei Xiao-xue Zhang Yue Zhang Xin Zheng Yang wang Ya chen jing-jiang Xie Fei He Qiao Song Wei-Guo Zong Xiu-Qing Hu Peng Zhang jing-Song wang Zhong-Dong Yang Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchunChina State Key Laboratory of Applied Optics Chinese Academy of SciencesChangchunChina National Satellite Meteorological Center China Meteorological AdministrationBeijingChina Key Laboratory of Space Weather National Center for Space WeatherChina Meteorological AdministrationBeijingChina Innovation Center for Fengyun Meteorological Satellite(FYSIC) BeijingChina Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijingChina

The solar X-ray and Extreme Ultraviolet Imager(X-EUVI),developed by the Changchun Institute of Optics,Fine Mechanics and Physics,Chinese Academy of Sciences(CIOMP),is the first space-based solar X-ray and Extreme ultraviolet(EUV)imager of China loaded on the Fengyun-3E(FY-3E)satellite supported by the China Meteorological Administration(CMA)for solar *** started work on July 11,2021,X-EUVI has obtained many solar *** instrument employs an innovative dual-band design to monitor a much larger temperature range on the Sun,which covers 0.6-8.0 nm in the X-ray region with six channels and 19.5 nm in the EUV region.X-EUVI has a field of view of 42′,an angular resolution of 2.5″per pixel in the EUV band and an angular resolution of 4.1″per pixel in the X-ray *** instrument also includes an X-ray and EUV irradiance sensor(X-EUVS)with the same bands as its imaging optics,which measures the solar irradiance and regularly calibrates the solar *** radiometric calibration of X-EUVS on the ground has been completed,with a calibration accuracy of 12%.X-EUVI is loaded on the FY-3E satellite and rotates relative to the Sun at a uniform ***-field calibration is conducted by utilizing successive rotation solar *** agreement between preliminarily processed X-EUVI images and SDO/AIA and Hinode/XRT images indicates that X-EUVI and the data processing algorithm operate properly and that the data from X-EUVI can be applied to the space weather forecast system of CMA and scientific investigations on solar activity.

关键词： image instrument Solar

A practical community-based response strategy to interrupt Ebola transmission in sierra Leone, 2014–2015

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Infectious Diseases of Poverty 2016年第1期5卷 670-679页

作者： Zhong-jie Li Wen-Xiao Tu Xiao-Chun wang Guo-Qing Shi Zun-Dong Yin Hai-Jun Su Tao Shen Da-Peng Zhang jian-Dong Li Shan Lv Chun-Li Cao Rui-Qian Xie Hong-Zhou Lu Rong-Meng jiang Zheng Cao Zhi-jie An Lei-Lei Li jie Xu Yan-Wen Xiong Wei Zang Wei Zhang Hong-Wei Zhang Wen-Sen chen Hua Ling Wen Xu jian Cai Huan-jin Luo xue-Sheng Xing Can-Jun Zheng qiang Wei Xin-Xu Li Mei Li Hai jiang Li-Quan Deng Ming-Quan chen Xiang Huo Feng Xu xue-Hui Lai Xi-chen Bai Long-jie Ye jian-Yi Yao Wen-wu Yin jiao-jin Sun Lin Xiao Fu-qiang Liu Xiao-qiang Liu Hong-Wei Fan Zeng-qiang Kou ji-Kun Zhou Hao Zhang Da-Xin Ni Thomas TSamba Qun Li Hong-jie Yu Yu wang Xiao-Feng Liang Division of Infectious Disease Key Laboratory of Surveillance and Early-warning on Infectious DiseaseChinese Center for Disease Control and PreventionBeijingChina Public Health Emergency Center Chinese Center for Disease Control and PreventionBeijingChina National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Chinese Field Epidemiology Training Program Chinese Center for Disease Control and PreventionBeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Bureau of Disease Prevention and Control National Health and Family Planning Commission of the People’s Republic of ChinaBeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina National Institute of Parasitic Disease Chinese Center for Disease Control and PreventionShanghaiChina Chinese Center for Health Education BeijingChina Department of Infectious Diseases Shanghai Public Health Clinical CenterShanghaiChina Beijing Ditan Hospital Capital Medical UniversityBeijingChina Health News BeijingChina National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Department of Training Chinese Center for Health EducationBeijingChina Center for Infectious Diseases Beijing Youan HospitalCapital Medical UniversityBeijingChina Infection Management The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina Chongqing Municipal Center for Disease Control and Prevention ChongqingChina Yunnan Provincial Center for Disease Control and Prevention KunmingChina Division of Infectious Disease Control and Prevention Zhejiang Provincial Center for Disease Control and PreventionHangzhouChina Guangdong Provincial Center for Disease Control and Prevention GuangzhouChina Division of Acute Infectious Disease Control and Prevention Hubei Provincial Center for Disease Control and PreventionW

Background:The Ebola virus disease spread rapidly in West Africa in 2014,leading to the loss of thousands of *** engagement was one of the key strategies to interrupt Ebola transmission,and practical community level measures needed to be explored in the field and tailored to the specific context of ***:First,community-level education on Ebola virus disease(EVD)prevention was launched for the community’s social mobilizers in six districts in Sierra Leone beginning in November ***,from January to May of 2015,in three pilot communities,local trained community members were organized to engage in implementation of EVD prevention and transmission interruption measures,by involving them in alert case report,contact tracing,and social *** epidemiological indicators of transmission interruption in three study communities were ***:A total of 6016 community social mobilizers from 185 wards were trained by holding 279 workshops in the six districts,and EVD message reached an estimated 631680 *** three pilot communities,72 EVD alert cases were reported,with 70.8%of them detected by trained local community members,and 14 EVD cases were finally *** tracing detected 64.3%of EVD *** median duration of community infectivity for the cases was 1 *** secondary attack rate was 4.2%,and no third generation of infection was *** health worker was infected,and no unsafe burial and noncompliance to EVD control measures were *** community-based measures were modeled to reduce 77 EVD cases,and the EVD-free goal was achieved four months earlier in study communities than whole country of Sierra ***: The community-based strategy of social mobilization and community engagement was effective in casedetection and reducing the extent of Ebola transmission in a country with weak health system. The successfullypractical experience to reduce the risk of Ebola transmission in the

关键词： Ebola virus disease Community engagement Health education Outbreak control

Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao Zhang xue-Qian wang Feng-Qi Zhang Xiao-Ya Cui Bing-Bing Fan jia-Ming Guo Zhi-Min Guo Rui Huang Wen Huang Xu-Bo Li Meng-Ru Li Yan Ma Zhi-Hua Shen Yong-Gang Sun De-Zhuang wang Fei-Yang wang Li-qiang wang Nan wang Tian-Li wang Wei wang Xiao-Yang wang Yi-Han wang Fu-jie Yu Yu-Zhen Yin Ling-Kun Zhang Yi Zhang jian-Yang Zhang Qi Zhao Yu-Ping Zhao Xin-Dong Zhu Yasir Sohail Ya-Nan chen Tao Feng Qi-Long Gao Hai-Yan He Yong-jiang Huang Zeng-Bao jiao Hua ji Yao jiang qiang Li Xiao-Ming Li Wei-Bing Liao Huai-Jun Lin Hui Liu Qi Liu Qing-Feng Liu Wei-Di Liu Xiong-Jun Liu Yang Lu Yi-Ping Lu Wen Ma xue-Fei Miao jie Pan Qing wang Hong-Hui wu Yuan wu Tao Yang Wei-Ming Yang Qian Yu jin-Yu Zhang Zhi-Gang chen Liang Mao Yang Ren Bao-Long Shen Xun-Li wang Zhe jia He Zhu Zhen-Duo wu Si Lan School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and EngineeringSoutheast UniversityNanjing 211189China Department of Physics City University of Hong KongHongKong 999077China School of Materials Science and Engineering Tianjin UniversityTianjin 300072China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China Department of Mechanical Engineering Research Institute for Advanced ManufacturingThe Hong Kong Polytechnic UniversityHong Kong 100872China Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Solidification Control and Digital Preparation Technology(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China Institute of Advanced Wear&Corrosion Resistance and Functional Materials Jinan UniversityGuangzhou 510632China School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou 221116China School of Physical Sciences Great Bay UniversityDongguan 523000China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon NeutralityUniversity of Science and Technology BeijingBeijing 100083China Department of Mechanical Engineering The University of Hong KongHong Kong 999077China School of Computing Macquarie UniversitySydney 2113Australia Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China State Key Laborato

Owing to their exceptional properties,high-entropy alloys(HEAs)and high-entropy materials have emerged as promising research areas and shown diverse ***,the recent advances in the field are comprehensively reviewed,organized into five *** first section introduces the background of HEAs,covering their definition,significance,application prospects,basic properties,design principles,and *** subsequent section focuses on cutting-edge high-entropy structural materials,highlighting developments such as nanostructured alloys,grain boundary engineering,eutectic systems,cryogenic alloys,thin films,micro-nano-lattice structures,additive manufacturing,high entropy metallic glasses,nano-precipitate strengthened alloys,composition modulation,alloy fibers,and refractory *** the following section,the emphasis shifts to functional materials,exploring HEAs as catalysts,magneto-caloric materials,corrosion-resistant alloys,radiation-resistant alloys,hydrogen storage systems,and materials for ***,the review encompasses functional high-entropy materials outside the realm of alloys,including thermoelectric,quantum dots,nanooxide catalysts,energy storage materials,negative thermal expansion ceramics,and high-entropy wave absorption *** paper concludes with an outlook,discussing future directions and potential growth areas in the *** this comprehensive review,researchers,engineers,and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： High entropy alloys Cutting-edge structural materials Cutting-edgefunctional materials